CN1041106A

CN1041106A - A kind of production technology of Ganoderma essence

Info

Publication number: CN1041106A
Application number: CN88106427A
Authority: CN
Inventors: 李绪滨
Original assignee: Individual
Current assignee: Individual
Priority date: 1988-09-10
Filing date: 1988-09-10
Publication date: 1990-04-11

Abstract

The present invention is a kind of compound method of extracting the production technology of lucidum concentrating liquid and producing the Ganoderma essence.This process using low temperature reflux water extraction and Different concentrations of alcohol reflux extraction combine, and make that effective ingredient water-soluble and that be dissolved in alcohol all proposes in the Ganoderma, and the concentrated solution after the extraction is handled through precipitate with ethanol and low temperature Cryoprecipitation again.Abundant sediment exclusion, Ganoderma and Radix Ginseng, the Radix Polygoni Multiflori etc., with the Mel preparation, making promptly has tonic effect, medicative again Ganoderma extract oral liquid.

Description

A kind of production technology of Ganoderma essence

The present invention relates to the extraction production technology of Chinese crude drug, a kind of compound method of extracting the production technology of lucidum concentrating liquid and producing the Ganoderma essence of saying so more specifically.

" Ganoderma " is China's rare medicinal herbs, and the successive dynasties, the medicine scholar all thought the treasure of strengthening by means of tonics, the body resistance strengthening and constitution consolidating, was the cardiopathic active drug of treatment, and has higher nourishing value.At present, China still adopts traditional Chinese medicine processing method-high temperature decocting to the extraction of Ganoderma.This single extracting mode, poor effect, it is not only except that the impurity that does not fall in the Ganoderma, and high-temperature process also can be lost effective ingredient, as many effective ingredient such as the vitamin in the Ganoderma, enzyme have been destroyed, and the concentrated solution precipitate after extracting is more, and the oral liquid that is mixed with can't reach the medical standard of country.

The production technology that the purpose of this invention is to provide a kind of Ganoderma essence, this process not only can be removed the impurity in the Ganoderma, the more important thing is the effective ingredient that can extract fully in the Ganoderma, and the lucidum concentrating liquid precipitate that do not stay stored for a long time after extracting, to reach the purpose of keeping its essence and discarding its dross.

The chemical constituent of Ganoderma is comparatively complicated, and it mainly contains five class materials: reducing substances, aminoacid, protein, sterol or steroid saponin, anthraquinones.In addition, also contain multiple enzyme in the Ganoderma mycelium, as lipase, maltase, laccase, saccharase, amylase, cellulase etc.In order to remove the impurity in the Ganoderma, retain the plurality of active ingredients in the Ganoderma, the present invention has adopted twice technical process to extract, be the low temperature reflux water extraction process for the first time, adopt Different concentrations of alcohol reflux, extract, technology for the second time, twice technical process combines, make water-soluble and be dissolved in pure effective ingredient and all propose, concentrated solution after extracting simultaneously all passes through the processing of precipitate with ethanol and low temperature Cryoprecipitation, has fully got rid of precipitate, to have guaranteed the prescription of Ganoderma extract oral liquid.

Accompanying drawing is the smart technological process of production figure of Ganoderma.

Do to describe in detail below in conjunction with accompanying drawing: by accompanying drawing as can be seen flow process 1-flow process 5 are low temperature reflux extraction process by water.Flow process 6-flow process 10 is alcohol reflux extracting process.Flow process 1 is that raw material is handled, with exsiccant Ganoderma chopping.It is moistening to add water, enter flow process 2 reflux, extract, in retort then, it is an amount of to add water in retort, exceeds with the submergence crude drug, by timing after the Steam Heating, water was carried in two hours, and the retort water temperature must not surpass 80 ℃, emits medicinal liquid after airtight two hours, carrying out second time water again with the method carries, the secondary medicinal liquid merges filtration, collects medicinal residues, treats ethanol extraction.Medicinal liquid after secondary water is carried is put and is entered flow process 3 concentrating under reduced pressure in the retort, and concentrated solution is every milligram and contains 1 gram crude drug.Concentrated solution is entered flow process 4 precipitate with ethanol again, the precipitate with ethanol process is with above concentrated solution, slowly adds 95% ethanol, constantly stirs, make and contain alcohol amount and reach 70%, static more than 24 hours, treat that precipitation is complete, beat easily supernatant, decompression recycling ethanol, be concentrated into every milliliter and contain 2 gram crude drugs, enter flow process 5 then, carry out the low temperature Cryoprecipitation.The Cryoprecipitation process is with concentrated solution, slowly adds equivalent and heats up in a steamer water, constantly stirs, and places 2-5 ℃ of cold house static more than 48 hours then, treat that precipitation fully after, be filtered to clear and brightly, promptly get every milliliter of concentrated solution that contains 1 kairine sesame.Flow process 6-flow process 10 is ethanol reflux extractions.Flow process 6 is that the water in the Ganoderma raw material after water is carried is extruded, dried, enter flow process 7 and carry out ethanol extraction, Ganoderma raw material after water carried is put in the retort, the ethanol that adds 50% content, exceed with the submergence crude drug, adding opposing steam flow extracts, temperature must not surpass 70 ℃, extracts airtight 2 hours then 2 hours, emit first not good liquor, with the method, use content 60%, 70% ethanol reflux, extract, twice more respectively, enter

flow process

8,9,10 then,

flow process

8,9,10 be respectively concentrate, precipitate with ethanol and Cryoprecipitation technology, all identical with operational approach after water is carried.Concentrated solution after flow process 5 and flow process 10 are extracted enters flow process 11, carries out the preparation of Ganoderma essence.

Extraction to raw materials such as Radix Ginseng, the Radixs Polygoni Multiflori is all identical with the Ganoderma method, but mixed extraction also can divide Ganoderma, Radix Ginseng, all the other medical materials three groups of single files to extract, and its a whole set of operating procedure is fully identical with lucidum extracting method.

The finished product preparation of Ganoderma essence: concentrated solutions such as Ganoderma, Radix Ginseng, the Radix Polygoni Multiflori are mixed, and fine filtering places retort, be heated to 80 ℃, press the obtaining liq total amount then, add 50% bright Mel, stir, add 0.5% sodium benzoate antiseptic, place 2-5 ℃ of cold house, static more than 48 hours, treat that precipitation fully after, be filtered to clear and bright, add an amount of essence seasoning, pour in 10 milliliters of vials, the sealing, the dress box, Ganoderma extract oral liquid finished product.

Claims

1, the smart production technology of a kind of Ganoderma of the primary raw material with Ganoderma, extract and adopt the low temperature reflux extraction process by water to carry out the first time that it is characterized in that the Ganoderma raw material, and water at low temperature carries twice, and temperature is no more than 80 ℃; Extraction for the second time is that the Ganoderma raw material after water is carried carries out the extraction of Different concentrations of alcohol circumfluence method again, and the concentration of ethanol extraction is respectively 50 ℃, 60 ℃, 70 ℃ through three extractions, and the concentrated solution after the extraction is all handled through precipitate with ethanol and low temperature Cryoprecipitation.

2, the smart production technology of Ganoderma according to claim 1 is characterized in that alcohol precipitation process is with lucidum concentrating liquid, slowly adds 95% ethanol, constantly stirs, and contains the alcohol amount and reaches more than 70%, and is static more than 24 hours.After treating that precipitation fully, beat easily supernatant.

3, the smart production technology of Ganoderma according to claim 1 is characterized in that Cryoprecipitation technology is with concentrated solution, slowly adds equivalent and heats up in a steamer water, constantly stirs, and places 2-5 ℃ of cold house static more than 48 hours then, treat that precipitation fully after, be filtered to clear and bright.

4, the smart production technology of Ganoderma according to claim 1, it is characterized in that the smart preparation of producing of Ganoderma is that concentrated solutions such as Ganoderma, Radix Ginseng, the Radix Polygoni Multiflori are mixed, fine filtering, place retort, be heated to 80 ℃, the bright Mel of pressing obtaining liq total amount adding 50% then stirs, the antiseptic of adding 0.5%, place 2-5 ℃ of cold house, static more than 48 hours, be mixed with the Ganoderma seminal fluid.