CN115969933B - Polishing method for hemsleya amabilis stomach and intestine pills - Google Patents
Polishing method for hemsleya amabilis stomach and intestine pills Download PDFInfo
- Publication number
- CN115969933B CN115969933B CN202210696537.0A CN202210696537A CN115969933B CN 115969933 B CN115969933 B CN 115969933B CN 202210696537 A CN202210696537 A CN 202210696537A CN 115969933 B CN115969933 B CN 115969933B
- Authority
- CN
- China
- Prior art keywords
- insect
- wax
- pill
- white wax
- polishing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000006187 pill Substances 0.000 title claims abstract description 133
- 238000005498 polishing Methods 0.000 title claims abstract description 66
- 238000000034 method Methods 0.000 title claims abstract description 40
- 241000465412 Hemsleya amabilis Species 0.000 title abstract description 12
- 210000000936 intestine Anatomy 0.000 title description 9
- 210000002784 stomach Anatomy 0.000 title description 9
- 241000238631 Hexapoda Species 0.000 claims abstract description 131
- 229940045860 white wax Drugs 0.000 claims abstract description 100
- 239000000843 powder Substances 0.000 claims abstract description 34
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims abstract description 29
- 239000011248 coating agent Substances 0.000 claims abstract description 23
- 238000000576 coating method Methods 0.000 claims abstract description 23
- 239000000463 material Substances 0.000 claims abstract description 21
- 238000001035 drying Methods 0.000 claims abstract description 17
- 238000007873 sieving Methods 0.000 claims abstract description 17
- 230000002496 gastric effect Effects 0.000 claims abstract description 15
- 238000005096 rolling process Methods 0.000 claims abstract description 14
- 238000002156 mixing Methods 0.000 claims abstract description 9
- 238000002360 preparation method Methods 0.000 claims abstract description 6
- 238000005507 spraying Methods 0.000 claims abstract description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 43
- 238000003756 stirring Methods 0.000 claims description 17
- 238000010438 heat treatment Methods 0.000 claims description 16
- 238000001914 filtration Methods 0.000 claims description 13
- 235000012907 honey Nutrition 0.000 claims description 12
- 239000000203 mixture Substances 0.000 claims description 12
- 238000009835 boiling Methods 0.000 claims description 11
- 229910001220 stainless steel Inorganic materials 0.000 claims description 11
- 239000010935 stainless steel Substances 0.000 claims description 11
- 238000009495 sugar coating Methods 0.000 claims description 11
- 239000010410 layer Substances 0.000 claims description 10
- 239000002344 surface layer Substances 0.000 claims description 10
- 241000756943 Codonopsis Species 0.000 claims description 8
- 241000218176 Corydalis Species 0.000 claims description 8
- 239000009636 Huang Qi Substances 0.000 claims description 8
- AMTWCFIAVKBGOD-UHFFFAOYSA-N dioxosilane;methoxy-dimethyl-trimethylsilyloxysilane Chemical compound O=[Si]=O.CO[Si](C)(C)O[Si](C)(C)C AMTWCFIAVKBGOD-UHFFFAOYSA-N 0.000 claims description 8
- 238000001704 evaporation Methods 0.000 claims description 8
- 238000010298 pulverizing process Methods 0.000 claims description 8
- 229940083037 simethicone Drugs 0.000 claims description 8
- 125000000118 dimethyl group Chemical group [H]C([H])([H])* 0.000 claims description 4
- 229920002545 silicone oil Polymers 0.000 claims description 4
- 238000002844 melting Methods 0.000 claims description 3
- 230000008018 melting Effects 0.000 claims description 3
- 238000003892 spreading Methods 0.000 claims description 3
- 230000007480 spreading Effects 0.000 claims description 3
- 230000007306 turnover Effects 0.000 claims description 2
- 239000003814 drug Substances 0.000 abstract description 10
- 239000011812 mixed powder Substances 0.000 abstract 1
- 238000001816 cooling Methods 0.000 description 16
- 239000011324 bead Substances 0.000 description 13
- 239000012535 impurity Substances 0.000 description 12
- 238000007517 polishing process Methods 0.000 description 12
- 238000004519 manufacturing process Methods 0.000 description 11
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 10
- 229910052799 carbon Inorganic materials 0.000 description 9
- 230000001276 controlling effect Effects 0.000 description 8
- 238000007670 refining Methods 0.000 description 8
- 241000213006 Angelica dahurica Species 0.000 description 6
- 241000132012 Atractylodes Species 0.000 description 6
- 244000303040 Glycyrrhiza glabra Species 0.000 description 6
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 description 6
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 description 6
- 239000007788 liquid Substances 0.000 description 6
- 235000011477 liquorice Nutrition 0.000 description 6
- 239000008188 pellet Substances 0.000 description 6
- 238000005520 cutting process Methods 0.000 description 5
- 239000004615 ingredient Substances 0.000 description 5
- 230000008569 process Effects 0.000 description 5
- 235000011389 fruit/vegetable juice Nutrition 0.000 description 4
- 239000000314 lubricant Substances 0.000 description 4
- 238000011835 investigation Methods 0.000 description 3
- 238000010998 test method Methods 0.000 description 3
- 239000002253 acid Substances 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 235000019441 ethanol Nutrition 0.000 description 2
- 235000013312 flour Nutrition 0.000 description 2
- 230000001050 lubricating effect Effects 0.000 description 2
- 238000000465 moulding Methods 0.000 description 2
- 206010000087 Abdominal pain upper Diseases 0.000 description 1
- 206010012735 Diarrhoea Diseases 0.000 description 1
- 206010036774 Proctitis Diseases 0.000 description 1
- 206010067171 Regurgitation Diseases 0.000 description 1
- 208000007107 Stomach Ulcer Diseases 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 229940008099 dimethicone Drugs 0.000 description 1
- 235000013870 dimethyl polysiloxane Nutrition 0.000 description 1
- 239000004205 dimethyl polysiloxane Substances 0.000 description 1
- 208000000718 duodenal ulcer Diseases 0.000 description 1
- 206010013864 duodenitis Diseases 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 210000003238 esophagus Anatomy 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 201000005917 gastric ulcer Diseases 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 238000010792 warming Methods 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Medicinal Preparation (AREA)
Abstract
The invention discloses a polishing method of a hemsleya amabilis gastrointestinal pill, which comprises the steps of treating medicinal powder, crushing medicinal materials into fine powder, sieving, and uniformly mixing the sieved medicinal powder; making pill, adding appropriate amount of Mel into the mixed powder; coating, namely coating the pills by adopting activated carbon and drying; polishing, namely placing the pill into a polishing device, rolling for 10min, uniformly spraying the refined insect white wax with the total weight of 55-65% onto the pill, rolling for 35-45min, adding the rest refined insect white wax which is not added, and polishing for 115-125min. Also provides a preparation method of the refined insect white wax. The two modes can ensure smooth and flat surfaces of pills, are convenient for patients to swallow, and reduce the medicine taking pain of the patients.
Description
Technical Field
The invention belongs to the technical field of pharmaceutical preparations, and particularly relates to a polishing method for a hemsleya amabilis gastrointestinal pill.
Background
The Xuedan stomach intestine pill is a Chinese medicine variety of China company, and the execution standard is WS-10312 (ZD-0312) -2002-2011Z. The product is prepared from radix aucklandiae, herba Hedyotidis Diffusae, fructus evodiae, rhizoma paridis, etc. and appropriate amount of honeyed water pill, and is prepared by coating with active carbon, drying, polishing, and has effects of warming middle-jiao, dispelling cold, regulating qi-flowing and relieving pain. Can be used for treating stomach ache, belch, acid regurgitation, loose stool, gastric ulcer, duodenal ulcer, duodenitis, proctitis, etc. due to deficiency-cold of middle-jiao.
Polishing is an important link in pill production, and the link directly affects the appearance of pills, such as brightness degree and roughness degree of pill surface. The roughness of the pill surface can influence the medicine taking compliance of a patient, and if the pill surface is relatively rough, the pill surface is not easy to slide into the esophagus of the patient when taken, and the medicine taking pain of the patient can be increased. The polishing energy increases the surface evenness and brightness of the pill, and is convenient for patients to swallow. Therefore, the pill polishing process directly affects the quality of products, is a very important production link, and is strictly controlled and the process parameters are defined. Meanwhile, the quality of the insect white wax is also an important factor for influencing the polishing, when the insect white wax is impure in quality, dirty with sundries and not white or adulterated in color, insufficient brightness and even failure in polishing can be caused, so that the high-quality refined insect white wax is required to be used in polishing, and products meeting the quality requirements can be continuously, stably and controllably produced.
At present, pill production mainly adopts a molding method and a generalization method, pill flour produced by adopting the two methods is rough, and is usually polished by medicinal juice, honey, ethanol or lubricant in the production process, and the control level of the medicinal juice, the honey, the ethanol or the lubricant is low in the production process, so that the produced pill is easy to adhere, the glossiness is not ideal enough, the pill flour is rough and the like. Meanwhile, the polishing process is complex in operation and unstable in polishing quality.
Disclosure of Invention
The invention aims to provide a polishing method for a hemsley gall gastrointestinal pill, which aims to solve the problems that in the background technology, pill production mainly adopts a molding method and a generalization method, pill surfaces produced by adopting the two methods are rough, and in the production process, the pill surfaces are usually polished by using medicinal juice, honey, ethanol or lubricant, and the control level of the medicinal juice, the honey, the ethanol or the lubricant is low during the production, so that the produced pill is easy to be adhered, the glossiness is not ideal enough, the pill surfaces are rough, and the like. Meanwhile, the polishing process is complex in operation and unstable in polishing quality.
In order to solve the technical problems, the invention adopts the following technical scheme:
A polishing method of a hemsleya amabilis gastrointestinal pill comprises the following steps:
A: treating the medicinal powder; pulverizing the medicinal materials into fine powder, sieving, and mixing the sieved powder;
B: making pills; adding proper amount of honey water into the mixed medicinal powder for making pills;
C: coating; coating the pills with activated carbon and drying;
d: polishing; 1.0-1.4g of refined insect white wax is used for each 1kg of pill; rolling the pill in a polishing device for 10min, uniformly spraying refined insect white wax with total weight of 55-65% onto the pill, rolling for 35-45min, adding the rest refined insect white wax, and polishing for 115-125min.
Further, in the step A, the traditional Chinese medicine powder is specifically the powder of radix aucklandiae, hemsleyae, fructus evodiae, rhizoma paridis, rhizoma bletillae, rhizoma corydalis, cuttlebone, bighead atractylodes rhizome, chinese angelica, radix codonopsis pilosulae, radix astragali and liquorice.
Further, in the step A, the medicinal materials are firstly pretreated and then crushed by a powder crusher.
Further, in step D, the polishing apparatus employs a sugar coating pan.
Further, in step D, the ambient humidity during polishing is less than 50%, the polishing temperature: 20-28 ℃, the water content of the pill: 5.5-7.0%.
A preparation method of refined insect white wax comprises the following steps:
s1: adding the insect white wax into pure water, wherein the weight ratio of the insect white wax to the water is 5:1-10:1;
s2: heating to melt insect wax completely, stirring at 60-100 rpm, and keeping boiling for 30-60min;
s3: filtering the melted insect white wax at least twice by using a filter screen;
S4: placing Cera chinensis into container with smooth inner wall, adding 60-70deg.C water, standing, and maintaining the temperature for 30-60min;
s5: taking out the insect white wax, and removing the upper surface layer and the bottom layer of the insect white wax by using a tool after the insect white wax is cooled and solidified;
s6: heating and melting insect white wax, and evaporating to remove water in the insect white wax;
S7: when the insect white wax is slightly cold, adding 3-5% of dimethyl silicone oil, and stirring for 10-30min at 60-100 rpm;
s8: pouring the insect white wax into a mould, taking out and crushing the insect white wax after the insect white wax is cooled; sieving the crushed insect white wax for multiple times by using a filter screen to obtain the refined insect white wax.
Further, in step S2, the melted insect wax is stirred at 80 rpm and kept boiling for 45 minutes.
Further, in step S4, the container has a shape with a large top opening and a small bottom.
Further, in step S7, the white insect wax is slightly cooled, 4% of simethicone is added, and stirring is performed at 80 rpm for 20min.
Further, the filter screen used in step S3 is a 100 mesh stainless steel filter screen; the filter screen used in step S8 is a 80-120 mesh stainless steel filter screen.
Compared with the prior art, the invention has the following beneficial effects:
The preparation method has the advantages that the polishing process is improved, so that the hemsleya amabilis stomach and intestine pill surface is flat, smooth and bright, the appearance quality of the product is improved, meanwhile, as the product is bright like a bead after the polishing process is improved, the product is very smooth, the pill is convenient to swallow during taking, the medicine taking pain of patients is relieved, and the compliance of patients is improved.
The prescription and the forming process of the product are not changed, so that the material basis of the product is ensured to be consistent before and after the invention, and the safety and the effectiveness of the product are not affected.
The improved polishing process avoids the use of high-concentration ethanol in the polishing process, can reduce the explosion-proof level of a production site, improves the safety in the production process, and simultaneously, through the research of the polishing process, improves the appearance quality, reduces the use amount of the white insect wax (auxiliary material for polishing), reduces the use amount of the auxiliary material and reduces the intake of the auxiliary material.
Compared with the conventional polishing process, the polishing process has the advantages that a wetting agent is not added before polishing, so that the blocking of the pill surface caused by improper control in the polishing process is prevented.
Detailed Description
The following description of the technical solutions in the embodiments of the present invention will be clear and complete, and it is obvious that the described embodiments are only some embodiments of the present invention, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
Example 1
A polishing method of a hemsleya amabilis gastrointestinal pill comprises the following steps:
A: treating the medicinal powder; pulverizing the medicinal materials into fine powder, sieving, and mixing the sieved powder;
B: making pills; adding proper amount of honey water into the mixed medicinal powder for making pills;
c: coating; coating the pills with activated carbon and drying; the carbon coating of the pill can increase the stability of the medicine, reduce the irritation of the medicine, control the disintegration degree, improve the appearance and the like. In addition, the intake of sugar in the coating can be reduced, and the coating is especially suitable for diabetics.
The specific operation of drying is as follows: the obtained qualified pill is spread in a baking tray (thickness is not more than 3 cm), put on a griddle from top to bottom, and put into a baking oven for baking (drying temperature is less than or equal to 60 ℃). At the initial stage of drying, baking at 60 ℃ for about 1 hour to turn over the dish so as to avoid adhesion and sunny and cloudy surfaces; and then the tray is turned over every 2-3 hours. Drying until the water content is 5.5-7.0%, taking out the pill in the oven, and cooling to room temperature.
D: polishing; 1.0-1.4g of refined insect white wax is used for each 1kg of pill; the pill is firstly weighed before polishing, so that a sufficient amount of refined insect white wax is conveniently weighed. Rolling the pill in a polishing device for 10min, uniformly spraying refined insect white wax with total weight of 55-65% onto the pill, rolling for 35-45min, adding the rest refined insect white wax, and polishing for 115-125min; the insect wax is added step by step for polishing, so that the insect wax can be uniformly attached to the pill, the pill surface is smooth and bright, and the dosage of the insect wax can be reduced.
In a preferred embodiment, the traditional Chinese medicine powder in the step A is specifically powder of radix aucklandiae, herba Hedyotidis Diffusae, fructus evodiae, rhizoma paridis, rhizoma Bletillae, rhizoma corydalis, os Sepiae, atractylodis rhizoma, radix Angelicae sinensis, radix Codonopsis, radix astragali and Glycyrrhrizae radix. It should be noted that the hemsleya amabilis stomach and intestine pill used in the invention is a prior art, and specific formulation and proportion thereof are not described herein.
In a preferred embodiment, in step a, the medicinal material is pulverized by a pulverizer after being pretreated.
In a preferred embodiment, in step D, the polishing apparatus employs a sugar coating pan.
In a preferred embodiment, in step D, the ambient humidity at the time of the lighting is < 50%, the lighting temperature: 20-28 ℃, the water content of the pill: 5.5-7.0%.
A preparation method of refined insect white wax comprises the following steps:
s1: adding the insect white wax into pure water, wherein the weight ratio of the insect white wax to the water is 5:1-10:1;
s2: heating to melt insect wax completely, stirring at 60-100 rpm, and keeping boiling for 30-60min;
s3: filtering the melted insect white wax at least twice by using a filter screen; is used for removing impurities on the surface of the suspension and the wax liquid.
S4: placing Cera chinensis into container with smooth inner wall, adding 60-70deg.C water, standing, and maintaining the temperature for 30-60min;
s5: taking out the insect white wax, and removing the upper surface layer and the bottom layer of the insect white wax by using a tool after the insect white wax is cooled and solidified; the impurities at the top and the bottom of the cooled insect white wax are more, and the impurities in the cooled insect white wax are taken out by removing the upper surface layer and the lower layer of the cooled insect white wax.
S6: heating and melting insect white wax, and evaporating to remove water in the insect white wax;
S7: when the insect white wax is slightly cold, adding 3-5% of dimethyl silicone oil, and stirring for 10-30min at 60-100 rpm;
s8: pouring the insect white wax into a mould, taking out and crushing the insect white wax after the insect white wax is cooled; sieving the crushed insect white wax for multiple times by using a filter screen to obtain the refined insect white wax.
The method refines the insect white wax by knowing the property of the insect white wax and adopting a mild condition method and a proper container, and the refined insect white wax reaches the grade of the head wax, compared with other refining methods, the method avoids the use of organic solvents and acids, reduces the environmental protection requirement and the preparation cost, and simultaneously creatively adds the dimethyl silicone oil, thereby improving the lubricating effect and the thermal stability of the insect white wax.
In a preferred embodiment, in step S2, the melted insect wax is stirred at 80 revolutions per minute and kept boiling for 45 minutes.
In a preferred embodiment, in step S4, the container has a shape with a large top opening and a small bottom. When the container with the large top opening and the small bottom is used for refining the insect white wax, impurities in the insect white wax can be well separated, and when the container is used for separating the impurities, the impurities can be easily concentrated on the upper surface layer and the bottom layer, and the impurities can be well separated.
In a preferred embodiment, in step S7, the insect white wax is slightly cooled, 4% dimethicone is added and stirred at 80 rpm for 20 minutes. And by adding the simethicone, the lubricating effect and the thermal stability of the insect white wax can be improved, and the follow-up polishing and the stability of products are facilitated.
In a preferred embodiment, the filter screen used in step S3 is a 100 mesh stainless steel filter screen; the filter screen used in step S8 is a 80-120 mesh stainless steel filter screen.
The following table shows the comparison of commercially available insect wax with insect wax made by the method of the present invention: (it should be noted that the detection methods adopted in the present invention are all of the prior art)
From the detection results of the table, the commercial insect white wax is three wax grades, and after being refined by the method, the commercial insect white wax reaches the head wax grade according to the standard of Yichong white wax [ GH011-80 ] of the Ministry of the Cooperation and marketing of the people's republic of China, thereby having obvious refining effect and good quality and being beneficial to the subsequent polishing process.
Process parameter test method 1
Taking 1kg of hemsleya amabilis stomach intestine pills after being coated and dried by active carbon, and carrying out polishing temperature investigation. Placing the pill in a sugar coating pan, controlling polishing temperature, starting up and rolling for 10min, adding 0.72g refined insect wax, uniformly spreading onto the pill, rolling for 40min, adding 0.48g refined insect wax, and polishing for 2 hr. The appearance of the pill surface at different lighting temperatures was observed.
The following table shows the appearance of the pill surface at different polishing temperatures:
| Temperature (. Degree. C.) | Variation of surface brightness of pills |
| 16 | The pill surface has off-white powder |
| 18 | Microscopic small light of pill surface |
| 20 | The pill surface is obviously bright |
| 22 | The pill surface is bright like a bead |
| 24 | The pill surface is bright like a bead |
| 26 | The pill surface is bright like a bead |
| 28 | The pill surface is light and slightly light |
| 30 | The pill surface is bright and light and dark |
As can be seen from the table above, the polishing temperature is controlled at 20-28deg.C, so that the surface of the pill is clean and bright.
Process parameter test method 2
Taking 1kg of hemsleya amabilis stomach intestine pills after the activated carbon coating is dried for water content investigation of the pills. Placing pills with different moisture into a sugar coating pan, controlling the polishing temperature to 24 ℃, starting up and rolling for 10min, adding 0.72g of refined insect wax, uniformly scattering onto the pills, rolling for 40min, adding 0.48g of refined insect wax, and polishing for 2h. The appearance of pill surfaces of different moisture was observed.
The following table shows the appearance of the pill surface at different moisture contents:
As can be seen from the results of the above table, when the moisture of the pill is controlled to be 5.5-7.0%, the pill surface is smooth and bright.
Process parameter test method 3
Taking 1kg of hemsleyadin gastrointestinal pills after being coated and dried by active carbon, and carrying out the investigation of the dosage of the hemsleyadin. Placing the pill with water content of 6.0% in sugar coating pan, controlling polishing temperature at 24deg.C, rolling for 10min, adding refined insect wax (60% of total amount), spreading on the pill, rolling for 40min, adding the rest refined insect wax, and polishing for 2 hr. Observing the phenomenon of the pill surface under different refined insect white wax dosages.
The following table shows the appearance of the pill surface with different amounts of refined insect wax:
| total refined insect white wax (g) | Variation of surface brightness of pills |
| 0.8 | The pill surface has grey white and low light level |
| 1.0 | The pill surface has obvious brightness |
| 1.2 | The pill surface is bright like a bead |
| 1.4 | The pill surface is bright like a bead |
| 1.6 | The pearl of the pill surface is dull |
| 1.8 | The pill surface is bright and weak |
As can be seen from the above table data, when the total amount of insect wax is in the range of 1.0-1.4g, the pellet surface is smooth and bright.
Example 2
Taking twelve ingredients of radix aucklandiae, hemsleyae, fructus evodiae, rhizoma paridis, rhizoma bletillae, rhizoma corydalis, cuttlebone, bighead atractylodes rhizome, chinese angelica, radix codonopsis, radix astragali and liquorice:
(1) Pulverizing the medicinal materials into fine powder, sieving the pulverized medicinal materials, and mixing;
(2) Adding appropriate amount of honey water into the medicinal powder for making pills;
(3) Coating the pill with active carbon, and drying the coated pill
(4) Refining the insect white wax: adding pure water into insect white wax, controlling the weight ratio of pure water to insect white wax to be 5:1, heating until the wax is completely melted, stirring at 60 revolutions per minute, keeping micro boiling for 30 minutes, filtering the melted wax with a 100-mesh stainless steel screen while the melted wax is hot to remove impurities suspended on the surface of the wax liquid, repeating the steps once again after filtering, placing the wax into a basin with a large upper opening surface and a small bottom surface and smooth inside, preserving heat for 30 minutes in a water bath at 60 ℃, taking out, cooling until the wax is solidified, taking out the wax block from the basin, cutting the upper surface layer and the bottom layer of the wax block by a knife, then heating again to melt the wax block, evaporating to remove internal moisture, slightly cooling the wax block, adding 4% of simethicone, stirring at 60 revolutions per minute for 30 minutes to uniformly mix the wax, pouring the mixture into a mold box, taking out the mold box after cooling, crushing, and sieving the wax block by a 100-mesh sieve to obtain the insect white wax.
(5) 1Kg of the hemsleyadin pellets which had been dried by the activated carbon coating were taken and placed in a sugar-coating pan, and the moisture was kept at 5.0%. And (3) uniformly spraying 0.6g of refined insect wax onto the pill after the machine is started and rolled for 10min at the polishing temperature of 20 ℃, adding 0.4g of refined insect wax after the machine is rolled for 40min, and continuously polishing for 2h. The ambient humidity was controlled at 40%.
Example 3
Taking twelve ingredients of radix aucklandiae, hemsleyae, fructus evodiae, rhizoma paridis, rhizoma bletillae, rhizoma corydalis, cuttlebone, bighead atractylodes rhizome, chinese angelica, radix codonopsis, radix astragali and liquorice:
(1) Pulverizing the medicinal materials into fine powder, sieving the pulverized medicinal materials, and mixing;
(2) Adding appropriate amount of honey water into the medicinal powder for making pills;
(3) Coating the pill with active carbon, and drying the coated pill
(4) Refining the insect white wax: adding pure water into insect white wax, controlling the weight ratio of pure water to insect white wax to be 6:1, heating until the wax is completely melted, stirring at 60 revolutions per minute, keeping micro boiling for 30 minutes, filtering the melted wax with a 100-mesh stainless steel screen while the melted wax is hot to remove impurities suspended on the surface of the wax liquid, repeating the steps once again after filtering, placing the wax into a basin with a large upper opening surface and a small bottom surface, keeping the temperature in a water bath at 60 ℃ for 30 minutes, taking out, cooling until the wax solidifies, taking out the wax blocks from the basin, cutting the upper surface layer and the bottom layer of the wax blocks by a knife, then heating again to melt the wax blocks, evaporating to remove internal moisture, slightly cooling, adding 4% of simethicone, stirring at 60 revolutions per minute for 30 minutes to uniformly mix the wax, pouring the mixture into a mold box, taking out after cooling, crushing, and sieving with a 100-mesh sieve to obtain the insect white wax.
(5) 1Kg of the hemsleyadin pellets which had been dried by the activated carbon coating were taken and placed in a sugar-coating pan, and the moisture was kept at 5.5%. The polishing temperature is 22 ℃, after the machine is started and rolled for 10min, 0.72g of refined insect wax is uniformly sprayed on the pill, after the machine is rolled for 40min, 0.4g of refined insect wax is added, and polishing is continued for 2h. The ambient humidity was controlled at 40%.
Example 4
Taking twelve ingredients of radix aucklandiae, hemsleyae, fructus evodiae, rhizoma paridis, rhizoma bletillae, rhizoma corydalis, cuttlebone, bighead atractylodes rhizome, chinese angelica, radix codonopsis, radix astragali and liquorice:
(1) Pulverizing the medicinal materials into fine powder, sieving the pulverized medicinal materials, and mixing;
(2) Adding appropriate amount of honey water into the medicinal powder for making pills;
(3) Coating the pill with active carbon, and drying the coated pill
(4) Refining the insect white wax: adding pure water into insect white wax, controlling the weight ratio of pure water to insect white wax to be 8:1, heating until the wax is completely melted, stirring at 80 revolutions per minute, keeping micro boiling for 30 minutes, filtering the melted wax with a 100-mesh stainless steel screen while the melted wax is hot to remove impurities suspended on the surface of the wax liquid, repeating the steps once again after filtering, placing the wax into a basin with a large upper opening surface and a small bottom surface and smooth inside, preserving heat for 30 minutes in a water bath at 60 ℃, taking out, cooling until the wax is solidified, taking out the wax block from the basin, cutting the upper surface layer and the bottom layer of the wax block by a knife, then heating again to melt the wax block, evaporating to remove internal moisture, slightly cooling the wax block, adding 4% of simethicone, stirring at 60 revolutions per minute for 30 minutes to uniformly mix the wax, pouring the mixture into a mold box, taking out the mold box after cooling, crushing, and sieving the wax block by a 100-mesh sieve to obtain the insect white wax.
(5) 1Kg of the hemsleyadin pellets which had been dried by the activated carbon coating were taken and placed in a sugar-coating pan, and the moisture was kept at 6.0%. The polishing temperature is 24 ℃, after the machine is started and rolled for 10min, 0.84g of refined insect wax is uniformly sprayed on the pill, after the machine is rolled for 40min, 0.56g of refined insect wax is added, and polishing is continued for 2h. The ambient humidity was controlled at 45%.
Example 5
Taking twelve ingredients of radix aucklandiae, hemsleyae, fructus evodiae, rhizoma paridis, rhizoma bletillae, rhizoma corydalis, cuttlebone, bighead atractylodes rhizome, chinese angelica, radix codonopsis, radix astragali and liquorice:
(1) Pulverizing the medicinal materials into fine powder, sieving the pulverized medicinal materials, and mixing;
(2) Adding appropriate amount of honey water into the medicinal powder for making pills;
(3) Coating the pill with active carbon, and drying the coated pill
(4) Refining the insect white wax: adding pure water into insect white wax, controlling the weight ratio of the pure water to the insect white wax to be 9:1, heating until the wax is completely melted, stirring at 60 revolutions per minute, keeping micro boiling for 30 minutes, filtering the melted wax with a 100-mesh stainless steel screen while the melted wax is hot to remove impurities suspended on the surface of the wax liquid, repeating the steps once again after filtering, placing the wax into a basin with a large upper opening surface and a small bottom surface and smooth inside, preserving heat for 30 minutes in a water bath at 60 ℃, taking out, cooling until the wax is solidified, taking out the wax block from the basin, cutting the upper surface layer and the bottom layer of the wax block by a knife, then heating again to melt the wax block, evaporating to remove internal moisture, slightly cooling the wax block, adding 4% of simethicone, stirring at 60 revolutions per minute for 30 minutes to uniformly mix the wax, pouring the mixture into a mold box, taking out the mold box after cooling, crushing, and sieving the wax block with a 100-mesh sieve to obtain the insect white wax.
(5) 1Kg of the hemsleyadin pellets which had been dried by the activated carbon coating were taken and placed in a sugar-coating pan and kept at a moisture of 6.5%. The polishing temperature is 24 ℃, after the machine is started and rolled for 10min, 0.84g of refined insect wax is uniformly sprayed on the pill, after the machine is rolled for 40min, 0.56g of refined insect wax is added, and polishing is continued for 2h. The ambient humidity was controlled at 45%.
Example 6
Taking twelve ingredients of radix aucklandiae, hemsleyae, fructus evodiae, rhizoma paridis, rhizoma bletillae, rhizoma corydalis, cuttlebone, bighead atractylodes rhizome, chinese angelica, radix codonopsis, radix astragali and liquorice:
(1) Pulverizing the medicinal materials into fine powder, sieving the pulverized medicinal materials, and mixing;
(2) Adding appropriate amount of honey water into the medicinal powder for making pills;
(3) Coating the pill with active carbon, and drying the coated pill
(4) Refining the insect white wax: adding pure water into insect white wax, controlling the weight ratio of pure water to insect white wax to be 10:1, heating until the wax is completely melted, stirring at 100 revolutions per minute, keeping micro boiling for 60 minutes, filtering the melted wax with a 100-mesh stainless steel screen while the melted wax is hot to remove impurities suspended on the surface of the wax liquid, repeating the steps once again after filtering, placing the wax into a basin with a large upper opening surface and a small bottom surface and smooth inside, preserving heat for 60 minutes in a 70 ℃ water bath, taking out, cooling until the wax solidifies, taking out the wax block from the basin, cutting the upper surface layer and the bottom layer of the wax block by a knife, then heating again to melt the wax block, evaporating to remove internal moisture, slightly cooling, adding 4% of simethicone, stirring at 100 revolutions per minute for 10 minutes to uniformly mix the wax, pouring the mixture into a mold box, taking out after cooling, crushing, and sieving with a 100-mesh sieve to obtain the insect white wax.
(5) 1Kg of the hemsleyadin pellets which had been dried by the activated carbon coating were taken and placed in a sugar-coating pan, and the moisture was kept at 7.0%. The polishing temperature is 28 ℃, after the machine is started and rolled for 10min, 0.84g of refined insect wax is uniformly sprayed on the pill, after the machine is rolled for 40min, 0.56g of refined insect wax is added, and polishing is continued for 2h. The ambient humidity was controlled at 45%.
The appearance quality of the front and rear products is compared with that of the invention:
| Sample name | Appearance of |
| Sample of conventional production method of hemsleya amabilis stomach intestine pill | The pill surface is dull and dull, and the surface of the pill surface is rough |
| Example 1 sample | The pill surface is bright like a bead |
| Example 2 sample | The pill surface is bright like a bead |
| Example 3 sample | The pill surface is bright like a bead |
| Example 4 sample | The pill surface is bright like a bead |
| Example 5 sample | The pill surface is bright like a bead |
| Example 6 sample | The pill surface is bright like a bead |
The table shows that the surface of the hemsleya amabilis stomach intestine pill prepared by the invention is bright like a bead, and is convenient for patients to take. Meanwhile, the smooth and bright hemsleyash gastrointestinal pill is convenient for patients to swallow, and reduces the medicine taking pain of the patients.
Although embodiments of the present invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made therein without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.
Claims (8)
1. A polishing method of a hemsleyadin gastrointestinal pill is characterized by comprising the following steps of: the method comprises the following steps:
A: treating the medicinal powder; pulverizing the medicinal materials into fine powder, sieving, and mixing the sieved powder;
B: making pills; adding proper amount of honey water into the mixed medicinal powder for making pills;
C: coating; coating the pills with activated carbon and drying; spreading the qualified pill in a baking tray with thickness not exceeding 3cm, placing on a gridiron from top to bottom, pushing into a baking oven for baking, and drying at a temperature of less than or equal to 60deg.C; at the initial stage of drying, keeping baking for about 1 hour to turn over, and turning over every 2-3 hours; drying until the water content of the pill is 5.5-7.0%;
D: polishing; 1.0-1.4g of refined insect white wax is used for each 1kg of pill; placing the pill in a polishing device, rolling for 10min, uniformly spraying the total amount of 55-65% refined insect white wax onto the pill, rolling for 35-45min, adding the rest non-added refined insect white wax, polishing for 115-125min, and adding insect white wax step by step to polish, so that the insect white wax is uniformly adhered to the pill, the pill surface is smooth, smooth and bright, and meanwhile, the dosage of the insect white wax can be reduced; wherein, the ambient humidity is less than 50% when polishing, the polishing temperature: 20-28 ℃, the water content of the pill: 5.5-7.0%;
The preparation method of the refined insect white wax comprises the following steps:
s1: adding the insect white wax into pure water, wherein the weight ratio of the insect white wax to the water is 5:1-10:1;
s2: heating to melt insect wax completely, stirring at 60-100 rpm, and keeping boiling for 30-60min;
s3: filtering the melted insect white wax at least twice by using a filter screen;
S4: placing Cera chinensis into container with smooth inner wall, adding 60-70deg.C water, standing, and maintaining the temperature for 30-60min;
s5: taking out the insect white wax, and removing the upper surface layer and the bottom layer of the insect white wax by using a tool after the insect white wax is cooled and solidified;
s6: heating and melting insect white wax, and evaporating to remove water in the insect white wax;
S7: when the insect white wax is slightly cold, adding 3-5% of dimethyl silicone oil, and stirring for 10-30min at 60-100 rpm;
s8: pouring the insect white wax into a mould, taking out and crushing the insect white wax after the insect white wax is cooled; sieving the crushed insect white wax for multiple times by using a filter screen to obtain the refined insect white wax.
2. The method for polishing the hemsleyash gastrointestinal bolus according to claim 1, wherein the method comprises the following steps of: the Chinese medicinal powder in step A is specifically powder of radix aucklandiae, herba Hedyotidis Diffusae, fructus evodiae, rhizoma paridis, rhizoma Bletillae, rhizoma corydalis, os Sepiae, atractylodis rhizoma, radix Angelicae sinensis, radix Codonopsis, radix astragali and Glycyrrhrizae radix.
3. The method for polishing the hemsleyash gastrointestinal bolus according to claim 1, wherein the method comprises the following steps of: in the step A, the medicinal materials are firstly pretreated and then crushed by a powder crusher.
4. The method for polishing the hemsleyash gastrointestinal bolus according to claim 1, wherein the method comprises the following steps of: in step D, the polishing device adopts a sugar coating pan.
5. The method for polishing the hemsleyash gastrointestinal bolus according to claim 1, wherein the method comprises the following steps of: in step S2, the melted insect wax is stirred at 80 rpm and kept boiling for 45min.
6. The method for polishing the hemsleyash gastrointestinal bolus according to claim 1, wherein the method comprises the following steps of: in step S4, the container has a shape with a large top opening and a small bottom.
7. The method for polishing the hemsleyash gastrointestinal bolus according to claim 1, wherein the method comprises the following steps of: in step S7, the white insect wax is slightly cooled, 4% of simethicone is added, and the mixture is stirred at 80 rpm for 20min.
8. The method for polishing the hemsleyash gastrointestinal bolus according to claim 1, wherein the method comprises the following steps of: the filter screen used in step S3 is a 100 mesh stainless steel filter screen; the filter screen used in step S8 is a 80-120 mesh stainless steel filter screen.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210696537.0A CN115969933B (en) | 2022-06-20 | 2022-06-20 | Polishing method for hemsleya amabilis stomach and intestine pills |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210696537.0A CN115969933B (en) | 2022-06-20 | 2022-06-20 | Polishing method for hemsleya amabilis stomach and intestine pills |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN115969933A CN115969933A (en) | 2023-04-18 |
| CN115969933B true CN115969933B (en) | 2024-05-03 |
Family
ID=85974654
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202210696537.0A Active CN115969933B (en) | 2022-06-20 | 2022-06-20 | Polishing method for hemsleya amabilis stomach and intestine pills |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN115969933B (en) |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1493356A (en) * | 2003-09-12 | 2004-05-05 | 贵州苗药雪胆胃肠丸科技中心 | Medicine for treating gastrointestinal tract disease |
| CN1493355A (en) * | 2003-09-12 | 2004-05-05 | 贵州苗药雪胆胃肠丸科技中心 | Medicine for treating gastrointestinal tract diseases |
| CN101225345A (en) * | 2008-02-14 | 2008-07-23 | 中国林业科学研究院资源昆虫研究所 | Refining method for insect wax |
| CN102304434A (en) * | 2011-08-03 | 2012-01-04 | 中国林业科学研究院资源昆虫研究所 | Method for refining Chinese wax |
| CN106668548A (en) * | 2017-02-13 | 2017-05-17 | 昆明生达制药有限公司 | Hemsleya amabilis stomach and intestine pill and preparation method thereof |
| CN106668549A (en) * | 2017-02-13 | 2017-05-17 | 昆明生达制药有限公司 | Radix hemsleyae pills for stomach and intestine diseases as well as preparation method and detection method thereof |
| CN107551248A (en) * | 2017-09-26 | 2018-01-09 | 马鞍山天福康药业有限公司 | A kind of ease pill and production technology |
-
2022
- 2022-06-20 CN CN202210696537.0A patent/CN115969933B/en active Active
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1493356A (en) * | 2003-09-12 | 2004-05-05 | 贵州苗药雪胆胃肠丸科技中心 | Medicine for treating gastrointestinal tract disease |
| CN1493355A (en) * | 2003-09-12 | 2004-05-05 | 贵州苗药雪胆胃肠丸科技中心 | Medicine for treating gastrointestinal tract diseases |
| CN101225345A (en) * | 2008-02-14 | 2008-07-23 | 中国林业科学研究院资源昆虫研究所 | Refining method for insect wax |
| CN102304434A (en) * | 2011-08-03 | 2012-01-04 | 中国林业科学研究院资源昆虫研究所 | Method for refining Chinese wax |
| CN106668548A (en) * | 2017-02-13 | 2017-05-17 | 昆明生达制药有限公司 | Hemsleya amabilis stomach and intestine pill and preparation method thereof |
| CN106668549A (en) * | 2017-02-13 | 2017-05-17 | 昆明生达制药有限公司 | Radix hemsleyae pills for stomach and intestine diseases as well as preparation method and detection method thereof |
| CN107551248A (en) * | 2017-09-26 | 2018-01-09 | 马鞍山天福康药业有限公司 | A kind of ease pill and production technology |
Non-Patent Citations (4)
| Title |
|---|
| 中成药微粒丸"打光"技术的探讨;张海清;中成药研究;19840630;第06卷;44 * |
| 虫白蜡的简易精制法;王荣林;中国中药杂志;第15卷(第11期);36 * |
| 蜜丸"打光"的工艺探讨;沈烈行;中药材;19950630;第18卷(第6期);283 * |
| 蜜丸打光材料配方工艺初探;朱国强;中成药研究;19851231;8 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN115969933A (en) | 2023-04-18 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101766658A (en) | Method for preparing traditional Chinese medicinal liquor | |
| CN102742615A (en) | Purple basic material for healthy food and preparation method | |
| CN106616191A (en) | Honeysuckle flower and radix puerariae powder effervescent tablets and preparation method | |
| CN102618418A (en) | Black wine and brewing process thereof | |
| CN115501266A (en) | Effervescence granule containing pseudostellaria root and production process thereof | |
| CN107617036B (en) | Pill of six ingredients with rehmannia and preparation process thereof | |
| CN106562276A (en) | Extraction method and applications of betel nut effective component | |
| CN115969933B (en) | Polishing method for hemsleya amabilis stomach and intestine pills | |
| CN108041428A (en) | A kind of Poria cocos Layer cake | |
| CN110179109A (en) | A kind of dried orange peel Tortoise Shell Guiling Jelly and preparation method thereof | |
| CN103284262A (en) | Production method for rose hydrosol-tremella sanguinea drink | |
| CN1042189C (en) | Method for making mung bean coating tea | |
| CN111358719B (en) | Chinese herbal medicine lipstick with cheilitis prevention function and preparation method thereof | |
| CN108192790A (en) | Dendrobium officinale alcohol and preparation method thereof | |
| CN112890169A (en) | Preparation method and eating method of peach gum instant granule food | |
| CN105285223A (en) | Four-season nourishing tea and making method thereof | |
| CN104971295A (en) | Traditional Chinese medicine composition and application thereof in preparing sargassum fusiforme and lotus seed nutritional wine | |
| CN110679718A (en) | Preparation method of rose candy | |
| CN103627591A (en) | Gardenia jasminoides traditional Chinese medicinal liquor and preparation method thereof | |
| CN109258856A (en) | A kind of production method of jasmine perfume (or spice) mulberry clovershrub | |
| US20110200691A1 (en) | Medicine for Filterable Virus Infections and Its Processing Method | |
| CN102526162B (en) | Method suitable for preparing frankincense and myrrh by using vinegar | |
| CN115261111B (en) | Production method of wall-broken self-sourced aroma sesame oil | |
| CN105495616A (en) | Sandwich fresh ginger lozenges with functions of warming stomach and strengthening teeth and preparation method thereof | |
| CN1186634A (en) | Health-care beverage and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |