BRPI0709033A2 - composição farmacêutica, métodos de tratamento ou prevenção de doença neurodegenerativa numa pessoa, de inibição ou redução da fosforilação de uma proteìna tau num neurÈnio, célula glial ou corpo de lewy, de intensificação da atividade de pp2a e de inibição da atividade de gsk3 num neurÈnio ou célula glial e uso de selenato ou sal farmaceuticamamente aceitável do mesmo - Google Patents
composição farmacêutica, métodos de tratamento ou prevenção de doença neurodegenerativa numa pessoa, de inibição ou redução da fosforilação de uma proteìna tau num neurÈnio, célula glial ou corpo de lewy, de intensificação da atividade de pp2a e de inibição da atividade de gsk3 num neurÈnio ou célula glial e uso de selenato ou sal farmaceuticamamente aceitável do mesmo Download PDFInfo
- Publication number
- BRPI0709033A2 BRPI0709033A2 BRPI0709033-1A BRPI0709033A BRPI0709033A2 BR PI0709033 A2 BRPI0709033 A2 BR PI0709033A2 BR PI0709033 A BRPI0709033 A BR PI0709033A BR PI0709033 A2 BRPI0709033 A2 BR PI0709033A2
- Authority
- BR
- Brazil
- Prior art keywords
- selenate
- pp2a
- tau
- activity
- protein
- Prior art date
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- 230000002269 spontaneous effect Effects 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
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- 239000000829 suppository Substances 0.000 description 1
- 230000009182 swimming Effects 0.000 description 1
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- 229960001685 tacrine Drugs 0.000 description 1
- 239000008399 tap water Substances 0.000 description 1
- 235000020679 tap water Nutrition 0.000 description 1
- 229940000238 tasmar Drugs 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- MIQPIUSUKVNLNT-UHFFFAOYSA-N tolcapone Chemical compound C1=CC(C)=CC=C1C(=O)C1=CC(O)=C(O)C([N+]([O-])=O)=C1 MIQPIUSUKVNLNT-UHFFFAOYSA-N 0.000 description 1
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- QDWJJTJNXAKQKD-UHFFFAOYSA-N trihexyphenidyl hydrochloride Chemical compound Cl.C1CCCCC1C(C=1C=CC=CC=1)(O)CCN1CCCCC1 QDWJJTJNXAKQKD-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/04—Sulfur, selenium or tellurium; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
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- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Neurosurgery (AREA)
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- Psychology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Enzymes And Modification Thereof (AREA)
- Thiazole And Isothizaole Compounds (AREA)
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| JP (1) | JP5542430B2 (https=) |
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| NZ (2) | NZ571835A (https=) |
| RU (1) | RU2489155C2 (https=) |
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| HUE024953T2 (en) | 2004-08-23 | 2016-02-29 | Yeda Res & Dev | Peptide inhibitors to mediate stress responses |
| ES2394348T3 (es) | 2006-03-29 | 2013-01-30 | Velacor Therapeutics Pty Ltd | Tratamiento de enfermedades neurodegenerativas con selenato |
| EP2012806A4 (en) * | 2006-04-24 | 2010-07-28 | Alltech Inc | METHOD AND COMPOSITIONS FOR MODIFYING CELL FUNCTIONS |
| US20100247679A1 (en) * | 2006-04-24 | 2010-09-30 | Alltech, Inc. | Methods and compositions for altering cell function |
| WO2008119109A1 (en) * | 2007-03-29 | 2008-10-09 | Velacor Therapeutics Pty Ltd | Treatment of neurological disorders |
| US8580776B2 (en) * | 2007-07-10 | 2013-11-12 | The Board Of Trustees Of The University Of Illinois | Compositions and methods for treating neurodegenerating diseases |
| WO2009039586A2 (en) * | 2007-09-28 | 2009-04-02 | Powmri Limited | Biomarkers for parkinson's disease |
| WO2009043106A1 (en) * | 2007-10-03 | 2009-04-09 | Velacor Therapeutics Pty Ltd | Inorganic selenium and angiogenesis |
| WO2009043116A1 (en) * | 2007-10-03 | 2009-04-09 | Velacor Therapeutics Pty Ltd | Methods and compositions for the treatment of phosphatase- related disorders |
| EP2219649A2 (en) * | 2007-11-22 | 2010-08-25 | Boehringer Ingelheim International Gmbh | Use of mnk inhibitors for the treatment of alzheimer's disease |
| JP5328244B2 (ja) * | 2008-07-07 | 2013-10-30 | 株式会社ニュージェン・ファーマ | 筋萎縮性側索硬化症治療剤 |
| AU2010304755A1 (en) * | 2009-10-09 | 2012-05-24 | Teva Pharmaceutical Industries, Ltd. | Use of rasagiline for the treatment of Progressive Supranuclear Palsy |
| EP2715350B1 (en) | 2011-05-23 | 2017-09-27 | Yeda Research and Development Co. Ltd. | Use of akt phosphorylation as a biomarker for prognosing neurodegenerative diseases and treating same |
| WO2016150403A1 (en) | 2015-03-26 | 2016-09-29 | Fujian Tiantai Medical Technology Co. Ltd | Method of diagnosis or treatment of neurological disorders with p75ecd and/or p75 |
| WO2019216589A1 (ko) * | 2018-05-09 | 2019-11-14 | 한국과학기술연구원 | 타우 관련 질환의 예방 또는 치료용 조성물 |
| BR112020026456A2 (pt) * | 2018-06-29 | 2021-03-23 | Rejuvenate Biomed | Combinação farmacêutica para o uso em doenças relacionadas com a idade e/ou degenerativas |
| JP7518852B2 (ja) | 2019-03-26 | 2024-07-18 | シアー， インコーポレイテッド | 生物流体からのタンパク質コロナ分析のための組成物、方法およびシステム、ならびにそれらの使用 |
| WO2023029210A1 (zh) * | 2021-08-31 | 2023-03-09 | 上海交通大学医学院附属瑞金医院 | Pp2a激动剂、清除和/或溶解衰老细胞和/或抑制细胞衰老的化合物用于治疗精神障碍 |
| WO2023057422A1 (en) * | 2021-10-06 | 2023-04-13 | Bayer Aktiengesellschaft | Universal buffer in methods for safe and rapid detection of pathogen infection |
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| GB8601915D0 (en) * | 1986-01-27 | 1986-03-05 | Efamol Ltd | Pharmaceutical compositions |
| JPH04247033A (ja) | 1991-02-04 | 1992-09-03 | Yoshitomi Pharmaceut Ind Ltd | 神経細胞壊死抑制剤 |
| US6746678B1 (en) * | 1991-02-22 | 2004-06-08 | Howard K. Shapiro | Method of treating neurological diseases and etiologically related symptomology using carbonyl trapping agents in combination with medicaments |
| US5695752A (en) | 1992-09-11 | 1997-12-09 | The Regents Of The University Of California | Treating inflammation via the administration of specific sulfatase enzymes and/or sulfation inhibitor |
| EP0750511B1 (en) | 1994-03-16 | 2003-06-11 | The Regents Of The University Of California | Treating inflammation via the administration of specific sulfatase enzymes and/or sulfation inhibitor |
| US6524619B2 (en) | 2000-01-27 | 2003-02-25 | Chronorx, Inc. | Dosage forms useful for modifying conditions and functions associated with hearing loss and/or tinnitus |
| DE10059886A1 (de) | 2000-12-01 | 2002-06-20 | Basf Coatings Ag | Verwendung von wässrigen, physikalisch härtbaren Beschichtungsstoffen auf Polyurethanbasis als Haftgrundierung von Lackierungen |
| GB0202900D0 (en) * | 2002-02-07 | 2002-03-27 | Laxdale Ltd | Novel formulations of drugs |
| MXPA05001804A (es) | 2002-08-14 | 2005-05-27 | Vertex Pharma | Inhibidores de proteinas cinasas y usos de los mismos. |
| CN1812977A (zh) | 2003-04-30 | 2006-08-02 | 药物研发有限责任公司 | 取代羧酸 |
| AU2003904328A0 (en) | 2003-08-13 | 2003-08-28 | Garvan Institute Of Medical Research | Diagnosis and treatment of neurodegenerative disorders |
| WO2005023274A1 (en) | 2003-09-05 | 2005-03-17 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Treatment and prevention of inflammatory disease and mitochondrial dysfunction with high dose selenium |
| US20050142216A1 (en) | 2003-12-31 | 2005-06-30 | Rindlesbach Keith A. | Method for reversing Alzheimer dementia |
| TWI319708B (en) | 2005-10-14 | 2010-01-21 | Methods and compositions for altering cell fuction | |
| US20080004255A1 (en) | 2005-10-14 | 2008-01-03 | Alltech, Inc. | Methods and compositions for altering cell function |
| ES2394348T3 (es) | 2006-03-29 | 2013-01-30 | Velacor Therapeutics Pty Ltd | Tratamiento de enfermedades neurodegenerativas con selenato |
| CA2644445A1 (en) | 2006-03-29 | 2007-10-04 | Velacor Therapeutics Pty Ltd | Inorganic selenium for treatment of benign tumors |
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| US8920851B2 (en) | 2014-12-30 |
| US20090169649A1 (en) | 2009-07-02 |
| DK2004204T3 (da) | 2013-01-07 |
| NZ596244A (en) | 2013-05-31 |
| WO2007109851A1 (en) | 2007-10-04 |
| NZ571835A (en) | 2011-11-25 |
| AU2007231547A1 (en) | 2007-10-04 |
| KR101451439B1 (ko) | 2014-10-16 |
| RU2008142514A (ru) | 2010-05-10 |
| CA2644441A1 (en) | 2007-10-04 |
| RU2489155C2 (ru) | 2013-08-10 |
| EP2004204B1 (en) | 2012-09-12 |
| ES2394348T3 (es) | 2013-01-30 |
| CA2644441C (en) | 2014-09-09 |
| JP2009532340A (ja) | 2009-09-10 |
| KR20090015038A (ko) | 2009-02-11 |
| EP2004204A4 (en) | 2010-06-02 |
| CN101478977B (zh) | 2013-03-27 |
| CN101478977A (zh) | 2009-07-08 |
| AU2007231547B2 (en) | 2012-07-12 |
| JP5542430B2 (ja) | 2014-07-09 |
| EP2004204A1 (en) | 2008-12-24 |
| MX2008012479A (es) | 2009-08-13 |
| US20140141104A1 (en) | 2014-05-22 |
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