CN114366716A - Preparation process of fried gardenia prescription granule - Google Patents
Preparation process of fried gardenia prescription granule Download PDFInfo
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- CN114366716A CN114366716A CN202111565687.XA CN202111565687A CN114366716A CN 114366716 A CN114366716 A CN 114366716A CN 202111565687 A CN202111565687 A CN 202111565687A CN 114366716 A CN114366716 A CN 114366716A
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- gardenia
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- prescription granule
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- 239000008187 granular material Substances 0.000 title claims abstract description 30
- 238000002360 preparation method Methods 0.000 title claims abstract description 27
- 240000001972 Gardenia jasminoides Species 0.000 title 1
- 241000157835 Gardenia Species 0.000 claims abstract description 40
- 238000001694 spray drying Methods 0.000 claims abstract description 13
- 238000000034 method Methods 0.000 claims abstract description 11
- 239000000706 filtrate Substances 0.000 claims abstract description 10
- 239000000463 material Substances 0.000 claims abstract description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 9
- 238000001914 filtration Methods 0.000 claims abstract description 8
- 238000002156 mixing Methods 0.000 claims abstract description 8
- 238000003756 stirring Methods 0.000 claims abstract description 7
- 229920000858 Cyclodextrin Polymers 0.000 claims abstract description 6
- 239000001116 FEMA 4028 Substances 0.000 claims abstract description 6
- 229920002774 Maltodextrin Polymers 0.000 claims abstract description 6
- 239000005913 Maltodextrin Substances 0.000 claims abstract description 6
- WHGYBXFWUBPSRW-FOUAGVGXSA-N beta-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO WHGYBXFWUBPSRW-FOUAGVGXSA-N 0.000 claims abstract description 6
- 235000011175 beta-cyclodextrine Nutrition 0.000 claims abstract description 6
- 229960004853 betadex Drugs 0.000 claims abstract description 6
- 229940035034 maltodextrin Drugs 0.000 claims abstract description 6
- 238000002791 soaking Methods 0.000 claims abstract description 6
- 239000002671 adjuvant Substances 0.000 claims abstract description 4
- 239000003651 drinking water Substances 0.000 claims abstract description 4
- 235000020188 drinking water Nutrition 0.000 claims abstract description 4
- 239000007788 liquid Substances 0.000 claims abstract description 4
- 239000000203 mixture Substances 0.000 claims abstract description 4
- 239000000843 powder Substances 0.000 claims abstract description 4
- 238000003860 storage Methods 0.000 claims abstract description 4
- 238000000605 extraction Methods 0.000 claims description 11
- 238000001035 drying Methods 0.000 claims description 10
- 230000009290 primary effect Effects 0.000 claims description 6
- 238000004519 manufacturing process Methods 0.000 claims description 4
- 230000009291 secondary effect Effects 0.000 claims description 4
- 238000007908 dry granulation Methods 0.000 claims description 3
- 238000010438 heat treatment Methods 0.000 claims description 3
- 238000005507 spraying Methods 0.000 claims description 2
- 238000012546 transfer Methods 0.000 abstract description 7
- 239000003814 drug Substances 0.000 abstract description 6
- 239000000047 product Substances 0.000 description 6
- IBFYXTRXDNAPMM-BVTMAQQCSA-N Geniposide Chemical compound O([C@@H]1OC=C([C@@H]2[C@H]1C(=CC2)CO)C(=O)OC)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O IBFYXTRXDNAPMM-BVTMAQQCSA-N 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- IBFYXTRXDNAPMM-FZEIBHLUSA-N Geniposide Natural products COC(=O)C1=CO[C@@H](O[C@H]2O[C@@H](CO)[C@H](O)[C@@H](O)[C@@H]2O)[C@H]2[C@@H]1CC=C2CO IBFYXTRXDNAPMM-FZEIBHLUSA-N 0.000 description 3
- VGLLGNISLBPZNL-RBUKDIBWSA-N arborescoside Natural products O=C(OC)C=1[C@@H]2C([C@H](O[C@H]3[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O3)OC=1)=C(CO)CC2 VGLLGNISLBPZNL-RBUKDIBWSA-N 0.000 description 3
- 238000011160 research Methods 0.000 description 3
- 239000002245 particle Substances 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 1
- 238000010923 batch production Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/74—Rubiaceae (Madder family)
- A61K36/744—Gardenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Abstract
The invention discloses a preparation process of fried gardenia prescription granules, relating to the technical field of preparation of traditional Chinese medicine prescription granules, and the process comprises the following steps: step 1: firstly adding 8 times of drinking water, starting a feeding and extracting tank connecting device when the water temperature reaches 60-80 ℃, soaking for 60min, then decocting for 2h, and filtering decoction liquid with 120 meshes; step 2: decocting with 6 times of water for 1.5 hr, filtering with 120 mesh sieve, mixing filtrates, and storing in an extractive solution storage tank; step 3: feeding the extracting solution into a concentrator, concentrating the extracting solution to obtain an extract with the relative density of 1.02-1.04, and then performing spray drying; step 4: adding the weighed auxiliary materials of maltodextrin and beta-cyclodextrin in time when the mixture is hot, starting stirring and mixing uniformly; step 5: adding adjuvants, stirring, and spray drying to obtain extract; step 6: and (4) dry granulating the spray-dried extract powder. The process of the invention keeps the transfer rate of the fried gardenia above 70%, keeps the content of the fried gardenia to the maximum extent, and simultaneously well keeps various index components of the characteristic map.
Description
Technical Field
The invention relates to the technical field of preparation of traditional Chinese medicine formula granules, in particular to a preparation process of fried gardenia formula granules.
Background
The traditional Chinese medicine formula particle is a novel formula medicine which is processed and prepared by taking traditional Chinese medicine decoction pieces as raw materials through production processes of extraction, separation, concentration, drying, granulation, packaging and the like, has unified specification, unified dosage and unified quality standard, and a preparation method of fried gardenia is a preparation method of the fried gardenia;
the existing preparation process of fried gardenia prescription granule has poor extraction effect, the transfer rate of jasminoidin in fried gardenia is between 40 and 50 percent, the content is insufficient, various index components of a characteristic map are also insufficient, and certain limitation exists; therefore, a preparation process of fried gardenia prescription granules is provided.
Disclosure of Invention
The invention mainly aims to provide a preparation process of fried gardenia prescription granules, which improves the transfer rate of geniposide in fried gardenia by improving the process so as to solve the problems in the background technology.
In order to achieve the purpose, the invention adopts the technical scheme that: the preparation process of the fried gardenia prescription granule comprises an extraction process, a concentration process and a drying process;
the preparation and extraction process of the fried gardenia prescription granule comprises the following steps:
step 1: firstly adding 8 times of drinking water, starting a feeding and extracting tank connecting device when the water temperature reaches 60-80 ℃, soaking for 60min, then decocting for 2h, and filtering decoction liquid with 120 meshes;
step 2: decocting with 6 times of water for 1.5 hr, filtering with 120 mesh sieve, mixing filtrates, and storing in an extractive solution storage tank;
the preparation and concentration process of the fried gardenia prescription granule comprises the following steps:
step 3: feeding the extracting solution into a concentrator, concentrating the extracting solution to obtain an extract with the relative density of 1.02-1.04 (55-65 ℃), and then performing spray drying;
step 4: adding the weighed auxiliary materials of maltodextrin and beta-cyclodextrin in time when the mixture is hot, starting stirring and mixing uniformly;
the preparation and drying process of the fried gardenia prescription granule comprises the following steps:
step 5: adding adjuvants, stirring, and spray drying to obtain extract;
step 6: and (4) performing dry granulation on the extract powder after spray drying to prepare the fried gardenia formula granules.
Preferably, the state of the product is kept at normal temperature when the product is soaked in Step 1.
Preferably, the filtrate obtained in Step2 is combined into the filtrate obtained in Step1 and the filtrate obtained in Step 2.
Preferably, the primary effect temperature in the concentrator in Step3 is controlled to be 65-75 ℃, and the primary effect vacuum degree is controlled to be-0.06-0.07 Mpa; the temperature of the secondary effect is 50-60 ℃, and the vacuum degree of the secondary effect is-0.07 to-0.08 MPa.
Preferably, the auxiliary material of Step4 comprises 10% of maltodextrin and 5% of beta-cyclodextrin.
Preferably, the heating steam pressure is controlled to be 0.4-0.6 Mpa in the Step5, the air inlet temperature is controlled to be 110-120 ℃, the air exhaust temperature is controlled to be 80-90 ℃, the spraying pressure is controlled to be 10-14 Mpa, and the temperature in the tower is controlled to be 85-100 ℃.
The invention has the following beneficial effects:
compared with the common preparation process for extracting the geniposide from the fried gardenia, the preparation process for the fried gardenia formula granules has the transfer rate of 40-50%, can keep the transfer rate of the fried gardenia above 70%, and maximally keeps the content of the geniposide, thereby ensuring the quality of the product to the maximum extent.
Of course, it is not necessary for any product in which the invention is practiced to achieve all of the above-described advantages at the same time.
Drawings
FIG. 1 is a flow chart of the operation and preparation method of the preparation process of fried gardenia prescription granule of the invention.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below, and it should be understood that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
As shown in fig. 1: the preparation process of the fried gardenia prescription granule comprises an extraction process, a concentration process and a drying process;
the extraction process comprises the following steps:
step 1: firstly adding 8 times of drinking water, starting a feeding and extracting tank connecting device when the water temperature reaches 60-80 ℃, soaking for 60min (normal temperature), then decocting for 2h, and filtering decoction liquid by 120 meshes; step 2: decocting with 6 times of water for 1.5 hr, filtering with 120 mesh sieve, mixing filtrates, and storing in an extractive solution storage tank;
the concentration process comprises the following steps:
step 3: feeding the extracting solution into a concentrator, and controlling the primary effect temperature to be 65-75 ℃ and the primary effect vacuum degree to be-0.06-0.07 Mpa; concentrating the extract at a double-effect temperature of 50-60 ℃ and a double-effect vacuum degree of-0.07-0.08 Mpa to obtain an extract with a relative density of 1.02-1.04 (55-65 ℃), and then performing spray drying; step 4: adding the weighed auxiliary materials of maltodextrin (10 percent) and beta-cyclodextrin (5 percent) in time when the mixture is hot, starting stirring and mixing uniformly;
the drying process comprises the following steps:
step 5: drying the extract which is added with the auxiliary materials and uniformly stirred by a spray drying method, controlling the heating steam pressure to be 0.4-0.6 Mpa, controlling the air inlet temperature to be 110-120 ℃, the air exhaust temperature to be 80-90 ℃, the spray pressure to be 10-14 Mpa and the temperature in the tower to be 85-100 ℃ for spray drying; step 6: and performing dry granulation on the extract powder after spray drying to obtain fried gardenia formula granules.
The process can keep the transfer rate of the fried gardenia above 70 percent, maximally keep the content of the fried gardenia, and well keep various index components of a characteristic map.
In the extraction process of the invention, in the actual operation, the feeding sequence, the soaking time and temperature, the extraction times, the extraction time and the water consumption are required to be paid attention to; in the concentration step, attention is paid to the concentration temperature, the relative density of the extract and the addition amount of auxiliary materials; paying attention to the drying temperature in the drying link; the preparation process of the fried gardenia prescription granule of the invention can not only meet the national standard, but also reach the average value, and is stable and feasible.
According to the scheme, 18 batches of fried gardenia medicinal materials mainly produced in China are screened for quality comparison research, 18 batches of standard decoctions are prepared according to the management standard of Chinese medicine decoction rooms in medical institutions, the quality comparison research is carried out, after the transfer of the quantity values of the active ingredients of the fried gardenia is consistent, a small test of fried gardenia formula particles is carried out, influence factors are screened according to the time and the temperature of soaking, extracting, concentrating and spray drying, the small test product is obtained, the quality comparison research is carried out on the small test product and the standard decoction, and the pilot test and industrial batch production is carried out under the condition that the quality is determined to be not different, so that the stable quality is ensured, and the national quality standard is met.
In the description herein, references to the description of "one embodiment," "an example," "a specific example" or the like are intended to mean that a particular feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the invention. In this specification, the schematic representations of the terms used above do not necessarily refer to the same embodiment or example. Furthermore, the particular features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples.
The preferred embodiments of the invention disclosed above are intended to be illustrative only. The preferred embodiments are not intended to be exhaustive or to limit the invention to the precise forms disclosed. Obviously, many modifications and variations are possible in light of the above teaching. The embodiments were chosen and described in order to best explain the principles of the invention and the practical application, to thereby enable others skilled in the art to best utilize the invention. The invention is limited only by the claims and their full scope and equivalents.
Claims (6)
1. The preparation process of the fried gardenia prescription granule is characterized by comprising an extraction process, a concentration process and a drying process;
the preparation and extraction process of the fried gardenia prescription granule comprises the following steps:
step 1: firstly adding 8 times of drinking water, starting a feeding and extracting tank connecting device when the water temperature reaches 60-80 ℃, soaking for 60min, then decocting for 2h, and filtering decoction liquid with 120 meshes;
step 2: decocting with 6 times of water for 1.5 hr, filtering with 120 mesh sieve, mixing filtrates, and storing in an extractive solution storage tank;
the preparation and concentration process of the fried gardenia prescription granule comprises the following steps:
step 3: feeding the extracting solution into a concentrator, concentrating the extracting solution to obtain an extract with the relative density of 1.02-1.04, and then performing spray drying;
step 4: adding the weighed auxiliary materials of maltodextrin and beta-cyclodextrin in time when the mixture is hot, starting stirring and mixing uniformly;
the preparation and drying process of the fried gardenia prescription granule comprises the following steps:
step 5: adding adjuvants, stirring, and spray drying to obtain extract;
step 6: and (4) performing dry granulation on the extract powder after spray drying to prepare the fried gardenia formula granules.
2. The process for preparing fried gardenia prescription granule as claimed in claim 1, wherein the state of normal temperature is kept when the fried gardenia prescription granule is soaked in Step 1.
3. The process for preparing fried gardenia prescription granule as claimed in claim 1, characterized in that the combined filtrate in Step2 is the filtrate obtained in Step1 and the filtrate obtained in Step 2.
4. The preparation process of the fried gardenia prescription granule as claimed in claim 1, wherein the primary effect temperature of a concentrator in Step3 is controlled to be 65-75 ℃, and the primary effect vacuum degree is controlled to be-0.06-0.07 Mpa; the temperature of the secondary effect is 50-60 ℃, and the vacuum degree of the secondary effect is-0.07 to-0.08 MPa.
5. The process for preparing the fried gardenia prescription granule as claimed in claim 1, wherein the adjuvant maltodextrin is used in a proportion of 10% and the beta-cyclodextrin is used in a proportion of 5% in Step 4.
6. The preparation process of the fried gardenia prescription granule as claimed in claim 1, wherein the heating steam pressure in Step5 is controlled to be 0.4-0.6 Mpa, the air inlet temperature is controlled to be 110-120 ℃, the air exhaust temperature is controlled to be 80-90 ℃, the spraying pressure is controlled to be 10-14 Mpa, and the temperature in the tower is controlled to be 85-100 ℃.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111565687.XA CN114366716A (en) | 2021-12-20 | 2021-12-20 | Preparation process of fried gardenia prescription granule |
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| Application Number | Priority Date | Filing Date | Title |
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| CN202111565687.XA CN114366716A (en) | 2021-12-20 | 2021-12-20 | Preparation process of fried gardenia prescription granule |
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| CN114366716A true CN114366716A (en) | 2022-04-19 |
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| CN202111565687.XA Pending CN114366716A (en) | 2021-12-20 | 2021-12-20 | Preparation process of fried gardenia prescription granule |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115212244A (en) * | 2022-07-28 | 2022-10-21 | 黑龙江中医药大学 | Honeysuckle formula particle prescription and preparation process thereof |
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|---|---|---|---|---|
| CN101474273A (en) * | 2007-12-18 | 2009-07-08 | 北京康仁堂药业有限公司 | Stir-fried fructus gardenia dispensing granule as well as preparation method and quality control method thereof |
| CN109172665A (en) * | 2018-09-30 | 2019-01-11 | 康美药业股份有限公司 | A kind of preparation method of stir-fried fructus gardenia dispensing granule |
| CN109568417A (en) * | 2018-07-26 | 2019-04-05 | 广东方制药有限公司 | A kind of cape jasmine processes the preparation method of medicine materical crude slice granule |
-
2021
- 2021-12-20 CN CN202111565687.XA patent/CN114366716A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101474273A (en) * | 2007-12-18 | 2009-07-08 | 北京康仁堂药业有限公司 | Stir-fried fructus gardenia dispensing granule as well as preparation method and quality control method thereof |
| CN109568417A (en) * | 2018-07-26 | 2019-04-05 | 广东方制药有限公司 | A kind of cape jasmine processes the preparation method of medicine materical crude slice granule |
| CN109172665A (en) * | 2018-09-30 | 2019-01-11 | 康美药业股份有限公司 | A kind of preparation method of stir-fried fructus gardenia dispensing granule |
Non-Patent Citations (1)
| Title |
|---|
| 苏丽梅: "简述中药配方颗粒", 《海峡药学》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN115212244A (en) * | 2022-07-28 | 2022-10-21 | 黑龙江中医药大学 | Honeysuckle formula particle prescription and preparation process thereof |
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