CN101428131B

CN101428131B - Medicament for treating tympany

Info

Publication number: CN101428131B
Application number: CN2008102311743A
Authority: CN
Inventors: 宋树田
Original assignee: Individual
Current assignee: Individual
Priority date: 2008-12-02
Filing date: 2008-12-02
Publication date: 2011-05-11
Anticipated expiration: 2028-12-02
Also published as: CN101428131A

Abstract

A drug for treating tympanites belongs to the technical field of medical preparations. The drug is prepared by the following medicines: dried raw ginseng, raw membranous milkvetch root, raw largehead atractylodes rhizome, leech, ground beetle, sanchi, dragon's blood, prepared turtle shell, adulterated pangolin scales, danshen root, common burreed rhizome, zedoary, Chinese thorowax root, baical skullcap root, motherwort herb, officinal magnolia bark, green tangerine peel, areca peel, prepared nutgrass galingale rhizome, ark shell, piper cubeba, turmeric root-tuber, white mustard seed, pepperweed seed, chicken's gizzard-membrane, barley malt, platycodon root and villous amomum fruit. The drug can be prepared in honey pills and concentrated pills (tablets) with good effect for treating the tympanites (liver cirrhosis and liver cirrhosis ascites).

Description

The medicine of treatment abdominal tympanites

Technical field

The invention belongs to the medicinal preparation technical field, the medicine of particularly a kind of treatment abdominal tympanites (liver cirrhosis and cirrhotic ascites).

Background technology

It is a lot of to cause the liver cirrhosis reason, and common has: liver cirrhosis after the viral hepatitis, account for the 40-65% of China's liver cirrhosis cause of disease, and mainly because of second, third, hepatitis D virus cause, wherein modal is the hepatitis B virus liver cirrhosis; Alcoholic cirrhosis accounts for 7% of China's liver cirrhosis, and rising trend is arranged in recent years; The parasitic liver cirrhosis, blood sucker property liver cirrhosis is seen more by China, according to World Health Organization (WHO) in 1986, the whole world had 100,000,000 64 ten thousand people to infect schistosomicide; Other, as drug induced liver cirrhosis, metabolic liver cirrhosis etc., in hepatitis, about 10-20% is a drug-induced liver disease.No matter the liver cirrhosis which kind of cause of disease causes, its pathology of livers is basic identical, all is to cause the prolonged and repeated damage of liver cirrhosis factor hepatocyte, make hepatocyte that degeneration, necrosis take place, hepatic fibrosis appears in liver connective tissue proliferation in early days, develops into liver cirrhosis or hepatocarcinoma then.

According to 55 data that country provides to World Health Organization (WHO) in 1978, the number that liver cirrhosis is died from the annual whole world surpassed 310,000, has been increased to 500,000 in recent years, and global suffering from liver cirrhosis number reaches 2,500,000.But modern medicine lacks effective Therapeutic Method to liver cirrhosis.

Summary of the invention

The object of the invention is to provide a kind of medicine that can effectively treat abdominal tympanites (liver cirrhosis and cirrhotic ascites).

For reaching above-mentioned purpose, the present invention adopts following technical scheme: the medicine of treatment abdominal tympanites, make by following medicine materials in portions by weight:

Radix Ginseng 150-300 part, Radix Astragali 100-150 part, Rhizoma Atractylodis Macrocephalae 100-150 part,

Hirudo 100-150 part, Eupolyphaga Seu Steleophaga 100-150 part, Typhonium flagelliforme (Lodd.) Blume 100-150 part,

Sanguis Draxonis 100-150 part, Carapax Trionycis (processed) 150-300 part, stir-baked SQUAMA MANITIS 100-150 part,

Radix Salviae Miltiorrhizae 150-250 part, rhizoma sparganic 100-150 part, Rhizoma Curcumae 100-150 part,

Radix Bupleuri 50-75 part, Radix Scutellariae 100-150 part, Herba Leonuri 150-250 part,

Cortex Magnoliae Officinalis 100-150 part, Pericarpium Citri Reticulatae Viride 100-150 part, Pericarpium Arecae 50-100 part,

100-150 parts of Rhizoma Cyperi (processed), 100-250 parts of Concha Arcaes, 20-50 parts of Fructus Litseae,

100-150 parts of Radix Curcumaes, 50-150 parts of Semen Sinapis Albaes, 150-250 parts of Semen Lepidii (Semen Descurainiae)s,

50-150 parts of Endothelium Corneum Gigeriae Galli, 200-300 parts of Fructus Hordei Germinatus, 30-100 parts of Radix Platycodoniss,

70-150 parts of Fructus Amomis.

All medical materials are made fine powder, are crossed 100 mesh sieves, making pellets by mixing medical powder with honey.

All medical materials are made fine powder, are crossed 100 mesh sieves, and water is general to be ball, oven dry.

Preceding nine flavor medical materials are made fine powder, are crossed 100 mesh sieves; Back 19 flavor medical material cold water soak 0.5-1 hour, decocting were poured out medicinal liquid in 0.5-1 hour, and medicinal residues add decocting 0.5-1 hour pours out medicinal liquid, merges the medicinal liquid evaporation and concentration and becomes paste; Fine powder and condensed cream are mixed and made into concentrated pill or film-making, oven dry.

Drug administration method of the present invention is: with honeyed pill (every ball 10 grams) is example, and every day three times, each 1 ball is oral, three months 1 courses of treatment.Period in a medicine is avoided cold and uncooked food, greasy and irritable food, has ascites person to avoid salt, and the hypoproteinemia severe patient suitably replenishes albumen, can cooperate the few dosage diuretic of Western medicine to minority refractory ascites person.

Utilize medicine of the present invention (honeyed pill) (name of product tympanites ball) example surplus two or seven the People's Hospitals, Zhengzhou City treatment liver cirrhosis and cirrhotic ascites patient 100, write down more complete person's 50 examples; In Guanji, Zhengzhou City hospitalize liver cirrhosis and cirrhotic ascites patient 81 examples, write down complete person's 50 examples.Below to the record 100 comparatively complete routine observation on Clinical Application be summarized as follows:

1, clinical data: this is organized 100 examples and is the outpatient, and through western medicine poor effect person more than a year.Wherein male 78 examples, women 22 examples, male, women ratio is 3.5:1,32-66 years old ages, average 41 years old, the course of disease 2-14 years, average 7 years.A small amount of person's 42 examples of ascites, a large amount of ascites person's 58 examples.Traditional Chinese medical science typing: liver-depression and spleen-insufficiency type 30 examples, qi stagnation and blood stasis type 12 examples, stagnation of QI due to depression of the liver, insufficiency of the spleen damp-obstruction type 32 examples, blood stasis due to qi deficiency, wet type 26 examples of spreading unchecked of water.

2, diagnostic criteria (intending certainly) with reference to the 6th standard such as national viral hepatitis meeting in Shanghai in May nineteen ninety:

(1) have viral hepatitis, malnutrition, the hobby of drinking, take medicine and medical history that schistosomicide is relevant;

(2) symptom: inappetence, weak, feel sick abdominal distention and losing weight;

(3) sign: anemia, hepatic facies, jaundice, liver palm, spider angioma, breast development, splenomegaly, abdominal wall varicosis, the sign of ascites positive;

(4) abnormal liver function: albumin reduces, and globulin raises, and the Archon ratio is inverted, prolonged prothrombin, and icteric index or serum total bilirubin raise, and the transaminase raises;

(5) auxiliary examination: gastroscope, barium are pointed out esophageal varicosis thoroughly, and ultrasound wave is pointed out informative intensive middle small echo, small ripple, portal vein, splenic vein broadening.

3, Therapeutic Method: oral medicine of the present invention (nomenclature of drug-tympanites ball), every day three times, each 1 ball is oral, and three months was 1 course of treatment, and this group is all taken medicine 2 more than the course of treatment.Period in a medicine is avoided cold and uncooked food, greasy and irritable food, and the ascites severe patient is avoided salt.The hypoproteinemia severe patient suitably replenishes albumen, and serious ascites person can add hydrochlorothiazide and/or spironolactone.

4, therapeutic evaluation standard: branch level Four: (1) clinical cure: clinical symptoms all disappears, and does not have recurrence in three months, and appetite reaches arm's length standard, and liver function recovery is normal, can be competent at labor in general; (2) produce effects: clinical symptom disappearance, appetite reaches arm's length standard, and liver function is recovered normally substantially, and spleen obviously dwindles (but not recovering normal), and portal vein, splenic vein width have constriction before the treatment; (3) effective: clinical symptoms disappears substantially, and idol has abdominal distention, and liver function is undesired substantially, and spleen dwindles not obvious, portal vein, splenic vein width no change; (4) invalid: cardinal symptom, sign and laboratory diagnosis do not have significant change before and after the treatment.

5, efficacy analysis:

Traditional Chinese medical science typing and therapeutic effect relationship table

Traditional Chinese medical science typing

Case load

Clinical cure

Produce effects

Effectively

Invalid

Total effective rate (%)

Liver-depression and spleen-insufficiency type

30

12

4

2

93.3

Qi stagnation and blood stasis type

12

6

4

0

2

83.3

Stagnation of QI due to depression of the liver, insufficiency of the spleen damp-obstruction type

32?

12?

14?

2?

4?

87.5?

Blood stasis due to qi deficiency, the wet type that spreads unchecked of water

26?

8?

6?

76.9?

This group total effective rate is clinical cure rate+obvious effective rate+effective percentage=88%.From various total effective rate, liver-depression and spleen-insufficiency type 93.3%, effect is best; Qi stagnation and blood stasis type takes second place, and is 83.3%; Blood stasis due to qi deficiency, water wet and spreads unchecked type 76.9%, and is the poorest.Learn to handle by statistics, various total effective rate is compared there was no significant difference (P〉0.05).Show that medicine of the present invention to various liver cirrhosis and hepatic ascites, all has sure curative effect, promotional value is arranged.

The present invention is the pathogenic characteristic of deficiency in origin and excess in superficiality according to liver cirrhosis and cirrhotic ascites, treating both the principal and the secondary aspects of a disease at the same time, reinforcement and elimination in combination.Based on Radix Ginseng, Rhizoma Atractylodis Macrocephalae, the Radix Astragali etc., replenishing QI to invigorate the spleen, QI invigorating the lucid yang sending up, dehumidifying stomach function regulating are to control the disease of hoove patient deficiency in origin; With QI regulating medicine such as Pericarpium Citri Reticulatae Viride, Cortex Magnoliae Officinalis, Pericarpium Arecae, Radix Curcumaes is to assist one, regulates the flow of vital energy and separates the stasis of blood, eliminating stagnation relieving distension, mediation internal organs; With promoting blood circulation and breaking stagnation medicines such as Radix Salviae Miltiorrhizae, Radix Notoginseng, rhizoma sparganic, Rhizoma Curcumae, Herba Leonuris is to assist two, blood circulation promoting and blood stasis dispelling, removing blood stasis repercussive, mediation internal organs, tonneau meridians; With hard masses softening and resolving YIN nourishing such as stir-baked SQUAMA MANITIS, Carapax Trionycis, with Endothelium Corneum Gigeriae Galli, Fructus Hordei Germinatus etc. for making, the stomach function regulating that helps digestion, the kind gas that takes place; Semen Lepidii (Semen Descurainiae), Concha Arcae inducing diuresis to remove edema.The present invention carries out prescription according to the pathogeny of " abdominal tympanites ", and prescription science, reasonable can effectively be improved liver microcirculation, promotes hepatocyte function to recover, and energy enhancing human body immunity power, suppresses the interior sheath hypertrophy of liver.

The specific embodiment

The medicine of embodiment 1, treatment abdominal tympanites, make by following medicine materials in portions by weight:

150 parts of Radix Ginseng, 100 parts of Radix Astragali, 100 parts of Rhizoma Atractylodis Macrocephalae,

100 parts of Hirudos, 100 parts of Eupolyphaga Seu Steleophagas, 100 parts of Typhonium flagelliforme (Lodd.) Blume,

100 parts of Sanguis Draxonis, 150 parts of Carapax Trionycis (processed)s, 100 parts of stir-baked SQUAMA MANITISs,

150 parts of Radix Salviae Miltiorrhizaes, 100 parts of rhizoma sparganic, 100 parts of Rhizoma Curcumae,

50 parts of Radix Bupleuri, 100 parts of Radix Scutellariaes, 150 parts of Herba Leonuris,

100 parts of Cortex Magnoliae Officinalis, 100 parts on Pericarpium Citri Reticulatae Viride, 50 parts of Pericarpium Arecae,

100 parts of Rhizoma Cyperi (processed), 100 parts of Concha Arcaes, 20 parts of Fructus Litseae,

100 parts of Radix Curcumaes, 50 parts of Semen Sinapis Albaes, 150 parts of Semen Lepidii (Semen Descurainiae)s,

50 parts of Endothelium Corneum Gigeriae Galli, 200 parts of Fructus Hordei Germinatus, 30 parts of Radix Platycodoniss,

70 parts of Fructus Amomis.

All the components is made fine powder, is crossed 100 mesh sieves, and making pellets by mixing medical powder with honey, every ball weigh 10 grams.It is standby to bottle, case, sterilize.Every bottle 10 ball.

The present embodiment using method is: every day three times, each 1 ball is oral, three months 1 courses of treatment.

In embodiment 2, the present embodiment, each medical material parts by weight is:

225 parts of Radix Ginseng, 125 parts of Radix Astragali, 125 parts of Rhizoma Atractylodis Macrocephalae,

125 parts of Hirudos, 125 parts of Eupolyphaga Seu Steleophagas, 125 parts of Typhonium flagelliforme (Lodd.) Blume,

125 parts of Sanguis Draxonis, 225 parts of Carapax Trionycis (processed)s, 125 parts of stir-baked SQUAMA MANITISs,

200 parts of Radix Salviae Miltiorrhizaes, 125 parts of rhizoma sparganic, 125 parts of Rhizoma Curcumae,

68 parts of Radix Bupleuri, 125 parts of Radix Scutellariaes, 200 parts of Herba Leonuris,

125 parts of Cortex Magnoliae Officinalis, 125 parts on Pericarpium Citri Reticulatae Viride, 75 parts of Pericarpium Arecae,

125 parts of Rhizoma Cyperi (processed), 175 parts of Concha Arcaes, 35 parts of Fructus Litseae,

125 parts of Radix Curcumaes, 100 parts of Semen Sinapis Albaes, 200 parts of Semen Lepidii (Semen Descurainiae)s,

100 parts of Endothelium Corneum Gigeriae Galli, 250 parts of Fructus Hordei Germinatus, 65 parts of Radix Platycodoniss,

110 parts of Fructus Amomis.

Other are with embodiment 1.

In embodiment 3, the present embodiment, each medical material parts by weight is:

300 parts of Radix Ginseng, 150 parts of Radix Astragali, 150 parts of Rhizoma Atractylodis Macrocephalae,

150 parts of Hirudos, 150 parts of Eupolyphaga Seu Steleophagas, 150 parts of Typhonium flagelliforme (Lodd.) Blume,

150 parts of Sanguis Draxonis, 300 parts of Carapax Trionycis (processed)s, 150 parts of stir-baked SQUAMA MANITISs,

250 parts of Radix Salviae Miltiorrhizaes, 150 parts of rhizoma sparganic, 150 parts of Rhizoma Curcumae,

75 parts of Radix Bupleuri, 150 parts of Radix Scutellariaes, 250 parts of Herba Leonuris,

150 parts of Cortex Magnoliae Officinalis, 150 parts on Pericarpium Citri Reticulatae Viride, 100 parts of Pericarpium Arecae,

150 parts of Rhizoma Cyperi (processed), 250 parts of Concha Arcaes, 50 parts of Fructus Litseae,

150 parts of Radix Curcumaes, 150 parts of Semen Sinapis Albaes, 250 parts of Semen Lepidii (Semen Descurainiae)s,

150 parts of Endothelium Corneum Gigeriae Galli, 300 parts of Fructus Hordei Germinatus, 100 parts of Radix Platycodoniss,

150 parts of Fructus Amomis.

Other are with embodiment 1.

In embodiment 4, the present embodiment, preceding nine flavor medical materials are made fine powder, are crossed 100 mesh sieves; Back 19 flavor medical material cold water soak 1 hour, decocting were poured out medicinal liquid in 1 hour, and medicinal residues add decocting and poured out medicinal liquid in 1 hour, merge the medicinal liquid evaporation and concentration and become paste; It is standby that fine powder and condensed cream are mixed and made into concentrated pill, oven dry, bottling, vanning, sterilization.Every ball 0.1 gram, every bottle 100 ball.Each medical material parts by weight is with embodiment 1.

In embodiment 5, the present embodiment, each medical material parts by weight is with embodiment 2, and other are with embodiment 4.

In embodiment 6, the present embodiment, each medical material parts by weight is with embodiment 3, and other are with embodiment 4.

Claims

1. the medicine of treatment abdominal tympanites is characterized in that, is made by following medicine materials in portions by weight:

Rhizoma Cyperi (processed) 100-150 part, Concha Arcae 100-250 part, Fructus Litseae 20-50 part,

Radix Curcumae 100-150 part, Semen Sinapis Albae 50-150 part, Semen Lepidii (Semen Descurainiae) 150-250 part,

Endothelium Corneum Gigeriae Galli 50-150 part, Fructus Hordei Germinatus 200-300 part, Radix Platycodonis 30-100 part,

Fructus Amomi 70-150 part.

2. the medicine of treatment abdominal tympanites as claimed in claim 1 is characterized in that, all medical materials are made fine powder, crossed 100 mesh sieves, making pellets by mixing medical powder with honey.

3. the medicine of treatment abdominal tympanites as claimed in claim 1 is characterized in that, all medical materials are made fine powder, crossed 100 mesh sieves, and water is general to be ball, oven dry.

4. the medicine of treatment abdominal tympanites as claimed in claim 1 is characterized in that, preceding nine flavor medical materials are made fine powder, crossed 100 mesh sieves; Back 19 flavor medical material cold water soak 0.5-1 hour, decocting 0.5-1 hour are poured out medicinal liquid, and medicinal residues add decocting 0.5-1 hour pours out medicinal liquid, merges the medicinal liquid evaporation and concentration and becomes paste; Fine powder and condensed cream are mixed and made into concentrated pill or film-making, oven dry.