CN108030765A - A kind of production method of medicine lotion - Google Patents
A kind of production method of medicine lotion Download PDFInfo
- Publication number
- CN108030765A CN108030765A CN201711368554.7A CN201711368554A CN108030765A CN 108030765 A CN108030765 A CN 108030765A CN 201711368554 A CN201711368554 A CN 201711368554A CN 108030765 A CN108030765 A CN 108030765A
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- Prior art keywords
- lotion
- evaporimeter
- closed
- powder
- pure
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/04—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of ointments
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/37—Extraction at elevated pressure or temperature, e.g. pressurized solvent extraction [PSE], supercritical carbon dioxide extraction or subcritical water extraction
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
- Cosmetics (AREA)
Abstract
The invention discloses a kind of production method for the ointment for being used to treat conditioning insomnia,Chinese medicine is configured including (1),(2) powder is beaten,(3) it is put into container of steeping in wine,(4) demulcen,(5) pure extraction is analyzed,(6) water carries,(7) water carries,(8) upper strata immersion Chinese Medicines are taken out with siphon pipe,Closed preservation,(9) negative pressure low-temperature evaporation,(10) evaporimeter is observed,It was found that stable gas pressure,Solution is more and more thicker in evaporimeter,Can be on the evaporative flask in evaporation all into cream (wall built-up),Vapor in condenser condensation efficiency less than it is per minute drip 60 drop when close evaporimeter,Remove evaporative flask,(11) take out sub-fraction lotion and carry out lotion character confirmation,Confirm that the gentle lotion of being completed if beautiful of lotion makes,The present invention can ensure medicinal material pharmaceutical activity to greatest extent,Lotion expands fully fusion by complexity,Lotion quality is gentle as beautiful,Pharmacological property character is superior.
Description
Technical field
The present invention relates to a kind of production method of lotion, more particularly to a kind of production method of medicine lotion.
Background technology
A lot of Chinese medicines need to make lotion use, but existing production method be mostly with water at 100 degrees Celsius repeatedly
Boil or boiled repeatedly at hundreds of degrees Celsius with vegetable oil, this production method, can not be to greatest extent since temperature is excessive
Ensure medicinal material pharmaceutical activity, and plaster quality is also very impacted.
The content of the invention
To solve the above problems, the present invention provides a kind of production method of medicine lotion, the present invention is extracted using low temperature, can
To ensure medicinal material pharmaceutical activity to greatest extent, made of negative pressure of vacuum environment, lotion expands fully fusion, lotion by complexity
Quality is gentle as beautiful, and pharmacological property character is superior.
To achieve the above object, the present invention uses following technological means：
The present invention provides a kind of production method of medicine lotion, comprises the following steps：
(1) Chinese medicine is configured, configuring needs the various Chinese medicines for being fabricated to ointment；
(2) powder is beaten, the medicinal material in step (1) is all broken into powder, 80 mesh sieves is crossed, powder is crossed after the stronger drying of viscosity
Broken machine, crushes to full capacity, not used sieves after crushing, is then placed in and has above broken into the traditional Chinese medicine powder of powder, by whole medicinal materials
Powder uniformly mixes；
(3) according to steep in wine the big smallest number of container by the traditional Chinese medicine powder mixed by etc. reset into container of steeping in wine；
(4) demulcen, 35 degrees Celsius are heated to by pure water, pure by 1000 milliliters 35 degrees Celsius of every 1000 grams of traditional Chinese medicine powders addition
Water purification, is stirred using mixer, when then closed standing 24 is small；
(5) pure extraction is analyzed, the traditional Chinese medicine powder for being up to the demulcen time is taken the photograph for 7000 milliliter 35 by the addition of every 1000 grams of traditional Chinese medicine powders
The pure water analysis of family name's degree is pure, is then quickly stirred using mixer, then closed to stand 5-7 days；
(6) water carries, and the medicinal liquor that standing in step (5) is reached to the time is taken out with mixer in center agitation, side agitation
Side adds 3000 milliliters of 70 degree of pure water, then closed to stand 5-7 days；
(7) water carries, and the medicinal liquor that standing in step (6) is reached to the time is taken out with mixer in center agitation, side agitation
Side adds 7000 milliliters of 80 degree of pure water, then closed to stand 5-7 days；
(8) the upper strata Chinese Medicines that the medicinal liquor for reaching the time is stood in step (7), closed preservation are taken out with siphon pipe；
(9) debugging of ready evaporimeter is assembled, the Chinese Medicines obtained in step (8) is then connected into evaporation
Instrument, opens constent temperature heater, and temperature is adjusted to 65 degrees Celsius, opens evaporimeter, and slowly adjusting evaporimeter makes its range of negative pressure exist
0.07Pa to 0.095Pa, reduces air pressure in evaporative flask, Chinese Medicines in heating evaporation bottle, in being evaporated under negative pressure cryogenic conditions
Drug solns, adjust evaporimeter inlet valve, keep air pressure range；(10) evaporimeter is observed, finds stable gas pressure, solution in evaporimeter
It is more and more thicker, can be on the evaporative flask in evaporation all into cream (wall built-up), vapor condensation efficiency in condenser is less than every point
Clock drip 60 drop when close evaporimeter, remove evaporative flask；
(11) because important formula is different, different formulations medicinal material need to take out sub-fraction lotion and carry out lotion character confirmation, really
Recognize the gentle lotion of completing if beautiful of lotion to make.
Further, it is closed when pure extraction is analyzed in step (5) to stand 6 days.
Further, it is closed to stand 6 days when step (6) water carries.
Further, it is closed to stand 6 days when step (7) water carries.
Further, evaporation evaporimeter is adjusted in step (9) makes its range of negative pressure be 0.08Pa.
Beneficial effects of the present invention：
Boiled repeatedly with the medicinal water of conventional pastes (100 degrees Celsius boil repeatedly) or vegetable oil (boiling for hundreds of degrees Celsius repeatedly)
Compare, this cream method low temperature extraction processed, ensures medicinal material pharmaceutical activity to greatest extent；And the method preparation process is negative pressure of vacuum ring
Border, lotion expand fully fusion by complexity, and lotion quality is gentle as beautiful, and pharmacological property character is superior.
Embodiment
With reference to specific embodiment, the present invention will be further described.
Embodiment 1：The present embodiment provides a kind of production method for the ointment for being used to treat conditioning insomnia, including following step
Suddenly：
(1) Chinese medicine is configured, configuring needs each component Chinese medicine for being fabricated to ointment, is configured by following weight proportion, three
Seven 80-120 parts, 100-140 parts of Radix Salviae Miltiorrhizae, 180-220 parts of grass-leaved sweetflag, 200-210 parts of polygala, 70-100 parts of safflower, rhizoma cyperi 60-80
Part；
(2) powder is beaten, the medicinal material in step (1) is all broken into powder, 80 mesh sieves is crossed, powder is crossed after the stronger drying of viscosity
Broken machine, crushes to full capacity, not used sieves after crushing, is then placed in and has above broken into the traditional Chinese medicine powder of powder, by whole medicinal materials
Powder uniformly mixes；
(3) according to steep in wine the big smallest number of container by the traditional Chinese medicine powder mixed by etc. reset into container of steeping in wine；
(4) demulcen, 35 degrees Celsius are heated to by pure water, pure by 1000 milliliters 35 degrees Celsius of every 1000 grams of traditional Chinese medicine powders addition
Water purification, is stirred using mixer, when then closed standing 24 is small；
(5) pure extraction is analyzed, the medicinal powder for being up to the demulcen time is Celsius by 7000 milliliter 35 of every 1000 grams of traditional Chinese medicine powders addition
It is pure to spend pure water analysis, is then quickly stirred using mixer, it is then closed to stand 6 days；
(6) water carries, and the medicinal liquor that standing in step (5) is reached to the time is taken out with mixer in center agitation, side agitation
Side adds 3000 milliliters of 70 degree of pure water, then closed to stand 6 days；
(7) water carries, and the medicinal liquor that standing in step (6) is reached to the time is taken out with mixer in center agitation, side agitation
Side adds 7000 milliliters of 80 degree of pure water, then closed to stand 6 days；
(8) the upper strata Chinese Medicines that the medicinal liquor for reaching the time is stood in step (7), closed preservation are taken out with siphon pipe；
(9) debugging of ready evaporimeter is assembled, the Chinese Medicines obtained in step (8) is then connected into evaporation
Instrument, opens constent temperature heater, and temperature is adjusted to 65 degrees Celsius, opens evaporimeter, and slowly adjusting evaporimeter makes its negative pressure in 0.08Pa,
Air pressure in evaporative flask is reduced, Chinese Medicines in heating evaporation bottle, evaporate Chinese Medicines under negative pressure cryogenic conditions, adjust evaporimeter
Inlet valve, keeps air pressure range；
(10) evaporimeter is observed, finds stable gas pressure, solution is more and more thicker in evaporimeter, can be on the evaporative flask in evaporation
All into cream (wall built-up), vapor in condenser condensation efficiency less than it is per minute drip 60 drop when close evaporimeter, remove steaming
Send out bottle；
(11) because important formula is different, different formulations medicinal material need to take out sub-fraction lotion and carry out lotion character confirmation, really
Recognize the gentle lotion of completing if beautiful of lotion to make.
Lotion is gentle as beautiful, and using effect is better than the ointment of the treatment conditioning insomnia of other methods making, and therapeutic effect is more
Add significantly.
Embodiment 2：The present embodiment provides a kind of production method for the ointment for being used to treat irregular menstruation, including following step
Suddenly：
(1) Chinese medicine is configured, configuring needs each component Chinese medicine for being fabricated to ointment, is configured by following weight proportion, when
Return 280-330 parts, tag 260-310 parts of river, 270-320 parts of fennel seeds, 280-310 parts of galangal, 280-330 parts of Ligusticum wallichii, wood
280-330 parts fragrant, blue or green 200-280 parts of hair pilose antler, 260-330 parts of Chinese cassia tree, 230-280 parts of agalloch eaglewood；
(2) powder is beaten, the medicinal material in step (1) is all broken into powder, 80 mesh sieves is crossed, powder is crossed after the stronger drying of viscosity
Broken machine, comminuted powder, not used sieves after broken, are then placed in and have above broken into the traditional Chinese medicine powder of powder, by whole medicinal materials to full capacity
Powder uniformly mixes；
(3) according to steep in wine the big smallest number of container by the traditional Chinese medicine powder mixed by etc. reset into container of steeping in wine；
(4) demulcen, 35 degrees Celsius are heated to by pure water, pure by 1000 milliliters 35 degrees Celsius of every 1000 grams of traditional Chinese medicine powders addition
Water purification, is stirred using mixer, when then closed standing 24 is small；
(5) pure extraction is analyzed, the medicinal powder for being up to the demulcen time is Celsius by 7000 milliliter 35 of every 1000 grams of traditional Chinese medicine powders addition
It is pure to spend pure water analysis, is then quickly stirred using mixer, it is then closed to stand 5 days；
(6) water carries, and the medicinal liquor that standing in step (5) is reached to the time is taken out with mixer in center agitation, side agitation
Side adds 3000 milliliters of 70 degree of pure water, then closed to stand 5 days；
(7) water carries, and the medicinal liquor that standing in step (6) is reached to the time is taken out with mixer in center agitation, side agitation
Side adds 7000 milliliters of 80 degree of pure water, then closed to stand 5 days；
(8) the upper strata immersion Chinese Medicines that the medicinal liquor for reaching the time is stood in step (7), closed guarantor are taken out with siphon pipe
Deposit；
(9) debugging of ready evaporimeter is assembled, the Chinese Medicines obtained in step (8) is then connected into evaporation
Instrument, opens constent temperature heater, and temperature is adjusted to 65 degrees Celsius, opens evaporimeter, and slowly adjusting evaporimeter makes its negative pressure in 0.07Pa,
Air pressure in evaporative flask is reduced, Chinese Medicines in heating evaporation bottle, evaporate Chinese Medicines under negative pressure cryogenic conditions, adjust evaporimeter
Inlet valve, keeps air pressure range；
(10) evaporimeter is observed, finds stable gas pressure, solution is more and more thicker in evaporimeter, can be on the evaporative flask in evaporation
All into cream (wall built-up), vapor in condenser condensation efficiency less than it is per minute drip 60 drop when close evaporimeter, remove steaming
Send out bottle；
(11) take out sub-fraction lotion and carry out lotion character confirmation, confirm that the gentle lotion of being completed if beautiful of lotion makes；
Lotion is gentle as beautiful, and using effect is better than the ointment of the treatment irregular menstruation of other methods making, and therapeutic effect is more notable.
Claims (5)
1. a kind of production method of medicine lotion, it is characterised in that comprise the following steps：
(1) Chinese medicine is configured, configuring needs each component Chinese medicine for being fabricated to ointment；
(2) powder is beaten, the medicinal material in step (1) is all broken into powder, 80 mesh sieves is crossed, crosses and crush after the stronger drying of viscosity
Machine, crushes to full capacity, not used sieves after crushing, is put into and has above broken into the traditional Chinese medicine powder of powder, and whole medicinal material powders are uniform
Mixing；
(3) according to steep in wine the big smallest number of container by the traditional Chinese medicine powder mixed by etc. reset into container of steeping in wine；
(4) demulcen, 35 degrees Celsius are heated to by pure water, pure by 1000 milliliters 35 degrees Celsius of every 1000 grams of traditional Chinese medicine powders addition
Water, is stirred using mixer, when then closed standing 24 is small；
(5) pure extraction is analyzed, the medicinal powder for being up to the demulcen time is pure by 7000 milliliters 35 degrees Celsius of every 1000 grams of traditional Chinese medicine powders addition
Water purification analysis is pure, is then quickly stirred using mixer, then closed to stand 5-7 days；
(6) water carries, and the medicinal liquor that the middle standing of step (5) reaches the time is taken out and is stirred with mixer at center, is added in agitation
Enter 3000 milliliters of 70 degree of pure water, it is then closed to stand 5-7 days；
(7) water carries, and the medicinal liquor that the middle standing of step (6) reaches the time is taken out and is stirred with mixer at center, is added in agitation
Enter 7000 milliliters of 80 degree of pure water, it is then closed to stand 5-7 days；
(8) the upper strata Chinese Medicines that the medicinal liquor for reaching the time is stood in step (7), closed preservation are taken out with siphon pipe；
(9) debugging of ready evaporimeter is assembled, the Chinese Medicines obtained in step (8) is then connected into evaporimeter,
Constent temperature heater is opened, temperature is adjusted to 65 degrees Celsius, opens evaporimeter, and slowly adjusting evaporimeter makes its range of negative pressure in 0.07Pa
To 0.095Pa, air pressure in evaporative flask is reduced, Chinese Medicines in heating evaporation bottle, evaporate Chinese Medicines under negative pressure cryogenic conditions,
Evaporimeter inlet valve is adjusted, keeps air pressure range；
(10) evaporimeter is observed, finds stable gas pressure, solution is more and more thicker in evaporimeter, can be on the evaporative flask in evaporation all
Into cream (wall built-up), vapor in condenser condensation efficiency less than it is per minute drip 60 drop when close evaporimeter, remove evaporative flask；
(11) take out sub-fraction lotion and carry out lotion character confirmation, confirm that the gentle lotion of being completed if beautiful of lotion makes.
2. the production method of a kind of medicine lotion according to claim 1, it is characterised in that analysis is pure in step (5) carries
It is closed when taking to stand 6 days.
3. the production method of a kind of medicine lotion according to claim 1, it is characterised in that closed when step (6) water carries
Stand 6 days.
4. the production method of a kind of medicine lotion according to claim 1, it is characterised in that closed when step (7) water carries
Stand 6 days.
5. the production method of a kind of medicine lotion according to claim 1, it is characterised in that rotation is adjusted in step (9)
Evaporimeter makes its range of negative pressure be 0.08Pa.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711368554.7A CN108030765A (en) | 2017-12-18 | 2017-12-18 | A kind of production method of medicine lotion |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711368554.7A CN108030765A (en) | 2017-12-18 | 2017-12-18 | A kind of production method of medicine lotion |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108030765A true CN108030765A (en) | 2018-05-15 |
Family
ID=62099620
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201711368554.7A Pending CN108030765A (en) | 2017-12-18 | 2017-12-18 | A kind of production method of medicine lotion |
Country Status (1)
| Country | Link |
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| CN (1) | CN108030765A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108888516A (en) * | 2018-08-15 | 2018-11-27 | 北京康瑞博生物科技有限公司 | The extraction process of plaster liquid |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN201997129U (en) * | 2011-01-07 | 2011-10-05 | 广西正堂药业有限责任公司 | No. 2 evaporator for extracting ointment |
| CN104888187A (en) * | 2015-06-24 | 2015-09-09 | 无锡华诺威动物保健品有限公司 | Drug combination for preventing and curing allogynogenetic crucian carp gill hemorrhage disease and preparation method thereof |
-
2017
- 2017-12-18 CN CN201711368554.7A patent/CN108030765A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN201997129U (en) * | 2011-01-07 | 2011-10-05 | 广西正堂药业有限责任公司 | No. 2 evaporator for extracting ointment |
| CN104888187A (en) * | 2015-06-24 | 2015-09-09 | 无锡华诺威动物保健品有限公司 | Drug combination for preventing and curing allogynogenetic crucian carp gill hemorrhage disease and preparation method thereof |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108888516A (en) * | 2018-08-15 | 2018-11-27 | 北京康瑞博生物科技有限公司 | The extraction process of plaster liquid |
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Application publication date: 20180515 |
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