CN109172664A - A kind of preparation method of stir-baked FRUCTUS GARDENIAE granule - Google Patents
A kind of preparation method of stir-baked FRUCTUS GARDENIAE granule Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/74—Rubiaceae (Madder family)
- A61K36/744—Gardenia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1611—Inorganic compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
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Abstract
The invention discloses a kind of preparation methods of stir-baked FRUCTUS GARDENIAE granule, comprising: extracts concentration step: taking stir-baked FRUCTUS GARDENIAE medicine materical crude slice, water is added and extracts decoction, obtains extracting solution after filtering；Extracting solution is concentrated under reduced pressure, concentrate is obtained；Thickening temperature is 75-85 DEG C, and the relative density of concentrate is 1.06-1.08；Spray drying step: concentrate is heated, and is stirred evenly, and is then spray-dried, and stir-baked FRUCTUS GARDENIAE spray dried powder is obtained；Dry granulation procedure: silica is first added into stir-baked FRUCTUS GARDENIAE spray dried powder, after mixing, then carries out dry granulation, obtains stir-baked FRUCTUS GARDENIAE granule.The preparation method accounts for 5% silica and maltodextrin of stir-baked FRUCTUS GARDENIAE spray dried powder weight by being added in dry granulation procedure, optimize the parameter of each step simultaneously, it can effectively solve and generate electrostatic and agglomerating phenomenon, improve product yield and production efficiency, guarantee product quality.
Description
Technical field
The present invention relates to a kind of preparation methods of Chinese medicinal granule, and in particular to a kind of preparation of stir-baked FRUCTUS GARDENIAE granule
Method.
Background technique
Chinese medicinal granule is under guidance of traditional Chinese medicine theory, to be process to the prepared slices of Chinese crude drugs through various techniques, for facing
Bed tcm prescription deploys the granule used；Convenient to take compared with traditional Chinese medicine decoction, dose is small, quality controllable, holds
It is easy to maintain, it is easy to carry；Currently, Chinese medicinal granule is in pilot state, Product Process and quality standard disunity at home；
Chinese medicinal granule is essentially traditional water and extracts at present, or extracts water extraction after volatile oil, and have individual plants due to this at present
Body product immanent cause so that it is improper to control in production process there are certain technological difficulties, thus influence in final products
Quality.It is easy to produce static electricity in stir-baked FRUCTUS GARDENIAE spray powder mixed process to cause spray powder agglomerating, it is difficult to be uniformly mixed.
Summary of the invention
For overcome the deficiencies in the prior art, the object of the present invention is to provide a kind of preparation sides of stir-baked FRUCTUS GARDENIAE granule
Method, which, which can effectively solve, generates electrostatic and agglomerating phenomenon, improves product yield and production efficiency, guarantees product matter
Amount.
A kind of preparation method of stir-baked FRUCTUS GARDENIAE granule characterized by comprising
It extracts concentration step: taking stir-baked FRUCTUS GARDENIAE medicine materical crude slice, water is added and extracts decoction, obtains extracting solution after filtering；Extracting solution is subtracted
Pressure concentration, obtains concentrate；Thickening temperature is 75-85 DEG C, and the relative density of concentrate is 1.06-1.08；
Spray drying step: concentrate is heated, and is stirred evenly, and is then spray-dried, and stir-baked FRUCTUS GARDENIAE spray dried powder is obtained；
Dry granulation procedure: silica is first added into stir-baked FRUCTUS GARDENIAE spray dried powder, after mixing, then carries out dry method
Granulation, obtains stir-baked FRUCTUS GARDENIAE granule.
Further, it extracts in concentration step, the additional amount of water is 9 times of stir-baked FRUCTUS GARDENIAE medicine materical crude slice weight.
Further, it extracts in concentration step, Extracting temperature is 95-100 DEG C, and decocting time is 1 hour.
Further, it extracts in concentration step, thickening temperature is 80 DEG C, and the relative density of concentrate is 1.07.
Further, in spray drying step, concentrate is heated to 80 DEG C.
Further, in spray drying step, spray drying parameters: 165-185 DEG C of inlet air temperature, temperature 90-95 in tower
DEG C, air blast frequency 35-45Hz, air inducing frequency 40-50Hz are atomized frequency 30-45Hz, 45-60 DEG C of conveying temperature, concentrate heat preservation
75-85 DEG C of temperature.
Further, in dry granulation procedure, the additional amount of silica is the 5% of stir-baked FRUCTUS GARDENIAE spray dried powder weight.
Further, it in dry granulation procedure, while silica is added into stir-baked FRUCTUS GARDENIAE spray dried powder, also needs
Maltodextrin is added.
Further, in dry granulation procedure, the additional amount of maltodextrin is W1, and the weight of stir-baked FRUCTUS GARDENIAE spray dried powder is
W2, the weight of stir-baked FRUCTUS GARDENIAE medicine materical crude slice are W3, and the weight of silica is W4, W1=W3 × 80%-W2-W4.
Further, in dry granulation procedure, control mixing revolving speed 10rpm, incorporation time 20 minutes, dry granulation was joined
Number: oil cylinder working-pressure 5-20MPa, feeding speed 25-150rpm, tabletting revolving speed 8-40rpm, pelletize revolving speed 80-120rpm, obtains
The stir-baked FRUCTUS GARDENIAE granule of 12-60 mesh.
The beneficial effects of the present invention are:
Preparation method of the invention includes extracting concentration step, spray drying step, dry granulation procedure, by dry method
5% silica and maltodextrin for accounting for stir-baked FRUCTUS GARDENIAE spray dried powder weight are added in granulation step, while optimizing each step
Parameter, can effectively solve and generate electrostatic and agglomerating phenomenon, improve product yield and production efficiency, guarantee product quality.
Specific embodiment
In the following, being described further in conjunction with specific embodiment to the present invention, it should be noted that is do not collided
Under the premise of, new embodiment can be formed between various embodiments described below or between each technical characteristic in any combination.
A kind of preparation method of stir-baked FRUCTUS GARDENIAE granule characterized by comprising
It extracts concentration step: taking stir-baked FRUCTUS GARDENIAE medicine materical crude slice, water is added and extracts decoction, obtains extracting solution after filtering；Extracting solution is subtracted
Pressure concentration, obtains concentrate；Thickening temperature is 75-85 DEG C, and the relative density of concentrate is 1.06-1.08；
Spray drying step: concentrate is heated, and is stirred evenly, and is then spray-dried, and stir-baked FRUCTUS GARDENIAE spray dried powder is obtained；
Dry granulation procedure: being first added silica into stir-baked FRUCTUS GARDENIAE spray dried powder, and the additional amount of silica is coke
The 5% of cape jasmine spray dried powder weight after mixing, then carries out dry granulation, obtains stir-baked FRUCTUS GARDENIAE granule.
It as preferred embodiment, extracts in concentration step, the additional amount of water is 9 times of stir-baked FRUCTUS GARDENIAE medicine materical crude slice weight.
It as preferred embodiment, extracts in concentration step, Extracting temperature is 95-100 DEG C, and decocting time is 1 hour.
It as preferred embodiment, extracts in concentration step, thickening temperature is 80 DEG C, and the relative density of concentrate is
1.07。
As preferred embodiment, in spray drying step, concentrate is heated to 80 DEG C.
As preferred embodiment, in spray drying step, spray drying parameters: 165-185 DEG C of inlet air temperature, in tower
90-95 DEG C of temperature, air blast frequency 35-45Hz, air inducing frequency 40-50Hz, atomization frequency 30-45Hz, 45-60 DEG C of conveying temperature,
75-85 DEG C of concentrate holding temperature.
As preferred embodiment, in spray drying step, spray drying parameters: 175 DEG C of inlet air temperature, temperature in tower
92 DEG C, air blast frequency 40Hz, air inducing frequency 45Hz, atomization frequency 40Hz, conveying temperature 50 C, 80 DEG C of concentrate holding temperature.
As preferred embodiment, in dry granulation procedure, the additional amount of silica is stir-baked FRUCTUS GARDENIAE spray dried powder
The 5% of weight.
As preferred embodiment, in dry granulation procedure, silica is being added into stir-baked FRUCTUS GARDENIAE spray dried powder
While, it is also necessary to maltodextrin is added.
As preferred embodiment, in dry granulation procedure, the additional amount of maltodextrin is W1, stir-baked FRUCTUS GARDENIAE spray drying
The weight of powder is W2, and the weight of stir-baked FRUCTUS GARDENIAE medicine materical crude slice is W3, and the weight of silica is W4, W1=W3 × 80%-W2-W4.
As preferred embodiment, in dry granulation procedure, control mixing revolving speed 10rpm incorporation time 20 minutes, is done
Method grain made parameter: oil cylinder working-pressure 5-20MPa, feeding speed 25-150rpm, tabletting revolving speed 8-40rpm, pelletize revolving speed 80-
120rpm obtains the stir-baked FRUCTUS GARDENIAE granule of 12-60 mesh.
The following are specific embodiments of the present invention, and used raw material, equipment etc. remove special limit in the following embodiments
It can be obtained by buying pattern outside fixed.
Embodiment 1:
A kind of preparation method of stir-baked FRUCTUS GARDENIAE granule, comprising:
It extracts concentration step: taking stir-baked FRUCTUS GARDENIAE medicine materical crude slice 100kg, the water of 9 times of stir-baked FRUCTUS GARDENIAE medicine materical crude slice weight amounts is added, temperature is extracted in control
98 DEG C of degree is extracted and is decocted 1 hour, extracting solution filtering；80 DEG C of thickening temperature of control, is concentrated under reduced pressure into the concentration of relative density 1.07
Liquid；
Spray drying step: concentrate is heated to 80 DEG C, stirs evenly, control spray drying parameters: 175 DEG C of inlet air temperature, tower
92 DEG C of interior temperature, air blast frequency 40Hz, air inducing frequency 45Hz are atomized frequency 40Hz, conveying temperature 50 C, concentrate holding temperature
It 80 DEG C, is spray-dried, obtains stir-baked FRUCTUS GARDENIAE spray dried powder 15.1kg, yield 97%；(note: theoretical spray powder weight=
Concentrate weight × concentrate solid content；Spray drying yield (%)=practical spray powder weight (g)/theory spray powder weight ×
100%)；
Dry granulation procedure: maltodextrin and silica is added in stir-baked FRUCTUS GARDENIAE spray dried powder, is uniformly mixed, and carries out dry method
Granulation, control mixing revolving speed 10rpm, incorporation time 20 minutes, after mixing, no powder was attached in mixer wall and agglomerating existing
As to mix homogeneity with spray powder good for, auxiliary material, dry granulation parameter oil cylinder working-pressure 10MPa, feeding speed 100rpm, pressure are controlled
Piece revolving speed 25rpm, pelletize revolving speed 100rpm, obtains the stir-baked FRUCTUS GARDENIAE granule of 40 mesh；Wherein, the additional amount of silica is coke
The 5% of cape jasmine spray dried powder weight；The additional amount of maltodextrin is W1, and the weight of stir-baked FRUCTUS GARDENIAE spray dried powder is W2, burnt Cape jasmine
The weight of sub- medicine materical crude slice is W3, and the weight of silica is W4, W1=W3 × 80%-W2-W4.
Embodiment 2:
A kind of preparation method of stir-baked FRUCTUS GARDENIAE granule, comprising:
It extracts concentration step: taking stir-baked FRUCTUS GARDENIAE medicine materical crude slice 100kg, the water of 9 times of stir-baked FRUCTUS GARDENIAE medicine materical crude slice weight amounts is added, temperature is extracted in control
100 DEG C of degree is extracted and is decocted 1 hour, extracting solution filtering；85 DEG C of thickening temperature of control, is concentrated under reduced pressure into the dense of relative density 1.08
Contracting liquid；
Spray drying step: concentrate is heated to 80 DEG C, stirs evenly, control spray drying parameters: 185 DEG C of inlet air temperature, tower
95 DEG C of interior temperature, air blast frequency 45Hz, air inducing frequency 50Hz are atomized frequency 45Hz, conveying temperature 60 C, concentrate holding temperature
It 85 DEG C, is spray-dried to obtain stir-baked FRUCTUS GARDENIAE spray dried powder 14.5kg, yield 93%；(note: theoretical spray powder weight=dense
Contracting liquid weight × concentrate solid content；Spray drying yield (%)=practical spray powder weight (g)/theory spray powder weight ×
100%)；
Dry granulation procedure: maltodextrin and silica is added in stir-baked FRUCTUS GARDENIAE spray dried powder, is uniformly mixed, and carries out dry method
Granulation, control mixing revolving speed 10rpm, incorporation time 20 minutes, after mixing, no powder was attached in mixer wall, not agglomerating, auxiliary
It is good that material mix homogeneity with spray powder, control dry granulation parameter oil cylinder working-pressure 20MPa, feeding speed 150rpm, tabletting turn
Fast 40rpm, pelletize revolving speed 120rpm, obtains the stir-baked FRUCTUS GARDENIAE granule of 60 mesh.Wherein, the additional amount of silica is stir-baked FRUCTUS GARDENIAE
The 5% of spray dried powder weight；The additional amount of maltodextrin is W1, and the weight of stir-baked FRUCTUS GARDENIAE spray dried powder is W2, stir-baked FRUCTUS GARDENIAE drink
The weight of piece is W3, and the weight of silica is W4, W1=W3 × 80%-W2-W4.
Comparative example 1:
A kind of preparation method of stir-baked FRUCTUS GARDENIAE granule, comprising:
It extracts concentration step: taking stir-baked FRUCTUS GARDENIAE medicine materical crude slice 910g, the water of 9 times of stir-baked FRUCTUS GARDENIAE medicine materical crude slice weight amounts is added, temperature is extracted in control
98 DEG C of degree is extracted and is decocted 1 hour, extracting solution filtering；80 DEG C of thickening temperature of control, is concentrated under reduced pressure into the concentration of relative density 1.07
Liquid；
Spray drying step: concentrate is heated to 80 DEG C, stirs evenly, control spray drying parameters: 175 DEG C of inlet air temperature, tower
92 DEG C of interior temperature, air blast frequency 40Hz, air inducing frequency 45Hz are atomized frequency 40Hz, conveying temperature 50 C, concentrate holding temperature
It 80 DEG C, is spray-dried, obtains stir-baked FRUCTUS GARDENIAE spray dried powder 162g, yield 95%；(note: theoretical spray powder weight=dense
Contracting liquid weight × concentrate solid content；Spray drying yield (%)=practical spray powder weight (g)/theory spray powder weight ×
100%)；
Dry granulation procedure: maltodextrin is added in stir-baked FRUCTUS GARDENIAE spray dried powder, is uniformly mixed, dry granulation, control mixing
Revolving speed 10rpm, incorporation time 20 minutes, after the completion of mixing, powder was attached in mixer wall, agglomerating, and spray powder and malt are pasted
Essence layering is obvious, unmixed uniform, can not carry out dry granulation；Wherein, the additional amount of maltodextrin is W1, and stir-baked FRUCTUS GARDENIAE is done by spraying
The weight of dry powder is W2, and the weight of stir-baked FRUCTUS GARDENIAE medicine materical crude slice is W3, and the weight of silica is W4, W1=W3 × 80%-W2-W4.
According to spray dried powder yield data such as the following table 1 in the preparation method of embodiment 1-2 and comparative example 1:
Table 1
Seen from table 1, comparative example 1 is compared, the embodiment of the present invention 1-2 is added silica in spray-drying process and carries out
Hybrid manipulation can significantly improve powder and stick equipment and agglomerating phenomenon, to achieve the purpose that improve mixed effect, yield energy
It accesses and is obviously improved, the effect of especially embodiment 1 is best；Therefore it is glutinous to can solve production process for the technical program
Applying equipment and agglomerating phenomenon improve product yield, guarantee product quality.
The above embodiment is only the preferred embodiment of the present invention, and the scope of protection of the present invention is not limited thereto,
The variation and replacement for any unsubstantiality that those skilled in the art is done on the basis of the present invention belong to institute of the present invention
Claimed range.
Claims (10)
1. a kind of preparation method of stir-baked FRUCTUS GARDENIAE granule characterized by comprising
It extracts concentration step: taking stir-baked FRUCTUS GARDENIAE medicine materical crude slice, water is added and extracts decoction, obtains extracting solution after filtering；Extracting solution is depressurized dense
Contracting, obtains concentrate；Thickening temperature is 75-85 DEG C, and the relative density of concentrate is 1.06-1.08；
Spray drying step: concentrate is heated, and is stirred evenly, and is then spray-dried, and stir-baked FRUCTUS GARDENIAE spray dried powder is obtained；
Dry granulation procedure: silica is first added into stir-baked FRUCTUS GARDENIAE spray dried powder, after mixing, then carries out dry method system
Grain, obtains stir-baked FRUCTUS GARDENIAE granule.
2. the preparation method of stir-baked FRUCTUS GARDENIAE granule as described in claim 1, which is characterized in that extract in concentration step, water
Additional amount be 9 times of stir-baked FRUCTUS GARDENIAE medicine materical crude slice weight.
3. the preparation method of stir-baked FRUCTUS GARDENIAE granule as described in claim 1, which is characterized in that extract in concentration step, mention
Taking temperature is 95-100 DEG C, and decocting time is 1 hour.
4. the preparation method of stir-baked FRUCTUS GARDENIAE granule as described in claim 1, which is characterized in that it extracts in concentration step, it is dense
Contracting temperature is 80 DEG C, and the relative density of concentrate is 1.07.
5. the preparation method of stir-baked FRUCTUS GARDENIAE granule as described in claim 1, which is characterized in that, will in spray drying step
Concentrate is heated to 80 DEG C.
6. the preparation method of stir-baked FRUCTUS GARDENIAE granule as described in claim 1, which is characterized in that in spray drying step, spray
Mist drying parameter: 165-185 DEG C of inlet air temperature, 90-95 DEG C of temperature, air blast frequency 35-45Hz, air inducing frequency 40-50Hz in tower,
It is atomized frequency 30-45Hz, 45-60 DEG C of conveying temperature, 75-85 DEG C of concentrate holding temperature.
7. the preparation method of stir-baked FRUCTUS GARDENIAE granule as described in claim 1, which is characterized in that in dry granulation procedure, two
The additional amount of silica is the 5% of stir-baked FRUCTUS GARDENIAE spray dried powder weight.
8. the preparation method of stir-baked FRUCTUS GARDENIAE granule as described in claim 1, which is characterized in that in dry granulation procedure,
While silica is added into stir-baked FRUCTUS GARDENIAE spray dried powder, it is also necessary to maltodextrin be added.
9. the preparation method of stir-baked FRUCTUS GARDENIAE granule as claimed in claim 8, which is characterized in that in dry granulation procedure, wheat
The additional amount of bud dextrin is W1, and the weight of stir-baked FRUCTUS GARDENIAE spray dried powder is W2, and the weight of stir-baked FRUCTUS GARDENIAE medicine materical crude slice is W3, silica
Weight is W4, W1=W3 × 80%-W2-W4.
10. the preparation method of stir-baked FRUCTUS GARDENIAE granule as described in claim 1, which is characterized in that in dry granulation procedure, control
It makes and mixes revolving speed 10rpm, incorporation time 20 minutes, dry granulation parameter: oil cylinder working-pressure 5-20MPa, feeding speed 25-
150rpm, tabletting revolving speed 8-40rpm, pelletize revolving speed 80-120rpm, obtains the stir-baked FRUCTUS GARDENIAE granule of 12-60 mesh.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN114159394A (en) * | 2021-11-08 | 2022-03-11 | 陕西孙思邈高新制药有限公司 | Preparation process of gardenia prescription granule |
| CN114272214A (en) * | 2021-12-27 | 2022-04-05 | 陕西孙思邈高新制药有限公司 | Preparation process of scorched gardenia formula granules |
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| CN101474273A (en) * | 2007-12-18 | 2009-07-08 | 北京康仁堂药业有限公司 | Stir-fried fructus gardenia dispensing granule as well as preparation method and quality control method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114159394A (en) * | 2021-11-08 | 2022-03-11 | 陕西孙思邈高新制药有限公司 | Preparation process of gardenia prescription granule |
| CN114272214A (en) * | 2021-12-27 | 2022-04-05 | 陕西孙思邈高新制药有限公司 | Preparation process of scorched gardenia formula granules |
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Application publication date: 20190111 |
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