CN115969933A - Polishing method for hemsleya amabilis gastrointestinal pills - Google Patents
Polishing method for hemsleya amabilis gastrointestinal pills Download PDFInfo
- Publication number
- CN115969933A CN115969933A CN202210696537.0A CN202210696537A CN115969933A CN 115969933 A CN115969933 A CN 115969933A CN 202210696537 A CN202210696537 A CN 202210696537A CN 115969933 A CN115969933 A CN 115969933A
- Authority
- CN
- China
- Prior art keywords
- wax
- polishing
- pill
- insect
- pills
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000006187 pill Substances 0.000 title claims abstract description 134
- 238000005498 polishing Methods 0.000 title claims abstract description 71
- 238000000034 method Methods 0.000 title claims abstract description 38
- 230000002496 gastric effect Effects 0.000 title claims abstract description 33
- 241000465412 Hemsleya amabilis Species 0.000 title claims description 23
- 241000238631 Hexapoda Species 0.000 claims abstract description 104
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 54
- 239000000843 powder Substances 0.000 claims abstract description 36
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims abstract description 24
- 238000005096 rolling process Methods 0.000 claims abstract description 24
- 239000011248 coating agent Substances 0.000 claims abstract description 16
- 238000000576 coating method Methods 0.000 claims abstract description 16
- 238000007873 sieving Methods 0.000 claims abstract description 16
- 229910052799 carbon Inorganic materials 0.000 claims abstract description 14
- 238000001035 drying Methods 0.000 claims abstract description 13
- 241000906682 Hemsleya Species 0.000 claims abstract description 11
- 239000000463 material Substances 0.000 claims abstract description 10
- 238000002156 mixing Methods 0.000 claims abstract description 9
- 238000005507 spraying Methods 0.000 claims abstract description 9
- 238000012545 processing Methods 0.000 claims abstract description 4
- 239000001993 wax Substances 0.000 claims description 102
- 229940045860 white wax Drugs 0.000 claims description 55
- 238000001914 filtration Methods 0.000 claims description 17
- 238000010438 heat treatment Methods 0.000 claims description 14
- 238000003756 stirring Methods 0.000 claims description 14
- 238000001816 cooling Methods 0.000 claims description 12
- 238000009495 sugar coating Methods 0.000 claims description 11
- 238000009835 boiling Methods 0.000 claims description 10
- 229910001220 stainless steel Inorganic materials 0.000 claims description 10
- 239000010935 stainless steel Substances 0.000 claims description 10
- 125000000118 dimethyl group Chemical group [H]C([H])([H])* 0.000 claims description 9
- 229920002545 silicone oil Polymers 0.000 claims description 9
- 239000002344 surface layer Substances 0.000 claims description 9
- 241000218176 Corydalis Species 0.000 claims description 8
- 239000010410 layer Substances 0.000 claims description 8
- 238000010298 pulverizing process Methods 0.000 claims description 8
- 238000001704 evaporation Methods 0.000 claims description 7
- 239000012174 chinese wax Substances 0.000 claims description 4
- 241000756943 Codonopsis Species 0.000 claims description 3
- 239000009636 Huang Qi Substances 0.000 claims description 3
- 238000002844 melting Methods 0.000 claims description 3
- 230000008018 melting Effects 0.000 claims description 3
- 238000000227 grinding Methods 0.000 claims description 2
- AMTWCFIAVKBGOD-UHFFFAOYSA-N dioxosilane;methoxy-dimethyl-trimethylsilyloxysilane Chemical compound O=[Si]=O.CO[Si](C)(C)O[Si](C)(C)C AMTWCFIAVKBGOD-UHFFFAOYSA-N 0.000 claims 1
- 229940083037 simethicone Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 abstract description 24
- 238000002360 preparation method Methods 0.000 abstract description 7
- 229940079593 drug Drugs 0.000 description 15
- 239000000203 mixture Substances 0.000 description 14
- 238000004519 manufacturing process Methods 0.000 description 13
- 239000012535 impurity Substances 0.000 description 12
- 238000007517 polishing process Methods 0.000 description 12
- 239000011324 bead Substances 0.000 description 11
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 10
- 230000001276 controlling effect Effects 0.000 description 8
- 238000007670 refining Methods 0.000 description 7
- 241000125175 Angelica Species 0.000 description 5
- 241001061264 Astragalus Species 0.000 description 5
- 241000132012 Atractylodes Species 0.000 description 5
- 241000007126 Codonopsis pilosula Species 0.000 description 5
- 244000303040 Glycyrrhiza glabra Species 0.000 description 5
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 description 5
- 235000001287 Guettarda speciosa Nutrition 0.000 description 5
- 235000006533 astragalus Nutrition 0.000 description 5
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 description 5
- 239000007788 liquid Substances 0.000 description 5
- 235000011477 liquorice Nutrition 0.000 description 5
- 230000008569 process Effects 0.000 description 5
- 210000004233 talus Anatomy 0.000 description 5
- 238000005520 cutting process Methods 0.000 description 4
- 235000011389 fruit/vegetable juice Nutrition 0.000 description 4
- 235000012907 honey Nutrition 0.000 description 4
- 239000000314 lubricant Substances 0.000 description 4
- 238000001514 detection method Methods 0.000 description 3
- 238000011835 investigation Methods 0.000 description 3
- 238000000926 separation method Methods 0.000 description 3
- 238000003892 spreading Methods 0.000 description 3
- 230000007480 spreading Effects 0.000 description 3
- 238000010998 test method Methods 0.000 description 3
- 239000002253 acid Substances 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 229940008099 dimethicone Drugs 0.000 description 2
- 235000013870 dimethyl polysiloxane Nutrition 0.000 description 2
- 239000004205 dimethyl polysiloxane Substances 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 230000001050 lubricating effect Effects 0.000 description 2
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 2
- 206010000087 Abdominal pain upper Diseases 0.000 description 1
- 206010012735 Diarrhoea Diseases 0.000 description 1
- 206010036774 Proctitis Diseases 0.000 description 1
- 206010067171 Regurgitation Diseases 0.000 description 1
- 208000007107 Stomach Ulcer Diseases 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 238000010981 drying operation Methods 0.000 description 1
- 208000000718 duodenal ulcer Diseases 0.000 description 1
- 206010013864 duodenitis Diseases 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 210000003238 esophagus Anatomy 0.000 description 1
- 235000019441 ethanol Nutrition 0.000 description 1
- 235000013312 flour Nutrition 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 201000005917 gastric ulcer Diseases 0.000 description 1
- 235000008216 herbs Nutrition 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 230000007306 turnover Effects 0.000 description 1
- 238000010792 warming Methods 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Medicinal Preparation (AREA)
Abstract
The invention discloses a polishing method of hemsleya root gastrointestinal pills, which comprises the steps of processing medicinal powder, crushing medicinal materials into fine powder, sieving, and uniformly mixing the sieved medicinal powder; making into pill, adding appropriate amount of Mel and water into the mixed medicinal powder; coating, namely coating the pills with active carbon and drying; polishing, rolling the pill in polishing device for 10min, spraying 55-65% of refined Cera chinensis onto the pill, rolling for 35-45min, adding the rest refined Cera chinensis, and polishing for 115-125min. Also provides a preparation method of the refined Chinese insect wax. The pill can be ensured to have smooth and flat surface by the two modes, is convenient for patients to swallow and reduces the pain of the patients in taking the medicine.
Description
Technical Field
The invention belongs to the technical field of medicinal preparations, and particularly relates to a polishing method of hemsleya root gastrointestinal pills.
Background
The hemsleya root gastrointestinal pill is a Chinese medicinal variety of our company, and has an execution standard of WS-10312 (ZD-0312) -2002-2011Z. The product is prepared from radix aucklandiae, radix Hemsleyae Macrospermae, fructus evodiae, rhizoma paridis, and appropriate amount of Mel water by making into pill, coating with active carbon, drying, and polishing, and has effects of warming spleen and stomach, dispelling cold, regulating qi-flowing, and relieving pain. Can be used for treating gastralgia, belch, acid regurgitation, loose stool, gastric ulcer, duodenal ulcer, duodenitis, and rectitis due to deficiency-cold of middle-jiao.
Polishing is an important link in pill production, and the link directly influences the appearance of pills, such as the brightness degree and the roughness of pill surfaces. The roughness of the pill surface can influence the compliance of the patient for taking medicine, and if the pill surface is relatively rough, the pill surface is not easy to slide into the esophagus of the patient when in use, and the pain of the patient for taking medicine can be increased. The polishing can increase the surface smoothness and brightness of the pill, and is convenient for patients to swallow. Therefore, the quality of the product is directly affected by the pill polishing process, and the method is a very important production link, and the process parameters are strictly controlled and defined. Meanwhile, the quality of the insect white wax is another important factor influencing polishing, when the insect white wax is impure in quality, polluted with impurities, not white in color or adulterated, insufficient brightness during polishing and even failure in polishing can be caused, so that high-quality refined insect white wax needs to be used during polishing so as to continuously, stably and controllably produce products meeting quality requirements.
At present, the pill production mainly adopts a plastic preparation method and a general preparation method, the pill surfaces of the pills produced by the two methods are rough, and the medicine juice, the honey, the ethanol or the lubricant is polished in the production process, and the control level of the medicine juice, the honey, the ethanol or the lubricant is low during the production, so that the produced pills are easy to adhere, have unsatisfactory glossiness, and have rough pill surfaces. Meanwhile, the polishing process has the conditions of complicated operation and unstable polishing quality.
Disclosure of Invention
The invention aims to provide a polishing method of hemsleya amabilis gastrointestinal pills, which aims at solving the problems that the production of pills in the background technology mainly adopts a plastic manufacturing method and a flood manufacturing method, pills produced by the two methods have rough surfaces, and pills are polished by medicinal juice, honey, ethanol or a lubricant and the like in the production process, and the control level of the medicinal juice, the honey, the ethanol or the lubricant is low during production, so that the produced pills are easy to adhere, have unsatisfactory glossiness, and have rough surfaces. Meanwhile, the polishing process has the conditions of complicated operation and unstable polishing quality.
In order to solve the technical problems, the technical scheme adopted by the invention is as follows:
a polishing method of hemsleya root gastrointestinal pills comprises the following steps:
a: processing the medicinal powder; pulverizing the medicinal materials into fine powder, sieving, and mixing the sieved medicinal powder;
b: preparing pills; adding appropriate amount of Mel and water into the mixed medicinal powder to make into pill;
c: coating; coating the pills with active carbon and drying;
d: polishing; 1.0-1.4g of refined Chinese insect wax is used per 1kg of pill; rolling the pill in a polishing device for 10min, spraying 55-65% of refined Cera chinensis on the pill, rolling for 35-45min, adding the rest refined Cera chinensis, and polishing for 115-125min.
Further, the Chinese medicinal powder in step A is powder of radix aucklandiae, radix Hemsleyae Macrospermae, fructus evodiae, rhizoma paridis, rhizoma Bletillae, rhizoma corydalis, os Sepiae, atractylodis rhizoma, radix Angelicae sinensis, radix Codonopsis, radix astragali and Glycyrrhrizae radix.
Further, in the step A, the medicinal materials are pretreated and then crushed by a powder grinding machine.
Further, in step D, the polishing device is a sugar coating pan.
Further, in step D, the ambient humidity during polishing is less than 50%, the polishing temperature: 20-28 ℃, water content of the pill: 5.5 to 7.0 percent.
A preparation method of refined Chinese insect wax comprises the following steps:
s1: adding Chinese insect wax into pure water, wherein the weight ratio of the Chinese insect wax to the water is 5:1-10;
s2: heating to melt the Chinese insect wax, stirring at 60-100 rpm, and boiling for 30-60min;
s3: filtering the melted Chinese insect wax at least twice by using a filter sieve;
s4: putting Cera chinensis into a container with smooth inner wall, adding 60-70 deg.C water, standing, and keeping the temperature for 30-60min;
s5: taking out the insect white wax, cooling and solidifying the insect white wax, and removing the upper surface layer and the bottom layer part of the insect white wax by using a tool;
s6: heating and melting insect white wax, and evaporating to remove water in the insect white wax;
s7: adding 3-5% of dimethyl silicone oil when the insect white wax is slightly cold, and stirring for 10-30min at 60-100 r/min;
s8: pouring the insect white wax into a mold, and taking out and crushing the insect white wax after the insect white wax is cooled; and sieving the crushed Chinese insect wax for multiple times by using a filter sieve to obtain the refined Chinese insect wax.
Further, in step S2, the melted chinese insect wax is stirred at 80 rpm and kept boiling for 45min.
Further, in step S4, the container has a shape with a large top opening and a small bottom.
Further, in step S7, 4% dimethicone is added to the insect wax after it is slightly cold, and stirred at 80 rpm for 20min.
Further, the filter sieve used in step S3 is a 100 mesh stainless steel filter sieve; the filtering sieve used in the step S8 adopts a stainless steel filtering sieve with 80-120 meshes.
Compared with the prior art, the invention has the following beneficial effects:
the snow gall gastrointestinal pill has the advantages that the surface of the snow gall gastrointestinal pill is flat, smooth and bright by improving the polishing process, the appearance quality of the snow gall gastrointestinal pill is improved, and meanwhile, the snow gall gastrointestinal pill is bright like a bead and very smooth after the product is improved in the polishing process, is convenient to swallow when being taken, relieves the pain of patients in taking medicine, and improves the compliance of patients.
The prescription and the forming process of the product are not changed, so that the material basis of the product is kept consistent before and after the invention, and the safety and the effectiveness of the product are not influenced.
The improved polishing process avoids the use of high-concentration ethanol in the polishing process, can reduce the explosion-proof level of a production site, improves the safety in the production process, and simultaneously reduces the use amount of insect wax (auxiliary materials for polishing) and the use amount of the auxiliary materials and the intake amount of the auxiliary materials while improving the appearance quality through the research of the polishing process.
Compared with the conventional polishing process, the polishing process of the product does not add a wetting agent before polishing, thereby preventing the conglutination of the pill and the flour caused by improper control in the polishing process.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example 1
A polishing method of hemsleya amabilis gastrointestinal pills comprises the following steps:
a: processing the medicinal powder; pulverizing the medicinal materials into fine powder, sieving, and mixing the sieved medicinal powder;
b: preparing pills; adding appropriate amount of Mel and water into the mixed medicinal powder to make into pill;
c: coating; coating the pills with active carbon and drying; the pill coated with carbon can improve stability of the medicine, reduce irritation of the medicine, control disintegration degree and improve appearance. In addition, the intake of sugar in the coating can be reduced, and the coating is especially suitable for diabetic patients.
The drying operation is as follows: the prepared qualified pills are flatly spread in a baking pan (the thickness is not more than 3 cm), placed on a grill from top to bottom and pushed into the baking oven for baking (the drying temperature is less than or equal to 60 ℃). At the initial stage of drying, baking at 60 ℃ for about 1h, and turning the tray to avoid adhesion and sunny and shady sides; and then the plate turnover is carried out every 2-3 h. Drying to water content of 5.5-7.0%, taking out the pill from the oven, and cooling to room temperature.
D: polishing; 1.0-1.4g of refined Chinese insect wax is used per 1kg of pill; the pills are weighed before polishing so as to conveniently weigh enough refined Chinese insect wax. Placing the pill in a polishing device, rolling for 10min, spraying 55-65% of refined Cera chinensis on the pill, rolling for 35-45min, adding the rest refined Cera chinensis, and polishing for 115-125min; the insect wax is added step by step for polishing, so that the insect wax can be uniformly attached to the pill, the pill surface is flat, smooth and bright, and the consumption of the insect wax can be reduced.
In a preferred embodiment, the Chinese medicinal powder in step A is powder of radix aucklandiae, radix Hemsleyae Macrospermae, fructus evodiae, rhizoma paridis, rhizoma Bletillae, rhizoma corydalis, os Sepiae, atractylodis rhizoma, radix Angelicae sinensis, radix Codonopsis, radix astragali and Glycyrrhrizae radix. It should be noted that the hemsleya root gastrointestinal pill used in the present invention is a prior art, and the specific formulation and mixture ratio thereof are not described herein.
In a preferred embodiment, in step a, the herbs are pretreated and then pulverized by a pulverizer.
In a preferred embodiment, in step D, the polishing device is a sugar coating pan.
In a preferred embodiment, in step D, the ambient humidity at the time of polishing is < 50%, the polishing temperature: 20-28 ℃, water content of the pill: 5.5 to 7.0 percent.
A preparation method of refined Chinese insect wax comprises the following steps:
s1: adding Chinese wax into pure water, wherein the weight ratio of the Chinese wax to the water is 5:1-10;
s2: heating to melt the Chinese insect wax, stirring at 60-100 rpm, and boiling for 30-60min;
s3: filtering the melted Chinese insect wax at least twice by using a filter sieve; used for removing impurities on the surfaces of suspension and wax liquid.
S4: putting Cera chinensis into a container with smooth inner wall, adding 60-70 deg.C water, standing and keeping the temperature for 30-60min;
s5: taking out the insect white wax, cooling and solidifying the insect white wax, and removing the upper surface layer and the bottom layer part of the insect white wax by using a tool; the impurities at the top and the bottom of the cooled insect wax are more, and the upper surface layer and the bottom layer of the cooled insect wax are removed to take out the impurities wrapped in the insect wax.
S6: heating and melting Chinese insect wax, and evaporating to remove water in the Chinese insect wax;
s7: adding 3-5% dimethyl silicone oil when insect white wax is slightly cold, and stirring at 60-100 rpm for 10-30min;
s8: pouring the insect white wax into a mold, and taking out and crushing the insect white wax after the insect white wax is cooled; and sieving the crushed Chinese insect wax for multiple times by using a filter sieve to obtain the refined Chinese insect wax.
According to the method, through understanding of the properties of the insect wax, the insect wax is refined by adopting a method with mild conditions and a suitable container, the refined insect wax reaches the grade of the wax, compared with other refining methods, the use of an organic solvent and acid is avoided, the environmental protection requirement and the preparation cost are reduced, and meanwhile, the lubricating effect and the thermal stability of the insect wax can be improved by creatively adding the dimethyl silicone oil.
In a preferred embodiment, in step S2, the melted insect wax is stirred at 80 rpm and kept boiling for 45min.
In a preferred embodiment, in step S4, the container is in the shape of a large top opening and a small bottom. When carrying out worm white wax with the big small container in bottom of open-top, impurity in can better separation worm white wax when carrying out impurity separation with this container, can make impurity easily concentrate on upper surface layer and bottom, separation impurity that can be better.
In a preferred embodiment, in step S7, 4% dimethicone is added to the mixture after the insect wax is slightly cooled, and the mixture is stirred at 80 rpm for 20min. The addition of the dimethyl silicone oil can improve the lubricating effect and the thermal stability of the insect wax, and is beneficial to subsequent polishing and the stability of products.
In a preferred embodiment, the filter sieve used in step S3 is a 100 mesh stainless steel filter sieve; the filtering sieve used in the step S8 adopts a stainless steel filtering sieve with 80-120 meshes.
The following table shows the detection comparison between the insect wax sold in the market and the insect wax manufactured by the method of the invention: (it should be noted that the detection methods employed in the present invention are all prior art)
From the results of the above-mentioned detection, the insect white wax sold in the market is in three wax grades, the wax grade is achieved according to the standard of 'insect white wax of the ministry of supply and marketing of the people's republic of China '(GH 011-80)', after the insect white wax is refined by the method, the refining effect is remarkable, the quality is good, and the subsequent polishing process is facilitated.
Process parameter test method 1
1kg of hemsleya amabilis gastrointestinal pill which is coated and dried by active carbon is taken for polishing temperature investigation. Placing the pill in a sugar-coating pan, controlling polishing temperature, rolling for 10min, adding 0.72g refined Cera chinensis, spreading on the pill, rolling for 40min, adding 0.48g refined Cera chinensis, and polishing for 2 hr. The surface of the pill was observed at different polishing temperatures.
The following table shows the appearance of the pill surface at different polishing temperatures:
temperature (. Degree.C.) | Variation of surface brightness of pill |
16 | The pill powder appears gray powder cream |
18 | Micro-bright of pill surface |
20 | The pill has obvious bright surface |
22 | The ball surface is bright like beads |
24 | The ball surface is bright like beads |
26 | The ball surface is bright like a pearl |
28 | Slightly light bright surface of the pill |
30 | Bright and dark pill surface |
As can be seen from the table above, when the polishing temperature is controlled at 20-28 ℃, the pill surface of the pill can be ensured to be smooth and bright.
Process parameter test method 2
1kg of hemsleya gastrointestinal pills which are coated and dried by active carbon are taken for pill moisture investigation. Placing the pills with different water contents in a sugar coating pan, controlling the polishing temperature to be 24 ℃, starting the pan, rolling for 10min, adding 0.72g of refined insect white wax, uniformly spreading the refined insect white wax on the pills, rolling for 40min, adding 0.48g of refined insect white wax, and continuously polishing for 2h. The surface of the pill was observed for different water contents.
The following table shows the appearance of the pill surface at different water contents:
from the above results, the water content of the pill is controlled to be 5.5-7.0%, and the pill surface is smooth and bright.
Process parameter test method 3
1kg of hemsleya amabilis gastrointestinal pill which is coated and dried by active carbon is taken for the dosage investigation of insect white wax. Placing the pill with water content of 6.0% in a sugar-coating pan, controlling polishing temperature at 24 deg.C, starting and rolling for 10min, adding refined insect white wax (60% of the total amount), spreading on the pill uniformly, rolling for 40min, adding the rest refined insect white wax, and polishing for 2 hr. And observing the phenomenon of the surface of the pill under different dosages of the refined insect wax.
The following table shows the appearance of the pill at different dosages of refined insect wax:
total amount of refined insect wax (g) | Variation of surface brightness of pill |
0.8 | The pill has off-white and glimmer color |
1.0 | The pill has remarkable bright surface |
1.2 | The ball surface is bright like beads |
1.4 | The ball surface is bright like beads |
1.6 | A pill with light and dim light |
1.8 | The pill has weak brightness |
As can be seen from the above data, when the total amount of insect wax is in the range of 1.0-1.4g, the pill has a smooth and bright surface.
Example 2
Taking radix aucklandiae, hemsleya amabilis, fructus evodiae, rhizoma paridis, rhizoma bletillae, rhizoma corydalis, cuttlebone, bighead atractylodes rhizome, angelica, codonopsis pilosula, astragalus and liquorice, wherein the twelve medicines are as follows:
(1) Pulverizing the medicines into fine powder, sieving the pulverized medicines, and uniformly mixing;
(2) Adding appropriate amount of Mel water into the medicinal powder, and making into pill;
(3) Coating the pills with active carbon, and drying the coated pills
(4) Refining insect white wax: adding insect white wax into pure water, controlling the weight ratio of the pure water to the insect white wax to be 5:1, heating until the wax is completely melted, stirring at 60 revolutions per minute and keeping slightly boiling for 30 minutes, then filtering the melted wax with a 100-mesh stainless steel sieve while the melted wax is hot to remove impurities suspended on the surface of the wax liquid, repeating the steps after filtering, then putting the wax into a basin with a large upper opening surface and a small bottom surface and a smooth inner part, keeping the temperature in a 60 ℃ water bath for 30 minutes, taking out, cooling to solidify the wax, taking out the wax block from the basin, cutting off the upper surface layer and the bottom layer of the wax block with a knife, then heating to melt the wax, evaporating to remove the water in the wax block, adding 4% dimethyl silicone oil after the wax is slightly cooled, stirring at 60 revolutions per minute for 30 minutes to uniformly mix the wax block, pouring the wax block into a mold box, cooling, taking out, crushing, and sieving with a 100-mesh sieve to obtain the insect white wax.
(5) 1kg of hemsleya amabilis gastrointestinal pills which are coated and dried by activated carbon are put into a sugar coating pan, and the water content is kept to be 5.0 percent. Polishing at 20 deg.C, rolling for 10min, spraying 0.6g refined Cera chinensis on the pill, rolling for 40min, adding 0.4g refined Cera chinensis, and polishing for 2 hr. The ambient humidity was controlled at 40%.
Example 3
Taking radix aucklandiae, hemsleya amabilis, fructus evodiae, rhizoma paridis, rhizoma bletillae, rhizoma corydalis, cuttlebone, bighead atractylodes rhizome, angelica, codonopsis pilosula, astragalus and liquorice, wherein the twelve medicines are as follows:
(1) Pulverizing the medicines into fine powder, sieving the pulverized medicines, and uniformly mixing;
(2) Adding appropriate amount of Mel water into the medicinal powder, and making into pill;
(3) Coating the pills with active carbon, and drying the coated pills
(4) Refining insect white wax: adding pure water into insect white wax, controlling the weight ratio of the pure water to the insect white wax to be 6:1, heating until the wax is completely melted, stirring at 60 revolutions per minute and keeping the mixture slightly boiling for 30 minutes, then filtering the melted wax with a 100-mesh stainless steel sieve while the wax is hot to remove impurities suspended on the surface of the wax liquid, repeating the step after filtering, then placing the wax into a basin with a large upper opening surface and a small bottom surface and a smooth inner part, keeping the temperature in a water bath at 60 ℃ for 30 minutes, taking out, cooling to solidify the wax, taking out the wax block from the basin, cutting off the upper surface layer and the bottom layer of the wax block with a knife, then heating to melt the wax block, evaporating to remove the water in the wax block, adding 4% of dimethyl silicone oil when the wax block is slightly cold, stirring at 60 revolutions per minute for 30 minutes to uniformly mix the wax block, pouring the mixture into a mold box, taking out after cooling, crushing and sieving with a 100-mesh sieve to obtain the insect white wax.
(5) 1kg of hemsleya amabilis gastrointestinal pills which are coated and dried by activated carbon are put into a sugar coating pan, and the water content is kept to be 5.5 percent. Polishing at 22 deg.C, rolling for 10min, spraying 0.72g refined Cera chinensis on the pill, rolling for 40min, adding 0.4g refined Cera chinensis, and polishing for 2 hr. The ambient humidity was controlled at 40%.
Example 4
Taking radix aucklandiae, hemsleya amabilis, fructus evodiae, rhizoma paridis, rhizoma bletillae, rhizoma corydalis, cuttlebone, bighead atractylodes rhizome, angelica, codonopsis pilosula, astragalus and liquorice, wherein the twelve medicines are as follows:
(1) Pulverizing the medicines into fine powder, sieving the pulverized medicines, and uniformly mixing;
(2) Adding appropriate amount of Mel water into the medicinal powder, and making into pill;
(3) Coating the pills with active carbon, and drying the coated pills
(4) Refining insect white wax: adding pure water into insect white wax, controlling the weight ratio of the pure water to the insect white wax to be 8:1, heating until the wax is completely melted, stirring at 80 revolutions per minute and keeping the mixture slightly boiling for 30 minutes, then filtering the melted wax with a 100-mesh stainless steel sieve while the wax is hot to remove impurities suspended on the surface of the wax liquid, repeating the step after filtering, then placing the wax into a basin with a large upper opening surface and a small bottom surface and a smooth inner part, keeping the temperature in a 60 ℃ water bath for 30 minutes, taking out, cooling to solidify the wax, taking out the wax block from the basin, cutting off the upper surface layer and the bottom layer part of the wax block with a knife, then heating to melt the wax, evaporating to remove the inner water, adding 4% dimethyl silicone oil when the wax is slightly cold, stirring at 60 revolutions per minute for 30 minutes to uniformly mix the wax block, pouring the mixture into a mold box, taking out after cooling, crushing and sieving with a 100-mesh sieve to obtain the insect white wax.
(5) 1kg of hemsleya amabilis gastrointestinal pills which are coated and dried by activated carbon are put into a sugar coating pan, and the water content is kept to be 6.0 percent. Polishing at 24 deg.C, rolling for 10min, spraying 0.84g refined Cera chinensis on the pill, rolling for 40min, adding 0.56g refined Cera chinensis, and polishing for 2 hr. The ambient humidity was controlled at 45%.
Example 5
Taking radix aucklandiae, hemsleya amabilis, fructus evodiae, rhizoma paridis, rhizoma bletillae, rhizoma corydalis, cuttlebone, bighead atractylodes rhizome, angelica, codonopsis pilosula, astragalus and liquorice, wherein the twelve medicines are as follows:
(1) Pulverizing the medicines into fine powder, sieving the pulverized medicines, and uniformly mixing;
(2) Adding appropriate amount of Mel water into the medicinal powder, and making into pill;
(3) Coating the pill with active carbon, and drying the coated pill
(4) Refining insect white wax: adding pure water into insect white wax, controlling the weight ratio of the pure water to the insect white wax to be 9:1, heating until the wax is completely melted, stirring at 60 revolutions per minute and keeping the mixture slightly boiling for 30 minutes, then filtering the melted wax with a 100-mesh stainless steel sieve while the wax is hot to remove impurities suspended on the surface of the wax liquid, repeating the step after filtering, then placing the wax into a basin with a large upper opening surface and a small bottom surface and a smooth inner part, keeping the temperature in a water bath at 60 ℃ for 30 minutes, taking out, cooling to solidify the wax, taking out the wax block from the basin, cutting off the upper surface layer and the bottom layer of the wax block with a knife, then heating to melt the wax block, evaporating to remove the water in the wax block, adding 4% of dimethyl silicone oil when the wax block is slightly cold, stirring at 60 revolutions per minute for 30 minutes to uniformly mix the wax block, pouring the mixture into a mold box, taking out after cooling, crushing and sieving with a 100-mesh sieve to obtain the insect white wax.
(5) 1kg of hemsleya amabilis gastrointestinal pills which are coated and dried by activated carbon are put into a sugar coating pan, and the water content is kept to be 6.5 percent. Polishing at 24 deg.C, rolling for 10min, spraying 0.84g refined Cera chinensis on the pill, rolling for 40min, adding 0.56g refined Cera chinensis, and polishing for 2 hr. The ambient humidity was controlled at 45%.
Example 6
Taking radix aucklandiae, hemsleya amabilis, fructus evodiae, rhizoma paridis, rhizoma bletillae, rhizoma corydalis, cuttlebone, bighead atractylodes rhizome, angelica, codonopsis pilosula, astragalus and liquorice, wherein the twelve medicines are as follows:
(1) Pulverizing the medicines into fine powder, sieving the pulverized medicines, and uniformly mixing;
(2) Adding appropriate amount of Mel and water into the medicinal powder to make into pill;
(3) Coating the pills with active carbon, and drying the coated pills
(4) Refining insect white wax: adding insect wax into pure water, controlling the weight ratio of the pure water to the insect wax to be 10.
(5) 1kg of hemsleya amabilis gastrointestinal pills which are coated and dried by activated carbon are put into a sugar coating pan, and the water content is kept to be 7.0 percent. Polishing at 28 deg.C, rolling for 10min, spraying 0.84g refined Cera chinensis on the pill, rolling for 40min, adding 0.56g refined Cera chinensis, and polishing for 2 hr. The ambient humidity was controlled at 45%.
The appearance quality of the product is compared before and after the invention:
sample name | Appearance of the product |
Sample of hemsleya root gastrointestinal pill by conventional production method | The pill surface is dull and dull, and rough |
EXAMPLE 1 samples | The ball surface is bright like beads |
EXAMPLE 2 samples | The ball surface is bright like beads |
Example 3 sample | The ball surface is bright like beads |
Example 4 sample | The ball surface is bright like beads |
Example 5 sample | The ball surface is bright like beads |
Example 6 sample | The ball surface is bright like beads |
As can be seen from the above table, the hemsleya root gastrointestinal pill prepared by the invention has a bright and pearl-like surface, and is convenient for patients to take. Meanwhile, the bright and smooth hemsleya root gastrointestinal pill is convenient for patients to swallow, and the pain of the patients in taking medicine is reduced.
Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.
Claims (10)
1. A polishing method of hemsleya amabilis gastrointestinal pills is characterized by comprising the following steps: the method comprises the following steps:
a: processing the medicinal powder; pulverizing the medicinal materials into fine powder, sieving, and mixing the sieved medicinal powder;
b: preparing pills; adding appropriate amount of Mel and water into the mixed medicinal powder to make into pill;
c: coating; coating the pills with active carbon and drying;
d: polishing; 1.0-1.4g of refined Chinese insect wax is used per 1kg of pill; rolling the pill in a polishing device for 10min, spraying 55-65% of refined Cera chinensis on the pill, rolling for 35-45min, adding the rest refined Cera chinensis, and polishing for 115-125min.
2. The method for polishing hemsleya amabilis gastrointestinal pills as claimed in claim 1, wherein the method comprises the following steps: the Chinese medicinal powder in step A is powder of radix aucklandiae, radix Hemsleyae Macrospermae, fructus evodiae, rhizoma paridis, rhizoma Bletillae, rhizoma corydalis, os Sepiae, atractylodis rhizoma, radix Angelicae sinensis, radix Codonopsis, radix astragali and Glycyrrhrizae radix.
3. The polishing method of the hemsleya root gastrointestinal pill as claimed in claim 1, which is characterized in that: in the step A, the medicinal materials are pretreated and then crushed by a powder grinding machine.
4. The method for polishing hemsleya amabilis gastrointestinal pills as claimed in claim 1, wherein the method comprises the following steps: in step D, the polishing device adopts a sugar coating pan.
5. The method for polishing hemsleya amabilis gastrointestinal pills as claimed in claim 1, wherein the method comprises the following steps: in step D, the ambient humidity is less than 50% when polishing is carried out, and the polishing temperature is as follows: 20-28 ℃, water content of the pill: 5.5 to 7.0 percent.
6. A method for preparing refined Chinese insect wax is characterized in that: the method comprises the following steps:
s1: adding Chinese wax into pure water, wherein the weight ratio of the Chinese wax to the water is 5:1-10;
s2: heating to melt the Chinese insect wax, stirring at 60-100 rpm, and boiling for 30-60min;
s3: filtering the melted Chinese insect wax at least twice by using a filter sieve;
s4: putting Cera chinensis into a container with smooth inner wall, adding 60-70 deg.C water, standing, and keeping the temperature for 30-60min;
s5: taking out the insect white wax, cooling and solidifying the insect white wax, and removing the upper surface layer and the bottom layer part of the insect white wax by using a tool;
s6: heating and melting Chinese insect wax, and evaporating to remove water in the Chinese insect wax;
s7: adding 3-5% of dimethyl silicone oil when the insect white wax is slightly cold, and stirring for 10-30min at 60-100 r/min;
s8: pouring the insect white wax into a mold, and taking out and crushing the insect white wax after the insect white wax is cooled; and sieving the crushed Chinese insect wax for multiple times by using a filter sieve to obtain the refined Chinese insect wax.
7. The method for polishing hemsleya amabilis gastrointestinal pills as claimed in claim 6, wherein the method comprises the following steps: in step S2, the melted insect wax is stirred at 80 rpm and kept boiling for 45min.
8. The method for polishing hemsleya amabilis gastrointestinal pills as claimed in claim 6, wherein the method comprises the following steps: in step S4, the container has a shape with a large top opening and a small bottom.
9. The polishing method of the hemsleya root gastrointestinal pill as claimed in claim 6, characterized in that: in step S7, after the insect white wax is slightly cold, 4% of simethicone is added and stirred for 20min at 80 rpm.
10. The method for polishing hemsleya amabilis gastrointestinal pills as claimed in claim 6, wherein the method comprises the following steps: the filter sieve used in step S3 is a 100-mesh stainless steel filter sieve; the filtering sieve used in the step S8 adopts a stainless steel filtering sieve with 80-120 meshes.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202210696537.0A CN115969933B (en) | 2022-06-20 | 2022-06-20 | Polishing method for hemsleya amabilis stomach and intestine pills |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202210696537.0A CN115969933B (en) | 2022-06-20 | 2022-06-20 | Polishing method for hemsleya amabilis stomach and intestine pills |
Publications (2)
Publication Number | Publication Date |
---|---|
CN115969933A true CN115969933A (en) | 2023-04-18 |
CN115969933B CN115969933B (en) | 2024-05-03 |
Family
ID=85974654
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN202210696537.0A Active CN115969933B (en) | 2022-06-20 | 2022-06-20 | Polishing method for hemsleya amabilis stomach and intestine pills |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN115969933B (en) |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1493355A (en) * | 2003-09-12 | 2004-05-05 | 贵州苗药雪胆胃肠丸科技中心 | Medicine for treating gastrointestinal tract diseases |
CN1493356A (en) * | 2003-09-12 | 2004-05-05 | 贵州苗药雪胆胃肠丸科技中心 | Medicine for treating gastrointestinal tract disease |
CN101225345A (en) * | 2008-02-14 | 2008-07-23 | 中国林业科学研究院资源昆虫研究所 | Refining method for insect wax |
CN102304434A (en) * | 2011-08-03 | 2012-01-04 | 中国林业科学研究院资源昆虫研究所 | Method for refining Chinese wax |
CN106668549A (en) * | 2017-02-13 | 2017-05-17 | 昆明生达制药有限公司 | Radix hemsleyae pills for stomach and intestine diseases as well as preparation method and detection method thereof |
CN106668548A (en) * | 2017-02-13 | 2017-05-17 | 昆明生达制药有限公司 | Hemsleya amabilis stomach and intestine pill and preparation method thereof |
CN107551248A (en) * | 2017-09-26 | 2018-01-09 | 马鞍山天福康药业有限公司 | A kind of ease pill and production technology |
-
2022
- 2022-06-20 CN CN202210696537.0A patent/CN115969933B/en active Active
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1493355A (en) * | 2003-09-12 | 2004-05-05 | 贵州苗药雪胆胃肠丸科技中心 | Medicine for treating gastrointestinal tract diseases |
CN1493356A (en) * | 2003-09-12 | 2004-05-05 | 贵州苗药雪胆胃肠丸科技中心 | Medicine for treating gastrointestinal tract disease |
CN101225345A (en) * | 2008-02-14 | 2008-07-23 | 中国林业科学研究院资源昆虫研究所 | Refining method for insect wax |
CN102304434A (en) * | 2011-08-03 | 2012-01-04 | 中国林业科学研究院资源昆虫研究所 | Method for refining Chinese wax |
CN106668549A (en) * | 2017-02-13 | 2017-05-17 | 昆明生达制药有限公司 | Radix hemsleyae pills for stomach and intestine diseases as well as preparation method and detection method thereof |
CN106668548A (en) * | 2017-02-13 | 2017-05-17 | 昆明生达制药有限公司 | Hemsleya amabilis stomach and intestine pill and preparation method thereof |
CN107551248A (en) * | 2017-09-26 | 2018-01-09 | 马鞍山天福康药业有限公司 | A kind of ease pill and production technology |
Non-Patent Citations (4)
Title |
---|
张海清: "中成药微粒丸"打光"技术的探讨", 中成药研究, vol. 06, 30 June 1984 (1984-06-30), pages 44 * |
朱国强: "蜜丸打光材料配方工艺初探", 中成药研究, 31 December 1985 (1985-12-31), pages 8 * |
沈烈行: "蜜丸"打光"的工艺探讨", 中药材, vol. 18, no. 6, 30 June 1995 (1995-06-30), pages 283 * |
王荣林: "虫白蜡的简易精制法", 中国中药杂志, vol. 15, no. 11, pages 36 * |
Also Published As
Publication number | Publication date |
---|---|
CN115969933B (en) | 2024-05-03 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN105462773A (en) | Nourishing health-care liquor and preparation method thereof | |
CN111903898A (en) | Preparation method of medicinal and edible health-care powder for tonifying kidney, invigorating spleen and removing dampness | |
CN107980866A (en) | A kind of moon cake and preparation method thereof | |
CN106616191A (en) | Honeysuckle flower and radix puerariae powder effervescent tablets and preparation method | |
CN100394943C (en) | Medicine and food dual purpose Chinese medicinal product for preventing and treating sorethroat and its manufacturing method | |
CN100394942C (en) | Medicine and food dual purpose Chinese medicinal product for preventing and treating laryngitis and its manufacturing method | |
CN103461629B (en) | Rose honey date capable of nourishing beauty | |
CN115969933A (en) | Polishing method for hemsleya amabilis gastrointestinal pills | |
CN105901223A (en) | Preparation method of mulberry leaf tea | |
CN110169576A (en) | It is a kind of to grow drink with the tanning cream of kidney tonifying and the effect that keeps fit and healthy | |
CN108192790A (en) | Dendrobium officinale alcohol and preparation method thereof | |
CN112890169A (en) | Preparation method and eating method of peach gum instant granule food | |
CN112471510A (en) | A nutritional product suitable for people with poor mood and its preparation method | |
CN113951509A (en) | Medlar and chrysanthemum cream and preparation method thereof | |
CN112971122A (en) | Donkey-hide gelatin, agastache rugosus and sealwort extract and preparation method thereof | |
CN1204827C (en) | Xinhui dried orange peel jam and its making method | |
CN112226330A (en) | Preparation method of health vinegar tea | |
CN111567652A (en) | Health tea for conditioning constitution of qi stagnation and preparation method thereof | |
CN105296305B (en) | A kind of preparation method of bitter bamboo bamboo wine | |
CN1272339A (en) | Preparation method of ginger sugar tea | |
CN109777691A (en) | Peach blossom wine and preparation method thereof | |
CN112056503A (en) | Preparation process for producing big cakes | |
CN109833393A (en) | A kind of medical ointment plaster of function of spleen and stomach regulating and preparation method thereof | |
CN113331278A (en) | Frost mulberry leaf health-care tea and preparation method thereof | |
CN117919329A (en) | Preparation method and detection method of uterus warming patch |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
GR01 | Patent grant | ||
GR01 | Patent grant |