CN101472587A - 包含氨氯地平和氯沙坦的药物组合物 - Google Patents
包含氨氯地平和氯沙坦的药物组合物 Download PDFInfo
- Publication number
- CN101472587A CN101472587A CNA2007800229752A CN200780022975A CN101472587A CN 101472587 A CN101472587 A CN 101472587A CN A2007800229752 A CNA2007800229752 A CN A2007800229752A CN 200780022975 A CN200780022975 A CN 200780022975A CN 101472587 A CN101472587 A CN 101472587A
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- Prior art keywords
- amlodipine
- materia medica
- acceptable salt
- losartan
- compositions
- Prior art date
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
- A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
Description
时间(min) | 流动相A% | 流动相B% |
0 | 80 | 20 |
10 | 40 | 60 |
11 | 80 | 20 |
15 | 80 | 20 |
制剂 | 0 | 1个月 | 2个月 | 4个月 | 6个月 |
实施例1 | 100.3% | 100.2% | 99.6% | 98.9% | 99.1% |
比较例1 | 100.2% | 97.8% | 94.9% | 90.3% | 85.7% |
Claims (13)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1020060124552 | 2006-12-08 | ||
KR10-2006-0124552 | 2006-12-08 | ||
KR1020060124552A KR101247583B1 (ko) | 2006-12-08 | 2006-12-08 | 암로디핀 또는 이의 약제학적 허용가능한 염, 및 로자탄또는 이의 약제학적 허용가능한 염을 함유하는 약제학적조성물 |
PCT/KR2007/006352 WO2008069612A1 (en) | 2006-12-08 | 2007-12-07 | Pharmaceutical composition comprising amlodipine and losartan |
Publications (2)
Publication Number | Publication Date |
---|---|
CN101472587A true CN101472587A (zh) | 2009-07-01 |
CN101472587B CN101472587B (zh) | 2013-11-20 |
Family
ID=39492408
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN2007800229752A Expired - Fee Related CN101472587B (zh) | 2006-12-08 | 2007-12-07 | 包含氨氯地平和氯沙坦的药物组合物 |
Country Status (20)
Country | Link |
---|---|
US (1) | US20100233261A1 (zh) |
EP (1) | EP2037917B1 (zh) |
JP (1) | JP4995912B2 (zh) |
KR (1) | KR101247583B1 (zh) |
CN (1) | CN101472587B (zh) |
AU (1) | AU2007328630B2 (zh) |
BR (1) | BRPI0713306A8 (zh) |
CA (1) | CA2654054C (zh) |
EC (1) | ECSP088980A (zh) |
ES (1) | ES2522567T3 (zh) |
HK (1) | HK1131916A1 (zh) |
IL (1) | IL195581A (zh) |
MX (1) | MX2008016099A (zh) |
MY (1) | MY144857A (zh) |
NO (1) | NO20085302L (zh) |
NZ (1) | NZ573223A (zh) |
RU (1) | RU2401107C2 (zh) |
UA (1) | UA92641C2 (zh) |
WO (1) | WO2008069612A1 (zh) |
ZA (2) | ZA200910116B (zh) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
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CN102335172A (zh) * | 2011-07-20 | 2012-02-01 | 海南锦瑞制药股份有限公司 | 一种氨氯地平与氯沙坦钾药用组合物及其制备方法 |
Families Citing this family (17)
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TWI503119B (zh) * | 2009-01-23 | 2015-10-11 | Hanmi Science Co Ltd | 含有氨氯地平(amlodipine)及洛沙坦(losartan)之固體藥學組成物及其製造方法 |
CA2749903C (en) * | 2009-01-23 | 2016-09-06 | Jae Hyun Park | Solid pharmaceutical composition comprising amlodipine and losartan and process for producing same |
CN101849942B (zh) * | 2009-04-02 | 2012-05-23 | 鲁南制药集团股份有限公司 | 治疗高血压的药物组合物 |
CN101849941B (zh) * | 2009-04-02 | 2012-04-18 | 鲁南制药集团股份有限公司 | 一种治疗高血压的药物组合物 |
PT2448561E (pt) * | 2009-06-30 | 2013-11-21 | Sanofi Sa | Composições farmacêuticas sólidas de dose fixa compreendendo irbesartan e amlodipina, sua preparação e seu aplicação terapêutica |
JP2011136908A (ja) * | 2009-12-25 | 2011-07-14 | Kyowa Yakuhin Kogyo Kk | アンギオテンシンii受容体拮抗剤を含む固形製剤および固形製剤におけるアンギオテンシンii受容体拮抗剤の保存安定性向上方法 |
EP2632438A1 (en) * | 2010-10-27 | 2013-09-04 | KRKA, tovarna zdravil, d.d., Novo mesto | Multilayer pharmaceutical composition comprising telmisartan and amlodipine |
KR101907881B1 (ko) * | 2011-12-30 | 2018-12-11 | 한미약품 주식회사 | 로자탄, 암로디핀 및 히드로클로로티아자이드를 포함하는 고정 용량 조합 제형 |
KR101392364B1 (ko) * | 2012-04-17 | 2014-05-07 | 한국유나이티드제약 주식회사 | 안정성이 향상된 암로디핀 및 로잘탄을 함유하는 복합제 조성물 |
KR101910901B1 (ko) * | 2013-11-29 | 2018-10-24 | 한미약품 주식회사 | 암로디핀, 로자탄 및 로수바스타틴을 포함하는 약제학적 복합 제제 |
KR20150078215A (ko) * | 2013-12-30 | 2015-07-08 | (주) 드림파마 | 에프로사탄 및 암로디핀을 포함하는 복합제제 및 이의 제조방법 |
KR102369607B1 (ko) * | 2014-09-30 | 2022-03-03 | 한미약품 주식회사 | 암로디핀 및 로잘탄을 포함하는 고형 약제학적 조성물 |
KR101914930B1 (ko) * | 2015-03-31 | 2018-11-05 | 한미약품 주식회사 | 암로디핀, 로자탄 및 클로르탈리돈을 포함하는 약제학적 복합 제제 |
KR101750689B1 (ko) * | 2015-09-15 | 2017-06-26 | 주식회사 종근당 | 약제학적 복합제제 |
KR101710441B1 (ko) * | 2015-12-28 | 2017-02-28 | 신풍제약주식회사 | 안정성 및 용출성이 향상된 정제 |
CN110215455A (zh) * | 2019-03-26 | 2019-09-10 | 山东省药学科学院 | 一种用于降血压的药物配方 |
CN112274490B (zh) * | 2020-11-19 | 2022-11-22 | 四川尚锐生物医药有限公司 | 一种氨氯地平氯沙坦钾复方组合物的制备方法 |
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WO1997049392A1 (en) * | 1996-06-24 | 1997-12-31 | Merck & Co., Inc. | A composition of enalapril and losartan |
AU1042199A (en) * | 1998-11-06 | 2000-05-29 | Boehringer Ingelheim International Gmbh | Antihypertensive medicaments containing lacidipine and telmisartan |
CA2420844A1 (en) * | 2000-08-30 | 2003-02-28 | Sankyo Company, Limited | Medicinal compositions for preventing or treating heart failure |
US20040137062A1 (en) * | 2001-05-25 | 2004-07-15 | Sham Chopra | Chronotherapy tablet and methods related thereto |
KR100558505B1 (ko) * | 2003-01-27 | 2006-03-07 | 한미약품 주식회사 | 안정한 무정형 암로디핀 캠실레이트, 이의 제조방법 및이를 포함하는 경구투여용 조성물 |
NZ541454A (en) * | 2003-01-31 | 2008-04-30 | Daiichi Sankyo Co Ltd | Medicine for prevention of and treatment for arteriosclerosis and hypertension |
AR043395A1 (es) * | 2003-02-28 | 2005-07-27 | Recordati Ireland Ltd | Terapia de combinacion para la hipertension utilizando lercanidipina y un bloqueante de los receptores de angiotensina ii |
US20040253305A1 (en) * | 2003-06-12 | 2004-12-16 | Luner Paul E. | Pharmaceutical compositions of atorvastatin |
US20050209288A1 (en) * | 2004-01-12 | 2005-09-22 | Grogan Donna R | Compositions comprising (S)-amlodipine malate and an angiotensin receptor blocker and methods of their use |
US20060068010A1 (en) * | 2004-09-30 | 2006-03-30 | Stephen Turner | Method for improving the bioavailability of orally delivered therapeutics |
ES2452019T5 (es) * | 2004-11-05 | 2021-06-28 | Boehringer Ingelheim Int | Comprimido bicapa que comprende telmisartán y amlodipino |
JP5110697B2 (ja) * | 2005-06-27 | 2012-12-26 | 第一三共株式会社 | 固形製剤 |
KR100888131B1 (ko) * | 2006-10-10 | 2009-03-11 | 한올제약주식회사 | 시간차 투약 원리를 이용한 심혈관계 질환 치료용 복합제제 |
-
2006
- 2006-12-08 KR KR1020060124552A patent/KR101247583B1/ko active IP Right Grant
-
2007
- 2007-12-07 UA UAA200814649A patent/UA92641C2/ru unknown
- 2007-12-07 ZA ZA200910116A patent/ZA200910116B/xx unknown
- 2007-12-07 CA CA2654054A patent/CA2654054C/en not_active Expired - Fee Related
- 2007-12-07 MY MYPI20084882A patent/MY144857A/en unknown
- 2007-12-07 WO PCT/KR2007/006352 patent/WO2008069612A1/en active Application Filing
- 2007-12-07 US US12/303,034 patent/US20100233261A1/en not_active Abandoned
- 2007-12-07 NZ NZ573223A patent/NZ573223A/en not_active IP Right Cessation
- 2007-12-07 JP JP2009522726A patent/JP4995912B2/ja not_active Expired - Fee Related
- 2007-12-07 ES ES07851323.1T patent/ES2522567T3/es active Active
- 2007-12-07 EP EP07851323.1A patent/EP2037917B1/en not_active Not-in-force
- 2007-12-07 MX MX2008016099A patent/MX2008016099A/es unknown
- 2007-12-07 BR BRPI0713306A patent/BRPI0713306A8/pt active Search and Examination
- 2007-12-07 CN CN2007800229752A patent/CN101472587B/zh not_active Expired - Fee Related
- 2007-12-07 AU AU2007328630A patent/AU2007328630B2/en not_active Ceased
- 2007-12-07 RU RU2008150477/15A patent/RU2401107C2/ru not_active IP Right Cessation
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2008
- 2008-11-27 ZA ZA2008/10116A patent/ZA200810116B/en unknown
- 2008-11-27 IL IL195581A patent/IL195581A/en not_active IP Right Cessation
- 2008-12-12 EC EC2008008980A patent/ECSP088980A/es unknown
- 2008-12-18 NO NO20085302A patent/NO20085302L/no not_active Application Discontinuation
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102335172A (zh) * | 2011-07-20 | 2012-02-01 | 海南锦瑞制药股份有限公司 | 一种氨氯地平与氯沙坦钾药用组合物及其制备方法 |
CN102335172B (zh) * | 2011-07-20 | 2012-12-12 | 海南锦瑞制药股份有限公司 | 一种氨氯地平与氯沙坦钾药用组合物及其制备方法 |
Also Published As
Publication number | Publication date |
---|---|
MY144857A (en) | 2011-11-30 |
ZA200910116B (en) | 2010-07-28 |
BRPI0713306A2 (pt) | 2012-04-17 |
EP2037917A1 (en) | 2009-03-25 |
ES2522567T3 (es) | 2014-11-17 |
JP4995912B2 (ja) | 2012-08-08 |
ECSP088980A (es) | 2009-02-27 |
CA2654054A1 (en) | 2008-06-12 |
RU2008150477A (ru) | 2010-06-27 |
WO2008069612A1 (en) | 2008-06-12 |
AU2007328630A1 (en) | 2008-06-12 |
NZ573223A (en) | 2012-07-27 |
CN101472587B (zh) | 2013-11-20 |
HK1131916A1 (en) | 2010-02-12 |
EP2037917B1 (en) | 2014-10-08 |
EP2037917A4 (en) | 2010-08-04 |
IL195581A (en) | 2015-08-31 |
MX2008016099A (es) | 2009-01-19 |
JP2009544752A (ja) | 2009-12-17 |
ZA200810116B (en) | 2010-07-28 |
NO20085302L (no) | 2009-06-17 |
AU2007328630B2 (en) | 2010-03-11 |
KR101247583B1 (ko) | 2013-03-26 |
IL195581A0 (en) | 2009-09-01 |
BRPI0713306A8 (pt) | 2016-06-07 |
KR20080052852A (ko) | 2008-06-12 |
RU2401107C2 (ru) | 2010-10-10 |
UA92641C2 (ru) | 2010-11-25 |
US20100233261A1 (en) | 2010-09-16 |
CA2654054C (en) | 2013-01-08 |
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