CN101460156B - 抗痴呆药的经皮吸收制剂 - Google Patents

抗痴呆药的经皮吸收制剂 Download PDF

Info

Publication number
CN101460156B
CN101460156B CN200680054495XA CN200680054495A CN101460156B CN 101460156 B CN101460156 B CN 101460156B CN 200680054495X A CN200680054495X A CN 200680054495XA CN 200680054495 A CN200680054495 A CN 200680054495A CN 101460156 B CN101460156 B CN 101460156B
Authority
CN
China
Prior art keywords
drug
meth
acrylate
absorption preparation
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN200680054495XA
Other languages
English (en)
Chinese (zh)
Other versions
CN101460156A (zh
Inventor
伊东健
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Teikoku Seiyaku Co Ltd
Original Assignee
Teikoku Seiyaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teikoku Seiyaku Co Ltd filed Critical Teikoku Seiyaku Co Ltd
Publication of CN101460156A publication Critical patent/CN101460156A/zh
Application granted granted Critical
Publication of CN101460156B publication Critical patent/CN101460156B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7084—Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Hospice & Palliative Care (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN200680054495XA 2006-05-08 2006-12-25 抗痴呆药的经皮吸收制剂 Active CN101460156B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US79829606P 2006-05-08 2006-05-08
US60/798,296 2006-05-08
PCT/JP2006/325813 WO2007129427A1 (ja) 2006-05-08 2006-12-25 抗認知症薬物の経皮吸収製剤

Publications (2)

Publication Number Publication Date
CN101460156A CN101460156A (zh) 2009-06-17
CN101460156B true CN101460156B (zh) 2011-06-08

Family

ID=38667540

Family Applications (1)

Application Number Title Priority Date Filing Date
CN200680054495XA Active CN101460156B (zh) 2006-05-08 2006-12-25 抗痴呆药的经皮吸收制剂

Country Status (16)

Country Link
US (2) US7858114B2 (cg-RX-API-DMAC7.html)
EP (1) EP2016939B1 (cg-RX-API-DMAC7.html)
JP (1) JP5122445B2 (cg-RX-API-DMAC7.html)
KR (1) KR20090009951A (cg-RX-API-DMAC7.html)
CN (1) CN101460156B (cg-RX-API-DMAC7.html)
AU (1) AU2006343077B2 (cg-RX-API-DMAC7.html)
BR (1) BRPI0621655A2 (cg-RX-API-DMAC7.html)
CA (1) CA2651596C (cg-RX-API-DMAC7.html)
ES (1) ES2466647T3 (cg-RX-API-DMAC7.html)
IL (1) IL195174A0 (cg-RX-API-DMAC7.html)
IN (1) IN266817B (cg-RX-API-DMAC7.html)
MY (1) MY149152A (cg-RX-API-DMAC7.html)
NO (1) NO20084614L (cg-RX-API-DMAC7.html)
NZ (1) NZ572809A (cg-RX-API-DMAC7.html)
RU (1) RU2428179C2 (cg-RX-API-DMAC7.html)
WO (1) WO2007129427A1 (cg-RX-API-DMAC7.html)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101588802A (zh) * 2006-12-01 2009-11-25 日东电工株式会社 含有稳定化的多奈哌齐的贴剂
CA2671006A1 (en) * 2006-12-01 2008-06-05 Nitto Denko Corporation Method for suppressing discoloration over time of adhesive preparation containing donepezil
WO2009119673A1 (ja) * 2008-03-25 2009-10-01 帝國製薬株式会社 経皮吸収製剤
US20090291127A1 (en) * 2008-05-21 2009-11-26 Jianye Wen Transdermal anti-dementia active agent formulations and methods for using the same
CN102014905B (zh) * 2008-05-30 2012-11-14 日东电工株式会社 含有多奈哌齐的贴剂及其包装体
CA2725484A1 (en) * 2008-05-30 2009-12-03 Eisai R&D Management Co., Ltd. Percutaneously absorbable preparation
JP2012504163A (ja) * 2008-09-30 2012-02-16 テイコク ファーマ ユーエスエー インコーポレーテッド 経皮持続送達ドネペジル組成物および該組成物を使用する方法
US20100278895A1 (en) 2009-04-30 2010-11-04 Medtronic, Inc. Antioxidants and antimicrobial accessories including antioxidants
KR101325104B1 (ko) 2009-09-16 2013-11-07 주식회사 삼양바이오팜 경피 투여 제형 및 그 제조 방법
CN102834092A (zh) * 2009-12-16 2012-12-19 后藤武 抗痴呆药物的经皮吸收制剂
KR20120101704A (ko) 2009-12-16 2012-09-14 고토 다케시 항인지증 약물의 경피흡수제제
JP2012236773A (ja) * 2009-12-16 2012-12-06 Goto Takeshi 抗認知症薬物の経皮吸収製剤
US8962014B2 (en) * 2009-12-22 2015-02-24 Acino Ag Transdermal therapeutic system for administering rivastigmine or derivatives thereof
US10076502B2 (en) 2009-12-22 2018-09-18 Luye Pharma Ag Transdermal therapeutic system for administering rivastigmine or derivatives thereof
US20100178307A1 (en) * 2010-01-13 2010-07-15 Jianye Wen Transdermal anti-dementia active agent formulations and methods for using the same
NZ605352A (en) 2010-06-30 2013-10-25 Nal Pharmaceuticals Ltd Process for producing glycosaminoglycans
PL2468274T3 (pl) 2010-12-14 2015-11-30 Luye Pharma Ag Przezskórny układ terapeutyczny do podawania substancji czynnej
US8911427B2 (en) * 2010-12-28 2014-12-16 Medtronic, Inc. Therapeutic agent reservoir delivery system
TWI433904B (zh) * 2011-01-12 2014-04-11 Taiwan Biotech Co Ltd 多奈哌齊經皮貼片
KR101054317B1 (ko) 2011-01-28 2011-08-08 신신제약 주식회사 리바스티그민을 함유하는 경피흡수제제
KR101317158B1 (ko) 2011-02-18 2013-10-15 조선대학교산학협력단 갈란타민 또는 그의 염을 함유하는 경피흡수제제
EP2711002A4 (en) * 2011-05-20 2014-10-29 Sk Chemicals Co Ltd PLASTER WITH RIVASTIGMIN
KR101395557B1 (ko) * 2011-08-25 2014-05-16 아이큐어 주식회사 경피 흡수 제제 및 그 제조방법
KR101239150B1 (ko) * 2012-02-28 2013-03-06 에스케이케미칼주식회사 도네페질-함유 경피흡수제제 및 그의 제조방법
KR101964295B1 (ko) * 2012-09-05 2019-04-01 주식회사 한독 피부 자극이 감소된 메만틴 경피전달 시스템
PL2931276T3 (pl) * 2012-12-13 2018-06-29 H. Lundbeck A/S Kompozycje zawierające wortioksetynę i donepezil
JP6151935B2 (ja) * 2013-03-11 2017-06-21 日東電工株式会社 経皮吸収促進用組成物および貼付製剤
ES2829807T3 (es) 2014-02-20 2021-06-02 Nal Pharmaceutical Group Ltd Sistema de administración transdérmica de fármacos que contiene donepezilo
US20180185298A1 (en) 2015-06-22 2018-07-05 Corium International, Inc. Transdermal Adhesive Composition Comprising A Poorly Soluble Therapeutic Agent
JP6148416B2 (ja) 2015-06-29 2017-06-14 積水化学工業株式会社 コアシェル構造体及び外用剤
MX2018008190A (es) 2015-12-30 2018-11-12 Corium Int Inc Sistemas y metodos para la administracion transdermica a largo plazo.
CN109922796B (zh) 2016-06-23 2023-04-07 考里安有限责任公司 具有亲水和疏水域的粘合剂基质和治疗剂
SG11201900712SA (en) * 2016-07-27 2019-02-27 Corium Int Inc Memantine transdermal delivery systems
JP7071330B2 (ja) 2016-07-27 2022-05-18 コリウム， インコーポレイテッド 炭酸水素ナトリウムのｉｎ ｓｉｔｕ変換で促進されたアミン薬物の経皮送達
JP7469879B2 (ja) * 2016-07-27 2024-04-17 コリウム， エルエルシー 経口送達と生物学的に同等である薬物動態を有する経皮送達システム
GB2574534B (en) * 2017-02-28 2022-06-08 Kimberly Clark Co Synergistic composition for maintenance of healthy balance of microflora
CN108096690B (zh) * 2017-04-07 2019-08-20 杭州多泰科技有限公司 一种诱导循环肿瘤细胞转移的可移植支架的制备方法
KR102033686B1 (ko) 2017-05-19 2019-10-18 보령제약 주식회사 도네페질을 함유하는 마이크로니들 경피 패치
AU2018307792B2 (en) * 2017-07-26 2024-08-08 Corium, LLC. Transdermal delivery system with a microporous membrane having solvent-filled pores
CN111818914A (zh) 2017-12-13 2020-10-23 考里安公司 透皮药物递送期间创建储库的方法
AU2018392686A1 (en) 2017-12-20 2020-07-09 Corium Pharma Solutions, Inc. Transdermal adhesive composition comprising a volatile liquid therapeutic agent having low melting point
CN108926549A (zh) * 2018-09-27 2018-12-04 安徽安科余良卿药业有限公司 卡巴拉汀凝胶贴膏及其制备方法
JP2023553010A (ja) 2020-12-03 2023-12-20 バテル・メモリアル・インスティテュート 非ウイルス性送達のためのポリマーナノ粒子およびｄｎａナノ構造組成物ならびに方法
JP2024516108A (ja) 2021-04-07 2024-04-12 バテル・メモリアル・インスティテュート 非ウイルス性担体を同定および使用するための迅速な設計、構築、試験、および学習技術
KR102489860B1 (ko) * 2021-09-02 2023-01-19 동아에스티 주식회사 메만틴 에난트산염을 포함하는 치매 치료용 경피흡수 제제
CN115957200A (zh) * 2023-02-23 2023-04-14 广州新济药业科技有限公司 一种美金刚透皮贴剂及制备方法
WO2025072751A1 (en) 2023-09-29 2025-04-03 Battelle Memorial Institute Polymer nanoparticle compositions for in vivo expression of polypeptides
WO2025122954A1 (en) 2023-12-08 2025-06-12 Battelle Memorial Institute Use of dna origami nanostructures for molecular information based data storage systems

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2065403C (en) * 1989-09-14 1996-06-18 Gary W. Cleary Transdermal delivery device having delayed onset
JP2977254B2 (ja) * 1990-09-04 1999-11-15 積水化学工業株式会社 経皮吸収貼付剤
US5273756A (en) * 1991-08-23 1993-12-28 Cygnus Therapeutic Systems Transdermal drug delivery device using a membrane-protected microporous membrane to achieve delayed onset
JPH06199659A (ja) * 1992-10-28 1994-07-19 Hisamitsu Pharmaceut Co Inc 経皮治療用装置
EP0705097B2 (en) * 1993-06-25 2004-01-14 Alza Corporation Incorporating poly-n-vinyl amide in a transdermal system
FR2717689B1 (fr) * 1994-03-28 1996-07-05 Lhd Lab Hygiene Dietetique Système matriciel transdermique d'administration d'un oestrogène et/ou un progestatif à base de copolymère styrène-isoprène-styrène.
US5635203A (en) 1994-09-29 1997-06-03 Alza Corporation Transdermal device having decreased delamination
DE19533772C1 (de) * 1995-09-12 1998-01-02 Hexal Ag Tacrin/Selegilin-Pflaster
DE19653605C2 (de) * 1996-12-20 2002-11-28 Roehm Gmbh Haft- und Bindemittel für dermale oder transdermale Therapiesysteme und dessen Verwendung zur Herstellung eines transdermalen Therapiesystems
JPH10315016A (ja) 1997-05-15 1998-12-02 Nissan Diesel Motor Co Ltd チャック装置
JP3987655B2 (ja) 1998-03-03 2007-10-10 エーザイ・アール・アンド・ディー・マネジメント株式会社 抗痴呆薬を含有した経皮適用製剤又は坐剤
DE19918106A1 (de) * 1999-04-22 2000-10-26 Lohmann Therapie Syst Lts Transdermales therapeutisches System mit neutralisierten Acrylathaftklebern
GB9917290D0 (en) 1999-07-22 1999-09-22 Glaxo Wellcome Spa Pharmaceutical composition
DE10033853A1 (de) * 2000-07-12 2002-01-31 Hexal Ag Transdermales therapeutisches System mit hochdispersem Siliziumdioxid
FR2814368B1 (fr) * 2000-09-26 2004-05-07 Pf Medicament Preparation pharmaceutique a base d'oxans
CA2428181A1 (en) * 2000-11-07 2002-05-16 Hisamitsu Pharmaceutical Co., Inc. Pharmaceutical preparation of percutaneous absorption type
DE10060550C1 (de) 2000-12-06 2002-04-18 Lohmann Therapie Syst Lts Transdermales therapeutisches System mit dem Wirkstoff Oxybutynin und Verfahren zur Herstellung Oxybutynin enthaltender Wirkstoffschichten
CN1571664A (zh) * 2001-10-17 2005-01-26 久光制药株式会社 经皮吸收型制剂
DE10220230A1 (de) * 2002-05-06 2003-11-27 Sanol Arznei Schwarz Gmbh Verwendung von Rotigotine zur Behandlung des Restless Leg Syndroms
JP4274951B2 (ja) * 2004-01-07 2009-06-10 久光製薬株式会社 異型断面繊維を使用した支持体を有するテーピング型貼付剤
WO2005115355A1 (ja) * 2004-05-28 2005-12-08 Hisamitsu Pharmaceutical Co., Inc. 貼付製剤

Also Published As

Publication number Publication date
KR20090009951A (ko) 2009-01-23
MY149152A (en) 2013-07-15
US20070259028A1 (en) 2007-11-08
RU2008148131A (ru) 2010-06-20
HK1130175A1 (en) 2009-12-24
EP2016939A1 (en) 2009-01-21
IN266817B (cg-RX-API-DMAC7.html) 2015-06-03
RU2428179C2 (ru) 2011-09-10
EP2016939B1 (en) 2014-03-19
NZ572809A (en) 2011-02-25
CN101460156A (zh) 2009-06-17
JP5122445B2 (ja) 2013-01-16
WO2007129427A1 (ja) 2007-11-15
ES2466647T3 (es) 2014-06-10
JPWO2007129427A1 (ja) 2009-09-17
EP2016939A4 (en) 2013-01-09
CA2651596A1 (en) 2007-11-15
AU2006343077B2 (en) 2012-11-08
CA2651596C (en) 2014-03-25
BRPI0621655A2 (pt) 2011-12-20
NO20084614L (no) 2009-02-06
US7858114B2 (en) 2010-12-28
AU2006343077A1 (en) 2007-11-15
US20110059141A1 (en) 2011-03-10
IL195174A0 (en) 2009-08-03

Similar Documents

Publication Publication Date Title
CN101460156B (zh) 抗痴呆药的经皮吸收制剂
CN102834093B (zh) 含有抗痴呆药物的经皮吸收制剂
CN102026664B (zh) 稳定化β阻断剂的组合物以及含有该组合物的透皮吸收制剂
KR101617927B1 (ko) 도네페질 경피 패치제
KR20190032512A (ko) 도네페질 경피 전달 시스템
CN102753158A (zh) 抗痴呆药物的经皮吸收制剂
CN102834092A (zh) 抗痴呆药物的经皮吸收制剂
EP1711170B1 (en) Transdermal delivery device for dihydropyridine type calcium antagonists containing two fatty acids
US20140370077A1 (en) Transdermal drug delivery system containing fentanyl
HK1130175B (en) Tansdermally absorbable preparation comprising anti-dementia agent
MX2008014151A (es) Preparaciones de absorcion percutanea de drogas contra demencia.
JPH05294832A (ja) 経皮吸収貼付剤
HK1179184B (en) Transdermally absorbed preparation of anti-dementia drug
HK1179184A (en) Transdermally absorbed preparation of anti-dementia drug
WO2014159778A1 (en) Transdermal drug delivery system containing fentanyl

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 1130175

Country of ref document: HK

C14 Grant of patent or utility model
GR01 Patent grant
REG Reference to a national code

Ref country code: HK

Ref legal event code: GR

Ref document number: 1130175

Country of ref document: HK