CN101495486B - 具有抗肿瘤活性的喜树碱衍生物 - Google Patents

具有抗肿瘤活性的喜树碱衍生物 Download PDF

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Publication number
CN101495486B
CN101495486B CN2007800283564A CN200780028356A CN101495486B CN 101495486 B CN101495486 B CN 101495486B CN 2007800283564 A CN2007800283564 A CN 2007800283564A CN 200780028356 A CN200780028356 A CN 200780028356A CN 101495486 B CN101495486 B CN 101495486B
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CN
China
Prior art keywords
mmol
nmr
cdcl
acoet
camptothecin
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Expired - Fee Related
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CN2007800283564A
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English (en)
Chinese (zh)
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CN101495486A (zh
Inventor
G·丰塔纳
E·邦巴尔代利
C·曼佐蒂
A·巴塔哥利亚
C·萨莫里
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)
CN2007800283564A 2006-07-26 2007-07-13 具有抗肿瘤活性的喜树碱衍生物 Expired - Fee Related CN101495486B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ITMI2006A001473 2006-07-26
IT001473A ITMI20061473A1 (it) 2006-07-26 2006-07-26 Derivati della camptotecina ad attivita antitumorale
PCT/EP2007/006243 WO2008011994A1 (en) 2006-07-26 2007-07-13 Camptothecin derivatives with antitumor activity

Publications (2)

Publication Number Publication Date
CN101495486A CN101495486A (zh) 2009-07-29
CN101495486B true CN101495486B (zh) 2013-05-15

Family

ID=38668829

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2007800283564A Expired - Fee Related CN101495486B (zh) 2006-07-26 2007-07-13 具有抗肿瘤活性的喜树碱衍生物

Country Status (20)

Country Link
US (1) US8217053B2 (cg-RX-API-DMAC7.html)
EP (1) EP2044079B1 (cg-RX-API-DMAC7.html)
JP (1) JP5313894B2 (cg-RX-API-DMAC7.html)
KR (1) KR101412157B1 (cg-RX-API-DMAC7.html)
CN (1) CN101495486B (cg-RX-API-DMAC7.html)
AU (1) AU2007278500B2 (cg-RX-API-DMAC7.html)
BR (1) BRPI0714553B8 (cg-RX-API-DMAC7.html)
CA (1) CA2658900C (cg-RX-API-DMAC7.html)
DK (1) DK2044079T3 (cg-RX-API-DMAC7.html)
ES (1) ES2561356T3 (cg-RX-API-DMAC7.html)
HU (1) HUE027890T2 (cg-RX-API-DMAC7.html)
IL (1) IL196653A (cg-RX-API-DMAC7.html)
IT (1) ITMI20061473A1 (cg-RX-API-DMAC7.html)
MX (1) MX2009000827A (cg-RX-API-DMAC7.html)
NO (1) NO341812B1 (cg-RX-API-DMAC7.html)
PL (1) PL2044079T3 (cg-RX-API-DMAC7.html)
PT (1) PT2044079E (cg-RX-API-DMAC7.html)
RU (1) RU2450008C2 (cg-RX-API-DMAC7.html)
SI (1) SI2044079T1 (cg-RX-API-DMAC7.html)
WO (1) WO2008011994A1 (cg-RX-API-DMAC7.html)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014057687A1 (ja) * 2012-10-11 2014-04-17 第一三共株式会社 抗体－薬物コンジュゲート
WO2014061277A1 (ja) 2012-10-19 2014-04-24 第一三共株式会社 親水性構造を含むリンカーで結合させた抗体－薬物コンジュゲート
KR101586030B1 (ko) * 2014-01-22 2016-01-15 주식회사 엘지생활건강 캄프토테신을 유효성분으로 포함하는 체모 성장 억제용 조성물
SI3101032T1 (sl) 2014-01-31 2019-02-28 Daiichi Sankyo Company, Limited Konjugat zdravila s protitelesci ANTI-HER2
US11173213B2 (en) 2015-06-29 2021-11-16 Daiichi Sankyo Company, Limited Method for selectively manufacturing antibody-drug conjugate
EP3552626A4 (en) 2016-12-12 2020-06-10 Daiichi Sankyo Company, Limited ASSOCIATION OF AN ANTIBODY DRUG CONJUGATE AND AN IMMUNE CONTROL POINT INHIBITOR
CN110382535A (zh) 2017-01-17 2019-10-25 第一三共株式会社 抗-gpr20抗体以及抗-gpr20抗体-药物缀合物
TW202530219A (zh) 2017-05-15 2025-08-01 日商第一三共股份有限公司 抗體－藥物結合物之製造方法
WO2019044946A1 (ja) 2017-08-31 2019-03-07 第一三共株式会社 抗体－薬物コンジュゲートの新規製造方法
JP7366745B2 (ja) 2017-08-31 2023-10-23 第一三共株式会社 抗体－薬物コンジュゲートの改良製造方法
US12479926B2 (en) 2018-05-18 2025-11-25 Daiichi Sankyo Co., Ltd. Anti-MUC1 antibody-drug conjugate
TWI846717B (zh) 2018-07-27 2024-07-01 日商第一三共股份有限公司 辨識抗體-藥物結合物之藥物部位的蛋白質
CN112805036A (zh) 2018-07-31 2021-05-14 第一三共株式会社 通过施用抗体-药物缀合物对转移性脑肿瘤的治疗
US10568873B1 (en) * 2019-02-14 2020-02-25 United Arab Emirates University Safranal-sorafenib combination therapy for liver cancer
CN112225745B (zh) * 2020-11-16 2021-10-12 烟台大学 一种具有抗肿瘤活性的异片螺素类化合物、制备方法及用途
CN114805377A (zh) * 2021-01-29 2022-07-29 明慧医药（杭州）有限公司 适用于抗体-药物偶联物的毒素分子
CN117510515A (zh) * 2022-07-28 2024-02-06 明慧医药（杭州）有限公司 适用于抗体-药物偶联物的毒素分子
WO2024230752A1 (zh) * 2023-05-08 2024-11-14 甘李药业股份有限公司 喜树碱衍生物、接头、配体-药物偶联物及其医药用途

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1221421A (zh) * 1996-06-05 1999-06-30 雷迪博士研究基金会 20(s)－喜树碱的新型水溶性c－环类似物

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4391909A (en) * 1979-03-28 1983-07-05 Damon Corporation Microcapsules containing viable tissue cells
FR2757515B1 (fr) * 1996-12-20 2000-05-05 Sod Conseils Rech Applic Formes prodrogues et nouveaux analogues de la camptothecine, leurs procedes de preparation, leur application comme medicaments et les compositions pharmaceutiques les contenant
US6881555B2 (en) * 1999-03-19 2005-04-19 Aventis Pharmaceuticals Inc. AKT nucleic acids, polypeptides, and uses thereof
EP1430059B1 (en) * 2001-09-25 2006-03-01 Dr. Reddy's Laboratories Ltd. Pharmaceutically acceptable salts of 20(s)-camptothecins
US20060084167A1 (en) * 2004-10-16 2006-04-20 Cohenford Menashi A Formation of Hybrid Cells by Fusion of Lineage Committed Cells with Stem Cells

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1221421A (zh) * 1996-06-05 1999-06-30 雷迪博士研究基金会 20(s)－喜树碱的新型水溶性c－环类似物

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
杨松等.高喜树碱-极具开发价值的拓扑异构酶I抑制剂.《药学学报》.2004,第39卷(第5期),396-400. *
罗猛等.喜树碱及其衍生物结构修饰及构效关系的研究.《中国药学杂志》.2006,第41卷(第11期),804-806. *

Also Published As

Publication number Publication date
EP2044079B1 (en) 2015-12-09
HK1135691A1 (en) 2010-06-11
CA2658900A1 (en) 2008-01-31
AU2007278500A1 (en) 2008-01-31
SI2044079T1 (sl) 2016-02-29
BRPI0714553B8 (pt) 2021-05-25
CN101495486A (zh) 2009-07-29
CA2658900C (en) 2015-09-15
IL196653A (en) 2015-04-30
ITMI20061473A1 (it) 2008-01-27
PT2044079E (pt) 2016-03-09
HUE027890T2 (en) 2016-11-28
BRPI0714553A2 (pt) 2013-03-26
PL2044079T3 (pl) 2016-06-30
US8217053B2 (en) 2012-07-10
RU2450008C2 (ru) 2012-05-10
US20100120816A1 (en) 2010-05-13
NO20090251L (no) 2009-01-16
JP2009544634A (ja) 2009-12-17
JP5313894B2 (ja) 2013-10-09
WO2008011994A1 (en) 2008-01-31
DK2044079T3 (en) 2016-02-29
IL196653A0 (en) 2009-11-18
AU2007278500B2 (en) 2012-06-07
KR101412157B1 (ko) 2014-06-25
KR20090033456A (ko) 2009-04-03
BRPI0714553B1 (pt) 2020-11-17
AU2007278500A2 (en) 2010-09-09
EP2044079A1 (en) 2009-04-08
MX2009000827A (es) 2009-02-03
RU2009102243A (ru) 2010-07-27
NO341812B1 (no) 2018-01-29
ES2561356T3 (es) 2016-02-25

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