CN101454026B - 成像剂 - Google Patents

成像剂 Download PDF

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Publication number
CN101454026B
CN101454026B CN2007800192052A CN200780019205A CN101454026B CN 101454026 B CN101454026 B CN 101454026B CN 2007800192052 A CN2007800192052 A CN 2007800192052A CN 200780019205 A CN200780019205 A CN 200780019205A CN 101454026 B CN101454026 B CN 101454026B
Authority
CN
China
Prior art keywords
imaging
chelate
imaging agent
cbp
precursor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN2007800192052A
Other languages
English (en)
Chinese (zh)
Other versions
CN101454026A (zh
Inventor
S·彻蒂比
B·纽顿
M·赫斯拜恩
M·索尔巴肯
P·B·艾夫森
R·巴拉
D·克雷默
J·布朗
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GE Healthcare Ltd
GE Healthcare AS
Original Assignee
GE Healthcare Ltd
GE Healthcare AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GE Healthcare Ltd, GE Healthcare AS filed Critical GE Healthcare Ltd
Publication of CN101454026A publication Critical patent/CN101454026A/zh
Application granted granted Critical
Publication of CN101454026B publication Critical patent/CN101454026B/zh
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0002—General or multifunctional contrast agents, e.g. chelated agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
CN2007800192052A 2006-05-25 2007-05-25 成像剂 Expired - Fee Related CN101454026B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0610395.6 2006-05-25
GBGB0610395.6A GB0610395D0 (en) 2006-05-25 2006-05-25 Novel imaging agents
PCT/GB2007/001964 WO2007138291A2 (en) 2006-05-25 2007-05-25 Novel imaging agents

Publications (2)

Publication Number Publication Date
CN101454026A CN101454026A (zh) 2009-06-10
CN101454026B true CN101454026B (zh) 2012-12-12

Family

ID=36687722

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2007800192052A Expired - Fee Related CN101454026B (zh) 2006-05-25 2007-05-25 成像剂

Country Status (8)

Country Link
US (1) US8304388B2 (enExample)
EP (1) EP2026844A2 (enExample)
JP (1) JP2009537624A (enExample)
CN (1) CN101454026B (enExample)
BR (1) BRPI0711937A2 (enExample)
GB (1) GB0610395D0 (enExample)
RU (1) RU2441668C2 (enExample)
WO (1) WO2007138291A2 (enExample)

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JP5604305B2 (ja) * 2007-12-13 2014-10-08 アンセルム（アンスチチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル） 線維症の非侵襲性の特異的イメージングのための、ポリペプチド、環状ポリペプチドおよびそれを含む医薬
HUE044239T2 (hu) 2008-03-27 2019-10-28 Purdue Research Foundation Kollagén-kötõ szintetikus peptidoglikánok, elõállításuk és alkalmazási eljárásaik
JP2010215572A (ja) * 2009-03-17 2010-09-30 Japan Health Science Foundation 歯髄炎診断マーカー及び歯髄炎診断システム
WO2011128931A1 (ja) * 2010-04-12 2011-10-20 財団法人ヒューマンサイエンス振興財団 歯髄炎診断マーカー及び歯髄炎診断システム
US9173919B2 (en) * 2011-02-16 2015-11-03 Purdue Research Foundation Collagen-targeted nanoparticles
US9217016B2 (en) 2011-05-24 2015-12-22 Symic Ip, Llc Hyaluronic acid-binding synthetic peptidoglycans, preparation, and methods of use
WO2014055253A1 (en) * 2012-10-04 2014-04-10 The General Hospital Corporation Methods of synthesizing and using peg-like fluorochromes
EP4091624A1 (en) 2013-03-15 2022-11-23 Protagonist Therapeutics, Inc. Hepcidin analogues and uses thereof
EP2970509B1 (en) 2013-03-15 2020-05-13 Purdue Research Foundation Extracellular matrix-binding synthetic peptidoglycans
US20140294901A1 (en) * 2013-04-02 2014-10-02 Protagonist Therapeutics, Inc. Novel a4b7 peptide dimer antagonists
US20140294902A1 (en) * 2013-04-02 2014-10-02 Protagonist Therapeutics, Inc. Novel a4b7 peptide antagonists
WO2015164822A1 (en) 2014-04-25 2015-10-29 Purdue Research Foundation Collagen binding synthetic peptidoglycans for treatment of endothelial dysfunction
CA2949215C (en) 2014-05-16 2023-03-14 Protagonist Therapeutics, Inc. .alpha.4.beta.7 integrin thioether peptide antagonists
SG10201810154WA (en) 2014-07-17 2018-12-28 Protagonist Therapeutics Inc Oral peptide inhibitors of interleukin-23 receptor and their use to treat inflammatory bowel diseases
WO2016054445A1 (en) 2014-10-01 2016-04-07 Protagonist Therapeutics, Inc. Novel cyclic monomer and dimer peptides having integrin antagonist activity
JP2017535527A (ja) 2014-10-01 2017-11-30 プロタゴニスト セラピューティクス， インコーポレイテッド 新規のα４β７ペプチド単量体及び二量体拮抗薬
EP3250240A4 (en) * 2015-01-30 2018-10-10 University of Utah Research Foundation Dimeric collagen hybridizing peptides and methods of using
US10787490B2 (en) 2015-07-15 2020-09-29 Protaganist Therapeutics, Inc. Peptide inhibitors of interleukin-23 receptor and their use to treat inflammatory diseases
CA3009834A1 (en) 2015-12-30 2017-07-06 Protagonist Therapeutics, Inc. Analogues of hepcidin mimetics with improved in vivo half lives
WO2017184683A1 (en) * 2016-04-21 2017-10-26 The Board Of Regents Of The University Of Taxas System Methods and compositions for detecting aneurysms
WO2018022937A1 (en) 2016-07-27 2018-02-01 Protagonist Therapeutics, Inc. Peptide inhibitors of interleukin-23 and their use to treat inflammatory diseases
WO2019010484A2 (en) 2017-07-07 2019-01-10 Symic Ip, Llc SYNTHETIC BIOCONJUGATES
WO2019044894A1 (ja) * 2017-08-31 2019-03-07 学校法人早稲田大学 コラーゲンへの結合活性を有する環状ペプチド
EP3681900A4 (en) 2017-09-11 2021-09-08 Protagonist Therapeutics, Inc. OPIOID AGONIST PEPTIDES AND THEIR USES
WO2019157268A1 (en) 2018-02-08 2019-08-15 Protagonist Therapeutics, Inc. Conjugated hepcidin mimetics
CA3104418A1 (en) 2018-07-12 2020-01-16 Protagonist Therapeutics, Inc. Peptide inhibitors of interleukin-23 receptor and their use to treat inflammatory diseases
AU2020311395A1 (en) 2019-07-10 2022-02-03 Protagonist Therapeutics, Inc. Peptide inhibitors of interleukin-23 receptor and their use to treat inflammatory diseases
MX2022008740A (es) 2020-01-15 2022-09-23 Janssen Biotech Inc Peptidos inhibidores del receptor de interleucina-23 y su uso para tratar enfermedades inflamatorias.
SMT202500254T1 (it) 2020-01-15 2025-09-12 Janssen Biotech Inc Inibitori peptidici del recettore dell'interleuchina-23 e loro uso per trattare malattie infiammatorie
AU2021383828A1 (en) 2020-11-20 2023-07-06 Janssen Pharmaceutica Nv Compositions of peptide inhibitors of interleukin-23 receptor
KR20240034224A (ko) 2021-07-14 2024-03-13 얀센 바이오테크 인코포레이티드 인터류킨-23 수용체의 지질화된 펩티드 억제제

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US7488792B2 (en) 2002-08-28 2009-02-10 Burnham Institute For Medical Research Collagen-binding molecules that selectively home to tumor vasculature and methods of using same
GB0326546D0 (en) 2003-11-14 2003-12-17 Amersham Plc Inhibitor imaging agents
GB0327494D0 (en) 2003-11-26 2003-12-31 Amersham Plc Novel imaging agents
WO2005082941A1 (en) 2004-02-27 2005-09-09 The University Of Western Ontario Bone sialoprotein collagen-binding peptides
US7575738B2 (en) 2004-08-13 2009-08-18 General Electric Company Heat shock protein as a targeting agent for endothelium-specific in vivo transduction
GB0421308D0 (en) * 2004-09-24 2004-10-27 Amersham Plc Enzyme inhibitor imaging agents
AU2005307195A1 (en) * 2004-11-22 2006-05-26 Ge Healthcare As Contrast agents to target extracellular matrix

Non-Patent Citations (2)

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Title
Thomas M. Chiang and Andrew H. Kang.A Synthetic Peptide Derived from the Sequence of a Type I Collagen Receptor Inhibits Type I Collagen-mediated Platelet Aggregation.《The Journal of Clinical Investigation》.1997,第100卷(第8期),第2079–2084页. *
THOMAS M. CHIANG.A Synthetic Nonapeptide Derived from the Sequence of a Platelet Type I Collagen Receptor Inhibits Type I Collagen-Mediated Platelet Aggregation.《THE AMERICAN JOURNAL OF THE MEDICAL SCIENCES》.2000,第320卷(第6期),第362-367页. *

Also Published As

Publication number Publication date
CN101454026A (zh) 2009-06-10
US8304388B2 (en) 2012-11-06
BRPI0711937A2 (pt) 2012-07-24
WO2007138291A2 (en) 2007-12-06
RU2008146031A (ru) 2010-06-27
RU2441668C2 (ru) 2012-02-10
JP2009537624A (ja) 2009-10-29
US20090191123A1 (en) 2009-07-30
WO2007138291A3 (en) 2008-05-29
EP2026844A2 (en) 2009-02-25
GB0610395D0 (en) 2006-07-05

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Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
C17 Cessation of patent right
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20121212

Termination date: 20140525