CN101443340B - 前列腺特异性膜抗原的拟肽抑制剂、含该拟肽抑制剂的化合物及用法 - Google Patents

前列腺特异性膜抗原的拟肽抑制剂、含该拟肽抑制剂的化合物及用法 Download PDF

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CN101443340B
CN101443340B CN2007800176204A CN200780017620A CN101443340B CN 101443340 B CN101443340 B CN 101443340B CN 2007800176204 A CN2007800176204 A CN 2007800176204A CN 200780017620 A CN200780017620 A CN 200780017620A CN 101443340 B CN101443340 B CN 101443340B
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CN101443340A (zh
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克利夫·伯克曼
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Cancer Targeted Technology LLC
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    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
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    • C07F9/06—Phosphorus compounds without P—C bonds
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    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

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  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
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CN2007800176204A 2006-03-14 2007-03-14 前列腺特异性膜抗原的拟肽抑制剂、含该拟肽抑制剂的化合物及用法 Active CN101443340B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US78221106P 2006-03-14 2006-03-14
US60/782,211 2006-03-14
PCT/US2007/064002 WO2007106869A1 (en) 2006-03-14 2007-03-14 Peptidomimetic inhibitors of psma,compounds comprising them, and methods of use

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CN101443340A CN101443340A (zh) 2009-05-27
CN101443340B true CN101443340B (zh) 2013-12-04

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US (3) US7696185B2 (enExample)
EP (1) EP1999136B1 (enExample)
JP (1) JP2009532338A (enExample)
CN (1) CN101443340B (enExample)
AU (1) AU2007226542B2 (enExample)
CA (1) CA2645809C (enExample)
ES (1) ES2397973T3 (enExample)
PL (1) PL1999136T3 (enExample)
WO (1) WO2007106869A1 (enExample)

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CA2926573C (en) * 2007-06-26 2018-08-28 The Johns Hopkins University Labeled inhibitors of prostate specific membrane antigen (psma), biological evaluation, and use as imaging agents
US9193763B2 (en) 2007-08-17 2015-11-24 Purdue Research Foundation PSMA binding ligand-linker conjugates and methods for using
WO2010045598A2 (en) * 2008-10-17 2010-04-22 Purdue Research Foundation Psma binding ligand-linker conjugates and methods for using
WO2010149666A1 (en) * 2009-06-22 2010-12-29 Medexis S.A. Methods for treating neoplasia
EP2338892A1 (en) 2009-12-18 2011-06-29 Bayer Schering Pharma Aktiengesellschaft Prostate specific membrane antigen inhibitors
US9951324B2 (en) 2010-02-25 2018-04-24 Purdue Research Foundation PSMA binding ligand-linker conjugates and methods for using
WO2011106639A1 (en) * 2010-02-25 2011-09-01 Purdue Research Foundation Psma binding ligand-linker conjugates and methods for using
JP5657902B2 (ja) * 2010-03-17 2015-01-21 株式会社コスモステクニカルセンター ポリオキシアルキレンステロールエーテル誘導体及び／又はポリオキシアルキレンスタノールエーテル誘導体、及びそれを含有する外用剤組成物
US9328129B2 (en) 2010-11-12 2016-05-03 Washington State University Peptidomimetic inhibitors of PSMA
CN103930432B (zh) * 2011-06-15 2017-06-23 癌靶技术有限责任公司 螯合的psma抑制剂
WO2013173583A1 (en) 2012-05-16 2013-11-21 Cancer Targeted Technology, Llc Psma inhibitors
AU2013344778C1 (en) 2012-11-15 2024-06-27 Endocyte, Inc. Conjugates for treating diseases caused by PSMA expressing cells
EP2970345B1 (en) 2013-03-15 2019-06-19 Cancer Targeted Technology LLC 18f-labeled psma-targeted pet imaging agents
EP2842578B1 (en) * 2013-08-27 2018-06-27 GILUPI GmbH Diagnostic device for the detection of biomarkers
EP3456700A1 (en) 2013-10-18 2019-03-20 Deutsches Krebsforschungszentrum Labeled inhibitors of prostate specific membrane antigen (psma), their use as imaging agents and pharmaceutical agents for the treatment of prostate cancer
CN105849568B (zh) 2013-11-14 2018-05-04 恩多塞特公司 用于正电子发射断层术的化合物
US10383912B2 (en) * 2014-08-18 2019-08-20 Washington State University Tunable pH-sensitive linker for controlled drug release
US10188759B2 (en) 2015-01-07 2019-01-29 Endocyte, Inc. Conjugates for imaging
US9808538B2 (en) * 2015-09-09 2017-11-07 On Target Laboratories, LLC PSMA-targeted NIR dyes and their uses
WO2018031809A1 (en) 2016-08-10 2018-02-15 Cancer Targeted Technology Llc Chelated psma inhibitors
KR20210003135A (ko) 2018-04-17 2021-01-11 엔도사이트, 인코포레이티드 암의 치료 방법
IL287989B2 (en) * 2019-05-13 2025-07-01 Bracco Imaging Spa Modified cyanine dyes and their conjugates
JP7604397B2 (ja) 2019-05-20 2024-12-23 エンドサイト・インコーポレイテッド Ｐｓｍａコンジュゲートの調製方法
WO2021046233A1 (en) 2019-09-03 2021-03-11 Cancer Targeted Technology Llc Chelate-containing psma inhibitors
CN113117099B (zh) * 2019-12-31 2022-07-15 广东精观生物医药科技有限公司 一种靶向psma的荧光分子探针及其制备方法和应用
CN111675747B (zh) * 2020-07-30 2021-04-27 中国医学科学院医药生物技术研究所 抗肿瘤药物和用途

Citations (3)

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US20040110723A1 (en) * 2001-02-07 2004-06-10 Frangioni John V. Modified psma ligands and uses related thereto
CN1537170A (zh) * 2000-11-20 2004-10-13 ����ҽѧԺ 定量检测前列腺特异性膜抗原和其它前列腺标记的方法和装置
CN1652821A (zh) * 2002-01-28 2005-08-10 米德列斯公司 抗前列腺特异性膜抗原(psma)的人单克隆抗体

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CN1537170A (zh) * 2000-11-20 2004-10-13 ����ҽѧԺ 定量检测前列腺特异性膜抗原和其它前列腺标记的方法和装置
US20040110723A1 (en) * 2001-02-07 2004-06-10 Frangioni John V. Modified psma ligands and uses related thereto
CN1652821A (zh) * 2002-01-28 2005-08-10 米德列斯公司 抗前列腺特异性膜抗原(psma)的人单克隆抗体

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EP1999136B1 (en) 2012-10-24
AU2007226542A1 (en) 2007-09-20
CN101443340A (zh) 2009-05-27
PL1999136T3 (pl) 2013-03-29
US8293725B2 (en) 2012-10-23
US20070219165A1 (en) 2007-09-20
USRE42275E1 (en) 2011-04-05
CA2645809A1 (en) 2007-09-20
WO2007106869A1 (en) 2007-09-20
EP1999136A1 (en) 2008-12-10
US20100183517A1 (en) 2010-07-22
JP2009532338A (ja) 2009-09-10
AU2007226542B2 (en) 2013-08-22
ES2397973T3 (es) 2013-03-12
CA2645809C (en) 2015-05-26
US7696185B2 (en) 2010-04-13

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