CN101474219B - Detection method of achyranthes bidentata dispensing granule - Google Patents
Detection method of achyranthes bidentata dispensing granule Download PDFInfo
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- CN101474219B CN101474219B CN 200810184566 CN200810184566A CN101474219B CN 101474219 B CN101474219 B CN 101474219B CN 200810184566 CN200810184566 CN 200810184566 CN 200810184566 A CN200810184566 A CN 200810184566A CN 101474219 B CN101474219 B CN 101474219B
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- achyranthis bidentatae
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Abstract
The invention discloses an achyranthes prescription granule and a preparation method as well as a quality control method thereof. The prescription granule uses achyranthes decoction pieces as raw materials to prepare the achyranthes prescription granule through the technique procedures, such as twice water extraction, vacuum concentration, sponging drying, etc. 1g of the achyranthes prescription granule is equal to 3-5g of crude drug. The quality of the achyranthes decoction pieces and the achyranthes prescription granule are identified by using infrared fingerprint spectra. The achyranthes prescription granule of the invention has complete and advanced production technique, specific and controllable quality control standard, scientific, advanced, rapid and operable detecting method related to the quality standard. A great number of experiments prove that the prepared soup of the achyranthes prescription granule and the mixed simmered liquid of the classical prescription decoction pieces containing achyranthes have equal components, thus realizing the technique of full ingredient prescription granule and proving the reasonability of the technique of the invention; and in the invention, infrared spectroscopy technology is used for the quality control of the traditional Chinese medicines, rapidly solving a primary problem in macroscopic quality control of the traditional Chinesemedicines-the identification of the truth of traditional Chinese medicines.
Description
Technical field
The present invention relates to a kind of Chinese medicinal granule and preparation method thereof and method of quality control, particularly a kind of Radix Achyranthis Bidentatae granule and preparation method thereof and method of quality control.
Background technology
Chinese medicinal granule is under Chinese medical theory instructs, and the prepared slices of Chinese crude drugs are formed through various processes, is used for the granule that clinical tcm prescription allotment is used; Compare with the traditional Chinese medicines decoct, its taking convenience, dose is little, and is quality controllable, and easy storing is easy to carry; Chinese medicinal granule is in the pilot production status at home at present, product technology and quality standard disunity.At present mostly Chinese medicinal granule is that traditional water extracts, and perhaps extracts water extraction behind the volatile oil, and different production unit causes the product quality of different manufacturers inconsistent because production equipment is different with production technology, and there is difference in drug effect.The specificity of its quality standard is limit by certain test conditions and scope, lacks other due quality informations of product, and present standard can't be judged the quality good or not and the overall picture of Chinese medicinal granule product comprehensively.
Infrared spectrometry is one of conventional means of differentiating chemical compound and definite structure of matter.In pharmaceutical analysis, " fingerprint " characteristic that has with infrared spectrum is the common method that adopts of various countries' pharmacopeia as the foundation of drug identification.But since Chinese crude drug, the prepared slices of Chinese crude drugs and Chinese patent medicine itself all be more than Western medicine complicated many mixture systems, the spectrum analysis difficulty makes conventional infrared spectrometry in the long term, fail its due effect of performance in Chinese medicine quality control and management.
Summary of the invention
The objective of the invention is to disclose a kind of Radix Achyranthis Bidentatae granule; The present invention also aims to disclose the method for preparing of this granule; The present invention also aims to disclose the method for quality control of this granule.
The present invention seeks to realize through following technical scheme:
The suitable crude drug amount of the every gram of Radix Achyranthis Bidentatae granule according to the invention 3-5 gram, the IR fingerprint spectra of this granule such as Fig. 1.The method for preparing of Radix Achyranthis Bidentatae granule according to the invention comprises: get the Radix Achyranthis Bidentatae decoction pieces, with twice of water extraction; Wherein the Radix Achyranthis Bidentatae decoction pieces adopts IR fingerprint spectra to carry out quality discrimination, Radix Achyranthis Bidentatae decoction pieces standard IR fingerprint spectra such as Fig. 2.
The method for preparing of Radix Achyranthis Bidentatae granule according to the invention comprises the steps: to get the Radix Achyranthis Bidentatae decoction pieces, adds the water of 5-15 times of weight portion, extracts 0.5-3 hour, promptly one fries in shallow oil; One fries in shallow oil the water that the back medicinal residues add 5-15 times of weight portion of Radix Achyranthis Bidentatae decoction pieces, extracts 0.5-3 hour, promptly two fries in shallow oil; Merge two liquid of boiling medicine, be evaporated to the concentrated solution of relative density 1.00-1.15; The concentrated solution spray drying gets the Radix Achyranthis Bidentatae spray drying powder; The Radix Achyranthis Bidentatae spray drying powder is directly granulated or in the Radix Achyranthis Bidentatae spray drying powder, is added adjuvant dextrin or the lactose dry granulation of himself weight portion 0-25%, 20-60 purpose Radix Achyranthis Bidentatae granule.
The preferred following steps of the method for preparing of Radix Achyranthis Bidentatae granule according to the invention: get the Radix Achyranthis Bidentatae decoction pieces, add the water of 8 times of weight portions, extracted 2 hours, promptly one fry in shallow oil; One fries in shallow oil the water that the back medicinal residues add 7 times of weight portions of Radix Achyranthis Bidentatae decoction pieces, extracts 1.5 hours, promptly two fries in shallow oil; Merge two liquid of boiling medicine, be evaporated to the concentrated solution of relative density 1.05-1.10; The concentrated solution spray drying gets the Radix Achyranthis Bidentatae spray drying powder; The Radix Achyranthis Bidentatae spray drying powder is directly granulated or in the Radix Achyranthis Bidentatae spray drying powder, is added adjuvant dextrin or the lactose dry granulation of himself weight portion 0-25%, 20-60 purpose Radix Achyranthis Bidentatae granule.
The preferred following steps of the method for preparing of Radix Achyranthis Bidentatae granule according to the invention: get the Radix Achyranthis Bidentatae decoction pieces, add the water of 10 times of weight portions, extracted 2 hours, promptly one fry in shallow oil; One fries in shallow oil the water that the back medicinal residues add 6 times of weight portions of Radix Achyranthis Bidentatae decoction pieces, extracts 1 hour, promptly two fries in shallow oil; Merge two liquid of boiling medicine, be evaporated to the concentrated solution of relative density 1.00-1.05; The concentrated solution spray drying gets the Radix Achyranthis Bidentatae spray drying powder; The Radix Achyranthis Bidentatae spray drying powder is directly granulated or in the Radix Achyranthis Bidentatae spray drying powder, is added adjuvant dextrin or the lactose dry granulation of himself weight portion 0-25%, 20-60 purpose Radix Achyranthis Bidentatae granule.
The preferred following steps of the method for preparing of Radix Achyranthis Bidentatae granule according to the invention: get the Radix Achyranthis Bidentatae decoction pieces, add the water of 14 times of weight portions, extracted 2.5 hours, promptly one fry in shallow oil; One fries in shallow oil the water that the back medicinal residues add 11 times of weight portions of Radix Achyranthis Bidentatae decoction pieces, extracts 2.5 hours, promptly two fries in shallow oil; Merge two liquid of boiling medicine, be evaporated to the concentrated solution of relative density 1.10-1.15; The concentrated solution spray drying gets the Radix Achyranthis Bidentatae spray drying powder; The Radix Achyranthis Bidentatae spray drying powder is directly granulated or in the Radix Achyranthis Bidentatae spray drying powder, is added adjuvant dextrin or the lactose dry granulation of himself weight portion 0-25%, 20-60 purpose Radix Achyranthis Bidentatae granule.
The drying process with atomizing parameter is in the above-mentioned method for preparing: 40 ℃-50 ℃ of medicinal liquid preheat temperatures; 170 ℃-185 ℃ of EATs; 450-700 rev/min of material revolution speed; 70 ℃-85 ℃ of leaving air temps; Wind send 40 ℃-50 ℃ of temperature.
The granulation parameter is in the above-mentioned method for preparing: main pinch roller pressure: 4-6MPa; Side pressure wheel pressure: 0.4-0.6MPa; The speed of mainshaft: 300-500 rev/min; Feed voltage: 100-150V; Granular size: 20-60 order.
The method of quality control of Radix Achyranthis Bidentatae granule according to the invention comprises the steps: that the Radix Achyranthis Bidentatae granule adopts IR fingerprint spectra to carry out quality discrimination, and the IR fingerprint spectra discrimination method is: use FTIS, measurement range is 4000cm
-1-400cm
-1, DTGS detector, resolution 4cm
-1, scanning times 16 times is deducted water and carbon dioxide constantly and is disturbed in the scanning process, and envionmental humidity is lower than 60%, and the potassium bromide direct compression process detects; Radix Achyranthis Bidentatae granule IR fingerprint spectra has following characteristic: at 1025cm shown in accompanying drawing 1
-1Maximum absorption band is arranged, and this place's absworption peak is stairstepping, and its absorption is 1025cm from high to low
-1, 1078cm
-1, 1152cm
-1At 2929cm
-1, 1626cm
-1, 1415cm
-1, 1243cm
-1, 778cm
-1There is characteristic absorption at the place.
The method of quality control of the Radix Achyranthis Bidentatae decoction pieces described in the Radix Achyranthis Bidentatae granule method for preparing of the present invention comprises the steps: that the Radix Achyranthis Bidentatae decoction pieces is the certified products that meet a regulation of Pharmacopoeia of the People's Republic of China version in 2005; The Radix Achyranthis Bidentatae decoction pieces adopts IR fingerprint spectra to carry out quality discrimination, and the IR fingerprint spectra discrimination method is: use FTIS, measurement range is 4000cm
-1-400cm
-1, DTGS detector, resolution 4cm
-1, scanning times 16 times is deducted water and carbon dioxide constantly and is disturbed in the scanning process, and envionmental humidity is lower than 60%, and the potassium bromide direct compression process detects; The IR fingerprint spectra of Radix Achyranthis Bidentatae decoction pieces has following characteristic: at 1000cm shown in accompanying drawing 2
-1-1100cm
-1Scope in two significantly strong absworption peak, i.e. 1059cm are arranged
-1, 1027cm
-1, 1059cm wherein
-1Be maximum absorption band; At 2934cm
-1, 1732cm
-1, 1638cm
-1, 1411cm
-1, 1254cm
-1, 1128cm
-1, 928cm
-1, 819cm
-1There is characteristic absorption at the place.
IR fingerprint spectra wherein of the present invention can be to reach the IR fingerprint spectra more than 90% with its dependency.
Description of drawings:
Fig. 1: the IR fingerprint spectra of Radix Achyranthis Bidentatae granule;
Fig. 2: the IR fingerprint spectra of Radix Achyranthis Bidentatae decoction pieces Radix Achyranthis Bidentatae;
Fig. 3: Radix Achyranthis Bidentatae granule and Radix Achyranthis Bidentatae decoction pieces thin layer chromatography are relatively;
Fig. 4: Radix Achyranthis Bidentatae granule and Radix Achyranthis Bidentatae decoction pieces thin-layer sample IR fingerprint spectra are relatively;
Fig. 5: contain Radix Achyranthis Bidentatae classics side decoction pieces decocting liquid and Radix Achyranthis Bidentatae soup that granule is joined " whole part " infrared spectrogram relatively.
Radix Achyranthis Bidentatae granule of the present invention has complete, advanced production technology and strong, the controlled quality control standard of specificity, and technology advanced person can realize, the detection method science that quality standard relates to, advanced person, quick, workable.Through a large amount of experiments; Contrast the classical side's decoction pieces that contains the Radix Achyranthis Bidentatae decoction pieces and closed decocting liquid and Radix Achyranthis Bidentatae soup that granule is joined of the present invention " whole part " infrared spectrogram; Radix Achyranthis Bidentatae granule of the present invention and Radix Achyranthis Bidentatae decoction pieces thin-layer chromatogram have been contrasted; Radix Achyranthis Bidentatae granule and Radix Achyranthis Bidentatae decoction pieces thin-layer sample IR fingerprint spectra have been contrasted; The result shows that the classical side's decoction pieces that contains the Radix Achyranthis Bidentatae decoction pieces closes decocting liquid and Radix Achyranthis Bidentatae granule of the present invention is joined soup IR fingerprint spectra peak shape, peak position, relative peak intensity basically identical; It is suitable to be that Radix Achyranthis Bidentatae soup that granule is joined of the present invention and decoction pieces close the decocting liquid composition; And the IR fingerprint spectra peak shape of Radix Achyranthis Bidentatae granule of the present invention and decoction pieces thin-layer sample, peak position, peak intensity basically identical, so Radix Achyranthis Bidentatae granule of the present invention relatively realized the technology of whole part granule, proves the reasonability of technology of the present invention; And the present invention is applied to infrared spectrum technology the quality control of Chinese medicine; This is the innovation on a kind of thinking, and this not only meets the theory of Chinese medicine about " monarch, minister, help, make ", has also given prominence to the group effect of Chinese medicine; Simultaneously complicated problems is oversimplified; Make certain Chinese medicine as a whole, observe its " fingerprint property ", thereby solved a matter of utmost importance--the evaluation of-Chinese medicine true and false in the control of Chinese medicine macroscopic quality apace.
Following experimental example and embodiment are used to further specify but are not limited to the present invention.
Experimental example 1
(1) Radix Achyranthis Bidentatae granule and Radix Achyranthis Bidentatae decoction pieces thin layer chromatography are relatively
Differentiate a thin layer chromatography test down according to middle Radix Achyranthis Bidentatae of Pharmacopoeia of the People's Republic of China version in 2005; Prepare sample with Radix Achyranthis Bidentatae decoction pieces and Radix Achyranthis Bidentatae granule of the present invention; Measure, the gained result is shown in accompanying drawing 3, in the Radix Achyranthis Bidentatae granule chromatograph; With the corresponding position of Radix Achyranthis Bidentatae decoction pieces chromatograph on, show the speckle of same color.
(2) Radix Achyranthis Bidentatae granule and Radix Achyranthis Bidentatae decoction pieces thin-layer sample IR fingerprint spectra are relatively
Measure the Radix Achyranthis Bidentatae decoction pieces of preparation in (1) and the thin-layer sample of Radix Achyranthis Bidentatae granule with FTIS; Its result shown in accompanying drawing 4, the thin-layer sample IR fingerprint spectra peak shape of Radix Achyranthis Bidentatae granule and Radix Achyranthis Bidentatae decoction pieces, peak position, peak intensity basically identical relatively.
The result proves that Radix Achyranthis Bidentatae granule of the present invention is consistent with Radix Achyranthis Bidentatae decoction pieces composition, and technology of the present invention is rational.
Experimental example 2 contains Radix Achyranthis Bidentatae classics side decoction pieces decocting liquid and Radix Achyranthis Bidentatae soup that granule is joined " whole part " infrared spectrogram comparative experiments
SIMIAO WAN comes from " becoming conveniently to read ", and prescription is formed and comprised Cortex Phellodendri, Rhizoma Atractylodis, Radix Achyranthis Bidentatae, 4 flavour of a drug of Semen Coicis; The effect promoting diuresis to eliminate damp pathogen.
1, experiment purpose: the similarities and differences of research SIMIAO WAN decoction pieces decocting liquid and granular recipe, confirm Radix Achyranthis Bidentatae granule technology and normal reasonability.
2, experimental technique: get 4 flavour of a drug prescriptions such as Radix Achyranthis Bidentatae by SIMIAO WAN prescription proportioning, the decocting method of pressing the decoction pieces decoction decocts preparation decoction pieces decocting liquid sample; Get other decoction pieces except that Radix Achyranthis Bidentatae respectively by SIMIAO WAN prescription proportioning in addition; The decocting method of pressing the decoction pieces decoction decocts, and medicinal liquid suitably concentrates, and gets the Radix Achyranthis Bidentatae granule by SIMIAO WAN prescription proportioning and equivalent relation and adds in the concentrated medicament; Be stirred to dissolving fully, preparation granular recipe sample; Drinking sheet decocting liquid sample, granular recipe sample respectively carries out infrared spectrum and detects.
3, testing conditions: instrument is a FTIS, and measurement range is 4000cm
-1-400cm
-1, DTGS detector, resolution 4cm
-1, scanning times 16 times is deducted water and carbon dioxide constantly and is disturbed in the scanning process, and envionmental humidity is lower than 60%, and the potassium bromide direct compression process detects.
4, testing result: decoction pieces decocting liquid sample and granular recipe sample IR fingerprint spectra peak shape, peak position, relative peak intensity basically identical shown in accompanying drawing 5, dependency reaches 97.10%.It is consistent to prove that Radix Achyranthis Bidentatae soup that granule is joined of the present invention and decoction pieces close the decocting liquid composition; It is consistent with a Radix Achyranthis Bidentatae decoction pieces fried composition promptly to add Radix Achyranthis Bidentatae granule of the present invention, and equivalent and production technology that Radix Achyranthis Bidentatae granule 1g of the present invention is equivalent to Radix Achyranthis Bidentatae decoction pieces 3-5g are rational.
Following embodiment all can realize the effect of above-mentioned experimental example, and required Radix Achyranthis Bidentatae decoction pieces adopts IR fingerprint spectra to carry out quality discrimination among the following embodiment, meets the standard IR fingerprint spectra of the Radix Achyranthis Bidentatae decoction pieces in the technique scheme; The Radix Achyranthis Bidentatae granule that following embodiment makes adopts IR fingerprint spectra to carry out quality discrimination, meets the IR fingerprint spectra of the Radix Achyranthis Bidentatae granule in the technique scheme; The every gram of Radix Achyranthis Bidentatae granule described in the following embodiment contains suitable crude drug amount 3-5 gram.
The specific embodiment
Embodiment 1: the Radix Achyranthis Bidentatae granule
Get Radix Achyranthis Bidentatae decoction pieces 100kg, add the water of 800kg, extracted 2 hours, promptly one fry in shallow oil; One fries in shallow oil the back medicinal residues adds 800kg water, extracts 1.5 hours, promptly two fries in shallow oil; Merge two liquid of boiling medicine, be evaporated to relative density 1.05-1.10; Concentrated solution is 45 ℃ of preheatings, and 180 ℃ of EATs, 550 rev/mins of material revolution speeds, 80 ℃ of leaving air temps, wind send spray drying under the condition of 45 ℃ of temperature, the Radix Achyranthis Bidentatae spray drying powder; The adjuvant dextrin that in the Radix Achyranthis Bidentatae spray drying powder, adds himself weight portion 0-5%; The Radix Achyranthis Bidentatae spray drying powder is 5MPa at main pinch roller pressure, and side pressure wheel pressure is 0.5MPa, and the speed of mainshaft is 400 rev/mins, and feed voltage is a dry granulation under the condition of 120V, 20-60 purpose Radix Achyranthis Bidentatae granule, suitable crude drug amount 5 grams of the every gram of Radix Achyranthis Bidentatae granule.
Embodiment 2: the Radix Achyranthis Bidentatae granule
Get Radix Achyranthis Bidentatae decoction pieces 100kg, add the water of 1000kg, extracted 2 hours, promptly one fry in shallow oil; One fries in shallow oil the back medicinal residues adds 600kg water, extracts 1 hour, promptly two fries in shallow oil; Merge two liquid of boiling medicine, be evaporated to relative density 1.00-1.05; Concentrated solution is 50 ℃ of preheatings, and 170 ℃ of EATs, 600 rev/mins of material revolution speeds, 75 ℃ of leaving air temps, wind send spray drying under the condition of 50 ℃ of temperature, the Radix Achyranthis Bidentatae spray drying powder; The adjuvant dextrin that in the Radix Achyranthis Bidentatae spray drying powder, adds himself weight portion 5-15%; At main pinch roller pressure is 6MPa, and side pressure wheel pressure is 0.4MPa, and the speed of mainshaft is 450 rev/mins, and feed voltage is a dry granulation under the condition of 110V, 20-60 purpose Radix Achyranthis Bidentatae granule, suitable crude drug amount 4 grams of the every gram of Radix Achyranthis Bidentatae granule;
The method of quality control of wherein said Radix Achyranthis Bidentatae decoction pieces comprises the steps: that the Radix Achyranthis Bidentatae decoction pieces adopts IR fingerprint spectra to carry out quality discrimination, and the IR fingerprint spectra discrimination method is: use FTIS, measurement range is 4000cm
-1-400cm
-1, DTGS detector, resolution 4cm
-1, scanning times 16 times is deducted water and carbon dioxide constantly and is disturbed in the scanning process, and envionmental humidity is lower than 60%, and the potassium bromide direct compression process detects; The IR fingerprint spectra of Radix Achyranthis Bidentatae decoction pieces has following characteristic: at 1000cm shown in accompanying drawing 2
-1-1100cm
-1Scope in two significantly strong absworption peak, i.e. 1059cm are arranged
-1, 1027cm
-1, 1059cm wherein
-1Be maximum absorption band; At 2934cm
-1, 1732cm
-1, 1638cm
-1, 1411cm
-1, 1254cm
-1, 1128cm
-1, 928cm
-1, 819cm
-1There is characteristic absorption at the place.
Embodiment 3: the Radix Achyranthis Bidentatae granule
Get Radix Achyranthis Bidentatae decoction pieces 100kg, add the water of 1400kg, extracted 2.5 hours, promptly one fry in shallow oil; One fries in shallow oil the back medicinal residues adds 1100kg water, extracts 2.5 hours, promptly two fries in shallow oil; Merge two liquid of boiling medicine, be evaporated to relative density 1.10-1.15; Concentrated solution is 45 ℃ of preheatings, and 170 ℃ of EATs, 600 rev/mins of material revolution speeds, 75 ℃ of leaving air temps, wind send spray drying under the condition of 50 ℃ of temperature, the Radix Achyranthis Bidentatae spray drying powder; The lactose that in the Radix Achyranthis Bidentatae spray drying powder, adds himself weight portion 15-25%; At main pinch roller pressure is 4MPa, and side pressure wheel pressure is 0.4MPa, and the speed of mainshaft is 500 rev/mins, and feed voltage is a dry granulation under the condition of 130V, 20-60 purpose Radix Achyranthis Bidentatae granule, suitable crude drug amount 3 grams of the every gram of Radix Achyranthis Bidentatae granule;
The method of quality control of gained Radix Achyranthis Bidentatae granule comprises the steps: to adopt IR fingerprint spectra to carry out quality discrimination, and the IR fingerprint spectra discrimination method is: use FTIS, measurement range is 4000cm
-1-400cm
-1, DTGS detector, resolution 4cm
-1, scanning times 16 times is deducted water and carbon dioxide constantly and is disturbed in the scanning process, and envionmental humidity is lower than 60%, and the potassium bromide direct compression process detects; Radix Achyranthis Bidentatae granule IR fingerprint spectra has following characteristic: at 1025cm shown in accompanying drawing 1
-1Maximum absorption band is arranged, and this place's absworption peak is stairstepping, and its absorption is 1025cm from high to low
-1, 1078cm
-1, 1152cm
-1At 2929cm
-1, 1626cm
-1, 1415cm
-1, 1243cm
-1, 778cm
-1There is characteristic absorption at the place.
Claims (2)
1. the detection method of a Radix Achyranthis Bidentatae granule is characterized in that this method comprises the steps:
Use FTIS, measurement range is 4000cm
-1-400cm
-1, DTGS detector, resolution 4cm
-1, scanning times 16 times is deducted water and carbon dioxide constantly and is disturbed in the scanning process, and envionmental humidity is lower than 60%, and the potassium bromide direct compression process detects; Radix Achyranthis Bidentatae granule IR fingerprint spectra has following characteristic: at 1025cm shown in accompanying drawing 1
-1Maximum absorption band is arranged, and this place's absworption peak is stairstepping, and its absorption is 1025cm from high to low
-1, 1078cm
-1, 1152cm
-1At 2929cm
-1, 1626cm
-1, 1415cm
-1, 1243cm
-1, 778cm
-1There is characteristic absorption at the place;
Wherein, the suitable crude drug amount of the every gram of said Radix Achyranthis Bidentatae granule 3-5 gram; This Radix Achyranthis Bidentatae granule is prepared from following method:
Get the Radix Achyranthis Bidentatae decoction pieces, add the water of 5-15 times of weight portion, extracted 0.5-3 hour, promptly one fry in shallow oil; One fries in shallow oil the water that the back medicinal residues add 5-15 times of weight portion of Radix Achyranthis Bidentatae decoction pieces, extracts 0.5-3 hour, promptly two fries in shallow oil; Merge two liquid of boiling medicine, be evaporated to the concentrated solution of relative density 1.00-1.15; The concentrated solution spray drying gets the Radix Achyranthis Bidentatae spray drying powder; The Radix Achyranthis Bidentatae spray drying powder is directly granulated or in the Radix Achyranthis Bidentatae spray drying powder, is added adjuvant dextrin or the lactose dry granulation of himself weight portion 0-25%, 20-60 purpose Radix Achyranthis Bidentatae granule; Wherein the Radix Achyranthis Bidentatae decoction pieces adopts IR fingerprint spectra to differentiate that the IR fingerprint spectra discrimination method is: use FTIS, measurement range is 4000cm
-1-400cm
-1, DTGS detector, resolution 4cm
-1, scanning times 16 times is deducted water and carbon dioxide constantly and is disturbed in the scanning process, and envionmental humidity is lower than 60%, and the potassium bromide direct compression process detects; The IR fingerprint spectra of Radix Achyranthis Bidentatae decoction pieces has following characteristic: at 1000cm shown in accompanying drawing 2
-1-1100cm
-1Scope in two significantly strong absworption peak, i.e. 1059cm are arranged
-1, 1027cm
-1, 1059cm wherein
-1Be maximum absorption band; At 2934cm
-1, 1732cm
-1, 1638cm
-1, 1411cm
-1, 1254cm
-1, 1128cm
-1, 928cm
-1, 819cm
-1There is characteristic absorption at the place;
Wherein, described drying process with atomizing parameter is: 40 ℃-50 ℃ of medicinal liquid preheat temperatures; 170 ℃-185 ℃ of EATs; 450-700 rev/min of material revolution speed; 70 ℃-85 ℃ of leaving air temps; Wind send 40 ℃-50 ℃ of temperature; Wherein said granulation parameter is: main pinch roller pressure: 4-6MPa; Side pressure wheel pressure: 0.4-0.6MPa; The speed of mainshaft: 300-500 rev/min; Feed voltage: 100-150V; Granular size: 20-60 order.
2. the detection method of Radix Achyranthis Bidentatae granule as claimed in claim 1 is characterized in that the method for preparing of Radix Achyranthis Bidentatae granule in this method comprises the steps:
Get the Radix Achyranthis Bidentatae decoction pieces, add the water of 8 times of weight portions, extracted 2 hours, promptly one fry in shallow oil; One fries in shallow oil the water that the back medicinal residues add 7 times of weight portions of Radix Achyranthis Bidentatae decoction pieces, extracts 1.5 hours, promptly two fries in shallow oil; Merge two liquid of boiling medicine, be evaporated to the concentrated solution of relative density 1.05-1.10; The concentrated solution spray drying gets the Radix Achyranthis Bidentatae spray drying powder; The Radix Achyranthis Bidentatae spray drying powder is directly granulated or in the Radix Achyranthis Bidentatae spray drying powder, is added adjuvant dextrin or the lactose dry granulation of himself weight portion 0-25%, 20-60 purpose Radix Achyranthis Bidentatae granule; Wherein the Radix Achyranthis Bidentatae decoction pieces adopts IR fingerprint spectra to differentiate that the IR fingerprint spectra discrimination method is: use FTIS, measurement range is 4000cm
-1-400cm
-1, DTGS detector, resolution 4cm
-1, scanning times 16 times is deducted water and carbon dioxide constantly and is disturbed in the scanning process, and envionmental humidity is lower than 60%, and the potassium bromide direct compression process detects; The IR fingerprint spectra of Radix Achyranthis Bidentatae decoction pieces has following characteristic: at 1000cm shown in accompanying drawing 2
-1-1100cm
-1Scope in two significantly strong absworption peak, i.e. 1059cm are arranged
-1, 1027cm
-1, 1059cm wherein
-1Be maximum absorption band; At 2934cm
-1, 1732cm
-1, 1638cm
-1, 1411cm
-1, 1254cm
-1, 1128cm
-1, 928cm
-1, 819cm
-1There is characteristic absorption at the place;
Or get the Radix Achyranthis Bidentatae decoction pieces, and add the water of 10 times of weight portions, extracted 2 hours, promptly one fry in shallow oil; One fries in shallow oil the water that the back medicinal residues add 6 times of weight portions of Radix Achyranthis Bidentatae decoction pieces, extracts 1 hour, promptly two fries in shallow oil; Merge two liquid of boiling medicine, be evaporated to the concentrated solution of relative density 1.00-1.05; The concentrated solution spray drying gets the Radix Achyranthis Bidentatae spray drying powder; The Radix Achyranthis Bidentatae spray drying powder is directly granulated or in the Radix Achyranthis Bidentatae spray drying powder, is added adjuvant dextrin or the lactose dry granulation of himself weight portion 0-25%, 20-60 purpose Radix Achyranthis Bidentatae granule; Wherein the Radix Achyranthis Bidentatae decoction pieces adopts IR fingerprint spectra to differentiate that the IR fingerprint spectra discrimination method is: use FTIS, measurement range is 4000cm
-1-400cm
-1, DTGS detector, resolution 4cm
-1, scanning times 16 times is deducted water and carbon dioxide constantly and is disturbed in the scanning process, and envionmental humidity is lower than 60%, and the potassium bromide direct compression process detects; The IR fingerprint spectra of Radix Achyranthis Bidentatae decoction pieces has following characteristic: at 1000cm shown in accompanying drawing 2
-1-1100cm
-1Scope in two significantly strong absworption peak, i.e. 1059cm are arranged
-1, 1027cm
-1, 1059cm wherein
-1Be maximum absorption band; At 2934cm
-1, 1732cm
-1, 1638cm
-1, 1411cm
-1, 1254cm
-1, 1128cm
-1, 928cm
-1, 819cm
-1There is characteristic absorption at the place;
Or get the Radix Achyranthis Bidentatae decoction pieces, and add the water of 14 times of weight portions, extracted 2.5 hours, promptly one fry in shallow oil; One fries in shallow oil the water that the back medicinal residues add 11 times of weight portions of Radix Achyranthis Bidentatae decoction pieces, extracts 2.5 hours, promptly two fries in shallow oil; Merge two liquid of boiling medicine, be evaporated to the concentrated solution of relative density 1.10-1.15; The concentrated solution spray drying gets the Radix Achyranthis Bidentatae spray drying powder; The Radix Achyranthis Bidentatae spray drying powder is directly granulated or in the Radix Achyranthis Bidentatae spray drying powder, is added adjuvant dextrin or the lactose dry granulation of himself weight portion 0-25%, 20-60 purpose Radix Achyranthis Bidentatae granule; Wherein the Radix Achyranthis Bidentatae decoction pieces adopts IR fingerprint spectra to differentiate that the IR fingerprint spectra discrimination method is: use FTIS, measurement range is 4000cm
-1-400cm
-1, DTGS detector, resolution 4cm
-1, scanning times 16 times is deducted water and carbon dioxide constantly and is disturbed in the scanning process, and envionmental humidity is lower than 60%, and the potassium bromide direct compression process detects; The IR fingerprint spectra of Radix Achyranthis Bidentatae decoction pieces has following characteristic: at 1000cm shown in accompanying drawing 2
-1-1100cm
-1Scope in two significantly strong absworption peak, i.e. 1059cm are arranged
-1, 1027cm
-1, 1059cm wherein
-1Be maximum absorption band; At 2934cm
-1, 1732cm
-1, 1638cm
-1, 1411cm
-1, 1254cm
-1, 1128cm
-1, 928cm
-1, 819cm
-1There is characteristic absorption at the place.
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| CN 200810184568 Active CN101474232B (en) | 2007-12-18 | 2008-12-17 | White atractylodes rhizome dispensing granule as well as preparation method and quality control method |
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| CN 200810184571 Active CN101474241B (en) | 2007-12-18 | 2008-12-17 | Detection method of astragalus dispensing granule |
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