CN101506237B - 具有改进性能的抗-C5aR抗体 - Google Patents

具有改进性能的抗-C5aR抗体 Download PDF

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CN101506237B
CN101506237B CN200780031002.5A CN200780031002A CN101506237B CN 101506237 B CN101506237 B CN 101506237B CN 200780031002 A CN200780031002 A CN 200780031002A CN 101506237 B CN101506237 B CN 101506237B
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antibody
c5ar
cell
val
leu
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CN101506237A (zh
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查尔斯·雷伊·麦凯
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Novonotice Co ltd
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G2 Inflammation Pty Ltd
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    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C07K2317/00—Immunoglobulins specific features
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    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
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    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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CN200780031002.5A 2006-08-22 2007-08-22 具有改进性能的抗-C5aR抗体 Expired - Fee Related CN101506237B (zh)

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CN201410134435.5A CN104059149B (zh) 2006-08-22 2007-08-22 具有改进性能的抗‑C5aR抗体

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US83963406P 2006-08-22 2006-08-22
US60/839,634 2006-08-22
PCT/AU2007/001207 WO2008022390A1 (en) 2006-08-22 2007-08-22 Anti-c5ar antibodies with improved properties

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CN101506237A CN101506237A (zh) 2009-08-12
CN101506237B true CN101506237B (zh) 2014-05-07

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US (1) US8337852B2 (enExample)
EP (2) EP2051997B1 (enExample)
JP (1) JP5162587B2 (enExample)
KR (1) KR20090053899A (enExample)
CN (2) CN101506237B (enExample)
AU (1) AU2007288118A1 (enExample)
BR (1) BRPI0715703A2 (enExample)
CA (1) CA2660156A1 (enExample)
ES (1) ES2570153T3 (enExample)
IL (1) IL196960A0 (enExample)
MX (1) MX2009001914A (enExample)
NO (1) NO20091181L (enExample)
RU (1) RU2009110154A (enExample)
WO (1) WO2008022390A1 (enExample)
ZA (1) ZA200900954B (enExample)

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AU2003202297C1 (en) 2002-01-25 2006-05-18 G2 Therapies Ltd Anti-C5aR antibodies and uses thereof
AU2007288118A1 (en) 2006-08-22 2008-02-28 G2 Inflammation Pty Ltd Anti-C5aR antibodies with improved properties
KR20100117120A (ko) 2008-02-20 2010-11-02 지투 인플레메이션 피티와이 엘티디 인간화된 항-Ｃ5ａＲ 항체
KR101800913B1 (ko) 2010-04-30 2017-12-20 알렉시온 파마슈티칼스, 인코포레이티드 항-c5a 항체들과 이 항체들을 이용하는 방법
US11130801B2 (en) * 2011-01-13 2021-09-28 Case Western Reserve University Method for inhibiting platelet derived growth factor signaling with C3aR or C5aR antibodies
RU2616881C2 (ru) * 2011-06-06 2017-04-18 Ново Нордиск А/С Терапевтические антитела
KR102006997B1 (ko) * 2012-07-03 2019-08-02 한국생명공학연구원 ＩｇＧ Ｆｃ 위치선택적 결합 펩티드 및 이를 포함하는 하이브리드 분자
CN106957366B (zh) * 2016-01-12 2022-02-01 上海昀怡健康科技发展有限公司 一种C5aR抗体及其制备方法和应用
WO2017142055A1 (ja) * 2016-02-17 2017-08-24 国立大学法人 東京医科歯科大学 動脈硬化性疾患の発症の予測因子および検査方法
CN106614260B (zh) * 2016-09-06 2019-11-08 广东省人民医院 一种C5aR基因敲除小鼠cGVHD模型的建立方法
US10376595B2 (en) 2017-04-03 2019-08-13 Inflarx Gmbh Treatment of inflammatory diseases with inhibitors of C5a activity
PL3411400T3 (pl) * 2017-04-03 2021-12-20 Inflarx Gmbh Leczenie chorób zapalnych za pomocą inhibitorów aktywności c5a
TWI869528B (zh) 2020-01-13 2025-01-11 美商威特拉公司 C5ar1抗體分子及其用途
AU2022207985A1 (en) 2021-01-13 2023-07-06 Visterra, Inc. Humanized complement 5a receptor 1 antibodies and methods of use thereof
US12180274B2 (en) 2023-05-26 2024-12-31 Inflarx Gmbh Treatment of pneumonia and ARDS with inhibitors of C5a and IL-6 activity

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CN101506237A (zh) 2009-08-12
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AU2007288118A1 (en) 2008-02-28

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