CN101437853B - 用于固定生物物质的生物相容性三维基体 - Google Patents
用于固定生物物质的生物相容性三维基体 Download PDFInfo
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- CN101437853B CN101437853B CN2007800163280A CN200780016328A CN101437853B CN 101437853 B CN101437853 B CN 101437853B CN 2007800163280 A CN2007800163280 A CN 2007800163280A CN 200780016328 A CN200780016328 A CN 200780016328A CN 101437853 B CN101437853 B CN 101437853B
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- UOKUUKOEIMCYAI-UHFFFAOYSA-N trimethoxysilylmethyl 2-methylprop-2-enoate Chemical compound CO[Si](OC)(OC)COC(=O)C(C)=C UOKUUKOEIMCYAI-UHFFFAOYSA-N 0.000 description 1
- QKMNLIDNGUCJIK-UHFFFAOYSA-N trimethyl(4-trimethylsilylbutoxy)silane Chemical compound C[Si](C)(C)CCCCO[Si](C)(C)C QKMNLIDNGUCJIK-UHFFFAOYSA-N 0.000 description 1
- JDYCDPFQWXHUDL-UHFFFAOYSA-N trimethyl(methylsulfanyl)silane Chemical compound CS[Si](C)(C)C JDYCDPFQWXHUDL-UHFFFAOYSA-N 0.000 description 1
- KXFSUVJPEQYUGN-UHFFFAOYSA-N trimethyl(phenyl)silane Chemical compound C[Si](C)(C)C1=CC=CC=C1 KXFSUVJPEQYUGN-UHFFFAOYSA-N 0.000 description 1
- QXFASNHOOXGHDD-UHFFFAOYSA-N trimethyl(phenylselanylmethyl)silane Chemical compound C[Si](C)(C)C[Se]C1=CC=CC=C1 QXFASNHOOXGHDD-UHFFFAOYSA-N 0.000 description 1
- HYWCXWRMUZYRPH-UHFFFAOYSA-N trimethyl(prop-2-enyl)silane Chemical compound C[Si](C)(C)CC=C HYWCXWRMUZYRPH-UHFFFAOYSA-N 0.000 description 1
- OANGLGSZPSFVDY-UHFFFAOYSA-N trimethyl(thiophen-2-yl)silane Chemical compound C[Si](C)(C)C1=CC=CS1 OANGLGSZPSFVDY-UHFFFAOYSA-N 0.000 description 1
- OOKGNODSGMQGBN-UHFFFAOYSA-N triphenyl(1,2,2-triphenylethyl)silane Chemical compound C1=CC=CC=C1C(C=1C=CC=CC=1)C([Si](C=1C=CC=CC=1)(C=1C=CC=CC=1)C=1C=CC=CC=1)C1=CC=CC=C1 OOKGNODSGMQGBN-UHFFFAOYSA-N 0.000 description 1
- JUSVBJRMGYXQGV-UHFFFAOYSA-N triphenyl(trityl)silane Chemical compound C1=CC=CC=C1C([Si](C=1C=CC=CC=1)(C=1C=CC=CC=1)C=1C=CC=CC=1)(C=1C=CC=CC=1)C1=CC=CC=C1 JUSVBJRMGYXQGV-UHFFFAOYSA-N 0.000 description 1
- 210000005239 tubule Anatomy 0.000 description 1
- 210000004881 tumor cell Anatomy 0.000 description 1
- 229960005486 vaccine Drugs 0.000 description 1
- 239000013598 vector Substances 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- UKRDPEFKFJNXQM-UHFFFAOYSA-N vinylsilane Chemical compound [SiH3]C=C UKRDPEFKFJNXQM-UHFFFAOYSA-N 0.000 description 1
- 210000005253 yeast cell Anatomy 0.000 description 1
- 235000021241 α-lactalbumin Nutrition 0.000 description 1
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
- C07K17/14—Peptides being immobilised on, or in, an inorganic carrier
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
- C07K17/02—Peptides being immobilised on, or in, an organic carrier
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Life Sciences & Earth Sciences (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Materials For Medical Uses (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06009343.2 | 2006-05-05 | ||
| EP06009343A EP1852443A1 (en) | 2006-05-05 | 2006-05-05 | Biocompatible three dimensional matrix for the immobilization of biological substances |
| PCT/EP2007/004016 WO2007128550A1 (en) | 2006-05-05 | 2007-05-07 | Biocompatible three dimensional matrix for the immobilization of biological substances |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101437853A CN101437853A (zh) | 2009-05-20 |
| CN101437853B true CN101437853B (zh) | 2012-07-04 |
Family
ID=36975295
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2007800163280A Expired - Fee Related CN101437853B (zh) | 2006-05-05 | 2007-05-07 | 用于固定生物物质的生物相容性三维基体 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US9926383B2 (enExample) |
| EP (2) | EP1852443A1 (enExample) |
| JP (2) | JP5869201B2 (enExample) |
| CN (1) | CN101437853B (enExample) |
| AT (1) | ATE525402T1 (enExample) |
| BR (1) | BRPI0710920A2 (enExample) |
| RU (1) | RU2008147885A (enExample) |
| WO (1) | WO2007128550A1 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2058335B1 (en) * | 2007-11-07 | 2020-06-24 | Leukocare Ag | Biocompatible three dimensional matrix for the immobilization of biological substances |
| EP2236520A1 (en) * | 2009-03-31 | 2010-10-06 | Leukocare Ag | Stabilizing composition for immobilized biomolecules |
| EP2236617A1 (en) | 2009-03-31 | 2010-10-06 | Leukocare Ag | Methods of terminal sterilization of biofunctional compositions |
| CA2765540A1 (en) | 2009-06-17 | 2010-12-23 | Gilupi Gmbh | Detection device for in vivo and/or in vitro enrichment of sample material |
| EP2539435A2 (en) | 2010-02-23 | 2013-01-02 | Corning Incorporated | Modified substrates for protection of peptide-immobilized surfaces from gamma radiation degradation |
| AU2010202125B1 (en) * | 2010-05-26 | 2010-09-02 | Takeda Pharmaceutical Company Limited | A method to produce an immunoglobulin preparation with improved yield |
| TWI546122B (zh) * | 2011-02-25 | 2016-08-21 | 東麗股份有限公司 | 血液成分吸附用載體及血液成分吸附管柱 |
| JP2018128408A (ja) * | 2017-02-10 | 2018-08-16 | 東ソー株式会社 | 抗体凝集体形成予測方法 |
| US20230041240A1 (en) | 2020-01-30 | 2023-02-09 | Leukocare Ag | Reduction of Adsorption |
| CN111420119A (zh) * | 2020-04-16 | 2020-07-17 | 南通大学 | 促进神经再生的活性多肽在材料表面共价接枝的方法及其应用 |
| CN113201528A (zh) * | 2021-05-28 | 2021-08-03 | 南京工业大学 | 一种表面改性材料及其制备方法和在酵母细胞吸附与聚集生长中的应用 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1571204A1 (de) * | 2004-03-04 | 2005-09-07 | LeukoCare GmbH | Leukozytenstimulations-Matrix |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6187700A (ja) | 1984-10-05 | 1986-05-06 | Shimadzu Corp | ペプチド含有物質固定化物 |
| CH663728A5 (fr) | 1985-06-10 | 1988-01-15 | Battelle Memorial Institute | Procede de purification de substances bioactives par adsorption biospecifique. |
| JPS63230088A (ja) | 1987-03-19 | 1988-09-26 | Ngk Insulators Ltd | 微生物固定化用担体 |
| JP2641236B2 (ja) | 1988-03-09 | 1997-08-13 | 雪印乳業株式会社 | 固定化生体触媒の殺菌方法及び流動槽付反応器 |
| JPH07117519B2 (ja) | 1988-03-19 | 1995-12-18 | 株式会社堀場製作所 | 酵素固定膜の調製方法 |
| JPH01317389A (ja) | 1988-06-17 | 1989-12-22 | Tosoh Corp | 生化学反応用担体およびその製造方法 |
| US5077210A (en) * | 1989-01-13 | 1991-12-31 | Eigler Frances S | Immobilization of active agents on substrates with a silane and heterobifunctional crosslinking agent |
| US5283034A (en) * | 1989-06-29 | 1994-02-01 | Applied Immune Sciences, Inc. | Stabilization of sterilized surfaces for research and medical use |
| DE4005927A1 (de) * | 1990-02-25 | 1991-08-29 | Roehm Gmbh | Immobilisierung von proteinen an traegern |
| JPH0419561A (ja) | 1990-05-14 | 1992-01-23 | Nippon Shokubai Co Ltd | 免疫アッセイ用ブロッキング剤 |
| JP2813837B2 (ja) | 1990-09-07 | 1998-10-22 | 雪印乳業株式会社 | 高圧を利用した固定化酵素の殺菌方法 |
| JP2832760B2 (ja) | 1990-09-07 | 1998-12-09 | 雪印乳業株式会社 | 固定化酵素の殺菌方法 |
| JPH05219952A (ja) | 1992-02-14 | 1993-08-31 | Tdk Corp | 酵素固定用担体 |
| US5674292A (en) | 1995-06-07 | 1997-10-07 | Stryker Corporation | Terminally sterilized osteogenic devices and preparation thereof |
| US5691152A (en) * | 1995-11-09 | 1997-11-25 | E. R. Squibb & Sons, Inc. | Stable avidin composition |
| US6551794B1 (en) | 1995-11-09 | 2003-04-22 | E. R. Squibb & Sons, Inc. | Stable biotinylated biomolecule composition |
| US5730933A (en) * | 1996-04-16 | 1998-03-24 | Depuy Orthopaedics, Inc. | Radiation sterilization of biologically active compounds |
| US5760130A (en) * | 1997-05-13 | 1998-06-02 | Molecular Dynamics, Inc. | Aminosilane/carbodiimide coupling of DNA to glass substrate |
| JP3061598B2 (ja) | 1997-09-09 | 2000-07-10 | 高橋金物株式会社 | 戸当たり構造 |
| US6635269B1 (en) | 1997-11-24 | 2003-10-21 | Morphoplant Gmbh | Immobilizing mediator molecules via anchor molecules on metallic implant materials containing oxide layer |
| JP4252123B2 (ja) | 1998-04-23 | 2009-04-08 | ユニチカ株式会社 | 固定化線維素溶解活性酵素の活性安定化法 |
| DE19929787A1 (de) | 1999-06-29 | 2001-01-04 | Bayer Ag | Neue 4-(2-Oxodihydrooxadiazinylphenyl)amide und ihre Verwendung |
| SG93209A1 (en) | 1999-07-05 | 2002-12-17 | Inst Of Molecular Agrobiology | A novel immuno-diagnostic test method for veterinary disease |
| AU6093300A (en) * | 1999-07-14 | 2001-02-05 | Genometrix Genomics Incorporated | Arrays comprising non-covalently associated nucleic acid probes and methods for making and using them |
| KR20000071894A (ko) * | 1999-08-19 | 2000-12-05 | 김선영 | 단백질칩 및 이를 이용한 다목적 자동화 진단시스템 |
| US20030012687A1 (en) | 2000-03-23 | 2003-01-16 | Macphee Martin J. | Methods of sterilizing biological materials |
| AU2002216997A1 (en) * | 2000-11-17 | 2002-06-18 | Zeptosens Ag | Kit and method for multi-analyte determination with arrangements for the positionally resolved referencing of stimulating light intensity |
| US6749851B2 (en) | 2001-08-31 | 2004-06-15 | Clearant, Inc. | Methods for sterilizing preparations of digestive enzymes |
| US7252799B2 (en) | 2001-08-31 | 2007-08-07 | Clearant, Inc. | Methods for sterilizing preparations containing albumin |
| AU2003271637A1 (en) * | 2002-10-09 | 2004-05-04 | Hopitaux Universitaires De Geneve | Analytical chip for detection of 16s-rrna from clinically relevant bacteria and analytical method based thereon |
-
2006
- 2006-05-05 EP EP06009343A patent/EP1852443A1/en not_active Withdrawn
-
2007
- 2007-05-07 JP JP2009508232A patent/JP5869201B2/ja not_active Expired - Fee Related
- 2007-05-07 WO PCT/EP2007/004016 patent/WO2007128550A1/en not_active Ceased
- 2007-05-07 EP EP07724940A patent/EP2021374B1/en not_active Revoked
- 2007-05-07 US US12/299,382 patent/US9926383B2/en active Active
- 2007-05-07 RU RU2008147885/13A patent/RU2008147885A/ru unknown
- 2007-05-07 BR BRPI0710920-2A patent/BRPI0710920A2/pt not_active IP Right Cessation
- 2007-05-07 CN CN2007800163280A patent/CN101437853B/zh not_active Expired - Fee Related
- 2007-05-07 AT AT07724940T patent/ATE525402T1/de not_active IP Right Cessation
-
2014
- 2014-03-05 JP JP2014043050A patent/JP2014139575A/ja active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1571204A1 (de) * | 2004-03-04 | 2005-09-07 | LeukoCare GmbH | Leukozytenstimulations-Matrix |
Non-Patent Citations (2)
| Title |
|---|
| MANDENIUS C ET AL.The Interaction of Proteins and Cells with Affinity Ligands Covalently Coupled to Silicon Surfaces as Monitored by Elipsometry.《ANALYTICAL BIOCHEMISTRY》.1984,106-114. * |
| PIEHLER J ET AL.A high-density poly(ethylene glycol) polymer brush for immobilisation on glass-type surfaces.《BIOSENSORS AND BIOELECTRONICS》.2000,473-481. * |
Also Published As
| Publication number | Publication date |
|---|---|
| ATE525402T1 (de) | 2011-10-15 |
| US9926383B2 (en) | 2018-03-27 |
| JP2014139575A (ja) | 2014-07-31 |
| US20090269778A1 (en) | 2009-10-29 |
| CN101437853A (zh) | 2009-05-20 |
| WO2007128550A1 (en) | 2007-11-15 |
| EP2021374B1 (en) | 2011-09-21 |
| JP2009536025A (ja) | 2009-10-08 |
| EP2021374A1 (en) | 2009-02-11 |
| JP5869201B2 (ja) | 2016-02-24 |
| BRPI0710920A2 (pt) | 2012-03-06 |
| EP1852443A1 (en) | 2007-11-07 |
| RU2008147885A (ru) | 2010-06-10 |
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