CN101493446B - 一种检测样品或制品中游离聚乙二醇含量的方法 - Google Patents
一种检测样品或制品中游离聚乙二醇含量的方法 Download PDFInfo
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起始聚 乙二醇 浓度 | 游离聚乙二 醇的信号峰 面积 | 样品的 稀释倍 数Z | 游离的聚 乙二醇浓 度 | 修饰上的聚 乙二醇摩尔 浓度 | 精氨酸酶 的摩尔浓 度 | 精氨酸酶 的修饰度 |
12 (mg/ml) | 17520 | 2 | 3(mg/ml) | 4.5-7mol/l | 4.1-8mol/l | 11 |
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CN102507824B (zh) * | 2011-11-01 | 2013-10-09 | 北京三元基因工程有限公司 | 聚乙二醇修饰蛋白质的修饰位点分析方法 |
CN104991016B (zh) * | 2015-06-25 | 2017-04-05 | 吉林大学 | 一种生物样本中peg化药物的定量测定方法 |
CN104931637B (zh) * | 2015-06-25 | 2017-03-29 | 吉林大学 | 一种生物样本中peg含量的测定方法 |
CN105300972A (zh) * | 2015-10-10 | 2016-02-03 | 煤炭科学技术研究院有限公司 | 一种含酚含油复杂体系中乙二醇含量的测定方法 |
CN107219317B (zh) * | 2017-06-22 | 2020-01-21 | 广东省测试分析研究所(中国广州分析测试中心) | 一种快速测定聚乙二醇衍生物的分子量及其分布和杂质含量的方法 |
CN109682901A (zh) * | 2019-03-01 | 2019-04-26 | 重庆派金生物科技有限公司 | 聚乙二醇化蛋白类药物的平均修饰度测定方法 |
CN111855878A (zh) * | 2020-06-28 | 2020-10-30 | 中国食品药品检定研究院 | 一种克服质量歧视效应的聚乙二醇测定方法及应用 |
CN113092605B (zh) * | 2021-03-22 | 2023-06-23 | 中国日用化学研究院有限公司 | 一种用于低分子量聚乙二醇检测的分析方法 |
CN114405298B (zh) * | 2021-12-27 | 2024-05-14 | 苏州艾博生物科技有限公司 | 纯化聚乙二醇类缀合脂质的方法 |
CN114778712B (zh) * | 2022-03-21 | 2023-06-02 | 天津键凯科技有限公司 | 一种聚乙二醇脂质及含有该脂质的脂质纳米粒含量的检测方法 |
CN116223677B (zh) * | 2023-03-08 | 2023-07-28 | 浙江萃泽医药科技有限公司 | 一种美洛昔康粉末制剂中聚乙二醇400含量检测方法 |
CN117214342B (zh) * | 2023-10-18 | 2024-01-26 | 江苏诺和必拓新药研发有限公司 | 一种注射液胶束溶液中胶束浓度的测定方法 |
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