CN101437853B - 用于固定生物物质的生物相容性三维基体 - Google Patents

用于固定生物物质的生物相容性三维基体 Download PDF

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Publication number
CN101437853B
CN101437853B CN2007800163280A CN200780016328A CN101437853B CN 101437853 B CN101437853 B CN 101437853B CN 2007800163280 A CN2007800163280 A CN 2007800163280A CN 200780016328 A CN200780016328 A CN 200780016328A CN 101437853 B CN101437853 B CN 101437853B
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carrier
silane
antibody
biomaterial
volume
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CN2007800163280A
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Chinese (zh)
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CN101437853A (zh
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斯特凡·马格拉夫
马丁·肖尔茨
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Leukocare AG
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Leukocare AG
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
    • C07K17/14—Peptides being immobilised on, or in, an inorganic carrier
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
    • C07K17/02—Peptides being immobilised on, or in, an organic carrier

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CN2007800163280A 2006-05-05 2007-05-07 用于固定生物物质的生物相容性三维基体 Expired - Fee Related CN101437853B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP06009343.2 2006-05-05
EP06009343A EP1852443A1 (en) 2006-05-05 2006-05-05 Biocompatible three dimensional matrix for the immobilization of biological substances
PCT/EP2007/004016 WO2007128550A1 (en) 2006-05-05 2007-05-07 Biocompatible three dimensional matrix for the immobilization of biological substances

Publications (2)

Publication Number Publication Date
CN101437853A CN101437853A (zh) 2009-05-20
CN101437853B true CN101437853B (zh) 2012-07-04

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CN2007800163280A Expired - Fee Related CN101437853B (zh) 2006-05-05 2007-05-07 用于固定生物物质的生物相容性三维基体

Country Status (8)

Country Link
US (1) US9926383B2 (enExample)
EP (2) EP1852443A1 (enExample)
JP (2) JP5869201B2 (enExample)
CN (1) CN101437853B (enExample)
AT (1) ATE525402T1 (enExample)
BR (1) BRPI0710920A2 (enExample)
RU (1) RU2008147885A (enExample)
WO (1) WO2007128550A1 (enExample)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2058335B1 (en) * 2007-11-07 2020-06-24 Leukocare Ag Biocompatible three dimensional matrix for the immobilization of biological substances
EP2236520A1 (en) * 2009-03-31 2010-10-06 Leukocare Ag Stabilizing composition for immobilized biomolecules
EP2236617A1 (en) 2009-03-31 2010-10-06 Leukocare Ag Methods of terminal sterilization of biofunctional compositions
CA2765540A1 (en) 2009-06-17 2010-12-23 Gilupi Gmbh Detection device for in vivo and/or in vitro enrichment of sample material
EP2539435A2 (en) 2010-02-23 2013-01-02 Corning Incorporated Modified substrates for protection of peptide-immobilized surfaces from gamma radiation degradation
AU2010202125B1 (en) * 2010-05-26 2010-09-02 Takeda Pharmaceutical Company Limited A method to produce an immunoglobulin preparation with improved yield
TWI546122B (zh) * 2011-02-25 2016-08-21 東麗股份有限公司 血液成分吸附用載體及血液成分吸附管柱
JP2018128408A (ja) * 2017-02-10 2018-08-16 東ソー株式会社 抗体凝集体形成予測方法
US20230041240A1 (en) 2020-01-30 2023-02-09 Leukocare Ag Reduction of Adsorption
CN111420119A (zh) * 2020-04-16 2020-07-17 南通大学 促进神经再生的活性多肽在材料表面共价接枝的方法及其应用
CN113201528A (zh) * 2021-05-28 2021-08-03 南京工业大学 一种表面改性材料及其制备方法和在酵母细胞吸附与聚集生长中的应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1571204A1 (de) * 2004-03-04 2005-09-07 LeukoCare GmbH Leukozytenstimulations-Matrix

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JPS6187700A (ja) 1984-10-05 1986-05-06 Shimadzu Corp ペプチド含有物質固定化物
CH663728A5 (fr) 1985-06-10 1988-01-15 Battelle Memorial Institute Procede de purification de substances bioactives par adsorption biospecifique.
JPS63230088A (ja) 1987-03-19 1988-09-26 Ngk Insulators Ltd 微生物固定化用担体
JP2641236B2 (ja) 1988-03-09 1997-08-13 雪印乳業株式会社 固定化生体触媒の殺菌方法及び流動槽付反応器
JPH07117519B2 (ja) 1988-03-19 1995-12-18 株式会社堀場製作所 酵素固定膜の調製方法
JPH01317389A (ja) 1988-06-17 1989-12-22 Tosoh Corp 生化学反応用担体およびその製造方法
US5077210A (en) * 1989-01-13 1991-12-31 Eigler Frances S Immobilization of active agents on substrates with a silane and heterobifunctional crosslinking agent
US5283034A (en) * 1989-06-29 1994-02-01 Applied Immune Sciences, Inc. Stabilization of sterilized surfaces for research and medical use
DE4005927A1 (de) * 1990-02-25 1991-08-29 Roehm Gmbh Immobilisierung von proteinen an traegern
JPH0419561A (ja) 1990-05-14 1992-01-23 Nippon Shokubai Co Ltd 免疫アッセイ用ブロッキング剤
JP2813837B2 (ja) 1990-09-07 1998-10-22 雪印乳業株式会社 高圧を利用した固定化酵素の殺菌方法
JP2832760B2 (ja) 1990-09-07 1998-12-09 雪印乳業株式会社 固定化酵素の殺菌方法
JPH05219952A (ja) 1992-02-14 1993-08-31 Tdk Corp 酵素固定用担体
US5674292A (en) 1995-06-07 1997-10-07 Stryker Corporation Terminally sterilized osteogenic devices and preparation thereof
US5691152A (en) * 1995-11-09 1997-11-25 E. R. Squibb & Sons, Inc. Stable avidin composition
US6551794B1 (en) 1995-11-09 2003-04-22 E. R. Squibb & Sons, Inc. Stable biotinylated biomolecule composition
US5730933A (en) * 1996-04-16 1998-03-24 Depuy Orthopaedics, Inc. Radiation sterilization of biologically active compounds
US5760130A (en) * 1997-05-13 1998-06-02 Molecular Dynamics, Inc. Aminosilane/carbodiimide coupling of DNA to glass substrate
JP3061598B2 (ja) 1997-09-09 2000-07-10 高橋金物株式会社 戸当たり構造
US6635269B1 (en) 1997-11-24 2003-10-21 Morphoplant Gmbh Immobilizing mediator molecules via anchor molecules on metallic implant materials containing oxide layer
JP4252123B2 (ja) 1998-04-23 2009-04-08 ユニチカ株式会社 固定化線維素溶解活性酵素の活性安定化法
DE19929787A1 (de) 1999-06-29 2001-01-04 Bayer Ag Neue 4-(2-Oxodihydrooxadiazinylphenyl)amide und ihre Verwendung
SG93209A1 (en) 1999-07-05 2002-12-17 Inst Of Molecular Agrobiology A novel immuno-diagnostic test method for veterinary disease
AU6093300A (en) * 1999-07-14 2001-02-05 Genometrix Genomics Incorporated Arrays comprising non-covalently associated nucleic acid probes and methods for making and using them
KR20000071894A (ko) * 1999-08-19 2000-12-05 김선영 단백질칩 및 이를 이용한 다목적 자동화 진단시스템
US20030012687A1 (en) 2000-03-23 2003-01-16 Macphee Martin J. Methods of sterilizing biological materials
AU2002216997A1 (en) * 2000-11-17 2002-06-18 Zeptosens Ag Kit and method for multi-analyte determination with arrangements for the positionally resolved referencing of stimulating light intensity
US6749851B2 (en) 2001-08-31 2004-06-15 Clearant, Inc. Methods for sterilizing preparations of digestive enzymes
US7252799B2 (en) 2001-08-31 2007-08-07 Clearant, Inc. Methods for sterilizing preparations containing albumin
AU2003271637A1 (en) * 2002-10-09 2004-05-04 Hopitaux Universitaires De Geneve Analytical chip for detection of 16s-rrna from clinically relevant bacteria and analytical method based thereon

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1571204A1 (de) * 2004-03-04 2005-09-07 LeukoCare GmbH Leukozytenstimulations-Matrix

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
MANDENIUS C ET AL.The Interaction of Proteins and Cells with Affinity Ligands Covalently Coupled to Silicon Surfaces as Monitored by Elipsometry.《ANALYTICAL BIOCHEMISTRY》.1984,106-114. *
PIEHLER J ET AL.A high-density poly(ethylene glycol) polymer brush for immobilisation on glass-type surfaces.《BIOSENSORS AND BIOELECTRONICS》.2000,473-481. *

Also Published As

Publication number Publication date
ATE525402T1 (de) 2011-10-15
US9926383B2 (en) 2018-03-27
JP2014139575A (ja) 2014-07-31
US20090269778A1 (en) 2009-10-29
CN101437853A (zh) 2009-05-20
WO2007128550A1 (en) 2007-11-15
EP2021374B1 (en) 2011-09-21
JP2009536025A (ja) 2009-10-08
EP2021374A1 (en) 2009-02-11
JP5869201B2 (ja) 2016-02-24
BRPI0710920A2 (pt) 2012-03-06
EP1852443A1 (en) 2007-11-07
RU2008147885A (ru) 2010-06-10

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CP02 Change in the address of a patent holder

Address after: German Madingsilide

Patentee after: Leukocare GmbH

Address before: Munich, Germany

Patentee before: Leukocare GmbH

CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20120704

Termination date: 20190507

CF01 Termination of patent right due to non-payment of annual fee