CN1045164C - Process for extracting effective component of xizang oriental wormwood, equipment and its tablet preparation method - Google Patents
Process for extracting effective component of xizang oriental wormwood, equipment and its tablet preparation method Download PDFInfo
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- CN1045164C CN1045164C CN92108809A CN92108809A CN1045164C CN 1045164 C CN1045164 C CN 1045164C CN 92108809 A CN92108809 A CN 92108809A CN 92108809 A CN92108809 A CN 92108809A CN 1045164 C CN1045164 C CN 1045164C
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Abstract
The present invention relates to a technique and a device for extracting the effective components of Tibet oriental wormwood and a method for preparing a Tibet oriental wormwood tablet. The technique comprises the procedures of continuous extraction, concentration by a concentration pot, concentration by an open pan, drying, pulverization, etc. Tibet oriental wormwood is used as raw materials, and ethanol is used as an extraction agent. A continuous extraction device used in the continuous extraction procedure is characterized in that the continuous extraction device is provided with two extraction pots, the extraction pots are connected together by an extract flow pipe, and a heating chamber is arranged on the bottoms of the extraction pots. The method for preparing a Tibet oriental wormwood tablet is characterized in that the product can be prepared from 45 to 90% of extract powder and 10 to 55% of auxiliary material by the procedures of mixing, uniform stirring, moistening, drying, tabletting, molding, etc. The present invention has the advantages of little ethanol consumption, low energy consumption and capability of continuous extraction.
Description
The invention belongs to the extraction process of Chinese herbal medicine effective ingredients and the preparation method technical field of tablet, relate in particular to a kind of extraction process of ZANGYINCHEN effective ingredient, the production method of equipment and ZANGYINCHEN tablet.
ZANGYINCHEN derives from the gentianaceae plant Swertia mussotii Franch., Swertia franchetiana H.Smith, another name ZANGYINCHEN.ZANGYINCHEN has the active component of multiple treatment liver-gallbladder disease, and nontoxic, has no side effect, and the method for in the past extracting the ZANGYINCHEN effective ingredient is that ethanol refluxing process extracts extractum, and repress is made the extractum sheet.But this method mainly exists the extractum yield low, and ethanol consumes high, and energy consumption is big, and the extraction cost height such as can not extract continuously at shortcoming.
The purpose of this invention is to provide a kind of response rate that can improve the ZANGYINCHEN effective ingredient greatly, and significantly reduce alcohol consumption and energy resource consumption, thereby extraction cost is descended significantly and the novel process and the equipment that can extract continuously, and a kind of new process for producing of ZANGYINCHEN tablet is provided.
Fig. 1 is the process flow diagram of extraction process of the present invention.
Fig. 2 gets the sketch map of processing apparatus for Continuous Heat lixiviate in the technological process of the present invention.
Fig. 3 is the process flow diagram of production ZANGYINCHEN tablet of the present invention.
Respectively to extraction process of the present invention, the production method of equipment and Tibetan oriental wormwood tablet is described further below in conjunction with each accompanying drawing:
The extraction process of this ZANGYINCHEN effective ingredient, adopt cleaning drying in the sun ZANGYINCHEN grass be raw material, is that extractant extracts with ethanol, it is characterized by (1) technological process and gets for the Continuous Heat lixiviate, and it is jar concentrated that liquid contracts, and caldron is concentrated, drying, pulverizing, product; (2) ethanol in the careless slag after abstraction process extracts continuously, and concentrated through concentration tank, and the concentrated alcohol vapour that waits two step enrichment process to come out of caldron will carry out condensation and reclaim; (3) the alcoholic acid content of extractant is 75-85%, the continuous extraction time that operation is got in the Continuous Heat lixiviate is 9-14 hour, continuously extracting solution enters and enters caldron when concentration tank is concentrated into the alcohol meter survey measurements for 27-32 and concentrate, and baking temperature should be controlled at and be lower than 120 ℃ and be advisable.In order to make the higher extractant consumption of ethanol of saving more of this process extraction efficiency, the alcoholic acid content of extractant is preferably 80%, the continuous extraction time that operation is got in the Continuous Heat lixiviate kept 10 hours, continuously extracting solution enters concentration tank to be concentrated to the alcohol meter survey measurements is when entering caldron at 30 o'clock and concentrating, its best results.Extract continuously is to be raw material with clean drying in the sun ZANGYINCHEN medical herbs, the process of in Continuous Heat extraction equipment (as shown in Figure 2), extracting repeatedly with extractant ethanol, to be extracted can think when colourless to ethanol extracted fully, it is that the high concentration extracting solution that will come out from the Continuous Heat extraction equipment is sent to spissated process in the concentration tank that concentration tank concentrates, in this process, ethanol becomes steam and is removed, extracting solution is concentrated, when being concentrated to the ethanol survey measurements when being 27-32, then concentrated solution being sent in the caldron and concentrating.It is in order further to remove ethanol, to make the further spissated process of concentrated solution, enter drying process when being concentrated to extracting solution for extension flag state that caldron concentrates.Drying can adopt modes such as natural drying and heating, drying, but baking temperature should be lower than 120 ℃, otherwise can make effective ingredient lose medical value.When being dried to ethanol content and being lower than 5%, can become the dry extract semi-finished product, again dry extract is pulverized be the extract powder product, extract powder is exactly the effective ingredient in the ZANGYINCHEN medical herbs, it is patent medicine separately, also can fit over other medicine and make make preparations for sowing tablet and pill together.
Adopt this new extraction process, can make whole leaching process become batch extraction and be continuous leaching process, past repeatedly adds ethanol and becomes and once add ethanol, extraction and spissated effective site are carried out in an enclosed system basically, the recyclable utilization of the alcoholic acid major part of extractant reduces the ethanol unit consumption significantly, and the medicinal liquid that extracts in whole leaching process is constantly transported, and constantly add new solvent, the extraction balance is constantly destroyed, its leaching efficiency and leaching efficiency discontinuous more in the past extracts and improves about 18%, energy resource consumption also significantly reduces, thereby the whole production cost is obviously reduced, and better economic and social benefit are arranged.
Continuous Heat extraction equipment (as shown in Figure 2) in the continuous abstraction process of this ZANGYINCHEN technology for extracting effective component, it is characterized in that it has two extraction pot (1), (6), extraction pot (1) (6) links together by extracting solution runner pipe (7), and the bottom of extraction pot (1) (6) is provided with heating clamber (4).Extraction pot (1), the top of (6) are provided with extractant steam pipe (9), and extractant steam pipe (9) is connected with condenser (18), also are provided with feeding and discharging mouth and extractant return duct (12) on the extraction pot (1), and the same condenser of extractant return duct (12) (18) links to each other.Extraction pot (1), (6) be sealing extraction element during the Continuous Heat lixiviate is got, ZANGYINCHEN grass and extractant are contained in the inside and seal extraction, extracting solution runner pipe (7) is extraction pot (1), (6) mozzle of extracting solution in, in order to make its extraction effect the best, extracting solution runner pipe (7) preferably is located at extraction pot (1), (6) bottom, heating clamber (4) is the place to extraction pot (1) (6) heating, heating clamber (4) can use Steam Heating, electrical heating and other mode of heatings, extractant steam pipe (9) is the pipeline that extractant steam is sent to condenser (18) condensation, the feeding and discharging mouth is a passage of putting into and get rid of the ZANGYINCHEN grass, and it both can be made as one, also charging aperture and discharge gate can be set respectively, for easy to use, preferably charging aperture and discharge gate are provided with separately, charging aperture is located at the top of extraction pot (1), and the bottom extractant return duct (12) that discharge gate is located at it is the pipeline of carrying through the condensed extractant of condenser (18).In order to make in the operation evaporation of heating and extractant be convenient to control, be preferably on extracting solution runner pipe (7) and the extractant return duct (12) and respectively establish an effusion meter (11), (10).When using this Continuous Heat extraction equipment, earlier the ZANGYINCHEN grass is joined the extraction pot (1) from charging aperture (2), preferably being contained in jar 3/4ths high places gets final product, again extractant ethanol is sent to extraction pot (1), (6) in, extractant is installed to till jar high about 3/4ths, open the valve on extractant runner pipe (7) and extractant steam pipe (9) and the extractant return duct (12), close charging aperture (2), beginning is in extraction pot (1), (6) heating in the heating clamber (4), when being heated to extraction pot (1) boiling, then stop heating extraction jar (1), but continue heating extraction jar (6), condenser (18) is started, extraction pot (6) is heated the extractant steam condensation of coming out, condensed extractant flow in the extraction pot (1) through extractant return duct (12), along with extractant liquid level in the extraction pot (6) reduces and the middle extractant liquid level rising of extraction pot (1), the extracting solution of extraction pot (1) bottom constantly flows in the extraction pot (6) through extractant runner pipe (7), extraction pot (6) is the heating evaporation extractant constantly, make extractant through condensation constantly from the upper supplementary of extraction pot (1) to extraction pot (1), whole leaching process is carried out continuously, along with extraction time increases, effective ingredient constantly reduces in the middle ZANGYINCHEN grass of extraction pot (1), it is more and more shallow to can be observed the extractant runner pipe (7) mobile extracting solution color from sense organ, when to extract color be colourless, can stop heating extraction jar (6), close the valve on the extractant runner pipe (7), close condenser (18), be sent in the concentration tank enrichment process the dense extracting solution in the extraction pot (6) concentrated, discharging tube among Fig. 2 (15) is the dense extracting solution of discharging and cleans extraction pot (6) pipeline, low concentration extracting solution in the extraction pot (1) is emitted to deposit in the container and is made extractant special next time and use, and then heating extraction jar (1), open cold condenser (18), close the valve on the extractant return duct (12) at extraction pot (1) top, carrying out along with extraction pot (1) heating, the remaining continuous evaporative condenser of extractant is recovered as extracting next time and uses in the middle ZANGYINCHEN grass of extraction pot (1), treat then to stop heating after extractant remaining in the ZANGYINCHEN grass reclaims fully, close condenser (18) from, discharge gate takes out the ZANGYINCHEN grass slag after extracting, and can extract continuously next time.The bottom of extraction pot among Fig. 2 (1) is provided with discharge gate (16), and it is covered completely behind the discharge, makes extractant not leak this Continuous Heat extraction equipment extraction time is shortened dramatically, and significantly saves the extractant and the energy and reduces extraction expense, its remarkable in economical benefits.
The feature of the production method of this ZANGYINCHEN tablet is:
One. the ZANGYINCHEN extract powder is 45-90%, and adjuvant is 10-55%.Adjuvant comprises disintegrating agent, lubricant, binding agent etc.Disintegrating agent is the 5-50% of adjuvant amount, and lubricant is the 2-25% of adjuvant, and binding agent is the 5-48% (above percentage composition is weight percentage) of adjuvant;
Two. in proportion the preparation ZANGYINCHEN extract powder and adjuvant mix thoroughly through mixing, mix moistening, drying, operations such as compression molding can become product;
Three. mixing the wetting agent that adds in the moistening operation is the second alcohol and water, and the baking temperature of drying process is lower than 120 ℃.
Disintegrating agent is the material that plays disintegration in tablet, as Celluloasun Microcrystallisatum, and carboxymethyl cellulose, starch, soil temperature 80 etc.Lubricant is the material of lubricate in the compression molding process, as Pulvis Talci, and magnesium stearate etc.Binding agent is the material that plays cementation in the compression molding process, as dextrin, micropowder silica gel etc., in order to make the easily manufactured of tablet, cost is low, and the disintegrating agent in the adjuvant is preferably selected starch for use, Celluloasun Microcrystallisatum, carboxymethyl celluloses etc., lubricant are preferably selected Pulvis Talci for use, and binding agent is preferably selected dextrin for use.The baking temperature of drying process is preferably 70-85 ℃, mixes that to mix operation thoroughly be process with its medicine mixing.Mixing moistening operation is to add the process that wetting agent is made paste, and the compression molding operation is that the article of its paste are made lamellar or granulous process, and drying process is the process of removing more wetting agent in the tablet.In order to make tablet be convenient to swallow, it is simple to be preferably in after the compression molding operation on tablet the manufacture method of this tablet of a bag glace, has multiple treatment liver, and the active ingredient of biliary diseases, no side effects are livers preferably, the control medicine of biliary diseases.
The embodiment one of ZANGYINCHEN technology for extracting effective component of the present invention, get the ZANGYINCHEN grass of 100Kg, to be 80% extractant with ethanol content extract in extraction equipment continuously repeatedly extract 10 hours continuously after, then dense extracting solution is sent in the concentration tank and concentrates, when being concentrated to the alcohol meter survey measurements when being 30, move on in the caldron concentrated solution concentrated, when being concentrated to extension flag state, take out heating, drying, bake out temperature keeps about 80 ℃, dries ethanol content and is 2% and this product is pulverized can be become the extract powder product again.
Fig. 2 can be used as the embodiment sketch map of Continuous Heat extraction equipment of the present invention.Ethanol is driven into extraction pot (1) with the ethanol pump, (6) in, the cooling medium water of condenser (18), cooling water extrudes with water pump (8), water Steam Heating in the heating clamber (4), water vapour is controlled by steam valve (13), on extracting solution runner pipe (7) and extractant return duct (12), be provided with two effusion meters (11), (10), extracting solution runner pipe (7) is located at extraction pot (1), the bottom of (6), and charging aperture (2) is located at the top of extraction pot (1), discharge gate (16) is located at its bottom, and the concentrated solution in the extraction pot (6) is discharged from valve (15).
The embodiment one of the production method of ZANGYINCHEN tablet of the present invention: get extract powder 700 grams, disintegrating agent Celluloasun Microcrystallisatum 100 grams, binding agent dextrin 100 grams, lubricant Pulvis Talci 100 grams are mixed thoroughly through mixing, and reuse wetting agent ethanol is modulated into paste, 80 ℃ of oven dry down, compression molding can become product again.
Embodiment two: get 500 gram extract powders, disintegrating agent Celluloasun Microcrystallisatum 100 grams, carboxymethyl cellulose 100 grams, binding agent dextrin 80 grams, micropowder silica gel 20 grams, magnesium stearate lubricant 100 grams are mixed thoroughly through mixing, with the moistening paste of making of wetting agent water, dry compression molding down at 85 ℃, at a tablet external packets glace, oven dry can obtain qualified product again.
Claims (7)
1, the clean drying in the sun ZANGYINCHEN grass of a kind of extraction process of ZANGYINCHEN effective ingredient employing is a raw material, extract as extractant with ethanol, it is characterized by: (1) is used two interconnective extraction pot to take the Continuous Heat lixiviate to get operation and is extracted, one of them extraction pot takes the Continuous Heat lixiviate to get, and another extraction pot extracts resulting extracting solution to previous extraction pot and proceeds hot dipping and concentrate; (2) through the Continuous Heat lixiviate get in the careless slag after operation is extracted ethanol and through concentration tank concentrate, caldron concentrates etc., and alcohol vapour that two step operations come out will carry out condensation reclaims; (3) the alcoholic acid content of extractant is 75%-85%, and the continuous extraction time that operation is got in the Continuous Heat lixiviate is 9-14 hour, and continuously extracting solution enters and enters caldron when concentration tank is concentrated into the alcohol meter survey measurements for 27-32 and concentrate.
2, the extraction process of ZANGYINCHEN effective ingredient according to claim 1 is characterized in that the alcoholic acid content of extractant is 80%.
3. the extraction process of ZANGYINCHEN effective ingredient according to claim 1, it is characterized in that entering concentration tank by continuous extracting solution, to be concentrated to the alcohol meter survey measurements be to enter caldron at 30 o'clock to concentrate.
4, the Continuous Heat extraction equipment in the operation is got in a kind of Continuous Heat lixiviate of ZANGYINCHEN technology for extracting effective component, it is characterized in that it has two extraction pot (1), (6), extraction pot (1), (6) link together by extracting solution runner pipe (7), extraction pot (1), (6) bottom is provided with heating clamber (4), extraction pot (1), (6) top is provided with extractant steam pipe (9), extractant steam pipe (9) links to each other with condenser (18), extraction pot also is provided with on (1), discharge gate and extractant return duct (12), the same condenser of extractant return duct (12) (18) links to each other.
5, Continuous Heat extraction equipment according to claim 4 is characterized in that extracting solution runner pipe (7) is located at the bottom of extraction pot (1), (6).
6, Continuous Heat extraction equipment according to claim 4 is characterized in that advancing on the extraction pot (1), discharge gate are provided with separately, and charging aperture is located at the top of extraction pot (1), and discharge gate is located at its bottom.
7, Continuous Heat extraction equipment according to claim 4 is characterized in that respectively establishing an effusion meter (11), (10) on extracting solution runner pipe (7) and extractant return duct (12).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN92108809A CN1045164C (en) | 1992-07-25 | 1992-07-25 | Process for extracting effective component of xizang oriental wormwood, equipment and its tablet preparation method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN92108809A CN1045164C (en) | 1992-07-25 | 1992-07-25 | Process for extracting effective component of xizang oriental wormwood, equipment and its tablet preparation method |
Publications (2)
| Publication Number | Publication Date |
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| CN1070341A CN1070341A (en) | 1993-03-31 |
| CN1045164C true CN1045164C (en) | 1999-09-22 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN92108809A Expired - Fee Related CN1045164C (en) | 1992-07-25 | 1992-07-25 | Process for extracting effective component of xizang oriental wormwood, equipment and its tablet preparation method |
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Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1238944A (en) * | 1998-06-11 | 1999-12-22 | 西藏宇妥藏药研究所 | Process for preparing powdered bath lotion from liquid one of natural plant |
| CN101474290B (en) * | 2007-12-18 | 2012-07-25 | 北京康仁堂药业有限公司 | Detection method of figwort root dispensing granule |
| CN103007571B (en) * | 2012-12-19 | 2014-09-10 | 汪振朴 | Alcohol-recyclable medicine extracting device and process thereof |
| CN105944402B (en) * | 2014-08-10 | 2017-11-10 | 成都远泓生物科技有限公司 | The equipment for extracting total Flavone of Rhododendron |
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1992
- 1992-07-25 CN CN92108809A patent/CN1045164C/en not_active Expired - Fee Related
Non-Patent Citations (3)
| Title |
|---|
| 《中药药剂学》86年11月第1版 1986.11.30 曹春林等；上海科学技术出版社 * |
| 《中药药剂学》86年11月第1版 1986.11.30 曹春林等；上海科学技术出版社;《中药通报》1986年第119卷第11期 1986.11.30 宋万志，中国龙胆科药用植物概况 * |
| 《中药通报》1986年第119卷第11期 1986.11.30 宋万志，中国龙胆科药用植物概况 * |
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| CN1070341A (en) | 1993-03-31 |
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