CN101478977B - 神经变性疾病的治疗 - Google Patents

神经变性疾病的治疗 Download PDF

Info

Publication number
CN101478977B
CN101478977B CN2007800122806A CN200780012280A CN101478977B CN 101478977 B CN101478977 B CN 101478977B CN 2007800122806 A CN2007800122806 A CN 2007800122806A CN 200780012280 A CN200780012280 A CN 200780012280A CN 101478977 B CN101478977 B CN 101478977B
Authority
CN
China
Prior art keywords
disease
selenate
protein
pp2a
tau
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN2007800122806A
Other languages
English (en)
Chinese (zh)
Other versions
CN101478977A (zh
Inventor
C·霍文斯
N·科尔科兰
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Velacor Therapeutics Pty Ltd
Original Assignee
Velacor Therapeutics Pty Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Velacor Therapeutics Pty Ltd filed Critical Velacor Therapeutics Pty Ltd
Publication of CN101478977A publication Critical patent/CN101478977A/zh
Application granted granted Critical
Publication of CN101478977B publication Critical patent/CN101478977B/zh
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/04—Sulfur, selenium or tellurium; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Inorganic Chemistry (AREA)
  • Psychology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
CN2007800122806A 2006-03-29 2007-03-29 神经变性疾病的治疗 Expired - Fee Related CN101478977B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US78724006P 2006-03-29 2006-03-29
US60/787,240 2006-03-29
PCT/AU2007/000391 WO2007109851A1 (en) 2006-03-29 2007-03-29 Treatment of neurodegenerative diseases

Publications (2)

Publication Number Publication Date
CN101478977A CN101478977A (zh) 2009-07-08
CN101478977B true CN101478977B (zh) 2013-03-27

Family

ID=38540722

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2007800122806A Expired - Fee Related CN101478977B (zh) 2006-03-29 2007-03-29 神经变性疾病的治疗

Country Status (14)

Country Link
US (2) US8920851B2 (https=)
EP (1) EP2004204B1 (https=)
JP (1) JP5542430B2 (https=)
KR (1) KR101451439B1 (https=)
CN (1) CN101478977B (https=)
AU (1) AU2007231547B2 (https=)
BR (1) BRPI0709033A2 (https=)
CA (1) CA2644441C (https=)
DK (1) DK2004204T3 (https=)
ES (1) ES2394348T3 (https=)
MX (1) MX2008012479A (https=)
NZ (2) NZ596244A (https=)
RU (1) RU2489155C2 (https=)
WO (1) WO2007109851A1 (https=)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2005276117C1 (en) 2004-08-23 2013-04-18 Yeda Research And Development Co. Ltd. At The Weizmann Institute Of Science Peptide inhibitors for mediating stress responses
MX2008012479A (es) 2006-03-29 2009-08-13 Velacor Therapeutics Pty Ltd Tratamiento de enfermedades neurodegenerativas.
US20080107755A1 (en) * 2006-04-24 2008-05-08 Alltech, Inc. Methods and compositions for altering cell function
US20100247679A1 (en) * 2006-04-24 2010-09-30 Alltech, Inc. Methods and compositions for altering cell function
WO2008119109A1 (en) * 2007-03-29 2008-10-09 Velacor Therapeutics Pty Ltd Treatment of neurological disorders
US8580776B2 (en) * 2007-07-10 2013-11-12 The Board Of Trustees Of The University Of Illinois Compositions and methods for treating neurodegenerating diseases
WO2009039586A2 (en) * 2007-09-28 2009-04-02 Powmri Limited Biomarkers for parkinson's disease
WO2009043106A1 (en) * 2007-10-03 2009-04-09 Velacor Therapeutics Pty Ltd Inorganic selenium and angiogenesis
WO2009043116A1 (en) * 2007-10-03 2009-04-09 Velacor Therapeutics Pty Ltd Methods and compositions for the treatment of phosphatase- related disorders
WO2009065596A2 (en) * 2007-11-22 2009-05-28 Develogen Aktiengesellschaft Use of mnk inhibitors for the treatment of alzheimer's disease
JP5328244B2 (ja) * 2008-07-07 2013-10-30 株式会社ニュージェン・ファーマ 筋萎縮性側索硬化症治療剤
JP2013507352A (ja) * 2009-10-09 2013-03-04 テバ ファーマシューティカル インダストリーズ リミティド 進行性核上性麻痺の治療のためのラサギリンの使用
CA2836503C (en) 2011-05-23 2020-09-22 Yeda Research And Development Co. Ltd. Use of akt phosphorylation as a biomarker for prognosing neurodegenerative diseases and treating same
AU2016235685B2 (en) * 2015-03-26 2019-04-18 Shanghai Auzone Biological Technology Co., Ltd. Method of diagnosis or treatment of neurological disorders with p75ECD and/or p75
WO2019216589A1 (ko) * 2018-05-09 2019-11-14 한국과학기술연구원 타우 관련 질환의 예방 또는 치료용 조성물
KR102846956B1 (ko) * 2018-06-29 2025-08-14 리주베나떼 바이오메드 엔브이 노화-관련 질환 및/또는 퇴행성 질환에 사용하는 약제학적 결합물
JP7518852B2 (ja) 2019-03-26 2024-07-18 シアー， インコーポレイテッド 生物流体からのタンパク質コロナ分析のための組成物、方法およびシステム、ならびにそれらの使用
WO2023029210A1 (zh) * 2021-08-31 2023-03-09 上海交通大学医学院附属瑞金医院 Pp2a激动剂、清除和/或溶解衰老细胞和/或抑制细胞衰老的化合物用于治疗精神障碍
WO2023057422A1 (en) * 2021-10-06 2023-04-13 Bayer Aktiengesellschaft Universal buffer in methods for safe and rapid detection of pathogen infection

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003066071A1 (en) * 2002-02-07 2003-08-14 Laxdale Limited Formulations comprising psychotropic drugs and selenium

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8601915D0 (en) * 1986-01-27 1986-03-05 Efamol Ltd Pharmaceutical compositions
JPH04247033A (ja) 1991-02-04 1992-09-03 Yoshitomi Pharmaceut Ind Ltd 神経細胞壊死抑制剤
US6746678B1 (en) * 1991-02-22 2004-06-08 Howard K. Shapiro Method of treating neurological diseases and etiologically related symptomology using carbonyl trapping agents in combination with medicaments
US5695752A (en) * 1992-09-11 1997-12-09 The Regents Of The University Of California Treating inflammation via the administration of specific sulfatase enzymes and/or sulfation inhibitor
WO1995024920A1 (en) 1994-03-16 1995-09-21 The Regents Of The University Of California Treating inflammation via the administration of specific sulfatase enzymes and/or sulfation inhibitor
US6524619B2 (en) * 2000-01-27 2003-02-25 Chronorx, Inc. Dosage forms useful for modifying conditions and functions associated with hearing loss and/or tinnitus
DE10059886A1 (de) * 2000-12-01 2002-06-20 Basf Coatings Ag Verwendung von wässrigen, physikalisch härtbaren Beschichtungsstoffen auf Polyurethanbasis als Haftgrundierung von Lackierungen
AU2003262642B2 (en) * 2002-08-14 2010-06-17 Vertex Pharmaceuticals Incorporated Protein kinase inhibitors and uses thereof
BRPI0409914A (pt) 2003-04-30 2006-04-25 Inst For Pharm Discovery Inc ácidos carboxìlicos substituìdos
AU2003904328A0 (en) 2003-08-13 2003-08-28 Garvan Institute Of Medical Research Diagnosis and treatment of neurodegenerative disorders
WO2005023274A1 (en) 2003-09-05 2005-03-17 Yissum Research Development Company Of The Hebrew University Of Jerusalem Treatment and prevention of inflammatory disease and mitochondrial dysfunction with high dose selenium
US20050142216A1 (en) * 2003-12-31 2005-06-30 Rindlesbach Keith A. Method for reversing Alzheimer dementia
US20080004255A1 (en) * 2005-10-14 2008-01-03 Alltech, Inc. Methods and compositions for altering cell function
CN101073584B (zh) 2005-10-14 2012-10-10 全面技术公司 改变细胞功能的方法和组合物
MX2008012479A (es) 2006-03-29 2009-08-13 Velacor Therapeutics Pty Ltd Tratamiento de enfermedades neurodegenerativas.
EP2004205A4 (en) 2006-03-29 2010-06-09 Velacor Therapeutics Pty Ltd INORGANIC SELEN FOR THE TREATMENT OF GOOD TUMORS

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003066071A1 (en) * 2002-02-07 2003-08-14 Laxdale Limited Formulations comprising psychotropic drugs and selenium

Also Published As

Publication number Publication date
AU2007231547B2 (en) 2012-07-12
US20090169649A1 (en) 2009-07-02
KR101451439B1 (ko) 2014-10-16
EP2004204A1 (en) 2008-12-24
NZ596244A (en) 2013-05-31
US20140141104A1 (en) 2014-05-22
AU2007231547A1 (en) 2007-10-04
RU2008142514A (ru) 2010-05-10
EP2004204B1 (en) 2012-09-12
JP2009532340A (ja) 2009-09-10
NZ571835A (en) 2011-11-25
CN101478977A (zh) 2009-07-08
JP5542430B2 (ja) 2014-07-09
EP2004204A4 (en) 2010-06-02
KR20090015038A (ko) 2009-02-11
CA2644441A1 (en) 2007-10-04
MX2008012479A (es) 2009-08-13
US8920851B2 (en) 2014-12-30
CA2644441C (en) 2014-09-09
ES2394348T3 (es) 2013-01-30
DK2004204T3 (da) 2013-01-07
RU2489155C2 (ru) 2013-08-10
WO2007109851A1 (en) 2007-10-04
BRPI0709033A2 (pt) 2011-06-21

Similar Documents

Publication Publication Date Title
CN101478977B (zh) 神经变性疾病的治疗
JP5736421B2 (ja) 生理学的過程の調節およびこれに有用な薬剤
JP5616631B2 (ja) 細胞機能を変化させるための方法および組成物
Sharma et al. Synergistic effects of GSK-3β and HDAC inhibitors in intracerebroventricular streptozotocin-induced cognitive deficits in rats
Yabuki et al. Oral L-citrulline administration improves memory deficits following transient brain ischemia through cerebrovascular protection
Rozisky et al. Neonatal morphine administration leads to changes in hippocampal BDNF levels and antioxidant enzyme activity in the adult life of rats
ES2402365T3 (es) Uso de compuestos de selenio, especialmente levaduras de selenio, para modificar la función cognitiva
US20220195524A1 (en) Methods and compositions for diagnosis and management of neurodegerative diseases
PT2282779E (pt) Novas abordagens terapêuticas para o tratamento da doença de alzheimer e doenças relacionadas através de uma modulação de resposta ao stresse celular
Malavolta et al. Trace elements and minerals in health and longevity
Bignante et al. APP/Go protein Gβγ-complex signaling mediates Aβ degeneration and cognitive impairment in Alzheimer's disease models
JP2025024030A (ja) ミトコンドリア標的化及び抗癌治療のためのアルキルｔｐｐ化合物
Jesudason et al. Anti-inflammatory effect of melatonin on Aβ vaccination in mice
Zhang et al. TMEM175 downregulation participates in impairment of the autophagy related lysosomal dynamics following neonatal hypoxic‐ischemic brain injury
US20190105341A1 (en) Compositions and Methods for Treating Alzheimer's Disease and Other Tauopathies
WO2008119109A1 (en) Treatment of neurological disorders
Zhang et al. Therapeutic potential of salidroside in preserving rat cochlea organ of corti from gentamicin-induced injury through modulation of NRF2 signaling and GSK3β/NF-κB pathway
Park et al. Protective effects of phosphodiesterase 5 inhibitor, mirodenafil, on traumatic brain injury-induced neuron death
Zhang et al. Histone deacetylase inhibitors VPA and WT161 ameliorate the pathological features and cognitive impairments of the Alzheimer's disease mouse model by regulating the expression of App secretases
Wagih Pathogenesis of PARK-7 knocked out Parkinson’s disease in vitro using isogenic induced pluripotent stem cells
Falah The role of the cdk5 pathway and NMDA receptor phosphorylation in neurodegeneration in hippocampal sclerosis
Morgan-Bathke The role of autophagy in salivary gland dysfunction following targeted head and neck radiation
Zhao Role of TRPM2 in Autophagy of Vascular Smooth Muscle Cells and Cardiomyocytes
Lieb et al. www. nature. com/scientificreports OPEN Identification of disulfiram as a secretase-modulating compound with beneficial effects on Received: 1 September 2017
Kim Simultaneously inhibiting multiple nutrient acquisition pathways using synthetic sphingolipid compounds

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20130327

Termination date: 20180329

CF01 Termination of patent right due to non-payment of annual fee