CN1070341A - The production method of the extraction process of ZANGYINCHEN effective ingredient, equipment and ZANGYINCHEN tablet - Google Patents
The production method of the extraction process of ZANGYINCHEN effective ingredient, equipment and ZANGYINCHEN tablet Download PDFInfo
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- CN1070341A CN1070341A CN 92108809 CN92108809A CN1070341A CN 1070341 A CN1070341 A CN 1070341A CN 92108809 CN92108809 CN 92108809 CN 92108809 A CN92108809 A CN 92108809A CN 1070341 A CN1070341 A CN 1070341A
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Abstract
The present invention relates to the production method of extraction process, equipment and the ZANGYINCHEN tablet of ZANGYINCHEN effective ingredient.Operations such as technology is used continuously and extracted, concentration tank concentrates, caldron concentrates, drying, pulverizing are raw material with the ZANGYINCHEN grass, and ethanol is extractant.The feature of the continuous extraction equipment of abstraction process is that it has two extraction pot continuously, and extraction pot links together by the extracting solution runner pipe, and the extraction pot bottom is provided with heating clamber.The feature of the production method of ZANGYINCHEN tablet is that extract powder is 45-90%, and adjuvant is 10-55%, mixes, mixes operations such as moistening, dry, compression molding thoroughly through mixing and can become product.Ethanol consumption of the present invention is few, and energy consumption is low, can extract continuously.
Description
The invention belongs to the extraction process of Chinese herbal medicine active ingredient and the preparation method technical field of tablet, relate in particular to a kind of production method of extraction process, equipment and ZANGYINCHEN tablet of ZANGYINCHEN active ingredient.
ZANGYINCHEN derives from west, gentianaceae plant river Herba Swertiae bimaculatae, embraces the stem Herba Swertiae bimaculatae, the another name ZANGYINCHEN.ZANGYINCHEN has the active ingredient of multiple treatment liver-gallbladder disease, and nontoxic, have no side effect.The method of in the past extracting the ZANGYINCHEN active ingredient is that ethanol refluxing process extracts extractum, and repress is made the extractum sheet.But this method mainly exists the extractum yield low, and ethanol consumes high, and energy consumption is big, and extraction cost is low, shortcoming such as can not extract continuously.
The purpose of this invention is to provide and a kind ofly can improve the response rate of ZANGYINCHEN active ingredient greatly, and significantly reduce alcohol consumption and energy resource consumption, thereby extraction cost is descended significantly and the novel extraction process and the equipment that can extract continuously, and a kind of new process for producing of ZANGYINCHEN tablet is provided.
Fig. 1 is the process flow diagram of extraction process of the present invention.
Fig. 2 is the sketch map of continuous abstraction process equipment in the technological process of the present invention.
Fig. 3 is the process flow diagram of production ZANGYINCHEN tablet of the present invention.
Respectively the production method of extraction process of the present invention, equipment and Tibetan oriental wormwood tablet is described further below in conjunction with each accompanying drawing:
The extraction process of this ZANGYINCHEN active ingredient adopts and cleans drying in the sun ZANGYINCHEN grass be raw material, is that extractant extracts with ethanol, it is characterized by (1) technological process for continuous extraction → concentration tank concentrated → caldron is concentrated → drying → pulverizing → product; (2) ethanol in the careless slag after continuously abstraction process extracts, and through concentration tank concentrate, caldron concentrates etc., and alcohol vapour that two step enrichment process come out will carry out condensation reclaims; (3) the alcoholic acid content of extractant is 75-85%, the continuous extraction time of abstraction process is 9-14 hour continuously, continuously extracting solution enters and enters caldron when concentration tank is concentrated into the alcohol meter survey measurements for 27-32 and concentrate, and baking temperature should be controlled at and be lower than 120 ℃ and be advisable.In order to make this process extraction efficiency higher, save the extractant consumption of ethanol more, the alcoholic acid content of extractant is preferably 80%, the continuous extraction time of abstraction process kept 10 hours continuously, continuously extracting solution enters concentration tank to be concentrated to the alcohol meter survey measurements is when entering caldron at 30 o'clock and concentrating, its best results.Extracting continuously is to be raw material with clean drying in the sun ZANGYINCHEN medical herbs, to be extracted to ethanol when colourless with the process that extractant ethanol extracts in extraction equipment (as shown in Figure 2) continuously repeatedly, can think extracted complete.It is that the high concentration extracting solution that will come out from continuous extraction equipment is sent to spissated process in the concentration tank that concentration tank concentrates, in this process, ethanol becomes steam and is removed, and extracting solution is concentrated, when being concentrated to the ethanol survey measurements when being 27-32, then concentrated solution being sent in the caldron and concentrating.It is in order further to remove ethanol, to make the further spissated process of concentrated solution, enter drying process when being concentrated to extracting solution for extension flag state that caldron concentrates.Drying can adopt modes such as natural drying and heating, drying, but baking temperature should be lower than 120 ℃, otherwise can make active ingredient lose medical value.When being dried to ethanol content and being lower than 5%, can become the dry extract semi-finished product, again dry extract is pulverized be the extract powder product, extract powder is exactly the active ingredient in the ZANGYINCHEN medical herbs, it is patent medicine separately, also can fit over other medicine and make various tablets and pill together.
Adopt this new extraction process, can make whole leaching process become batch extraction and be continuous leaching process, past repeatedly adds ethanol and becomes and once add ethanol, extraction and spissated effective site are carried out in an enclosed system basically, the recyclable utilization of the alcoholic acid major part of extractant, the ethanol unit consumption is reduced significantly, and the medicinal liquid that extracts in whole leaching process is constantly transported, and constantly add new solvent, the extraction balance is constantly destroyed, and its leaching efficiency and leaching efficiency discontinuous more in the past extracts and improves about 18%, and energy resource consumption also significantly reduces, thereby the whole production cost is obviously reduced, better economic and social benefit are arranged.
Continuous extraction equipment (as shown in Figure 2) in the continuous abstraction process of this ZANGYINCHEN active ingredient extraction process, it is characterized in that it has two extraction pot (1), (6), extraction pot (1), (6) link together by extracting solution runner pipe (7), extraction pot (1), (6) bottom is provided with heating clamber (4), extraction pot (1), (6) top is provided with extractant steam pipe (9), extractant steam pipe (9) is connected with condenser (18), also be provided with feeding and discharging mouth and extractant return duct (12) on the extraction pot (1), the same condenser of extractant return duct (12) (18) links to each other.Extraction pot (1), (6) are continuously the sealing extraction elements in the extraction equipment, ZANGYINCHEN grass and extractant are contained in the inside and seal extraction, extracting solution runner pipe (7) is the mozzle of extracting solution in extraction pot (1), (6), in order to make its extraction get best results, extracting solution runner pipe (7) preferably is located at the bottom of extraction pot (1), (6).Heating clamber (4) is that heating clamber (4) can use Steam Heating, electrical heating and other mode of heating to the place of extraction pot (1), (6) heating.Extractant steam pipe (9) is the pipeline that extractant steam is sent to condenser (18) condensation.The feeding and discharging mouth is a passage of putting into and get rid of the ZANGYINCHEN grass, and it both can be made as one, also charging aperture and discharge gate can be set respectively, for easy to use, preferably charging aperture and discharge gate are provided with separately, charging aperture is located at the top of extraction pot (1), and discharge gate is located at its bottom.Extractant return duct (12) is the pipeline of carrying through the condensed extractant of condenser (18).In order to make in the operation evaporation of heating and extractant be convenient to control, be preferably on extracting solution runner pipe (7) and the extractant return duct (12) and respectively establish an effusion meter (11), (10).When using this continuous extraction equipment, earlier the ZANGYINCHEN grass is joined the extraction pot (1) from charging aperture (2), preferably being contained in jar 3/4ths high places gets final product, again extractant ethanol is sent to extraction pot (1), (6) in, extractant is installed to till jar high about 3/4ths, open the valve on extractant runner pipe (7) and extractant steam pipe (9) and the extractant return duct (12), close charging aperture (2), beginning is in extraction pot (1), (6) heating in the heating clamber (4), when being heated to extraction pot (1) boiling, then stop heating extraction jar (1), but continue heating extraction jar (6), condenser (18) is started, extraction pot (6) is heated the extractant steam condensation of coming out, condensed extractant flow in the extraction pot (1) through extractant return duct (12), along with extractant liquid level in the extraction pot (6) reduces and the middle extractant liquid level rising of extraction pot (1), the extracting solution of extraction pot (1) bottom constantly flows in the extraction pot (6) through extractant runner pipe (7), extraction pot (6) is the heating evaporation extractant constantly, make extractant through condensation constantly from the upper supplementary of extraction pot (1) to extraction pot (1), whole leaching process is carried out continuously.Along with extraction time increases, active ingredient constantly reduces in the middle ZANGYINCHEN grass of extraction pot (1), it is more and more shallow to can be observed the extractant runner pipe (7) mobile extracting solution color from sense organ, when to extract color be colourless, can stop heating extraction jar (6), close the valve on the extractant runner pipe (7), close condenser (18), be sent in the concentration tank enrichment process the dense extracting solution in the extraction pot (6) concentrated.Discharging tube among Fig. 2 (15) is the dense extracting solution of discharging and cleans extraction pot (6) pipeline.Low concentration extracting solution in the extraction pot (1) is emitted to deposit in and is treated to do next time the extractant use in the container, and then heating extraction jar (1), open cold condenser (18), close the valve on the extractant return duct (12) at extraction pot (1) top, carrying out along with extraction pot (1) heating, the remaining continuous evaporative condenser of extractant is recovered as extracting next time and uses in the middle ZANGYINCHEN grass of extraction pot (1), treat then to stop heating after extractant remaining in the ZANGYINCHEN grass reclaims fully, close condenser (18), from advancing, discharge gate takes out the ZANGYINCHEN grass slag after extracting, and can extract continuously next time.The bottom of extraction pot among Fig. 2 (1) is provided with discharge gate (16), and it is covered completely behind the discharge, and extractant is not leaked.This continuous extraction equipment shortens dramatically extraction time, significantly saves the extractant and the energy, reduces the extraction expense, its remarkable in economical benefits.
The feature of the production method of this ZANGYINCHEN tablet is:
One, the ZANGYINCHEN extract powder is 45-90%, and adjuvant is 10-55%.Adjuvant comprises disintegrating agent, lubricant, binding agent etc.Disintegrating agent is the 5-50% of adjuvant amount, and lubricant is the 2-25% of adjuvant, and binding agent is that the above percentage composition of the 5-48%(of adjuvant is weight percentage);
Two, the ZANGYINCHEN extract powder of preparation in proportion and adjuvant are mixed → mixed thoroughly moistening → operations such as drying → compression molding through mixing and can become product;
Three, mixing the wetting agent that adds in the moistening operation is the second alcohol and water, and the baking temperature of drying process is lower than 120 ℃.
Disintegrating agent is the material that plays disintegration in tablet, as Celluloasun Microcrystallisatum, carboxymethyl cellulose, starch, soil temperature 80 etc.Lubricant is the material of lubricate in the compression molding process, as Pulvis Talci, magnesium stearate etc.Binding agent is the material that plays cementation in the compression molding process, as dextrin, little sticking silica gel etc.In order to make the easily manufactured of tablet, cost is low, and the disintegrating agent in the adjuvant is preferably selected starch, Celluloasun Microcrystallisatum, carboxymethyl cellulose etc. for use, and lubricant is preferably selected Pulvis Talci for use, and binding agent is preferably selected dextrin for use.The baking temperature of drying process is preferably 70-85 ℃.Mix that to mix operation thoroughly be process with its medicine mixing, mixing moistening operation is to add the process that wetting agent is made paste, and the compression molding operation is that the article of its paste are made lamellar or granulous process, and drying process is the process of removing more wetting agent in the tablet.In order to make tablet be convenient to swallow, on tablet, wrap a glace after being preferably in the compression molding operation.The manufacture method of this tablet is simple, has the active ingredient of multiple treatment liver, biliary diseases, and no side effects is the control medicine of liver, biliary diseases preferably.
The embodiment of ZANGYINCHEN active ingredient extraction process of the present invention, get the ZANGYINCHEN grass of 100Kg, be that 80% extractant is extracting in the extraction equipment continuously repeatedly with ethanol content, extract after 10 hours continuously, then dense extracting solution is sent in the concentration tank and concentrates, when being concentrated to the alcohol meter survey measurements when being 30, move on in the caldron concentrated solution concentrated, when being concentrated to extension flag state, take out heating, drying, bake out temperature keeps about 80 ℃, dries ethanol content and is 2% and this product is pulverized can be become the extract powder product again.
Fig. 2 can be used as the embodiment sketch map that the present invention extracts equipment continuously.Ethanol is driven into extraction pot (1) with the ethanol pump, (6) in, the cooling medium water of condenser (18), cooling water extrudes with water pump (8), water Steam Heating in the heating clamber (4), water vapour is controlled by steam valve (13), on extracting solution runner pipe (7) and extractant return duct (12), be provided with two effusion meters (11), (10), extracting solution runner pipe (7) is located at extraction pot (1), (6) bottom, charging aperture (2) is located at the top of extraction pot (1), discharge gate (16) is located at its bottom, and the concentrated solution in the extraction pot (6) is discharged from valve (15).
The embodiment one of the production method of ZANGYINCHEN tablet of the present invention: get extract powder 700 grams, disintegrating agent Celluloasun Microcrystallisatum 100 grams, binding agent dextrin 100 grams, lubricant Pulvis Talci 100 grams are mixed thoroughly through mixing, and reuse wetting agent ethanol is modulated into paste, 80 ℃ of oven dry down, compression molding can become product again.
Embodiment two: get 500 gram extract powders, disintegrating agent Celluloasun Microcrystallisatum 100 grams, carboxymethyl cellulose 100 grams, binding agent dextrin 80 grams, little sticking silica gel 20 grams, magnesium stearate lubricant 100 grams are mixed thoroughly through mixing, with the moistening paste of making of wetting agent water, dry compression molding down at 85 ℃, at a tablet external packets glace, oven dry can obtain qualified product again.
Claims (13)
1, the clean drying in the sun ZANGYINCHEN grass of a kind of extraction process of ZANGYINCHEN active ingredient employing is a raw material, extracts as extractant with ethanol, it is characterized by:
(1) technological process is: continuously extractions → concentration tank concentrate → caldron is concentrated → drying → pulverizing → product;
(2) ethanol in the careless slag after continuously abstraction process extracts and through concentration tank concentrate, caldron concentrates etc., and alcohol vapour that two step enrichment process come out will carry out condensation reclaims;
(3) the alcoholic acid content of extractant is 75-85%, and continuously the continuous extraction time of abstraction process is 9-14 hour, and extracting solution enters and enters caldron when concentration tank is concentrated into the alcohol meter survey measurements for 27-32 and concentrate continuously, and baking temperature is controlled at and is lower than 120 ℃ and is advisable.
2, the extraction process of ZANGYINCHEN active ingredient according to claim 1 is characterized in that the alcoholic acid content of extractant is preferably 80%.
3, the extraction process of ZANGYINCHEN active ingredient according to claim 1 is characterized in that the continuous extraction time of continuous abstraction process is preferably 10 hours.
4, the extraction process of ZANGYINCHEN active ingredient according to claim 1 is characterized in that continuous extracting solution enters concentration tank and is concentrated to the alcohol meter survey measurements and is preferably at 30 o'clock and enters caldron and concentrate.
5, continuous extraction equipment in a kind of continuous abstraction process of ZANGYINCHEN active ingredient extraction process, it is characterized in that it has two extraction pot (1), (6), extraction pot (1), (6) link together by extracting solution runner pipe (7), extraction pot (1), (6) bottom is provided with heating clamber (4), extraction pot (1), (6) top is provided with extractant steam pipe (9), extractant steam pipe (9) links to each other with condenser (18), extraction pot also is provided with on (1), discharge gate and extractant return duct (12), the same condenser of extractant return duct (12) (18) links to each other.
6, continuous extraction equipment according to claim 5 is characterized in that extracting solution runner pipe (7) preferably is located at the bottom of extraction pot (1), (6).
7, continuous extraction equipment according to claim 5 is characterized in that advancing on the extraction pot (1), discharge gate preferably are provided with separately, and charging aperture is located at the top of extraction pot (1), and discharge gate is located at its bottom.
8, continuous extraction equipment according to claim 5 is characterized in that preferably respectively establishing an effusion meter (11), (10) on extracting solution runner pipe (7) and extractant return duct (12).
9, a kind of production method of ZANGYINCHEN tablet is characterized in that:
(1) the ZANGYINCHEN extract powder is 45-90%, adjuvant is 10-55%, and adjuvant comprises disintegrating agent, lubricant, binding agent etc., and disintegrating agent is the 5-50% of adjuvant amount, lubricant is the 2-25% of adjuvant amount, and binding agent is that the above percentage composition of the 5-48%(of adjuvant amount is weight percentage);
(2) the ZANGYINCHEN extract powder of preparation in proportion and adjuvant are mixed → mixed thoroughly moistening → operations such as drying → compression molding through mixing and can become product;
(3) mixing the wetting agent that adds in the moistening operation is the second alcohol and water, and the baking temperature of drying process is lower than 120 ℃.
10, production method according to claim 9 is characterized in that the disintegrating agent in the adjuvant is preferably selected starch, Celluloasun Microcrystallisatum, carboxymethyl cellulose for use.
11, production method according to claim 9 is characterized in that the lubricant in the adjuvant is preferably selected Pulvis Talci for use.
12, production method according to claim 9 is characterized in that binding agent is preferably selected dextrin for use in the adjuvant.
13, production method according to claim 9 is characterized in that the baking temperature of drying process is preferably 70-85 ℃.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN92108809A CN1045164C (en) | 1992-07-25 | 1992-07-25 | Process for extracting effective component of xizang oriental wormwood, equipment and its tablet preparation method |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN92108809A CN1045164C (en) | 1992-07-25 | 1992-07-25 | Process for extracting effective component of xizang oriental wormwood, equipment and its tablet preparation method |
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| Publication Number | Publication Date |
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| CN1070341A true CN1070341A (en) | 1993-03-31 |
| CN1045164C CN1045164C (en) | 1999-09-22 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN92108809A Expired - Fee Related CN1045164C (en) | 1992-07-25 | 1992-07-25 | Process for extracting effective component of xizang oriental wormwood, equipment and its tablet preparation method |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1084708A4 (en) * | 1998-06-11 | 2004-06-30 | Tibet Yutuo Inst Of Tibetan Me | A process of powder for bath from natural plants |
| CN101474229B (en) * | 2007-12-18 | 2012-05-30 | 北京康仁堂药业有限公司 | Oriental wormwood dispensing granule as well as preparation method and quality control method |
| CN103007571A (en) * | 2012-12-19 | 2013-04-03 | 温州市天龙轻工设备有限公司 | Alcohol-recyclable medicine extracting device and process thereof |
| CN105944402A (en) * | 2014-08-10 | 2016-09-21 | 胡刘满 | Equipment for extracting total flavones of rhododendron |
-
1992
- 1992-07-25 CN CN92108809A patent/CN1045164C/en not_active Expired - Fee Related
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1084708A4 (en) * | 1998-06-11 | 2004-06-30 | Tibet Yutuo Inst Of Tibetan Me | A process of powder for bath from natural plants |
| CN101474229B (en) * | 2007-12-18 | 2012-05-30 | 北京康仁堂药业有限公司 | Oriental wormwood dispensing granule as well as preparation method and quality control method |
| CN103007571A (en) * | 2012-12-19 | 2013-04-03 | 温州市天龙轻工设备有限公司 | Alcohol-recyclable medicine extracting device and process thereof |
| CN103007571B (en) * | 2012-12-19 | 2014-09-10 | 汪振朴 | Alcohol-recyclable medicine extracting device and process thereof |
| CN105944402A (en) * | 2014-08-10 | 2016-09-21 | 胡刘满 | Equipment for extracting total flavones of rhododendron |
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| Publication number | Publication date |
|---|---|
| CN1045164C (en) | 1999-09-22 |
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