CN109568402A - A kind of preparation method of white peony root dispensing granule - Google Patents
A kind of preparation method of white peony root dispensing granule Download PDFInfo
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- CN109568402A CN109568402A CN201810119004.XA CN201810119004A CN109568402A CN 109568402 A CN109568402 A CN 109568402A CN 201810119004 A CN201810119004 A CN 201810119004A CN 109568402 A CN109568402 A CN 109568402A
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- 244000236658 Paeonia lactiflora Species 0.000 title claims abstract description 43
- 235000008598 Paeonia lactiflora Nutrition 0.000 title claims abstract description 42
- 239000008187 granular material Substances 0.000 title claims abstract description 37
- 238000002360 preparation method Methods 0.000 title claims abstract description 21
- VYQNWZOUAUKGHI-UHFFFAOYSA-N monobenzone Chemical compound C1=CC(O)=CC=C1OCC1=CC=CC=C1 VYQNWZOUAUKGHI-UHFFFAOYSA-N 0.000 claims abstract description 45
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 27
- 239000000284 extract Substances 0.000 claims abstract description 20
- 230000002441 reversible effect Effects 0.000 claims abstract description 13
- 238000011084 recovery Methods 0.000 claims abstract description 10
- 239000003153 chemical reaction reagent Substances 0.000 claims abstract description 8
- 239000006071 cream Substances 0.000 claims abstract description 8
- 230000006837 decompression Effects 0.000 claims abstract description 8
- 238000007908 dry granulation Methods 0.000 claims abstract description 8
- 239000000706 filtrate Substances 0.000 claims abstract description 8
- 239000012535 impurity Substances 0.000 claims abstract description 8
- 241000196324 Embryophyta Species 0.000 claims abstract description 6
- 239000012530 fluid Substances 0.000 claims description 10
- 238000001914 filtration Methods 0.000 claims description 7
- 238000005119 centrifugation Methods 0.000 claims description 6
- 230000036961 partial effect Effects 0.000 claims description 5
- 238000004064 recycling Methods 0.000 claims description 5
- 238000009736 wetting Methods 0.000 claims description 2
- 238000005507 spraying Methods 0.000 claims 1
- 238000000605 extraction Methods 0.000 abstract description 41
- 239000002904 solvent Substances 0.000 abstract description 13
- 239000000047 product Substances 0.000 abstract description 4
- 230000002829 reductive effect Effects 0.000 abstract description 3
- 239000003814 drug Substances 0.000 description 15
- 238000000034 method Methods 0.000 description 7
- 229940079593 drug Drugs 0.000 description 6
- 239000004615 ingredient Substances 0.000 description 6
- 238000001694 spray drying Methods 0.000 description 6
- YKRGDOXKVOZESV-WRJNSLSBSA-N Paeoniflorin Chemical compound C([C@]12[C@H]3O[C@]4(O)C[C@](O3)([C@]1(C[C@@H]42)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)C)OC(=O)C1=CC=CC=C1 YKRGDOXKVOZESV-WRJNSLSBSA-N 0.000 description 5
- YKRGDOXKVOZESV-UHFFFAOYSA-N paeoniflorin Natural products O1C(C)(C2(CC34)OC5C(C(O)C(O)C(CO)O5)O)CC3(O)OC1C24COC(=O)C1=CC=CC=C1 YKRGDOXKVOZESV-UHFFFAOYSA-N 0.000 description 5
- 230000000052 comparative effect Effects 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- 239000002245 particle Substances 0.000 description 4
- 208000002193 Pain Diseases 0.000 description 3
- 235000006484 Paeonia officinalis Nutrition 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 238000000354 decomposition reaction Methods 0.000 description 2
- 230000007812 deficiency Effects 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000005265 energy consumption Methods 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 210000004185 liver Anatomy 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 238000009333 weeding Methods 0.000 description 2
- 208000004998 Abdominal Pain Diseases 0.000 description 1
- 206010019233 Headaches Diseases 0.000 description 1
- 208000037093 Menstruation Disturbances Diseases 0.000 description 1
- 206010027339 Menstruation irregular Diseases 0.000 description 1
- 241000736199 Paeonia Species 0.000 description 1
- 241001106477 Paeoniaceae Species 0.000 description 1
- 241000218201 Ranunculaceae Species 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 230000001914 calming effect Effects 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 208000035850 clinical syndrome Diseases 0.000 description 1
- 230000008602 contraction Effects 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 208000002173 dizziness Diseases 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 229930182470 glycoside Natural products 0.000 description 1
- 150000002338 glycosides Chemical class 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- 231100000869 headache Toxicity 0.000 description 1
- 208000006278 hypochromic anemia Diseases 0.000 description 1
- 230000005906 menstruation Effects 0.000 description 1
- 230000036565 night sweats Effects 0.000 description 1
- 206010029410 night sweats Diseases 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 230000003068 static effect Effects 0.000 description 1
- 230000035900 sweating Effects 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
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- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
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Abstract
The invention discloses a kind of preparation method of white peony root dispensing granule, comprising steps of a, white Peony Root selected, shaking weeds out except impurity, be crushed；B, broken radix paeoniae alba decoction pieces are inputted in continuous dynamic countercurrent extractor, it is reverse that the 11-14 times of hot water measured progress continuous dynamic countercurrent extraction 1.5-2.5h is added, extracting solution is collected, the Radix Paeoniae Alba dregs of a decoction are discharged；C, extracting solution filters, and relative density is the clear cream of 1.05-1.09 when filtrate decompression is condensed into 65 DEG C；D, qinghuo reagent is spray-dried, and obtains dry extract, and dry extract dry granulation obtains white peony root dispensing granule.The present invention uses continuous dynamic countercurrent extraction process, radix paeoniae alba decoction pieces are inversely contacted with Extraction solvent, entire extraction process concentration gradient can remain at higher level, compared with traditional conventional can extraction process, not only the consumption of solvent is few, but also greatly improves the recovery rate of effective component of paeonia lactiflora, ensure that product quality, entreprise cost is reduced, industrial competition is improved.
Description
Technical field
The invention belongs to Chinese medicinal granule technical fields, and in particular to a kind of preparation method of white peony root dispensing granule.
Background technique
Radix Paeoniae Alba is ranunculaceae plant Chinese herbaceous peony Paeonia lactifloraPall. dry root.Bitter, acid, it is slightly cold；Return
Liver, the spleen channel have calming the liver and relieving pain, the effect of nourishing blood for regulating menstruation, astringing YIN to stop sweating, are used for headache and dizziness, hypochondriac pain, abdominal pain, four limbs contraction pain,
Blood deficiency chlorosis, irregular menstruation, spontaneous perspiration, night sweat.
Chinese medicinal granule is to meet the traditional Chinese medicine medicine materical crude slice of concocted specification as raw material, extract, be concentrated through modern industry,
Dry, granulation, refined pure Chinese medicine series of products, as the new alternative prepared slices of Chinese crude drugs of medicine materical crude slice form for clinical syndrome differentiation opinion
It controls, added and subtracted with card, formula uses.Chinese medicinal granule realized in clinical use medication " highly effective and safe, it is stably and controllable,
It is convenient and healthy ".Since Chinese medicinal granule has small dosage form, good effect, quick, takes, carries, stores the features such as facilitating,
Adapt to very much the needs that modern society includes demand and fast pace life of the international community to natural drug.
Chinese medicinal granule industrialization at present is extracted mainly using the static decocting method extracted, most of traditional Chinese medicine extraction
The industrialization extraction process of object is all two pan-fried techniques, exist decoct temperature is high, decocting time is long, production efficiency is low, energy consumption at
The defects of this is big, loss of effective components is more.
Continuous dynamic countercurrent extraction is novel extraction process in recent years, it collects extraction, weight diacolation, dynamic and adverse current skill
What art was integrated has many advantages, such as that simple process, saving solvent, low energy consumption, extraction time is short, extraction efficiency is high.Currently, not yet
See the report that white peony root dispensing granule is prepared using continuous dynamic countercurrent extraction process.
Summary of the invention
In order to overcome the above-mentioned deficiencies of the prior art, the purpose of the present invention is to provide a kind of preparations of white peony root dispensing granule
Method, this method are extracted using continuous dynamic countercurrent, greatly improve the recovery rate of white peony root dispensing granule, ensure that product matter
Amount.
The present invention is achieved through the following technical solutions；
A kind of preparation method of white peony root dispensing granule, includes the following steps:
A, white Peony Root is selected, shaking weeds out except impurity, be crushed；
B, broken radix paeoniae alba decoction pieces are inputted in continuous dynamic countercurrent extractor, it is reverse that the 11-14 times of hot water measured progress is added
Continuous Countercurrent Extraction 1.5-2.5h collects extracting solution, and the Radix Paeoniae Alba dregs of a decoction are discharged；
C, extracting solution filters, and relative density is the clear cream of 1.05-1.09 when filtrate decompression is condensed into 65 DEG C；
D, qinghuo reagent is spray-dried, and obtains dry extract, and dry extract dry granulation obtains white peony root dispensing granule.
The present invention carries out the extraction process of Radix Paeoniae Alba using continuous dynamic countercurrent extractor, in continuous dynamic countercurrent extractor
Feed inlet input radix paeoniae alba decoction pieces enter extraction tube, and mobile to the slag-drip opening of continuous dynamic countercurrent extractor in extraction tube.?
The deslagging end of continuous dynamic countercurrent extractor is added Extraction solvent and enters extraction tube, and relative to continuous dynamic inverse in extraction tube
The leakage fluid dram of stream extractor inversely moves.In extraction tube, the flow direction of Radix Paeoniae Alba and Extraction solvent is on the contrary, making Radix Paeoniae Alba and extracting
Solvent comes into full contact with, and concentration gradient can remain at higher level, so that biggish mass transfer force is formed, it can be very big
Raising effective component recovery rate.
Whether the size of the broken partial size of radix paeoniae alba decoction pieces will affect effective component and can be fully dissolved out and extraction process object
Whether material movement is smooth, is unfavorable for solute if radix paeoniae alba decoction pieces partial size is excessive and quickly transmits into solvent, while existing to material
Smooth retard motion in Continuous Countercurrent Extraction, if radix paeoniae alba decoction pieces partial size is too small material be easy float, be unfavorable for effectively at
The abundant extraction divided, while subsequent shingle is filtered more difficult, it is preferred that in step a, the broken partial size is 0.2-
0.5cm。
Dry radix paeoniae alba decoction pieces are easy to appear in blanking process to get stuck, and the radix paeoniae alba decoction pieces after water soaks are easier blanking,
To guarantee Radix Paeoniae Alba can be made to come into full contact with Extraction solvent with the blanking of continuous and quantitative, while being conducive to effective component in material
Transfer is quickly extracted after blanking, it is preferred that in step b, after the 1-2 times of water measured wetting is first added in broken radix paeoniae alba decoction pieces
It is inputted in continuous dynamic countercurrent extractor again.
The present invention is to extract solvent with water, if the temperature of water is lower, may cause effective component and extracts not exclusively, if
The temperature of water is excessively high, and the heat-sensitive ingredients in radix paeoniae alba decoction pieces are easy loss, to extract effective component to greatest extent, preferably
, in step b, the temperature of the hot water is 75-85 DEG C.
Continuous dynamic countercurrent extractor of the invention is 10 section pipe of stage type, ensure that filling for effective component in radix paeoniae alba decoction pieces
Divide dissolution.
Preferably, in step b, the input speed of the broken radix paeoniae alba decoction pieces is 200-250kg/h, reverse that heat is added
The flow velocity of water is 1800-3250kg/h.The present invention is fed by continuous and quantitative, comes into full contact with radix paeoniae alba decoction pieces with Extraction solvent,
The extraction of equipment is easy to be added with certain flow velocity, constantly updates, so that radix paeoniae alba decoction pieces be made to locate always throughout the extraction process
It is poor in biggish concentration gradient, be conducive to being fully dissolved out for effective component, and then can greatly improve in radix paeoniae alba decoction pieces effectively at
The rate of transform divided.
For the recovery rate for further increasing effective component, it is preferred that in step b, by the Radix Paeoniae Alba dregs of a decoction through squeezing recovery section
It being then exhausted from after medical fluid, the part medical fluid of recycling merges with extracting solution, so as to further increase the rate of recovery of white paeony root extract,
Increase the rate of transform of effective component.
Contain heat-sensitive ingredients in radix paeoniae alba decoction pieces, in order to avoid heat-sensitive ingredients decomposition, further increases recovery rate, preferably
, it in step c, is refiltered after extracting solution is first cooled to 45-55 DEG C, to slow down the degradation of heat-sensitive ingredients.
Preferably, in step c, the filtering is filtered using centrifuge, and the revolving speed of centrifugation is 2000-3000r/min
For the decomposition for avoiding heat-sensitive ingredients, it is preferred that in step c, the temperature of the reduced pressure is 55-65 DEG C.
Preferably, in step d, the technological parameter of the spray drying are as follows: 175 DEG C ~ 185 DEG C of inlet air temperature of control, outlet air
85 DEG C ~ 95 DEG C of temperature.
Compared with prior art, the present invention having the following beneficial effects:
(1) present invention is to extract solvent with water, complies fully with what the prepared slices of Chinese crude drugs that traditional Chinese medicine theory is praised highly were used as medicine with decoction
Viewpoint, using continuous dynamic countercurrent extraction process, radix paeoniae alba decoction pieces are inversely contacted with Extraction solvent, entire extraction process concentration
Gradient can remain at higher level, and compared with traditional conventional can extraction process, not only the consumption of solvent is few, Er Qieji
The big recovery rate for improving effective component of paeonia lactiflora, ensure that product quality, reduces entreprise cost, improve industry competition
Power；
(2) present invention is according to the physicochemical properties of radix paeoniae alba decoction pieces, by process optimization, retain to greatest extent in raw material it is effective at
Point, it can be widely applied in mass production.
Specific embodiment
Further illustrate that the present invention, following embodiment are the specific embodiment party of the present invention below by specific embodiment
Formula, but embodiments of the present invention are not limited by following embodiments.
Embodiment 1:
A kind of preparation method of white peony root dispensing granule, includes the following steps:
A, white Peony Root is selected, shaking weeds out except impurity, be broken into 0.5cm particle；
B, 2 times of amount water of broken radix paeoniae alba decoction pieces are soaked, are inputted in the continuous dynamic countercurrent extractor of 10 section pipe of stage type,
Reverse 80 DEG C of hot water Continuous Countercurrent Extraction 2h that 11 times of amounts are added, collect extracting solution, by the Radix Paeoniae Alba dregs of a decoction through squeezing recoverer drug dispensing
It is then exhausted from after liquid, the part medical fluid of recycling merges with extracting solution；The input speed of the broken radix paeoniae alba decoction pieces is 220kg/
H, the reverse flow velocity that hot water is added are 2420kg/h；
C, centrifugal filtration after the extracting solution after merging is cooled to 50 DEG C, the revolving speed of centrifugation are 2500r/min, and filtered fluid is concentrated under reduced pressure
The clear cream for being 1.07 at relative density at 65 DEG C；
D, qinghuo reagent is spray-dried, and obtains dry extract, and dry extract dry granulation obtains white peony root dispensing granule；
The technological parameter of the spray drying are as follows: 175 DEG C ~ 185 DEG C of inlet air temperature, 85 DEG C ~ 95 DEG C of leaving air temp of control.
Embodiment 2:
A kind of preparation method of white peony root dispensing granule, includes the following steps:
A, white Peony Root is selected, shaking weeds out except impurity, be broken into 0.5cm particle；
B, 2 times of amount water of broken radix paeoniae alba decoction pieces are soaked, are inputted in the continuous dynamic countercurrent extractor of 10 section pipe of stage type,
Reverse 80 DEG C of hot water Continuous Countercurrent Extraction 2h that 11 times of amounts are added, collect extracting solution, by the Radix Paeoniae Alba dregs of a decoction through squeezing recoverer drug dispensing
It is then exhausted from after liquid, the part medical fluid of recycling merges with extracting solution；The input speed of the broken radix paeoniae alba decoction pieces is 220kg/
H, the reverse flow velocity that hot water is added are 2420kg/h；
C, the revolving speed of the extracting solution centrifugal filtration after merging, centrifugation is 2500r/min, and filtrate decompression is condensed into relatively close at 65 DEG C
The clear cream that degree is 1.07；
D, qinghuo reagent is spray-dried, and obtains dry extract, and dry extract dry granulation obtains white peony root dispensing granule；
The technological parameter of the spray drying are as follows: 175 DEG C ~ 185 DEG C of inlet air temperature, 85 DEG C ~ 95 DEG C of leaving air temp of control.
Embodiment 3:
A kind of preparation method of white peony root dispensing granule, includes the following steps:
A, white Peony Root is selected, shake the particle for weeding out and being broken into 0.5cm except impurity；
B, by the continuous dynamic countercurrent extractor of broken radix paeoniae alba decoction pieces input 10 section pipe of stage type, 13 times of reverse addition is measured
80 DEG C of hot water Continuous Countercurrent Extraction 2h, collect extracting solution, be discharged the Radix Paeoniae Alba dregs of a decoction；The input speed of the broken radix paeoniae alba decoction pieces
Degree is 220kg/h, and the reverse flow velocity that hot water is added is 2860kg/h；
C, the revolving speed of centrifugal filtration after extracting solution is cooled to 50 DEG C, centrifugation is 2500r/min, and filtrate decompression is condensed into 65 DEG C of phases
The clear cream for being 1.07 to density；
D, qinghuo reagent is spray-dried, and obtains dry extract, and dry extract dry granulation obtains white peony root dispensing granule；
The technological parameter of the spray drying are as follows: 175 DEG C ~ 185 DEG C of inlet air temperature, 85 DEG C ~ 95 DEG C of leaving air temp of control.
Embodiment 4:
A kind of preparation method of white peony root dispensing granule, includes the following steps:
A, white Peony Root is selected, shake the particle for weeding out and being broken into 0.4cm except impurity；
B, 1 times of amount water of broken radix paeoniae alba decoction pieces is soaked, is inputted in the continuous dynamic countercurrent extractor of 10 section pipe of stage type,
Reverse 75 DEG C of hot water Continuous Countercurrent Extraction 2.25h that 11 times of amounts are added, collect extracting solution, by the Radix Paeoniae Alba dregs of a decoction through squeezing recovery section
It is then exhausted from after medical fluid, the part medical fluid of recycling merges with extracting solution；The input speed of the broken radix paeoniae alba decoction pieces is
250kg/h, the reverse flow velocity that hot water is added are 2750kg/h；
C, the revolving speed of centrifugal filtration after the extracting solution after merging is cooled to 55 DEG C, centrifugation is 2650r/min, and filtrate decompression is condensed into
The clear cream that relative density is 1.08 at 65 DEG C；
D, qinghuo reagent is spray-dried, and obtains dry extract, and dry extract dry granulation obtains white peony root dispensing granule；
The technological parameter of the spray drying are as follows: 175 DEG C ~ 185 DEG C of inlet air temperature, 85 DEG C ~ 95 DEG C of leaving air temp of control.
Comparative example 1:
A kind of preparation method of white peony root dispensing granule, includes the following steps:
A, white Peony Root is selected, shaking weeds out except impurity；
B, radix paeoniae alba decoction pieces are added in Chinese medicine extracting tank, with water boiling and extraction 2 times, every time plus the water of 8 times of amounts, each 1.5h are closed
And filtrate, filtration；
C, the clear cream that relative density is 1.07 when filtrate decompression is condensed into 65 DEG C；
D, qinghuo reagent is spray-dried, and obtains dry extract, and dry extract dry granulation obtains white peony root dispensing granule；
The technological parameter of the spray drying are as follows: 175 DEG C ~ 185 DEG C of inlet air temperature, 85 DEG C ~ 95 DEG C of leaving air temp of control.
The white peony root dispensing granule that embodiment and comparative example is prepared tests its paste-forming rate, the content of Paeoniflorin and Chinese herbaceous peony
The rate of transform of medicine glycosides, the results are shown in Table 1:
1 embodiment of table is compared with comparative example extraction process
| Compare item | Embodiment 1 | Embodiment 2 | Embodiment 3 | Embodiment 4 | Comparative example 1 |
| Paste-forming rate % | 21.8 | 21.4 | 20.2 | 22.5 | 19.4 |
| Paeoniflorin content % | 8.33 | 7.56 | 7.61 | 8.45 | 6.48 |
| Paeoniflorin rate of transform % | 56.33 | 54.18 | 52.51 | 57.14 | 47.9 |
The present invention uses continuous dynamic countercurrent extraction process it can be seen from 1 result of table, not only molten compared with conventional can extraction process
The consumption of agent is few, and the rate of transform of paste-forming rate, Paeoniflorin significantly improves.Compared and can be seen by embodiment 1 and embodiment 2
Out, extracting solution cooling is handled, can be decomposed to avoid heat-sensitive ingredients, further improves the rate of transform of Paeoniflorin.
Claims (10)
1. a kind of preparation method of white peony root dispensing granule, which comprises the steps of:
A, white Peony Root is selected, shaking weeds out except impurity, be crushed；
B, broken radix paeoniae alba decoction pieces are inputted in continuous dynamic countercurrent extractor, it is reverse that the 11-14 times of hot water measured progress is added
Continuous dynamic countercurrent extracts 1.5-2.5h, collects extracting solution, and the Radix Paeoniae Alba dregs of a decoction are discharged；
C, extracting solution filters, and relative density is the clear cream of 1.05-1.09 when filtrate decompression is condensed into 65 DEG C；
D, qinghuo reagent is spray-dried, and obtains dry extract, and dry extract dry granulation obtains white peony root dispensing granule.
2. the preparation method of white peony root dispensing granule according to claim 1, which is characterized in that described broken in step a
Partial size is 0.2-0.5cm.
3. the preparation method of white peony root dispensing granule according to claim 1, which is characterized in that, will be broken in step b
Radix paeoniae alba decoction pieces input in continuous dynamic countercurrent extractor again after the 1-2 times of water measured wetting is first added.
4. the preparation method of white peony root dispensing granule according to claim 1, which is characterized in that in step b, the hot water
Temperature is 75-85 DEG C；The continuous dynamic countercurrent extractor is 10 section pipe of stage type.
5. the preparation method of white peony root dispensing granule according to claim 1, which is characterized in that in step b, by the Radix Paeoniae Alba dregs of a decoction
It is then exhausted from after squeezing recovery section medical fluid, the part medical fluid of recycling merges with extracting solution.
6. the preparation method of white peony root dispensing granule according to claim 1, which is characterized in that in step b, it is described it is broken after
The input speeds of radix paeoniae alba decoction pieces be 200-250kg/h, the reverse flow velocity that hot water is added is 1800-3250kg/h.
7. the preparation method of white peony root dispensing granule according to claim 1, which is characterized in that in step c, first by extracting solution
It is refiltered after being cooled to 45-55 DEG C.
8. the preparation method of white peony root dispensing granule according to claim 1, which is characterized in that in step c, the filtering is
It is filtered using centrifuge, the revolving speed of centrifugation is 2000-3000r/min.
9. the preparation method of white peony root dispensing granule according to claim 1, which is characterized in that in step c, the decompression is dense
The temperature of contracting is 55-65 DEG C.
10. the preparation method of white peony root dispensing granule according to claim 1, which is characterized in that described spraying in step d
Dry technological parameter are as follows: 175 DEG C ~ 185 DEG C of inlet air temperature, 85 DEG C ~ 95 DEG C of leaving air temp of control.
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