CN1015059B - 异喹啉衍生物的制备方法 - Google Patents

异喹啉衍生物的制备方法

Info

Publication number
CN1015059B
CN1015059B CN87105778A CN87105778A CN1015059B CN 1015059 B CN1015059 B CN 1015059B CN 87105778 A CN87105778 A CN 87105778A CN 87105778 A CN87105778 A CN 87105778A CN 1015059 B CN1015059 B CN 1015059B
Authority
CN
China
Prior art keywords
formula
compound
milliliters
salt
hydroxyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CN87105778A
Other languages
English (en)
Chinese (zh)
Other versions
CN87105778A (zh
Inventor
戈登·汉利·菲利普斯
保罗·斯潘塞·琼斯
马丁·爱德华·库珀
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB868618398A external-priority patent/GB8618398D0/en
Priority claimed from GB878710608A external-priority patent/GB8710608D0/en
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of CN87105778A publication Critical patent/CN87105778A/zh
Publication of CN1015059B publication Critical patent/CN1015059B/zh
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN87105778A 1986-07-29 1987-07-28 异喹啉衍生物的制备方法 Expired CN1015059B (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB868618398A GB8618398D0 (en) 1986-07-29 1986-07-29 Chemical compounds
GB8618398 1986-07-29
GB878710608A GB8710608D0 (en) 1987-05-05 1987-05-05 Chemical compounds
GB8710608 1987-05-05

Publications (2)

Publication Number Publication Date
CN87105778A CN87105778A (zh) 1988-02-24
CN1015059B true CN1015059B (zh) 1991-12-11

Family

ID=26291098

Family Applications (1)

Application Number Title Priority Date Filing Date
CN87105778A Expired CN1015059B (zh) 1986-07-29 1987-07-28 异喹啉衍生物的制备方法

Country Status (30)

Country Link
US (1) US4851399A (enExample)
JP (1) JPH02187A (enExample)
KR (1) KR880001652A (enExample)
CN (1) CN1015059B (enExample)
AT (1) ATA190987A (enExample)
AU (1) AU604731B2 (enExample)
BE (1) BE1002110A4 (enExample)
CH (1) CH672489A5 (enExample)
DE (1) DE3725185A1 (enExample)
DK (1) DK392187A (enExample)
ES (1) ES2007666A6 (enExample)
FI (1) FI873289A7 (enExample)
FR (1) FR2602233B1 (enExample)
GB (1) GB2195636B (enExample)
GR (1) GR871208B (enExample)
HK (1) HK8491A (enExample)
HU (1) HU201936B (enExample)
IL (1) IL83335A0 (enExample)
IT (1) IT1211683B (enExample)
LU (1) LU86956A1 (enExample)
MY (1) MY102457A (enExample)
NL (1) NL8701768A (enExample)
NO (1) NO872963L (enExample)
NZ (1) NZ221238A (enExample)
PH (1) PH25494A (enExample)
PL (1) PL267063A1 (enExample)
PT (1) PT85380B (enExample)
SE (1) SE8702986L (enExample)
SG (1) SG84490G (enExample)
SU (1) SU1676445A3 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8800312D0 (en) * 1988-01-07 1988-02-10 Glaxo Group Ltd Process
AU6836200A (en) * 1999-08-10 2001-03-05 Glaxo Group Limited Use of ep4 receptor ligands in the treatment of, inter alia, neuropathic pain and colon cancer
KR20030062812A (ko) * 2002-01-19 2003-07-28 한국과학기술원 금속주대용 플라스틱 자켓을 구비하는 인공보철물장치

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1087222A (en) * 1963-03-16 1967-10-18 Geigy Uk Ltd 12-nitronaphthindolizinediones and processes for their manufacture
US4029659A (en) * 1971-03-29 1977-06-14 Omnium Chimique Societe Anonyme N-disubstituted aminoethyl esters of 11-methoxy-raubasinic acid
US3894029A (en) * 1971-08-26 1975-07-08 Basf Ag Production of camptothecin and camptothecin-like compounds
US4042591A (en) * 1973-05-30 1977-08-16 Sandoz Ltd. Naphthoquinone compounds
US4033966A (en) * 1975-06-24 1977-07-05 Kanebo, Ltd. Novel berbine derivatives
US4087426A (en) * 1976-08-16 1978-05-02 Research Corporation Oxybisberberine and a process for its production
FR2387229A1 (fr) * 1977-04-13 1978-11-10 Anvar Dipyrido (4,3-b) (3,4-f) indoles, procede d'obtention, application therapeutique et compositions pharmaceutiques les contenant
FR2436786A1 (fr) * 1978-09-21 1980-04-18 Anvar Nouveaux derives des pyrido (4,3-b) carbazoles (ellipticines), substitues en position 1 par une chaine polyaminee, leur obtention et leur application a titre de medicaments
US4399282A (en) * 1979-07-10 1983-08-16 Kabushiki Kaisha Yakult Honsha Camptothecin derivatives
DK158666C (da) * 1982-11-04 1990-11-19 Glaxo Group Ltd Analogifremgangsmaade til fremstilling af 5,14-dihydrobenz-oe5,6aa-isoindolooe2,1-baa-isoquinolin-8,13-dion
NO163330C (no) * 1984-05-03 1990-05-09 Glaxo Group Ltd Analogifremgangsmaate ved fremstilling av terapeutisk aktive isokinolinderivater.

Also Published As

Publication number Publication date
AU7620387A (en) 1988-02-04
DK392187A (da) 1988-01-30
FI873289A0 (fi) 1987-07-28
DK392187D0 (da) 1987-07-28
JPH02187A (ja) 1990-01-05
BE1002110A4 (fr) 1990-07-10
PT85380A (en) 1987-08-01
ATA190987A (de) 1991-04-15
GR871208B (en) 1987-11-30
GB8717864D0 (en) 1987-09-03
US4851399A (en) 1989-07-25
CN87105778A (zh) 1988-02-24
SE8702986L (sv) 1989-01-29
NO872963D0 (no) 1987-07-15
LU86956A1 (fr) 1988-02-02
NL8701768A (nl) 1988-02-16
HK8491A (en) 1991-02-01
PT85380B (pt) 1990-04-30
KR880001652A (ko) 1988-04-25
SG84490G (en) 1991-01-04
PH25494A (en) 1991-07-24
AU604731B2 (en) 1991-01-03
SE8702986D0 (sv) 1987-07-28
GB2195636B (en) 1990-05-30
NO872963L (no) 1988-02-01
HUT46011A (en) 1988-09-28
PL267063A1 (en) 1988-09-01
FR2602233A1 (fr) 1988-02-05
IT1211683B (it) 1989-11-03
FR2602233B1 (fr) 1990-08-17
GB2195636A (en) 1988-04-13
ES2007666A6 (es) 1989-07-01
HU201936B (en) 1991-01-28
IT8748237A0 (it) 1987-07-28
CH672489A5 (enExample) 1989-11-30
NZ221238A (en) 1990-03-27
FI873289A7 (fi) 1988-01-30
DE3725185A1 (de) 1988-02-04
SU1676445A3 (ru) 1991-09-07
IL83335A0 (en) 1987-12-31
MY102457A (en) 1992-06-30

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PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C13 Decision
GR02 Examined patent application
AD01 Patent right deemed abandoned
C20 Patent right or utility model deemed to be abandoned or is abandoned