CN1284848C - Dry red persimmon wine and its brewing method - Google Patents

Abstract

The present invention discloses a dry red persimmon wine and a brewing method thereof. The dry red persimmon wine is prepared from the effective active components of the following weight ratio effective range (measured by the total amount of 100 parts): 70 to 80 parts of persimmon fruit, 7 to 8 parts of camptotheca acuminata, 2 to 3 parts of blister beetle, 2 to 3 parts of catharanthus roseus, 2 to 3 parts of purpleflower crotalaria herb, 1 to 2 parts of mongolian snakegourd root, 1 to 2 parts of fig, 1 to 2 parts of hedyotic diffusa, 1 to 2 parts of Chinese lobelia, 1 to 3 parts of Herba Scutellariae Barbatae, 1 to 2 parts of scorpion and 1 to 2 parts of centipede. The dry red persimmon wine is prepared by processing the effective active components through leaching through multiple temperature change, fermentation leaching, dissolution, secondary fermentation and ageing storage under the action of mildew. Nutrition and antineoplastic active components leached from the effective active components are dissolved in a home-brewed fruit wine. The fruit wine is used as a carrier, which is extremely easy to accept by humans and is extremely easy to absorb by human bodies. The nutrition, the antineoplastic active components and the fruit wine can mutually benefit and enhance curative effects, and the dry red persimmon wine has the remarkable effect on the prevention and the cure of cancer diseases. The dry red persimmon wine of the present invention has the advantages of scientific prescription, unique extraction method, less investment and obvious effect, and the dry red persimmon wine is a valuable product capable of being developed.

Description

Dry red persimmon wine and brewing method thereof

Technical field: the present invention relates to a kind of dry red persimmon wine and brewing method thereof.

Background technology: Cancerous disease is the difficult problem that the countries in the world medical circle is captured, it is as an incurable disease for a long time, human beings'health and life in serious threat, 7,000,000 people that have an appointment of cancer are died from the whole world every year, sickness rate continues soaring, mortality ratio is high, does not also effect a radical cure the effective ways and the specifics of cancer even to this day.At present, tradition is controlled the method for cancer and is: operation, radiotherapy, chemotherapy.The defective of this method is: 1, curative ratio is not high, easily recurrence; 2, operation, chemicotherapy make the patient become more painful aspect the body ﹠ mind two; 3, put, chemotherapy only payes attention to killing cancer cell, and thinks little of protecting human body, even injury human body; 4, put, chemotherapy can havoc the human immune system, make cancer cells out of hand, quicken growth of cancer cells, diffusion; 5, put, the huge toxic side effect of chemotherapy can cause systemic reaction, have to when serious to stop to put, chemotherapy; 6, put, chemotherapy action time is short and put for twice, the chemotherapy gap is long, can cause cancer cells to regrow like this, spread; 7, all at present anticarcinogen all can not anti-metastasis, anti-recurrence, therefore be unfavorable for patient's thorough rehabilitation.There are some defectives in existing employing Chinese medicinal materials goods treatment cancer: extracting method is science not, and extraction yield is low; The dense black strange taste of medicine is big, and people are difficult for accepting; Specific absorption is low, does not reach expected effect.

Summary of the invention: the purpose of this invention is to provide a kind of dry red persimmon wine with auxiliary anti-cancer curative effect; Another object of the present invention provides the brewing method of the cancer preventing and treating dry red persimmon wine of a kind of brewing method novelty, uniqueness, advanced person, science.In order to solve above-mentioned technical problem, the present invention is achieved by the following technical solutions: the present invention is a kind of dry red persimmon wine, and the effective active moiety that it comprises is in 100 parts of total amounts, and the useful range of ratio by weight is: Fructus persimmon 70-80 part; Camplotheca acuminata 7-8 part; Chinese blister beetle 2-3 part; Vinca 2-3 part; Purpleflower Crotalaria Herb 2-3 part; Snakegourd Root 1-2 part; Fructus Fici 1-2 part; Spreading Hedyotis Herb 1-2 part; Herba Lobeliae Chinensis 1-2 part; Herba Scutellariae Barbatae 1-3 part; Scorpio 1-2 part; Centipede 1-2 part.The present invention includes the following step of brewageing: (1), will carry out fragmentation through screening, the Fructus persimmon of removing impurity, granularity control is at the 4-8 micron, to add potassium metabisulfite 10-12g/100kg Fructus persimmon when broken, melt with softening water, to drip uniformly, then pulp liquid is pumped in the hold tank, control product temperature is 0-1 ℃, and is standby; (2), get the Camptotheca acuminata root of removing impurity, section, oven dry, stem, leaf, fruit and put in the pulverizer and pulverize, granularity control is at the 40-80 micron, it is standby to get powder; (3), get remove decaptitate, the Chinese blister beetle of foot, wing and impurity, oven dry puts in the pulverizer and pulverizes, granularity control is at the 40-80 micron, it is standby to get powder; (4), get the Vinca of removing impurity, edulcoration, segment, oven dry and put in the pulverizer and pulverize, granularity control is at the 40-80 micron, it is standby to get powder; (5), get the Purpleflower Crotalaria Herb of removing impurity, edulcoration, segment, oven dry and put in the pulverizer and pulverize, granularity control is at the 40-80 micron, it is standby to get powder; (6), get and remove impurity, soak 3-4 and become radices trichosanthis saturating, that pull out, run through, cut into slices, dry to put in the pulverizer to pulverize, granularity control is at the 40-80 micron, it is standby to get Snakegourd Root; (7), get the Fructus Fici of removing impurity, grey bits and anthocaulus, segment, oven dry and put in the pulverizer and pulverize, granularity control is at the 40-80 micron, it is standby to get powder; (8), get remove impurity, edulcoration, the Spreading Hedyotis Herb of profit, segment, oven dry is put in the pulverizer and pulverizes slightly, granularity control is at the 40-80 micron, it is standby to get powder; (9), get the Herba Lobeliae Chinensis of removing impurity, edulcoration, segment, oven dry and put in the pulverizer and pulverize, granularity control is at the 40-80 micron, it is standby to get powder; (10), get the Herba Scutellariae Barbatae of removing impurity, edulcoration, segment, oven dry and put in the pulverizer and pulverize, granularity control is at the 40-80 micron, it is standby to get powder; (11), get the scorpio of removing impurity, edulcoration, remove foot, truncating, drying and put in the pulverizer and pulverize, granularity control is at the 40-80 micron, it is standby to get powder; (12), get the centipede of removing bamboo chip, head, foot, the section of cutting, oven dry and put in the pulverizer and pulverize, granularity control is at the 40-80 micron, it is standby to get powder; (13), the pulp liquid collected in the above steps and powder put in the preheating lixiviate jar jointly mix, by weight than blended ratio be: step (1) Fructus persimmon pulp liquid 70-80 part, powder 7-8 part of step (2) camplotheca acuminata, powder 2-3 part of step (3) Chinese blister beetle, powder 2-3 part of step (4) Vinca, powder 2-3 part of step (5) Purpleflower Crotalaria Herb, step (6) Snakegourd Root 1-2 part, powder 1-2 part of step (7) Fructus Fici, powder 1-2 part of step (8) Spreading Hedyotis Herb, powder 1-2 part of step (9) Herba Lobeliae Chinensis, powder 1-3 part of step (10) Herba Scutellariae Barbatae, powder 1-2 part of step (11) scorpio, powder 1-2 part of step (12) centipede, stir, heat up with steam heating, temperature is controlled at 40-60 ℃, time is 30-50 minute, and it is standby to get preheating lixiviate pulp mixed solution; (14) the preheating lixiviate pulp mixed solution with step (13) pumps in the enzymatic vessel, the a-amylase of adding 0.001% and 0.05% compound pectinase stir in slurries, and control product temperature is 15-28 ℃, time is 30-50 minute, and the lixiviate slurries that get enzymolysis are standby; (15), in the slurries of step (14) enzymolysis, add so of 80-100mg/L slurries ₂, stir, heat up with steam heating, temperature is controlled at 60-80 ℃, and the time is 60-80 minute, and the slurries that get secondary lixiviate sterilization are standby; (16), the slurries of step (15) are pumped in the settling tank, in slurries, gradually add caco ₃, acidity is adjusted into 0.8-1.28g/L, when pH value is 3.3-3.5, add white sugar 4.7-5.7kg/100kg slurries, add honey 4.5-5.5kg/100kg slurries, stir, the slurries of the fermentation condition that must suit are standby; (17), with fermentor tank and each pipe fitting thereof under the vapor pressure of 1kgf/cm2 sterilization 30-50 minute, the slurries of step (16) are pumped in the fermentor tank, constant volume is 75-85%, heat up with steam heating, temperature is controlled at 60-80 ℃, time is 30-50 minute, then the product temperature drop of slurries during to 18-22 ℃, the grape wine dry yeast that adds the 1kg/10000kg slurries, the adding method is: get all clear juice of persimmon, mix with 1 to 1 softening water, the dry yeast of getting 1 part of quality mixes with the clear juice of all persimmons and the softening water of 10 parts of quality, stirs after 1 hour, add from the fermentation tank top, stir, carry out the lixiviate fermentation, the time is 4-6 days, every interval 12 hours is to the logical sterile air of fermentor tank 1 time, and fully spray medicine end and the skin slag that floats over fermented liquid top with circulation juice, each spray will make the fermented liquid in the jar all fall 1 time, and it is standby to get primary fermentation lixiviate slurries; (18), with the valve open of step (17) fermentor tank bottom, emit wine liquid through screen cloth, this wine liquid is former wine, after former wine flows to end, medicine end and skin slag are taken out, squeeze through bladder squeezing machine, the skin slag is discarded, expressed wine juice is mixed in 1 to 1 ratio with former wine, stir, the product temperature control is at 18-22 ℃, time is 3-5 days, carries out dissolved sealing fermentation, when the concentration of fermented liquid is that 1.01-1.03g/ml, residual sugar are below 0.5%, when aroma is arranged, the dissolving fermentation ends, it is standby to get secondary fermentation wine liquid; (19), with the product temperature control of step (18) fermentating wine 18-20 ℃ the time, PH is higher than at 3.2 o'clock, adds the sealing fermentation that living lactic acid bacteria carries out oxysuccinic acid-lactic acid, time is 14-16 days, whether fermentation is finished, and analyses with ply of paper and tests, and the lixiviate wine liquid that gets fermentation ends is standby; (20), in the wine liquid of step (19), add so of 110-120mg/L wine liquid immediately ₂Stir, carry out centrifugation, remove impurity such as yeast slurry with high-speed centrifugal pump again, is that 5-5.7g/L, PH be 2.8-3.4, ethanol content be the standard of 11-12% allocate by containing sugar for 0.2-0.4g/L, total acid with wine liquid, with deployed wine liquid is the strainer coarse filtration of 100-300 micron through granularity earlier, be 30,000-50,000 microns the smart filter of degerming plate again through granularity, the wine liquid pump of essence filter is gone in the aseptic hold tank, control product temperature is-4.5--5.5 ℃, time is more than 96 hours, and is standby; (21), the wine liquid of step (20) is carried out sterile filling, be this product.Owing to take technique scheme, the invention has the beneficial effects as follows: the content height that 1, contains antitumor activity component in the moiety Fructus persimmon of product of the present invention, camplotheca acuminata, Chinese blister beetle, Vinca, Purpleflower Crotalaria Herb, Snakegourd Root, Fructus Fici, Spreading Hedyotis Herb, Herba Lobeliae Chinensis, Herba Scutellariae Barbatae, scorpio, the centipede; 2, extracting method, extraction yield obviously is better than documents, the present invention takes repeatedly alternating temperature lixiviate, the fermentation lixiviate, dissolving is fermentation again, the Protocols in Molecular Biology that ageing is stored is from Fructus persimmon, camplotheca acuminata, Chinese blister beetle, Vinca, Purpleflower Crotalaria Herb, Snakegourd Root, Fructus Fici, Spreading Hedyotis Herb, Herba Lobeliae Chinensis, Herba Scutellariae Barbatae, scorpio, extract anti-cancer active matter in the centipede: camptothecine, Cantharidin, vinealeucoblastine(VLB), vincristine(VCR), leurosine, vincaleucoblastine, leurosidine, minorine, crotaline, Trichosanthin, Citric Acid, fumaric acid, succsinic acid, V-carotene, ficin, asperuloside, the woodruff thuja acid, Herba Paederiae time glycosides, alkaloid, rivularin, scorpion venom, class bee venom sample material, analogued histamine sample material, materials such as dissolved blood protein, through check, extraction yield is up to more than 94%, and documents adopts the primary immersion process, and the useful component of Chinese medicinal materials is difficult to extract; 3, specific absorption is apparently higher than documents, the present invention is in the process of fermentation lixiviate, the strange taste and the toxic side effect of Chinese medicinal materials have been reduced, nutritive ingredient and anti-tumor active substance that lixiviate is come out dissolve in the wine of making, with fruit wine is carrier: efficacy enhanced by wine, wine helps the efficacy of a drug, nowhere less than, the You Jie that proves effective has improved useful component absorption in vivo rate greatly, allow people when drinking good wine, played the effect of anti-cancer health, and documents is a medicinal powder, pained strange taste is big, people be difficult for to accept, the impression of the drink good wine and the medicine of bearing hardships and effect can't than; 4, function and curative effect are significantly better than documents, product of the present invention is to employ prevention to be the policy of main treatment for pair, its cancer preventing and treating mechanism is: (1) strengthens the immunologic function of human body, improve adhesive capacity and the affinity of human body, prevent, press down the growth and the diffusion of killing, blocking cancer cells cancer cells; (2), cut off tumor neogenetic blood vessels, make tumour can not get nutrition supply and hungry dead; (3), activate the vivo antitumor cell and attack cancer cells, make cancer cells dead rapidly; (4), make cancer cells generation change, necrosis, pyknosis, densely dye, morphological changes such as chromatin condensation, the many cavitys of endochylema, cancer cells and host liver cell ultrastructure are changed, finally cause carcinolysis to destroy and dead; (5), combat poison with poison, selectively destroy and poison with poison cancer cells; (6), generate a large amount of necrosins, the accelerate dissolution cancer cells disappears tumour rapidly.And documents is to go to treat it again when finding tumour, is a kind of methods of treatment of passiveness.Prevention and treatment tumor experiment with dry red persimmon wine illustrates its curative effect below: the A experiment material: the S180 cell strain is provided by Shanghai Medical Univ's tumour, and tumor inoculation and judgement criteria are undertaken by the method for " national antitumour drug object internal segment selects rules "; Kunming mouse, the male and female dual-purpose, in mouse 8-10 in age week, body weight 18-22g is provided by Guangxi Medical University's Experimental Animal Center, and animal pellet feed is fed, and the temperature 25-28 of animal housing ℃, animal is by sex sub-cage rearing, 7 in every cage; Electronic analytical balance, Zhenjiang, Jiangsu precision instrument factory is produced; Endoxan, the 100mg/ bottle faces with the fresh 5mg/ml of being mixed with, and experiment is a product of the present invention with dry red persimmon wine; B, method and result: medicine is prepared: dry red persimmon wine is prepared by the optimum dosage 25ml/kg body weight of the dose curve of doing in our preliminary experiment; Grouping: get 21 of mouse, be divided into 3 groups, every group 7, the strain of S180 knurl is made into 6 * 106 cell suspensions and is inoculated in the right front oxter of mouse, and every mouse inoculation 0.2ml is divided into the physiological saline model control group at random after the inoculation: give 0.5ml physiological saline, 1 time/d, continuous 7d, endoxan negative control group: 20mg/kg intraperitoneal injection, dry red persimmon wine experimental group: 1 time/d of administration, every mouse all gives 0.5ml wine liquid, successive administration 7d; The separation of tumour, check weighing: mouse is put to death in 12n dislocation after the last administration, cuts off the inoculated tumour position, and the complete tumor mass that separates with the filter paper liquid on it that exhausts, is weighed on electronic balance; Curative effect is judged: with tumor control rate 〉=30% for having antitumor action, this experiment successively again in the same way method hepatoma cell strain BFL-7402, W256, L1210 are experimentized, get the mean of four experimental results, compare its significance of difference through the t check; Experimental result: dry red persimmon wine experimental group, the knurl body weight is 0.09 ± 0.25m/g, inhibiting rate is 95.4%, remarkable antitumor effect endoxan negative control group is arranged, the knurl body weight is 0.61 ± 0.43m/g, inhibiting rate is 68.1%, good antitumor action, physiological saline control group are arranged, the knurl body weight is 1.91 ± 0.61m/g, inhibiting rate is 0.0%, no antitumor action, and experimental result shows, dry red persimmon wine can obviously kill, the division of anticancer and propagation, shows as the knurl body is alleviated; (7), the present invention's food therapy cancer preventing and treating; remedied the defective of traditional operation, chemicotherapy method treatment cancer: to change damaging treatment be the protectiveness treatment, change the indirect treatment for the continuity treatment, to change the obliquity treatment be that balance is treated; change treatment and be prevention; this is a kind of epoch-making methods of treatment that makes cancer therapy become and carry out easily, is the revolution of cancer therapy! (8) technology of the present invention, equipment are simple to operation, and raw material sources are wide, cost is low, have no side effect, and can produce and use; (9) the invention solves and be beyond one's reach at present repeatedly to ferment lixiviate Protocols in Molecular Biology and be carrier technique with fruit wine, it is extremely abundant to have invented nutrition, has the dry red persimmon wine of cancer preventing and treating.In sum, the present invention compares with documents, has practicality, novelty and creativeness, and has outstanding substantive distinguishing features and marked improvement, and can produce positive effect, can produce and use, and product color is pink, sweet and sour taste, inexpensive, people are acceptant.Below respectively to Fructus persimmon, camplotheca acuminata, Chinese blister beetle, Vinca, Purpleflower Crotalaria Herb, Snakegourd Root, Fructus Fici, Spreading Hedyotis Herb, Herba Lobeliae Chinensis, Herba Scutellariae Barbatae, scorpio, the pharmacological property analysis of centipede, Fructus persimmon: put down in writing in the pharmacopeia, persimmons all, have another name called blueberry, big sincere this, it is the Ericaceae genus vaccinium, wild machaka, with the wild fruit that is grown in border area, the big Xiaoxinanlin Mountains of Heilongjiang Province of China is good merchantable brand, be grown in the soil that has only the phase of freezing about 100 days in 1 year, take root in the soil layer on underground 30 centimeters permafrost horizons, the Fructus persimmon of unique growing environment, have unique nutrition and health care medical value, the Fructus persimmon flavor is sweet, acid, property is put down, go into liver, spleen, kidney channel.Have antitumor, anti-aging effects, to the activity, the protection that improve serum lactic dehydrogenase in the heart are cardiovascular good action arranged, antibechic is arranged simultaneously, eliminate the phlegm, antiasthmatic effect, to digestion such as stomach, bladder, urethras, the inflammation of excretory system has reliable curative effect; Camplotheca acuminata: bitter, suffering, cold in nature.Poisonous.Return spleen, stomach, Liver Channel.Antitumor action is arranged, immunosuppressive action, effect cures mainly: anticancer dispersing, clearing heat and detoxicating, activating blood circulation and reducing swelling.Cure mainly various cancers, acute and chronic leukemia, psoriasis, sore swell the schistosomicide hepatosplenomegaly; Chinese blister beetle: flavor is hot, warm in nature.Very toxic.Return liver, stomach, kidney channel.The poison strong attack diffusing.Antitumor action is arranged, to the influence of medulla hematopoietic system, to immune effect, the effect of resisting pathogenic microbes, to the effect of skin, effect cures mainly: attack malicious phagedenoma, broken blood dissipating bind.Cure mainly cancerous swelling, ulcer is not burst, scrofula mouse fistula, and stubborn dermatitis scabies leprosy, syphilis is through closing positive lump in the abdomen, hernia, wart, tetanus, lyssodexis, facial paralysis, numbness pain; Vinca: bitter, cold nature.Poisonous.The thoughts of returning home, liver, lung channel.The matter poison looses and falls.Antitumous effect is arranged, to the effect of cardiovascular systems, hypoglycemic, reducing blood lipid.Effect cures mainly: clearing heat and detoxicating, and anti-cancer and detumescence, flat liver step-down cures mainly multiple cancerous swelling, hypertension, carbuncle sore tumefacting virus burns and scalds.Purpleflower Crotalaria Herb: it is sweet, light to distinguish the flavor of, and property is flat.Poisonous.Return lung, liver, stomach warp.Antitumor action is arranged.Effect cures mainly: the long-pending dampness removing that disappears, and relieving cough and asthma, anticancer detoxifcation cures mainly pernicious cancerous swelling, infantile malnutrition due to digestive disturbances or intestinalparasites, dysentery, under the gonorrhoea band, rheumatic arthralgia, urgency, furunculosis sore furuncle, venomous snake bite are breathed heavily in cough; Snakegourd Root: sweet, little hardship of distinguishing the flavor of, cold nature.Attach to the lung and stomach meridians.The real gas of body and, can rise and can fall.Antitumous effect is arranged, cause miscarriage and antiearly pregnancy effect, immune influence, AIDS virus resisting, to the influence of blood sugar, effect cures mainly: heat-clearing rises Tianjin, moistening the lung and resolving the phlegm, the strongly fragrant detumescence of loosing, anticancer detoxifcation, cure mainly cancerous swelling, pyreticosis is thirsty, quenches one's thirst and draws drink, lung-heat type cough, hypochondriac pain, pharyngalgia, breast is few, acute mastitis and sore swollen toxin; Fructus Fici: sweet, little acid of distinguishing the flavor of, property is flat.Return spleen, stomach, lung channel.Antitumor action is arranged, immunoregulation effect.Effect cures mainly: anticancer detoxifcation, moisten the lung and relieve the cough spleen benefiting and stimulating the appetite.Cure mainly cancerous swelling, dryness of the lung dry cough, pharyngalgia trachyphonia, milk rareness, poor appetite, dysentery, the dry constipation of intestines, the carbuncle hemorrhoid that swell; Spreading Hedyotis Herb: bitter, little sweet, cold nature.Return lung, liver, stomach warp.Antitumor action is arranged, to Immune Effects, to the influence of enteron aisle.Effect cures mainly: detoxicating and fighting cancer, clearing heat and promoting diuresis.Cure mainly cancerous swelling, dyspnea and cough due to lung-heat, swelling and pain in the throat, jaundice due to damp-heat, heat is drenched puckery pain, oedema, dysentery, enteritis, acute appendicitis, the carbuncle sore that swells, venomous snake bite; Herba Lobeliae Chinensis: it is sweet, light, cool in nature to distinguish the flavor of.Slightly poisonous.The thoughts of returning home, lung, urinary bladder channel.Can loose and to fall.The cancer knurl effect of pressing down is arranged.Diuretic properties, to the effect of cardiovascular systems, to the effect of respiratory system, to neural effect, the antisnake venom effect.Effect cures mainly: clearing heat and detoxicating, and inducing diuresis to remove edema, dissipating bind is anticancer.Cure mainly various cancers, venomous snake bite, the carbuncle furunculosis that swells, pharyngalgia larynx numbness, jaundice due to damp-heat rushes down dysentery, rheumatic arthralgia, eczema tinea pedis, wound, oedema ascites; Herba Scutellariae Barbatae: flavor is hot, little hardship, and is cool in nature.Return lung, stomach, liver, kidney channel.Can loose and can fall, antitumous effect is arranged, to Immune Effects, the effect of resisting pathogenic microbes.Effect cures mainly: anticancer, clearing heat and detoxicating, and dissipating bind stagnation resolvation, hemostasis, Li Shui.Cure mainly multiple cancerous swelling, swelling and pain in the throat, lung carbuncle, acute appendicitis, hepatitis, dysentery, sore swollen toxin, venomous snake bite, the scrofula subcutaneous nodule, wound is spitted blood bleeding from five sense organs or subcutaneous tissue, blood pouring, oedema, ascites; Scorpio: flavor is hot, property is flat.Poisonous.Return Liver Channel.Search to pick away and scurry, can rise and to fall.Antitumor action is arranged, to neural effect, to the effect of cardiovascular systems, to metabolic effect, to the effect of blood system.Effect cures mainly: detoxicating and fighting cancer, relievng spasm by subduing liver-wind is removed obstruction in channels to relieve pain.Cure mainly anticancer, infantile convulsion, spasm is twitched, epilepsy, middle air port is askew, hemiplegia, tetanus, rheumatoid arthritis stubborn, migraine and general headache, toothache, deafness, hernia stomachache, scrofula subcutaneous nodule, carbuncle sore tumefacting virus, rubella stubborn dermatitis, worm snakebite, burn and scald; Centipede: flavor is hot, warm in nature.Poisonous.Return Liver Channel.Search to pick away and scurry, can rise and to fall.Antitumor action is arranged, central inhibitory action, the effect of resisting pathogenic microbes is to the effect of cardiovascular systems.Effect cures mainly: detoxicating and fighting cancer, relievng spasm by subduing liver-wind is removed obstruction in channels to relieve pain.Cure mainly the cancer knurl, infantile convulsion, epilepsy, spasm is twitched, and middle air port is askew, tetanus, rheumatoid arthritis stubborn, migraine and general headache, scrofula, anal fistula, sore, stubborn dermatitis, venomous snake bite.Cancer preventing and treating dry red persimmon wine of the present invention, with Fructus persimmon, camplotheca acuminata, Chinese blister beetle, Vinca, Purpleflower Crotalaria Herb, Snakegourd Root, Fructus Fici, Spreading Hedyotis Herb, Herba Lobeliae Chinensis, Herba Scutellariae Barbatae, scorpio, centipede is a raw material, under the effect of enzyme bacterium, through repeatedly alternating temperature lixiviate, the fermentation lixiviate, dissolving is fermentation again, the storage ageing forms, help mutually, heighten the effect of a treatment, remarkable to the cancer preventing and treating effect, it is the collection help, diseases prevention, cure the disease and be the nutritive food of one, scientific formulation of the present invention, technology is advanced unique, equipment is simple to operation, and raw material sources are wide, pollution-free, have no side effect, less investment, instant effect, be valuable can development product.

Embodiment: following the invention will be further described, and this law is called a kind of dry red persimmon wine, and the effective active moiety that it comprises is in 100 parts of total amounts, and the useful range of ratio by weight is: Fructus persimmon 70-80 part; Camplotheca acuminata 7-8 part; Chinese blister beetle 2-3 part; Vinca 2-3 part; Purpleflower Crotalaria Herb 2-3 part; Snakegourd Root 1-2 part; Fructus Fici 1-2 part; Spreading Hedyotis Herb 1-2 part; Herba Lobeliae Chinensis 1-2 part; Herba Scutellariae Barbatae 1-3 part; Scorpio 1-2 part; Centipede 1-2 part.The present invention includes the following step of brewageing: (1), will carry out fragmentation through screening, the Fructus persimmon of removing impurity, granularity control is at 6 microns, to add potassium metabisulfite 11g/100kg Fructus persimmon when broken, melt with softening water, to drip uniformly, then pulp liquid is pumped in the hold tank, control product temperature is 0 ℃, and is standby; (2), get the Camptotheca acuminata root of removing impurity, section, oven dry, stem, leaf, fruit and put in the pulverizer and pulverize, granularity control is at 60 microns, it is standby to get powder; (3), get remove decaptitate, the Chinese blister beetle of foot, wing and impurity, oven dry puts in the pulverizer and pulverizes, granularity control is at 60 microns, it is standby to get powder; (4), get the Vinca of removing impurity, edulcoration, segment, oven dry and put in the pulverizer and pulverize, granularity control is at 60 microns, it is standby to get powder; (5), get the Purpleflower Crotalaria Herb of removing impurity, edulcoration, segment, oven dry and put in the pulverizer and pulverize, granularity control is at 60 microns, it is standby to get powder; (6), get and remove impurity, soak 3-4 and become radices trichosanthis saturating, that pull out, run through, cut into slices, dry to put in the pulverizer to pulverize, granularity control is at 60 microns, it is standby to get Snakegourd Root; (7), get the Fructus Fici of removing impurity, grey bits and anthocaulus, segment, oven dry and put in the pulverizer and pulverize, granularity control is at 60 microns, it is standby to get powder; (8), get remove impurity, edulcoration, the Spreading Hedyotis Herb of profit, segment, oven dry is put in the pulverizer and pulverizes slightly, granularity control is at 60 microns, it is standby to get powder; (9), get the Herba Lobeliae Chinensis of removing impurity, edulcoration, segment, oven dry and put in the pulverizer and pulverize, granularity control is at 60 microns, it is standby to get powder; (10), get the Herba Scutellariae Barbatae of removing impurity, edulcoration, segment, oven dry and put in the pulverizer and pulverize, granularity control is at 60 microns, it is standby to get powder; (11), get the scorpio of removing impurity, edulcoration, remove foot, truncating, drying and put in the pulverizer and pulverize, granularity control is at 60 microns, it is standby to get powder; (12), get the centipede of removing bamboo chip, head, foot, the section of cutting, oven dry and put in the pulverizer and pulverize, granularity control is at 60 microns, it is standby to get powder; (13), the pulp liquid collected in the above steps and powder put in the preheating lixiviate jar jointly mix, by weight than blended ratio be: 75 parts of step (1) Fructus persimmon pulp liquid, 7.5 parts in the powder of step (2) camplotheca acuminata, 2.5 parts in the powder of step (3) Chinese blister beetle, 2.3 parts in the powder of step (4) Vinca, 2.2 parts in the powder of step (5) Purpleflower Crotalaria Herb, 1.5 parts of step (6) Snakegourd Root, 1.3 parts in the powder of step (7) Fructus Fici, 1.4 parts in the powder of step (8) Spreading Hedyotis Herb, 1.2 parts in the powder of step (9) Herba Lobeliae Chinensis, 2.1 parts in the powder of step (10) Herba Scutellariae Barbatae, 1.5 parts in the powder of step (11) scorpio, 1.5 parts in the powder of step (12) centipede, stir, heat up with steam heating, temperature is controlled at 50 ℃, time is 40 minutes, and it is standby to get preheating lixiviate pulp mixed solution; (14) the preheating lixiviate pulp mixed solution with step (13) pumps in the enzymatic vessel, and the a-amylase of adding 0.001% and 0.05% compound pectinase stir in slurries, and control product temperature is 20 ℃, and the time is 40 minutes, and the lixiviate slurries that get enzymolysis are standby; (15), in the slurries of step (14) enzymolysis, add so of 90mg/L slurries ₂, stir, heat up with steam heating, temperature is controlled at 70 ℃, and the time is 70 minutes, and the slurries that get secondary lixiviate sterilization are standby; (16), the slurries of step (15) are pumped in the settling tank, in slurries, gradually add caco ₃, acidity is adjusted into 1.0g/L, pH value is 3.4 o'clock, adds white sugar 5.0kg/100kg slurries, adds honey 5.0kg/100kg slurries, stirs, the slurries of the fermentation condition that must suit are standby; (17), with fermentor tank and each pipe fitting thereof sterilization 40 minutes under the vapor pressure of 1kgf/cm2, the slurries of step (16) are pumped in the fermentor tank, constant volume is 80%, heat up with steam heating, temperature is controlled at 70 ℃, time is 40 minutes, during then the product temperature drop to 20 of slurries ℃, the grape wine dry yeast that adds the 1kg/10000kg slurries, the adding method is: get all clear juice of persimmon, mix with 1 to 1 softening water, the dry yeast of getting 1 part of quality mixes with the clear juice of all persimmons and the softening water of 10 parts of quality, stirs after 1 hour, add from the fermentation tank top, stir, carry out the lixiviate fermentation, the time is 5 days, every interval 12 hours is to the logical sterile air of fermentor tank 1 time, and fully spray medicine end and the skin slag that floats over fermented liquid top with circulation juice, each spray will make the fermented liquid in the jar all fall 1 time, and it is standby to get primary fermentation lixiviate slurries; (18), with the valve open of step (17) fermentor tank bottom, emit wine liquid through screen cloth, this wine liquid is former wine, after former wine flows to end, medicine end and skin slag are taken out, squeeze through bladder squeezing machine, the skin slag is discarded, expressed wine juice is mixed in 1 to 1 ratio with former wine, stir, the product temperature control is at 20 ℃, time is 4 days, carries out dissolved sealing fermentation, when the concentration of fermented liquid is that 1.02g/ml, residual sugar are below 0.5%, when aroma is arranged, the dissolving fermentation ends, it is standby to get secondary fermentation wine liquid; (19), with the product temperature control of step (18) fermentating wine 19 ℃ the time, PH is higher than at 3.2 o'clock, adds the sealing fermentation that living lactic acid bacteria carries out oxysuccinic acid-lactic acid, time is 15 days, whether fermentation is finished, and analyses with ply of paper and tests, and the lixiviate wine liquid that gets fermentation ends is standby; (20), in the wine liquid of step (19), add so of 115mg/L wine liquid immediately ₂Stir, carry out centrifugation, remove impurity such as yeast slurry with high-speed centrifugal pump again, by containing sugar for 0.3g/L, total acid are that 5.3g/L, PH are 3.0, ethanol content is that 11.5% standard is allocated, earlier through granularity is 200 micron strainer coarse filtration with deployed wine liquid with wine liquid, is 40,000 microns the smart filter of degerming plate again through granularity, the wine liquid pump of essence filter is gone in the aseptic hold tank, control product temperature is-5.0 ℃, and the time is more than 96 hours, and is standby; (21), the wine liquid of step (20) is carried out sterile filling, be this product.

Clinical application and market survey: product of the present invention can effectively prevent and treat Cancerous disease, as liver cancer, lung cancer, cancer of the stomach, uterus carcinoma etc.Through more than 3 years to 500 example prevention volunteers and 120 routine Cancerous disease patients' clinical applications, obtained significant preventive effect and tangible curative effect, its prevention rate reaches 100%, the remarkable rate 70% of treatment, total effective rate are 95%.

Details are as follows: 1, volunteer and patient profile about clinical application and treatment situation: select no Cancerous disease and other disease, healthy volunteer; Select projects such as medical history, the state of an illness, age, sex and original therapy method.2, clinical application person source: the volunteer of cancer district occurred frequently and specialist hospital patient.3, go into the group standard: the method according to " national antitumour drug body in selected parts rules " is carried out, and sex, age are not limit, and other disease of serious body is got rid of in the course of disease＞2 month; Inactive various antitumor class medicines before the treatment.4, instructions of taking: (1) prevention volunteer: obey 150～200ml, obey once evening every day at every turn, and 2 months is a course of treatment; (2) cancer patients: obey 100～150ml at every turn, obey twice every day, morning and evening service once, 2 months is a course of treatment.5, efficacy evaluation: (1) prevention group: none routine Cancerous disease patient prevention rate 100%; (2) treatment group: A, recovery from illness: tumour completely dissolve, cure rate are 70%; B, produce effects: big disappearance of tumour, obvious effective rate is 18.3%; C, effective: tumour obviously alleviates, and efficient is 7.5%; D, invalid: tumour disappears not obvious, and inefficiency is 4.2%.6, efficacy analysis: 500 examples are organized in (1) sex: A, prevention, the male sex's 300 examples (60%) wherein, women's 200 examples (40%); 120 examples are organized in B, treatment, the male sex's 80 examples (67%) wherein, women's 40 examples (33%).(2) course of disease: A, prevention group, no medical history; B, treatment group: 6～12 months be 60 examples, 12～24 months be 50 examples, be 10 examples more than 24 months.(3) age group: A, prevention group: 16～20 years old be 50 examples, 21～30 years old be 100 examples, 31～40 years old be 100 examples, 41～50 years old be 100 examples, be 100 examples in 51～60 years old, the person is 50 examples more than 60 years old.B, treatment group: 16～20 years old be 10 examples, 21～30 years old be 10 examples, 31～40 years old be 30 examples, 41～50 years old be 40 examples, be 20 examples in 51～60 years old, the person is 10 examples more than 60 years old.(4) 500 examples are organized in disease type and curative effect: A, prevention, and efficient is 100%; B, treatment group: liver cancer patient 50 examples, 31 examples of wherein fully recovering, produce effects 11 examples, improvement 2 examples, invalid 1 example; Patients with lung cancer 30 examples, 20 examples of wherein fully recovering, produce effects 6 examples, improvement 4 examples, invalid 0 example; Patients with gastric cancer 25 examples, 15 examples of wherein fully recovering, produce effects 3 examples, improvement 3 examples, invalid 4 examples; Uterus carcinoma patient's 20 examples, 18 examples of wherein fully recovering, produce effects 2 examples, improvement 0 example, invalid 0 example.By product cancer preventing and treating of the present invention, significant preventive effect and satisfied curative effect have been received, the symptom of cancer is a lot, modal liver cancer, lung cancer, cancer of the stomach, four contents of uterus carcinoma are selected in this clinical experiment, clinical application is carried out jointly in cancer district occurred frequently and specialist hospital, wherein got rid of other type disease, all belonged to the cancer category so this treats selected case.Before this group case treatment all because of bear can't stand put, the misery of chemotherapy and the toxic side effect of anti-cancer class medicine stop to treat, in the process of taking product treatment of the present invention, must not put, chemotherapy and take other medicines, that the present invention uses is promoting blood circulation and removing blood stasis, softening and resolving hard mass, strengthen the body resistance to consolidate the constitution, strengthening immunity, the anticancer cell of human activin self is eliminated cancer cells in the body, its anticancer mechanism is: (1) strengthens the immunologic function of human body, improve adhesive capacity and the affinity of human body, the growth and the diffusion of prevention, inhibition, blocking-up cancer cells to cancer cells; (2), cut off tumor neogenetic blood vessels, make tumour can not get nutrition supply and hungry dead; (3), activate the vivo antitumor cell and attack cancer cells, make cancer cells dead rapidly; (4), make cancer cells generation change, necrosis, pyknosis, densely dye, morphological changes such as chromatin condensation, the many cavitys of endochylema, cancer cells and host liver cell ultrastructure are changed, finally cause carcinolysis to destroy and dead; (5), combat poison with poison, selectively destroy and poison with poison cancer cells; (6), generate a large amount of necrosins, the accelerate dissolution cancer cells disappears tumour rapidly.

Claims (1)

1, a kind of dry red persimmon wine is characterized in that: the effective active moiety that it comprises is in 100 parts of total amounts, and the useful range of ratio by weight is: Fructus persimmon 70-80 part; Camplotheca acuminata 7-8 part; Chinese blister beetle 2-3 part; Vinca 2-3 part; Purpleflower Crotalaria Herb 2-3 part; Snakegourd Root 1-2 part; Fructus Fici 1-2 part; Spreading Hedyotis Herb 1-2 part; Herba Lobeliae Chinensis 1-2 part; Herba Scutellariae Barbatae 1-3 part; Scorpio 1-2 part; Centipede 1-2 part, it comprises the following step of brewageing: (1), will carry out fragmentation through screening, the Fructus persimmon of removing impurity, granularity control is at the 4-8 micron, to add potassium metabisulfite 10-12g/100kg Fructus persimmon when broken, melt with softening water, drip uniformly, then pulp liquid is pumped in the hold tank, control product temperature is 0-1 ℃, and is standby; (2), get the Camptotheca acuminata root of removing impurity, section, oven dry, stem, leaf, fruit and put in the pulverizer and pulverize, granularity control is at the 40-80 micron, it is standby to get powder; (3), get remove decaptitate, the Chinese blister beetle of foot, wing and impurity, oven dry puts in the pulverizer and pulverizes, granularity control is at the 40-80 micron, it is standby to get powder; (4), get the Vinca of removing impurity, edulcoration, segment, oven dry and put in the pulverizer and pulverize, granularity control is at the 40-80 micron, it is standby to get powder; (5), get the Purpleflower Crotalaria Herb of removing impurity, edulcoration, segment, oven dry and put in the pulverizer and pulverize, granularity control is at the 40-80 micron, it is standby to get powder; (6), get and remove impurity, soak 3-4 and become radices trichosanthis saturating, that pull out, run through, cut into slices, dry to put in the pulverizer to pulverize, granularity control is at the 40-80 micron, it is standby to get Snakegourd Root; (7), get the Fructus Fici of removing impurity, grey bits and anthocaulus, segment, oven dry and put in the pulverizer and pulverize, granularity control is at the 40-80 micron, it is standby to get powder; (8), get remove impurity, edulcoration, the Spreading Hedyotis Herb of profit, segment, oven dry is put in the pulverizer and pulverizes slightly, granularity control is at the 40-80 micron, it is standby to get powder; (9), get the Herba Lobeliae Chinensis of removing impurity, edulcoration, segment, oven dry and put in the pulverizer and pulverize, granularity control is at the 40-80 micron, it is standby to get powder; (10), get the Herba Scutellariae Barbatae of removing impurity, edulcoration, segment, oven dry and put in the pulverizer and pulverize, granularity control is at the 40-80 micron, it is standby to get powder; (11), get the scorpio of removing impurity, edulcoration, remove foot, truncating, drying and put in the pulverizer and pulverize, granularity control is at the 40-80 micron, it is standby to get powder; (12), get the centipede of removing bamboo chip, head, foot, the section of cutting, oven dry and put in the pulverizer and pulverize, granularity control is at the 40-80 micron, it is standby to get powder; (13), the pulp liquid collected in the above steps and powder put in the preheating lixiviate jar jointly mix, by weight than blended ratio be: step (1) Fructus persimmon pulp liquid 70-80 part, powder 7-8 part of step (2) camplotheca acuminata, powder 2-3 part of step (3) Chinese blister beetle, powder 2-3 part of step (4) Vinca, powder 2-3 part of step (5) Purpleflower Crotalaria Herb, step (6) Snakegourd Root 1-2 part, powder 1-2 part of step (7) Fructus Fici, powder 1-2 part of step (8) Spreading Hedyotis Herb, powder 1-2 part of step (9) Herba Lobeliae Chinensis, powder 1-3 part of step (10) Herba Scutellariae Barbatae, powder 1-2 part of step (11) scorpio, powder 1-2 part of step (12) centipede, stir, heat up with steam heating, temperature is controlled at 40-60 ℃, time is 30-50 minute, and it is standby to get preheating lixiviate pulp mixed solution; (14) the preheating lixiviate pulp mixed solution with step (13) pumps in the enzymatic vessel, the a-amylase of adding 0.001% and 0.05% compound pectinase stir in slurries, and control product temperature is 15-28 ℃, time is 30-50 minute, and the lixiviate slurries that get enzymolysis are standby; (15), in the slurries of step (14) enzymolysis, add so of 80-100mg/L slurries ₂, stir, heat up with steam heating, temperature is controlled at 60-80 ℃, and the time is 60-80 minute, and the slurries that get secondary lixiviate sterilization are standby; (16), the slurries of step (15) are pumped in the settling tank, in slurries, gradually add caco ₃, acidity is adjusted into 0.8-1.28g/L, when pH value is 3.3-3.5, add white sugar 4.7-5.7kg/100kg slurries, add honey 4.5-5.5kg/100kg slurries, stir, the slurries of the fermentation condition that must suit are standby; (17), with fermentor tank and each pipe fitting thereof at 1kgf/cm ²Vapor pressure under sterilization 30-50 minute, the slurries of step (16) are pumped in the fermentor tank, constant volume is 75-85%, heat up with steam heating, temperature is controlled at 60-80 ℃, time is 30-50 minute, then the product temperature drop of slurries during to 18-22 ℃, is added the grape wine dry yeast of 1kg/10000kg slurries, the adding method is: get all clear juice of persimmon, mix with 1 to 1 softening water, the dry yeast of getting 1 part of quality mixes with the clear juice of all persimmons and the softening water of 10 parts of quality, stirs after 1 hour, add from the fermentation tank top, stir, carry out the lixiviate fermentation, the time is 4-6 days, every interval 12 hours is to the logical sterile air of fermentor tank 1 time, and fully spray medicine end and the skin slag that floats over fermented liquid top with circulation juice, each spray will make the fermented liquid in the jar all fall 1 time, and it is standby to get primary fermentation lixiviate slurries; (18), with the valve open of step (17) fermentor tank bottom, emit wine liquid through screen cloth, this wine liquid is former wine, after former wine flows to end, medicine end and skin slag are taken out, squeeze through bladder squeezing machine, the skin slag is discarded, expressed wine juice is mixed in 1 to 1 ratio with former wine, stir, the product temperature control is at 18-22 ℃, time is 3-5 days, carries out dissolved sealing fermentation, when the concentration of fermented liquid is that 1.01-1.03g/ml, residual sugar are below 0.5%, when aroma is arranged, the dissolving fermentation ends, it is standby to get secondary fermentation wine liquid; (19), with the product temperature control of step (18) fermentating wine 18-20 ℃ the time, PH is higher than at 3.2 o'clock, adds the sealing fermentation that living lactic acid bacteria carries out oxysuccinic acid-lactic acid, time is 14-16 days, whether fermentation is finished, and analyses with ply of paper and tests, and the lixiviate wine liquid that gets fermentation ends is standby; (20), in the wine liquid of step (19), add so of 110-120mg/L wine liquid immediately ₂Stir, carry out centrifugation, remove impurity such as yeast slurry with high-speed centrifugal pump again, is that 5-5.7g/L, PH be 2.8-3.4, ethanol content be the standard of 11-12% allocate by containing sugar for 0.2-0.4g/L, total acid with wine liquid, with deployed wine liquid is the strainer coarse filtration of 100-300 micron through granularity earlier, be 30,000-50,000 microns the smart filter of degerming plate again through granularity, the wine liquid pump of essence filter is gone in the aseptic hold tank, control product temperature is-4.5--5.5 ℃, time is more than 96 hours, and is standby; (21), the wine liquid of step (20) is carried out sterile filling, be this product.