CN101474278B - Processed fructus evodiae dispensing granule as well as preparation method and quality control method thereof - Google Patents
Processed fructus evodiae dispensing granule as well as preparation method and quality control method thereof Download PDFInfo
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- CN101474278B CN101474278B CN 200810184580 CN200810184580A CN101474278B CN 101474278 B CN101474278 B CN 101474278B CN 200810184580 CN200810184580 CN 200810184580 CN 200810184580 A CN200810184580 A CN 200810184580A CN 101474278 B CN101474278 B CN 101474278B
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Abstract
The invention discloses a prepared evodia rutaecarpa prescription granule, a preparation method and a quality control method thereof. The prescription granule takes prepared evodia rutaecarpa decoction pieces as the raw material and the evodia rutaecarpa prescription granule is prepared through the process flows such as twice water extraction, vaccum concentration, sponging drying, and the like; 1g of the prepared evodia rutaecarpa prescription granule is equal to 3-5g of crude drug; the quality of both prepared evodia rutaecarpa decoction pieces and prepared evodia rutaecarpa prescription granule are identified by infrared fingerprint spectra. The prepared evodia rutaecarpa prescription granule of the invention has complete and advanced production process, specific and controllable quality control standard, scientific, advanced and fast detecting method related to the quality standard and strong operability. A great number of experiments prove that the prepared soup of the prepared evodia rutaecarpa prescription granule of the invention and the mixed simmered liquid of the classical prescription decoction pieces containing the prepared evodia rutaecarpa have equal components,, thus realizing technique of the full ingredient prescription granule and proving the rationality of the technique of the invention; furthermore, the invention applies the infrared spectroscopy technology to the quality control of the traditional Chinese medicines, rapidly solving the primary problem in the macro quality control of the traditional Chinese medicines---the identification of the truth of the traditional Chinese medicines.
Description
Technical field
The present invention relates to a kind of Chinese medicinal granule and preparation method thereof and method of quality control, particularly a kind of Fructus Evodiae (processed) granule and preparation method thereof and method of quality control.
Background technology
Chinese medicinal granule is under Chinese medical theory instructs, and the prepared slices of Chinese crude drugs are formed through various processes, is used for the granule that clinical tcm prescription allotment is used; Compare with the traditional Chinese medicines decoct, its taking convenience, dose is little, and is quality controllable, and easy storing is easy to carry; Chinese medicinal granule is in the pilot production status at home at present, product technology and quality standard disunity.At present mostly Chinese medicinal granule is that traditional water extracts, and perhaps extracts water extraction behind the volatile oil, and different production unit causes the product quality of different manufacturers inconsistent because production equipment is different with production technology, and there is difference in drug effect.The specificity of its quality standard is limit by certain test conditions and scope, lacks other due quality informations of product, and present standard can't be judged the quality good or not and the overall picture of Chinese medicinal granule product comprehensively.
Infrared spectrometry is one of conventional means of differentiating chemical compound and definite structure of matter.In pharmaceutical analysis, " fingerprint " characteristic that has with infrared spectrum is the common method that adopts of various countries' pharmacopeia as the foundation of drug identification.But since Chinese crude drug, the prepared slices of Chinese crude drugs and Chinese patent medicine itself all be more than Western medicine complicated many mixture systems, the spectrum analysis difficulty makes conventional infrared spectrometry in the long term, fail its due effect of performance in Chinese medicine quality control and management.
Summary of the invention
The objective of the invention is to disclose a kind of Fructus Evodiae (processed) granule; The present invention also aims to disclose the method for preparing of this granule; The present invention also aims to disclose the method for quality control of this granule.
The present invention seeks to realize through following technical scheme:
The suitable crude drug amount of the every gram of Fructus Evodiae (processed) granule according to the invention 3-5 gram, the IR fingerprint spectra of this granule such as Fig. 1.The method for preparing of Fructus Evodiae (processed) granule according to the invention comprises: get the Fructus Evodiae (processed) decoction pieces, with twice of water extraction; Wherein the Fructus Evodiae (processed) decoction pieces adopts IR fingerprint spectra to carry out quality discrimination, Fructus Evodiae (processed) decoction pieces standard IR fingerprint spectra such as Fig. 2.
The method for preparing of Fructus Evodiae (processed) granule according to the invention comprises the steps: to get the Fructus Evodiae (processed) decoction pieces, adds the water of 5-15 times of weight portion, extracts 0.5-3 hour, promptly one fries in shallow oil; One fries in shallow oil the water that the back medicinal residues add 5-15 times of weight portion of Fructus Evodiae (processed) decoction pieces, extracts 0.5-3 hour, promptly two fries in shallow oil; Merge two liquid of boiling medicine, be evaporated to the concentrated solution of relative density 1.00-1.15; The concentrated solution spray drying gets the Fructus Evodiae (processed) spray drying powder; The Fructus Evodiae (processed) spray drying powder is directly granulated or in the Fructus Evodiae (processed) spray drying powder, is added adjuvant dextrin or the lactose dry granulation of himself weight portion 0-25%, 20-60 purpose Fructus Evodiae (processed) granule.
The preferred following steps of the method for preparing of Fructus Evodiae (processed) granule according to the invention: get the Fructus Evodiae (processed) decoction pieces, add the water of 8 times of weight portions, extracted 2 hours, promptly one fry in shallow oil; One fries in shallow oil the water that the back medicinal residues add 7 times of weight portions of Fructus Evodiae (processed) decoction pieces, extracts 1.5 hours, promptly two fries in shallow oil; Merge two liquid of boiling medicine, be evaporated to the concentrated solution of relative density 1.05-1.10; The concentrated solution spray drying gets the Fructus Evodiae (processed) spray drying powder; The Fructus Evodiae (processed) spray drying powder is directly granulated or in the Fructus Evodiae (processed) spray drying powder, is added adjuvant dextrin or the lactose dry granulation of himself weight portion 0-25%, 20-60 purpose Fructus Evodiae (processed) granule.
The preferred following steps of the method for preparing of Fructus Evodiae (processed) granule according to the invention: get the Fructus Evodiae (processed) decoction pieces, add the water of 10 times of weight portions, extracted 2 hours, promptly one fry in shallow oil; One fries in shallow oil the water that the back medicinal residues add 6 times of weight portions of Fructus Evodiae (processed) decoction pieces, extracts 1 hour, promptly two fries in shallow oil; Merge two liquid of boiling medicine, be evaporated to the concentrated solution of relative density 1.00-1.05; The concentrated solution spray drying gets the Fructus Evodiae (processed) spray drying powder; The Fructus Evodiae (processed) spray drying powder is directly granulated or in the Fructus Evodiae (processed) spray drying powder, is added adjuvant dextrin or the lactose dry granulation of himself weight portion 0-25%, 20-60 purpose Fructus Evodiae (processed) granule.
The preferred following steps of the method for preparing of Fructus Evodiae (processed) granule according to the invention: get the Fructus Evodiae (processed) decoction pieces, add the water of 14 times of weight portions, extracted 2.5 hours, promptly one fry in shallow oil; One fries in shallow oil the water that the back medicinal residues add 11 times of weight portions of Fructus Evodiae (processed) decoction pieces, extracts 2.5 hours, promptly two fries in shallow oil; Merge two liquid of boiling medicine, be evaporated to the concentrated solution of relative density 1.10-1.15; The concentrated solution spray drying gets the Fructus Evodiae (processed) spray drying powder; The Fructus Evodiae (processed) spray drying powder is directly granulated or in the Fructus Evodiae (processed) spray drying powder, is added adjuvant dextrin or the lactose dry granulation of himself weight portion 0-25%, 20-60 purpose Fructus Evodiae (processed) granule.
The drying process with atomizing parameter is in the above-mentioned method for preparing: 40 ℃-50 ℃ of medicinal liquid preheat temperatures; 170 ℃-185 ℃ of EATs; 450-700 rev/min of material revolution speed; 70 ℃-85 ℃ of leaving air temps; Wind send 40 ℃-50 ℃ of temperature.
The granulation parameter is in the above-mentioned method for preparing: main pinch roller pressure: 4-6MPa; Side pressure wheel pressure: 0.4-0.6MPa; The speed of mainshaft: 300-500 rev/min; Feed voltage: 100-150V; Granular size: 20-60 order.
The method of quality control of Fructus Evodiae (processed) granule according to the invention comprises the steps: that the Fructus Evodiae (processed) granule adopts IR fingerprint spectra to carry out quality discrimination; The IR fingerprint spectra discrimination method is: use FTIS, measurement range is 4000cm
-1-400cm
-1, DTGS detector, resolution 4cm
-1, scanning times 16 times is deducted water and carbon dioxide constantly and is disturbed in the scanning process, and envionmental humidity is lower than 60%, and the potassium bromide direct compression process detects; Fructus Evodiae (processed) granule IR fingerprint spectra has following characteristic: at 1609cm shown in accompanying drawing 1
-1There is maximum absorption band at the place; At 2929cm
-1, 1404cm
-1, 1284cm
-1, 1074cm
-1, 817cm
-1There is characteristic absorption at the place.
The method of quality control of the Fructus Evodiae (processed) decoction pieces described in the Fructus Evodiae (processed) granule method for preparing of the present invention comprises the steps: that the Fructus Evodiae (processed) decoction pieces is the certified products that meet a regulation of Pharmacopoeia of the People's Republic of China version in 2005; The Fructus Evodiae (processed) decoction pieces adopts IR fingerprint spectra to carry out quality discrimination, and the IR fingerprint spectra discrimination method is: use FTIS, measurement range is 4000cm
-1-400cm
-1, DTGS detector, resolution 4cm
-1, scanning times 16 times is deducted water and carbon dioxide constantly and is disturbed in the scanning process, and envionmental humidity is lower than 60%, and the potassium bromide direct compression process detects; The IR fingerprint spectra of Fructus Evodiae (processed) decoction pieces has following characteristic: at 1614cm shown in accompanying drawing 2
-1, 1444cm
-1, 1262cm
-1, 1063cm
-1There is obvious absorption at the place, and 1614cm
-1, 1063cm
-1Two absorption peak strength in the middle of the absorption peak strength at place obviously is better than; At 2922cm
-1, 763cm
-1There is characteristic absorption at the place.
IR fingerprint spectra wherein of the present invention can be to reach the IR fingerprint spectra more than 90% with its dependency.
Description of drawings:
Fig. 1: the IR fingerprint spectra of Fructus Evodiae (processed) granule;
Fig. 2: the IR fingerprint spectra of Fructus Evodiae (processed) decoction pieces Fructus Evodiae;
Fig. 3: Fructus Evodiae (processed) granule and Fructus Evodiae (processed) decoction pieces thin layer chromatography are relatively;
Fig. 4: Fructus Evodiae (processed) granule and Fructus Evodiae (processed) decoction pieces thin-layer sample IR fingerprint spectra are relatively;
Fig. 5: contain the classical medicine of Fructus Evodiae (processed) decoction pieces decocting liquid and Fructus Evodiae (processed) soup that granule is joined " whole part " infrared spectrogram are compared.
Fructus Evodiae (processed) granule of the present invention has complete, advanced production technology and strong, the controlled quality control standard of specificity, and technology advanced person can realize, the detection method science that quality standard relates to, advanced person, quick, workable.Through a large amount of experiments; Contrasted the classical medicine that contains the Fructus Evodiae (processed) decoction pieces decoction pieces has been closed decocting liquid and Fructus Evodiae (processed) soup that granule is joined of the present invention " whole part " infrared spectrogram; Fructus Evodiae (processed) granule of the present invention and Fructus Evodiae (processed) decoction pieces thin-layer chromatogram have been contrasted; Fructus Evodiae (processed) granule and Fructus Evodiae (processed) decoction pieces thin-layer sample IR fingerprint spectra have been contrasted; The result shows that the classical medicine that contains the Fructus Evodiae (processed) decoction pieces closes decocting liquid to decoction pieces and Fructus Evodiae (processed) granule of the present invention is joined soup IR fingerprint spectra peak shape, peak position, relative peak intensity basically identical; It is suitable to be that Fructus Evodiae (processed) soup that granule is joined of the present invention and decoction pieces close the decocting liquid composition; And the IR fingerprint spectra peak shape of Fructus Evodiae (processed) granule of the present invention and decoction pieces thin-layer sample, peak position, peak intensity basically identical, so Fructus Evodiae (processed) granule of the present invention relatively realized the technology of whole part granule, proves the reasonability of technology of the present invention; And the present invention is applied to infrared spectrum technology the quality control of Chinese medicine; This is the innovation on a kind of thinking, and this not only meets the theory of Chinese medicine about " monarch, minister, help, make ", has also given prominence to the group effect of Chinese medicine; Simultaneously complicated problems is oversimplified; Make certain Chinese medicine as a whole, observe its " fingerprint property ", thereby solved a matter of utmost importance--the evaluation of-Chinese medicine true and false in the control of Chinese medicine macroscopic quality apace.
Following experimental example and embodiment are used to further specify but are not limited to the present invention.
Experimental example 1
(1) Fructus Evodiae (processed) granule and Fructus Evodiae (processed) decoction pieces thin layer chromatography are relatively
Differentiate a thin layer chromatography test down according to middle Fructus Evodiae of Pharmacopoeia of the People's Republic of China version in 2005; Prepare sample with Fructus Evodiae (processed) decoction pieces and Fructus Evodiae (processed) granule of the present invention; Measure, the gained result is shown in accompanying drawing 3, in the Fructus Evodiae (processed) granule chromatograph; With the corresponding position of Fructus Evodiae (processed) decoction pieces chromatograph on, show the speckle of same color.
(2) Fructus Evodiae (processed) granule and Fructus Evodiae (processed) decoction pieces thin-layer sample IR fingerprint spectra are relatively
Measure the Fructus Evodiae (processed) decoction pieces of preparation in (1) and the thin-layer sample of Fructus Evodiae (processed) granule with FTIS; Its result shown in accompanying drawing 4, the thin-layer sample IR fingerprint spectra peak shape of Fructus Evodiae (processed) granule and Fructus Evodiae (processed) decoction pieces, peak position, peak intensity basically identical relatively.
The result proves that Fructus Evodiae (processed) granule of the present invention is consistent with Fructus Evodiae (processed) decoction pieces composition, and technology of the present invention is rational.
Experimental example 2 contains the classical medicine of Fructus Evodiae (processed) to decoction pieces decocting liquid and Fructus Evodiae (processed) soup that granule is joined " whole part " infrared spectrogram comparative experiments
Rhizoma Coptidis-Fructus Evodiae (processed) medicine is to coming from " danxi's experiential therapy ".
1, experiment purpose: research Rhizoma Coptidis-Fructus Evodiae (processed) medicine is confirmed Fructus Evodiae (processed) granule technology and normal reasonability to the similarities and differences that decoction pieces closes decocting liquid and granular recipe.
2, experimental technique: by Rhizoma Coptidis-Fructus Evodiae (processed) medicine the prescription proportioning is got 2 flavour of a drug prescriptions such as Fructus Evodiae (processed), the decocting method of pressing the decoction pieces decoction decocts preparation decoction pieces decocting liquid sample; By Rhizoma Coptidis-Fructus Evodiae (processed) medicine the prescription proportioning is got the Rhizoma Coptidis decoction pieces in addition; The decocting method of pressing the decoction pieces decoction decocts; Medicinal liquid suitably concentrates; By Rhizoma Coptidis-Fructus Evodiae (processed) medicine prescription proportioning and equivalent relation are got in the Fructus Evodiae (processed) granule adding concentrated medicament, be stirred to dissolving fully, preparation granular recipe sample; Drinking sheet decocting liquid sample, granular recipe sample respectively carries out infrared spectrum and detects.
3, testing conditions: instrument is a FTIS, and measurement range is 4000cm
-1-400cm
-1, DTGS detector, resolution 4cm
-1, scanning times 16 times is deducted water and carbon dioxide constantly and is disturbed in the scanning process, and envionmental humidity is lower than 60%, and the potassium bromide direct compression process detects.
4, testing result: decoction pieces decocting liquid sample and granular recipe sample IR fingerprint spectra peak shape, peak position, relative peak intensity basically identical shown in accompanying drawing 5, dependency reaches 97.44%.It is consistent to prove that Fructus Evodiae (processed) soup that granule is joined of the present invention and decoction pieces close the decocting liquid composition; It is consistent with a Fructus Evodiae (processed) decoction pieces fried composition promptly to add Fructus Evodiae (processed) granule of the present invention, and equivalent and production technology that Fructus Evodiae (processed) granule 1g of the present invention is equivalent to Fructus Evodiae (processed) decoction pieces 3-5g are rational.
Following embodiment all can realize the effect of above-mentioned experimental example, and required Fructus Evodiae (processed) decoction pieces adopts IR fingerprint spectra to carry out quality discrimination among the following embodiment, meets the standard IR fingerprint spectra of the Fructus Evodiae (processed) decoction pieces in the technique scheme; The Fructus Evodiae (processed) granule that following embodiment makes adopts IR fingerprint spectra to carry out quality discrimination, meets the IR fingerprint spectra of the Fructus Evodiae (processed) granule in the technique scheme; The every gram of Fructus Evodiae (processed) granule described in the following embodiment contains suitable crude drug amount 3-5 gram.
The specific embodiment
Embodiment 1: the Fructus Evodiae (processed) granule
Get Fructus Evodiae (processed) decoction pieces 100kg, add the water of 800kg, extracted 2 hours, promptly one fry in shallow oil; One fries in shallow oil the back medicinal residues adds 800kg water, extracts 1.5 hours, promptly two fries in shallow oil; Merge two liquid of boiling medicine, be evaporated to relative density 1.05-1.10; Concentrated solution is 45 ℃ of preheatings, and 180 ℃ of EATs, 550 rev/mins of material revolution speeds, 80 ℃ of leaving air temps, wind send spray drying under the condition of 45 ℃ of temperature, the Fructus Evodiae (processed) spray drying powder; The adjuvant dextrin that in the Fructus Evodiae (processed) spray drying powder, adds himself weight portion 0-5%; The Fructus Evodiae (processed) spray drying powder is 5MPa at main pinch roller pressure; Side pressure wheel pressure is 0.5MPa, and the speed of mainshaft is 400 rev/mins, and feed voltage is a dry granulation under the condition of 120V; Get 20-60 purpose Fructus Evodiae (processed) granule, suitable crude drug amount 5 grams of the every gram of Fructus Evodiae (processed) granule.
Embodiment 2: the Fructus Evodiae (processed) granule
Get Fructus Evodiae (processed) decoction pieces 100kg, add the water of 1000kg, extracted 2 hours, promptly one fry in shallow oil; One fries in shallow oil the back medicinal residues adds 600kg water, extracts 1 hour, promptly two fries in shallow oil; Merge two liquid of boiling medicine, be evaporated to relative density 1.00-1.05; Concentrated solution is 50 ℃ of preheatings, and 170 ℃ of EATs, 600 rev/mins of material revolution speeds, 75 ℃ of leaving air temps, wind send spray drying under the condition of 50 ℃ of temperature, the Fructus Evodiae (processed) spray drying powder; The adjuvant dextrin that in the Fructus Evodiae (processed) spray drying powder, adds himself weight portion 5-15%; At main pinch roller pressure is 6MPa, and side pressure wheel pressure is 0.4MPa, and the speed of mainshaft is 450 rev/mins, and feed voltage is a dry granulation under the condition of 110V, 20-60 purpose Fructus Evodiae (processed) granule, suitable crude drug amount 4 grams of the every gram of Fructus Evodiae (processed) granule;
The method of quality control of wherein said Fructus Evodiae (processed) decoction pieces comprises the steps: that the Fructus Evodiae (processed) decoction pieces adopts IR fingerprint spectra to carry out quality discrimination, and the IR fingerprint spectra discrimination method is: use FTIS, measurement range is 4000cm
-1-400cm
-1, DTGS detector, resolution 4cm
-1, scanning times 16 times is deducted water and carbon dioxide constantly and is disturbed in the scanning process, and envionmental humidity is lower than 60%, and the potassium bromide direct compression process detects; The IR fingerprint spectra of Fructus Evodiae (processed) decoction pieces has following characteristic: at 1614cm shown in accompanying drawing 2
-1, 1444cm
-1, 1262cm
-1, 1063cm
-1There is obvious absorption at the place, and 1614cm
-1, 1063cm
-1Two absorption peak strength in the middle of the absorption peak strength at place obviously is better than; At 2922cm
-1, 763cm
-1There is characteristic absorption at the place.
Embodiment 3: the Fructus Evodiae (processed) granule
Get Fructus Evodiae (processed) decoction pieces 100kg, add the water of 1400kg, extracted 2.5 hours, promptly one fry in shallow oil; One fries in shallow oil the back medicinal residues adds 1100kg water, extracts 2.5 hours, promptly two fries in shallow oil; Merge two liquid of boiling medicine, be evaporated to relative density 1.10-1.15; Concentrated solution is 45 ℃ of preheatings, and 170 ℃ of EATs, 600 rev/mins of material revolution speeds, 75 ℃ of leaving air temps, wind send spray drying under the condition of 50 ℃ of temperature, the Fructus Evodiae (processed) spray drying powder; The lactose that in the Fructus Evodiae (processed) spray drying powder, adds himself weight portion 15-25%; At main pinch roller pressure is 4MPa, and side pressure wheel pressure is 0.4MPa, and the speed of mainshaft is 500 rev/mins, and feed voltage is a dry granulation under the condition of 130V, 20-60 purpose Fructus Evodiae (processed) granule, suitable crude drug amount 3 grams of the every gram of Fructus Evodiae (processed) granule;
The method of quality control of gained Fructus Evodiae (processed) granule comprises the steps: to adopt IR fingerprint spectra to carry out quality discrimination, and the IR fingerprint spectra discrimination method is: use FTIS, measurement range is 4000cm
-1-400cm
-1, DTGS detector, resolution 4cm
-1, scanning times 16 times is deducted water and carbon dioxide constantly and is disturbed in the scanning process, and envionmental humidity is lower than 60%, and the potassium bromide direct compression process detects; Fructus Evodiae (processed) granule IR fingerprint spectra has following characteristic: at 1609cm shown in accompanying drawing 1
-1There is maximum absorption band at the place; At 2929cm
-1, 1404cm
-1, 1284cm
-1, 1074cm
-1, 817cm
-1There is characteristic absorption at the place.
Claims (1)
1. the quality determining method of a Fructus Evodiae (processed) granule is characterized in that this method comprises the steps:
Adopt IR fingerprint spectra to carry out quality discrimination, the IR fingerprint spectra discrimination method is: use FTIS, measurement range is 4000cm
-1-400cm
-1, DTGS detector, resolution 4cm
-1, scanning times 16 times is deducted water and carbon dioxide constantly and is disturbed in the scanning process, and envionmental humidity is lower than 60%, and the potassium bromide direct compression process detects; Fructus Evodiae (processed) granule IR fingerprint spectra has following characteristic: at 1609cm shown in accompanying drawing 1
-1There is maximum absorption band at the place; At 2929cm
-1, 1404cm
-1, 1284cm
-1, 1074cm
-1, 817cm
-1There is characteristic absorption at the place;
Suitable crude drug amount 3 grams of the every gram of wherein said Fructus Evodiae (processed) granule;
Wherein said Fructus Evodiae (processed) granule method for preparing is: get Fructus Evodiae (processed) decoction pieces 100kg, add the water of 1400kg, extracted 2.5 hours, promptly one fry in shallow oil; One fries in shallow oil the back medicinal residues adds 1100kg water, extracts 2.5 hours, promptly two fries in shallow oil; Merge two liquid of boiling medicine, be evaporated to relative density 1.10-1.15; Concentrated solution is 45 ℃ of preheatings, and 170 ℃ of EATs, 600 rev/mins of material revolution speeds, 75 ℃ of leaving air temps, wind send spray drying under the condition of 50 ℃ of temperature, the Fructus Evodiae (processed) spray drying powder; The lactose that in the Fructus Evodiae (processed) spray drying powder, adds himself weight portion 15-25%; At main pinch roller pressure is 4MPa, and side pressure wheel pressure is 0.4MPa, and the speed of mainshaft is 500 rev/mins, and feed voltage is a dry granulation under the condition of 130V, 20-60 purpose Fructus Evodiae (processed) granule.
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|---|---|---|---|
| CN 200810184580 CN101474278B (en) | 2007-12-18 | 2008-12-17 | Processed fructus evodiae dispensing granule as well as preparation method and quality control method thereof |
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| CN200710179748 | 2007-12-18 | ||
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| CN 200810184580 CN101474278B (en) | 2007-12-18 | 2008-12-17 | Processed fructus evodiae dispensing granule as well as preparation method and quality control method thereof |
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| CN101474278B true CN101474278B (en) | 2012-07-25 |
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| CN 200810184576 Active CN101474287B (en) | 2007-12-18 | 2008-12-17 | Detection method of prepared rehmannia root dispensing granule |
| CN 200810184572 Active CN101474221B (en) | 2007-12-18 | 2008-12-17 | Detection method of glehnia root dispensing granule |
| CN 200810184566 Active CN101474219B (en) | 2007-12-18 | 2008-12-17 | Detection method of achyranthes bidentata dispensing granule |
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| CN 200810184580 Active CN101474278B (en) | 2007-12-18 | 2008-12-17 | Processed fructus evodiae dispensing granule as well as preparation method and quality control method thereof |
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| CN 200810184576 Active CN101474287B (en) | 2007-12-18 | 2008-12-17 | Detection method of prepared rehmannia root dispensing granule |
| CN 200810184572 Active CN101474221B (en) | 2007-12-18 | 2008-12-17 | Detection method of glehnia root dispensing granule |
| CN 200810184566 Active CN101474219B (en) | 2007-12-18 | 2008-12-17 | Detection method of achyranthes bidentata dispensing granule |
| CN 200810184571 Active CN101474241B (en) | 2007-12-18 | 2008-12-17 | Detection method of astragalus dispensing granule |
| CN 200810184578 Active CN101474229B (en) | 2007-12-18 | 2008-12-17 | Oriental wormwood dispensing granule as well as preparation method and quality control method |
| CN 200810184575 Active CN101480420B (en) | 2007-12-18 | 2008-12-17 | Detection method of ballonflower dispensing granule |
| CN 200810184579 Pending CN101474318A (en) | 2007-12-18 | 2008-12-17 | Rhizoma alismatis dispensing granule as well as preparation method and quality control method thereof |
| CN 200810184574 Active CN101474263B (en) | 2007-12-18 | 2008-12-17 | White peony root dispensing granule as well as preparation method and quality control method thereof |
| CN 200810184573 Active CN101474293B (en) | 2007-12-18 | 2008-12-17 | Medlar dispensing granule as well as preparation method and quality control method thereof |
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| CN 200810184581 Active CN101474273B (en) | 2007-12-18 | 2008-12-17 | Stir-fried fructus gardenia dispensing granule as well as preparation method and quality control method thereof |
| CN 200810184577 Active CN101474228B (en) | 2007-12-18 | 2008-12-17 | Detection method of wild chrysanthemum dispensing granule |
| CN 200810184583 Pending CN101474244A (en) | 2007-12-18 | 2008-12-17 | Honey-fried licorice root dispensing granule as well as preparation method and quality control method |
| CN 200810184569 Active CN101474237B (en) | 2007-12-18 | 2008-12-17 | Detection method of trichosanthes dispensing granule |
| CN 200810184562 Active CN101474223B (en) | 2007-12-18 | 2008-12-17 | Chinese angelica root dispensing granule as well as preparation method and quality control method |
| CN 200810184561 Active CN101474225B (en) | 2007-12-18 | 2008-12-17 | Ledebouriella root granule as well as preparation method and quality control method |
| CN 200810184565 Pending CN101474352A (en) | 2007-12-18 | 2008-12-17 | Ophiopogon root dispensing granule as well as preparation method and quality control method thereof |
| CN 200810184564 Pending CN101474333A (en) | 2007-12-18 | 2008-12-17 | Yam dispensing granule as well as preparation method and quality control method thereof |
| CN 200810184582 Active CN101474265B (en) | 2007-12-18 | 2008-12-17 | Coptis root dispensing granule as well as preparation method and quality control method thereof |
| CN 200810184559 Active CN101518577B (en) | 2007-12-18 | 2008-12-17 | Fried bitter almond formula granules as well as preparation method and quality control method thereof |
| CN 200810184568 Active CN101474232B (en) | 2007-12-18 | 2008-12-17 | White atractylodes rhizome dispensing granule as well as preparation method and quality control method |
| CN 200810184570 Active CN101474290B (en) | 2007-12-18 | 2008-12-17 | Detection method of figwort root dispensing granule |
| CN 200810184563 Active CN101474253B (en) | 2007-12-18 | 2008-12-17 | Detection method of cassia twig dispensing granule |
| CN 200810184560 Active CN101518589B (en) | 2007-12-18 | 2008-12-17 | Rehmannia Root formula granules as well as preparation method and quality control method thereof |
| CN 200810184567 Active CN101474224B (en) | 2007-12-18 | 2008-12-17 | Notopterygium root dispensing granule as well as preparation method and quality control method |
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Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1045164C (en) * | 1992-07-25 | 1999-09-22 | 青海大地药业有限公司 | Process for extracting effective component of xizang oriental wormwood, equipment and its tablet preparation method |
| CN1065751C (en) * | 1995-05-10 | 2001-05-16 | 北京中医药大学 | Ledebouriella polysaccharide and its preparation |
| CN1456288A (en) * | 2003-04-10 | 2003-11-19 | 毛友昌 | Preparation of Rupishu tablets against hyperplasia of mammary glands |
| CN1246694C (en) * | 2003-10-16 | 2006-03-22 | 中山大学 | Method for constituting finger-print pyrogram of white atracty lodes and its standard finger-print pyrogram |
| CN1232287C (en) * | 2003-12-25 | 2005-12-21 | 南京中医药大学 | Chinese medicinal preparation for treating sicca syndrome and its preparing method |
| CN1634520A (en) * | 2004-11-30 | 2005-07-06 | 北京普兰特医药科技发展有限责任公司 | Preparation process of Tibet capilary artemisia |
| CN1723987A (en) * | 2005-06-23 | 2006-01-25 | 天津大学 | Preparing method of radix puerariae formula |
| CN1785233A (en) * | 2005-11-09 | 2006-06-14 | 天津大学 | Method for preparing glycyrrhiza dispensing granules |
| CN1785275A (en) * | 2005-11-09 | 2006-06-14 | 天津大学 | Preparation method of white peong formula granules |
| CN100372520C (en) * | 2006-04-03 | 2008-03-05 | 江阴天江药业有限公司 | Preparing method of scalded leech medicine granule |
| CN100998621B (en) * | 2007-01-19 | 2010-05-19 | 石任兵 | Radix sileris total chromone extractive and its preparation method |
-
2008
- 2008-12-17 CN CN 200810184576 patent/CN101474287B/en active Active
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Non-Patent Citations (2)
| Title |
|---|
| 王智民 等."吴茱萸配方颗粒等效性研究".《中国中药杂志》.2007,第32卷(第12期),1149－1154. |
| 王智民 等."吴茱萸配方颗粒等效性研究".《中国中药杂志》.2007,第32卷(第12期),1149-1154. * |
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