CN100394944C - Medicine and food duel purpose Chinese medicinal product for preventing and treating pharyngolaryngitis and its manufacturing method - Google Patents

Medicine and food duel purpose Chinese medicinal product for preventing and treating pharyngolaryngitis and its manufacturing method Download PDF

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CN100394944C
CN100394944C CNB2005101364453A CN200510136445A CN100394944C CN 100394944 C CN100394944 C CN 100394944C CN B2005101364453 A CNB2005101364453 A CN B2005101364453A CN 200510136445 A CN200510136445 A CN 200510136445A CN 100394944 C CN100394944 C CN 100394944C
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medicinal residues
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chinese medicine
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CN1824001A (en
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颜怀伟
颜怀玮
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Abstract

The present invention relates to a traditional Chinese medicine product used as medicine and food for preventing and treating laryngopharyngitis and a preparation method thereof. The traditional Chinese medicine product is prepared from official traditional Chinese medicine raw materials used as medicine and food of dandelion, balloonflower root, houttuynia, white Chinese olive, grosvenor momordica fruit, phyllanthus emblica, mint and mulberry leaf, has no toxic or side effect and is mainly used for long-term prevention. The traditional Chinese medicine product has the advantages of low production cost, no environment pollution, good mouth feel, low dosage and positive effect, and the medicine is suitable for different people of different ages, is easily accepted by patients, and has wide service aspect because all medicinal materials have official medicine and food purpose, positive efficacy and no toxic or side effect. The product traditional Chinese medicine product has simple and uniform medication variety and function and flexible and various prescription, adapts to various patient conditions, appropriately selects medication, and widens the concrete content and the application range of identifying and curing the diseases with traditional Chinese medicines.

Description

A kind of compositions is prevented and treated application in the medicine of pharyngolaryngitis in preparation
Chinese medicine and western modern medicine disease preventing and treating theory one significantly difference be that the former does not rest on analysis to the concrete cause of disease to pathological knowledge, show the nonantagonistic latter and then be antagonism, that is the former emphasizes is human body integral and the ability that how improves the antagonism disease from integral body, the latter then is that " sitting in the right seat " is as what microorganism, malnutrition or surplus, poisonous and harmful substance (comprising medicine) and effect etc. cause any disease, though theoretic dispute is very big, even opposition and antagonism, whom shows under a lot of situations whom does not persuade, mutual contradiction or do not have public opinion even, undisputable fact really but they can both be cured the disease and/or reach a cure, this also proved human to medicine especially in, cognitive level and ability between western modern medicine is mutual are also very limited, and arbitrarily in the dogmatize about, the western modern medicine theory who to whose mistake, can not declare that more which is right and which is wrong, because both sides do not have enough conclusive evidences to prove that the other side is wrong, so do not meet the view of science, so should advocate the pardon scientific research of promptly taking facts as the basis and deepen continuously progressively gets and improves relevant theoretical dispute clear with practice and argue, thereby in constantly enriching, the theoretical treasure-house of western modern medicine, make the two can both more effectively be human good health and a long life service, but not argue for arguement, even be negative arbitrarily even attack the other side, not science and responsible attitude and behavior because do like this by lack of evidence ground to argue, all be unfavorable for ensureing and developing human medical and health care system.
Though development along with medical and health care system, various diseases is corresponding also to be reduced to some extent, but this is not just can sleep without any anxiety, in fact various diseases still exist, there is no disappearance sign or trend, especially disease of the present invention is worked because of allegro modern society, study is bigger with life equal pressure, energy and physical load and overdraw are serious, the crowd who is in sub-health status is very big, resistance is often lower and at first especially easily suffer from this type of disease, so still be commonly encountered diseases and frequently-occurring disease, as untimely control, often drag the chronic disease that becomes to be difficult to be subjected to and to be difficult to healing, so still should actively prevent and treat.In present this class disease of control, the Western medicine product substantially all are to lay particular stress on treatment, poison, side effect is just more common, in no matter the more important thing is, the all rare officinal food dual purpose product of Western medicine, this is to forbid unauthorized medicine to use food (comprising health product) in any form because consider all to make laws from drug safety in China and a lot of countries and regions, otherwise call to account in accordance with the law, and that disease reaches the degree of essential treatment is very serious, say on the clinical meaning and increase the treatment difficulty greatly, let alone puted prevention first, even if also just can sell medicine as the U.S. because of the prescription drugs pharmacy that must the doctor prescribes in developed country and area, otherwise it is illegal, consumer then must pay expenses such as high prescription takes and surpass medicine valency itself outward, and nonprescription drugs, health food is that the dietotherapeutic product then need not prescription and expensive expense thereof, has alleviated consumer's financial burden greatly and made to buy to consume simple and direct and increase purchasing power, fulfill thereby making puts prevention first.Therefore unique legal effectively, economically feasible, to put prevention first, prevent and treat the scheme of taking into account just can only be screening, combination and design relevant new departure and new product in view of the above in legal dietotherapeutic medicine scope, because of such product could really accomplish good and cheap, consumer channel is unblocked, service group is extensive, its disease preventing and treating function and curative effect, safety and crowd's general applicability could also must gain public acceptance and serial relevant law such as state food health legislation is approved and protect.
Total be exactly the present invention at prior art not enough, for one for solve an above-mentioned serial difficult problem a kind of compositions of designing of inventive concept prevent and treat application in the medicine of pharyngolaryngitis in preparation, main Chinese medicine principle and functional advantage that its health that adopts officinal promulgated by the ministries or commissions of the Central Government is eaten dual-purpose raw material of Chinese medicine and the property of medicine and foundation are described below.
Herba Taraxaci sweet in the mouth, hardship, cold in nature, heat-clearing and toxic substances removing, dispersing swelling and dissipating binds cures mainly pyretic toxicity carbuncle sore, conjunctival congestion pharyngeal swelling, aphtha of the mouth and tongue, pathopyretic ulcer, and acute mastitis swells and ache, and lung abscess is coughed vomiting bloody pus, abdominalgia with intestinal abscess, heating.Can control the puckery pain of pyretic stranguria, and jaundice caused by damp-heat.
Radix Platycodonis bitter in the mouth, treatment pharyngeal swelling pain, medicine carrying rise, open the sharp heap soil or fertilizer over and around the roots of breast.Radix Platycodonis bitter in the mouth suffering, property are put down, that lung qi dispersing looses is evil, go the expectorant evacuation of pus, is the key medicine of treatment laryngopharynx swelling and pain, and the effect that medicine carrying rises, the guiding medicine of making the top disease are arranged, stagnation of phlegm in the also logical lung is jammed, has out the sharp effect of stopping up of breast, controls the cough chest pain, coughs the lung carbunculosis of vomiting bloody pus.
The Herba Houttuyniae heat-clearing and toxic substances removing, eliminating carbuncle evacuation of pus, inducing diuresis for treating stranguria syndrome.Be used for the lung abscess vomiting pus, the expectorant dyspnea of heat type is coughed, hematodiarrhoea, pyretic stranguria, carbuncle sore tumefacting virus.
The Fructus Canarii heat clearing away, sore-throat relieving promotes the production of body fluid, detoxifcation.Be used for laryngopharynx swelling and pain, cough, excessive thirst, the fish Eriocheir sinensis poisons.
The Fructus Momordicae clearing heat and moistening lung, the laxation relieving constipation.Be used for lung-fire cough caused by dryness, pharyngalgia aphonia, dryness of the intestine constipation.1-3 part.
Fructus Phyllanthi is little puckery, and is cool in nature.Relieving sore-throat by clearing away heat, nourishing the lung to arrest cough.Be used for cold, fever, throat pain, cough, xerostomia, excessive thirst, toothache, vitamin C deficiency.Deficiency and coldness of spleen and stomach the person should not obey more.
Herba Menthae acrid in the mouth, refresh oneself, go air slaking expectorant, hectic fever due to YIN-deficiency to obey.Herba Menthae acrid in the mouth, cool in nature, can clear up head's wind heat, control the wind heat disease of heads such as headache, conjunctival congestion, toothache, laryngopharynx swelling and pain, order part, because of the effect of Pulvis Diaphoreticus wind heat is arranged, so be usually used in anemopyretic cold or the epidemic febrile disease table disease from the beginning of fever without perspiration again, and skin is subjected to rubella that wind heat causes and measles initial stage to be difficult for saturating send out etc.
Folium Mori are cold in nature, the kind wind heat of loosing, the liver heat removing that makes eye bright, the removing heat from blood of holding concurrently again.Folium Mori sweet-bitter flavor, cold in nature, light weight is kind can dispelling wind and heat pathogens, cold in nature again can liver heat removing and eyesight improving, so diseases such as having a dizzy spell of can controlling that fever and cough, headache conjunctival congestion and the liver-yang of affection due to external wind and heat rise, this product also has the effect of lung moistening removing heat from blood concurrently in addition, can control dryness-heat impairing the lung, hemoptysis pharyngalgia etc.
Product of the present invention is by legal dietotherapeutic Chinese crude drug Herba Taraxaci 1-2 part, and Radix Platycodonis 1-3 part, Herba Houttuyniae 1-3 part, Fructus Canarii 1-2 part, Fructus Momordicae 1-3 part, Fructus Phyllanthi 1-3 part, Herba Menthae 0.5-3 part, Folium Mori 1-3 part are that raw material of Chinese medicine is formed.
The manufacture method of product of the present invention is as follows:
A. decoction pieces type Chinese crude drug Herba Taraxaci 1-2 part is on the waiting list in the choosing of raw material Chinese medicine, Radix Platycodonis 1-3 part, Herba Houttuyniae 1-3 part, Fructus Canarii 1-2 part, Fructus Momordicae 1-3 part, Fructus Phyllanthi 1-3 part, Herba Menthae 0.5-3 part, Folium Mori 1-3 part joins in the nonmetallic surface such as containers such as fiberglass, enamel of belt stirrer, filter and water bath with thermostatic control heater;
Preparation b. organic and inorganic mixed solvent is got the above ethanol of food stage (solubilized many be insoluble in the material of water and significantly improve drug effect) and adds the dilution of room temperature drinking water that to make ethanol (dense) degree be that alcohol content is the organic mixed solvent (mixed solution for extraction object Chinese medicinal ingredients material different liquids still can be considered solvent) with inorganic two kinds of solvent compositions of the sterilization type of 55-75% (V/V is a volume ratio), and alcoholic strength is lower than 55% or be higher than 75% equal difficulty and reach optimum extraction and sterilization effect;
C. use the described solvent of b to the raw material medicine extract with the described mixed solvent of b join a described added get in the container of whole Chinese crude drugs, addition is advisable for flooding Chinese crude drug fully, hermetic container soaked 20-30 minute, turn on agitator and with 20-60 rev/min of rotating speed agitating solution and Chinese crude drug 20-30 minute, open filter, 50-100 eye mesh screen isolated by filtration medicinal residues and solution, the centrifugal medicinal residues of 1000-3000 rev/min rotating speed, medicinal liquid is incorporated isolated by filtration solution into, open heating (evaporation) device medicinal residues and medicinal liquid accurately are heated to 78-80 ℃ of ethanol boiling point (to reduce evaporation of water and distillation as far as possible) vaporization ethanol respectively, collect vaporization ethanol and the alcohol gas liquid coolant is changed into liquid ethanol recycling use with in advance online water-cooled condenser with the room temperature cooling water, ensure that extracting solution utmost point low organic solvent is the high-quality of alcohol content, used cooling water extracts water as preheating, these measure and ensures the low energy consumption of production and product, low water consumption, low-cost, and avoided the pollution of organic solvent to environment and product, the airtight f merge extractive liquid, that is equipped with of medicinal liquid is used, medicinal residues add the following d step and proceed to handle;
D. inorganic solvent water to medicinal residues proceed extract at room temperature will the medicinal residues after c handles join in the described empty of a, with the described preheating water of c flood fully, hermetic container room temperature (because of contain the few breeding of bacterium limited guarantee not putrid and deteriorated) soaked Chinese crude drug 20-30 minute, turn on agitator was with 20-60 rev/min of rotating speed agitating solution and Chinese crude drug 20-30 minute, 150-200 eye mesh screen isolated by filtration medicinal residues and solution add the airtight f merge extractive liquid, that is equipped with of medicinal liquid the following e step with, medicinal residues and proceed processing;
E. inorganic solvent is proceeded to add (height) warm extraction to medicinal residues the medicinal residues after d handles is joined in the described empty of a, flood fully with the described preheating water of c, hermetic container, turn on agitator also stirs with 20-60 rev/min of rotating speed, add simultaneously (height) temperature (so the time contain bacterium may be than d for high) lower the temperature slowly naturally after 3-5 minute to boiling that (summer high temperature was lowered the temperature and can suitably be aided with the room temperature water-cooled too slowly in about 20-30 minute, the same recyclable described preheating water of c of incorporating into of cooling water) continues stripping and energy-saving and water-saving to 60-70 ℃ in order to pharmaceutical compositions, extract and must high temperature could propose and low temperature is not carried most material composition, and make and heat rapidly and evenly, reduce material damage and loss, with further raising drug effect and recovery rate, open filter, 150-200 eye mesh screen isolated by filtration solution and medicinal residues, the medicinal residues that discard behind the centrifugal medicinal residues of 1000-3000 rev/min rotating speed are the acyclic dirts of agricultural soil high-quality fertilizer of returning crop stocks to the field, and medicinal liquid is incorporated isolated by filtration solution into and is equipped with f merge extractive liquid, usefulness;
F. extracting solution merges the medicinal liquid merging with c, d and e extraction, gets Chinese medicine extraction liquid;
G. the preparation of product of the present invention is concentrated to 25-30% weight ratio concentration with Chinese medicine extraction liquid with triple effect or multi-effect evaporator, lactose is added Chinese medicine extraction liquid, is the solution dry matter content that concentration promotes and to be 35-40%, be spray dried into water content and get product below 3%, host or additive as food, nutriment, health product and medicine, consumption is that ordinary production needs an amount of use, no dose limitation by GMP; Any shape such as the sheet of compacting (lactose is compression moulding very easily) one-tenth 0.2-0.4 gram, grain, ball as food, nutriment, health product and medicine, are advised oral every day 2-3 time, each 0.4-0.8 gram, need not the branch of crowd and dosage.
The purposes of product of the present invention, usage and consumption: as food, nutriment, health product and medicine, oral every day 2-3 time, each 0.4-0.8 restrain, and need not the branch of crowd and dosage; As the host or the additive of food, nutriment, health product and medicine, consumption is that ordinary production needs an amount of use, no dose limitation by GMP.
Embodiment:
1, drinks 1 part of sheet type Chinese crude drug Herba Taraxaci, 1 part of Radix Platycodonis, 1 part of Herba Houttuyniae, 1 part of Fructus Canarii, 1 part of Fructus Momordicae, 1 part of Fructus Phyllanthi, 0.5 part of Herba Menthae, 1 part on Folium Mori are made compound Chinese medicine by the manufacture method of compound Chinese medicine product of the present invention and are got raw produce, and the Any shape such as sheet, grain, ball that are pressed into 0.2-0.4 gram get product.Be mainly used in the daily life health food that puts prevention first.
2, drink 2 parts of sheet type Chinese crude drug Herba Taraxacis, 2 parts of Radix Platycodoniss, 2 parts of Herba Houttuyniae, 2 parts of Fructus Canariis, 2 parts of Fructus Momordicaes, 2 parts of Fructus Phyllanthis, 1.5 parts of Herba Menthaes, 2 parts on Folium Mori are made compound Chinese medicine by the manufacture method of compound Chinese medicine product of the present invention and are got raw produce, product of the present invention is pressed into the Any shape such as sheet, grain, ball of 0.2-0.4 gram, must product.Be mainly used in the light patient of the their early stage or the state of an illness.
3, drink 2 parts of sheet type Chinese crude drug Herba Taraxacis, 3 parts of Radix Platycodoniss, 3 parts of Herba Houttuyniae, 2 parts of Fructus Canariis, 3 parts of Fructus Momordicaes, 3 parts of Fructus Phyllanthis, 3 parts of Herba Menthaes, 3 parts on Folium Mori are made compound Chinese medicine by the manufacture method of compound Chinese medicine product of the present invention and are got raw produce, and the Any shape such as sheet, grain, ball that product of the present invention are pressed into 0.2-0.4 gram get product.Be mainly used in the long or heavier patient of the state of an illness of the course of disease.
Supplementary copy inventive principle and advantage are as follows:
1, the present invention adopts the low lactose of water absorption to do complexion changed and easy preservation that filler can reduce duration of storage, so storage life is that the commodity shelf life is long, economic worth is high, and constitute most crowds with little sweet taste of lactose etc. and like the little sweet popular taste products of eating and easily be accepted, so service face and service group are the most extensive, its society and economic benefit are also just apparent naturally.
2; the property of medicine of Chinese prescription medical material is for flat; temperature; cool; be slightly cold and tremble with fear and take into account the alleviation property of medicine; to avoid cold side effect and the sequela such as colliding other new disease of too quickly generation controlled of calentura; also take into account the heart simultaneously; liver; lung; spleen; the protection of the function of kidney and coordination; Chinese medicine organic conception and advantage have been demonstrated fully; make drug effect and function more comprehensive and mark; this double controlling; realized the high boundary that Chinese medicine property of medicine general inclination is slightly cold in the Pingliang and avoids too urgent and promote drug effect mutually; and because of the legal dietotherapeutic of all medical materials; effect certainly and do not have a toxic and side effects; be suitable for any crowd and serve wide, these just the present invention to the wide main advantages imbody of Chinese medicine adaptive surface.
3, medicine variety and function all are legal medicine-food two-purposes and simple and clear and do not have a dispute, and the multiple state of an illness of prescription adaptation versatile and flexible and select medication properer has been opened up out Chinese medicine and debated disease and execute tool body content and range of application.
4, all medical materials all are conventional varieties and do not have hormone and toxic and side effects, so quality, the source is secure and aboundresources is cheap, product of the present invention can be consumed by vast general patient because of no patient crowd's branch event and obtain and afford to consume, and the realization new and high technology is served lofty aim for the most numerous common people.
5, innovate organic and inorganic mixed solvent and extract at room temperature and reclaim organic solvent and recycle molten and water-soluble substances and energy-conservation joint (cooling) water of Extraction oil with being beneficial to synchronously high-quality and high recovery rate, again with inorganic solvent and room temperature and high temperature combined extractive technique, scheme and technology, ensured extraction overall process asepticize, can carry substantially many to the greatest extent be insoluble in water or be insoluble in oil material and significantly improve drug effect and extract quality and content, and extraction ratio height, with short production cycle, energy-saving and water-saving, product cost is low, do not have (organic solvent) and pollute, its serial comprehensive advantage is traditional decocting and single with organic solvent or water or some other is because of expensive, highly difficult, the product of receiving single (fact proved and the generally acknowledged both at home and abroad compound composition extract of Chinese medicine than single composition extract good effect, this was exactly the essence and the inherent feature place of Chinese medicine originally and was determined by it), recovery rate low and short-term even long duration are difficult to that so-called modern Chinese medicine extractive technique that penetration and promotion uses is difficult to mention in the same breath.
6, become the favorable factor of the defective of China and Asia average 80% above population Lactose enzyme indigestibility absorption for want of (as milk) lactose into disease preventing and treating, can significantly slow down the medicine slow release speed and avoid taking the very big and beyond affordability historic difficult problem of traditional decocting Chinese medicine dose because adopt lactose to replace the starch easily digested and assimilated and dextrin to make adsorbent, adhesive and filler, thereby significantly prolong the efficacy of a drug persistent period and improve curative effect and possible medicine irritation is relieved to bottom line.
More than these also are the great novelty and the practicality of the legal approval of Patent Law.
Test method, data and presentation of results: disease that product of the present invention is controlled belongs to common frdquently encountered disease so tool is extensively representative, product of the present invention is because of good effect and have no side effect and crowd's branch, so treatment cycle is short and cure rate is high, and make test be easy to just satisfactorily be finished, now further be explained as follows (only for reference) under the prerequisite of necessary KNOW-HOW and business secret and please understand: different sexes allow keeping in Patent Law about situation, it is 2 groups that totally 40 of the patients at age, 20 people are divided into for one group: use product of the present invention and usage and dosage control for one group, one group of not medication compares; Test number and time on test reach 1 first quarter moon, all the event of tool statistical significance has suitable representativeness and credibility.The result is as follows: with the test group personnel of product of the present invention all healing in a week, the state of an illness be that rehabilitation, body constitution and mental status also are significantly improved in than the lighter 2-3 days, do not see recurrence in January, follow up a case by regular visits to and do not see recurrence in half a year; Matched group none in 2-3 days the rehabilitation clients, have in addition delay first quarter moon and even longer time, What is more transfers the utmost point is felt bad and utmost point refractory is healed chronic pharyngolaryngitis etc. to.Prompting: do not see that recurrence has just proved absolutely healing, has been that product of the present invention is effective and effect is remarkable.
To sum up state, raw material of the present invention, product and method belong to a total inventive concept, economic environmental protection good effect, be suitable for the crowd and market is all very wide, helpfulness and the degree of association are also very high.

Claims (1)

1. a compositions is prevented and treated application in the medicine of pharyngolaryngitis in preparation, it is characterized in that said composition makes by following step:
A. drink sheet type Chinese crude drug Herba Taraxaci 1-2 part, Radix Platycodonis 1-3 part, Herba Houttuyniae 1-3 part, Fructus Canarii 1-2 part, Fructus Momordicae 1-3 part, Fructus Phyllanthi 1-3 part, Herba Menthae 0.5-3 part, Folium Mori 1-3 part joins in the nonmetallic surface container of belt stirrer, filter and water bath with thermostatic control heater;
Preparation b. organic and inorganic mixed solvent is got the above ethanol of food stage and is added the dilution of room temperature drinking water and makes the organic and inorganic mixed solvent that alcohol content is 55-75%V/V;
C. use the described solvent of b to the raw material medicine extract with the described mixed solvent of b join a described added get in the container of whole Chinese crude drugs, addition is for flooding Chinese crude drug fully, hermetic container soaked 20-30 minute, turn on agitator and with 20-60 rev/min of rotating speed agitating solution and Chinese crude drug 20-30 minute, open filter, 50-100 eye mesh screen isolated by filtration medicinal residues and solution, the centrifugal medicinal residues of 1000-3000 rev/min rotating speed, medicinal liquid is incorporated isolated by filtration solution into, heater accurately is heated to 78-80 ℃ of vaporization of ethanol boiling point ethanol respectively with medicinal residues and medicinal liquid, collect vaporization ethanol and the alcohol gas liquid coolant is changed into liquid ethanol recycling use with in advance online water-cooled condenser with the room temperature cooling water, used cooling water extracts water as preheating, and the airtight f merge extractive liquid, that is equipped with of medicinal liquid is used, medicinal residues add the following d step and proceed to handle;
D. water to medicinal residues proceed extract at room temperature will the medicinal residues after c handles join in the described empty of a, with the described preheating water of c flood fully, hermetic container soak at room temperature Chinese crude drug 20-30 minute, turn on agitator was with 20-60 rev/min of rotating speed agitating solution and Chinese crude drug 20-30 minute, 150-200 eye mesh screen isolated by filtration medicinal residues and solution add the airtight f merge extractive liquid, that is equipped with of medicinal liquid the following e step with, medicinal residues and proceed processing;
E. water is proceeded high temperature extraction to medicinal residues the medicinal residues after d handles is joined in the described empty of a, flood fully with the described preheating water of c, hermetic container, turn on agitator also stirs with 20-60 rev/min of rotating speed, being warmed to boiling simultaneously slowly lowered the temperature about 20-30 minute to 60-70 ℃ after 3-5 minute naturally, the summer high temperature cooling can suitably be aided with the room temperature water-cooled too slowly, cooling water reclaims incorporates the described preheating water of c into, open filter, 150-200 eye mesh screen isolated by filtration solution and medicinal residues, discard medicinal residues behind the centrifugal medicinal residues of 1000-3000 rev/min rotating speed, medicinal liquid is incorporated isolated by filtration solution into and is equipped with f merge extractive liquid, usefulness;
F. extracting solution merges the medicinal liquid merging with c, d and e extraction, gets Chinese medicine extraction liquid;
G. the preparation of product is concentrated to 25-30% weight ratio concentration with Chinese medicine extraction liquid with triple effect or multi-effect evaporator, and lactose is added Chinese medicine extraction liquid, is the solution dry matter content that concentration promotes and to be 35-40%, be spray dried into water content below 3% promptly.
CNB2005101364453A 2005-12-29 2005-12-29 Medicine and food duel purpose Chinese medicinal product for preventing and treating pharyngolaryngitis and its manufacturing method Expired - Fee Related CN100394944C (en)

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CN1823998A (en) * 2005-12-29 2006-08-30 颜怀伟 Medicine and food dual purpose Chinese medicine for preventing and treating pharyngitis and its manufacturing method
CN1824003A (en) * 2005-12-29 2006-08-30 颜怀伟 Medicine and food dual purpose Chinese medicinal product for preventing and treating toothache and its manufacturing method

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