CN101829213B - Medicine composition for treating asthma and preparation method thereof - Google Patents

Medicine composition for treating asthma and preparation method thereof Download PDF

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Publication number
CN101829213B
CN101829213B CN201010199027XA CN201010199027A CN101829213B CN 101829213 B CN101829213 B CN 101829213B CN 201010199027X A CN201010199027X A CN 201010199027XA CN 201010199027 A CN201010199027 A CN 201010199027A CN 101829213 B CN101829213 B CN 101829213B
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Prior art keywords
asthma
ganoderma
semen armeniacae
radix notoginseng
parts
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CN101829213A (en
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方国璋
刘小彬
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Jitai'an (sichuan) Pharmaceutical Co Ltd
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Jitai'an (sichuan) Pharmaceutical Co Ltd
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Abstract

The invention relates to the field of medicines, in particular to a medicine composition for treating asthma and a preparation method thereof. The invention solves the technical problem of providing a new medicine composition for treating asthma, which is prepared by the following medicinal herbs in parts by weight: 6-12 parts of lucid ganoderma, 1-3 parts of pseudo-ginseng and 4.5-9 parts of semen armeniacae amarae. The medicine composition has accurate treatment effect on asthma and high cure rate, and provides a new selection for clinically treating asthma; in addition, the asthma does not recur within 1-2 years after the medicine composition is taken for a long time.

Description

Pharmaceutical composition of treatment asthma and preparation method thereof
Technical field
The present invention relates to be specifically related to pharmaceutical composition for the treatment of asthma and preparation method thereof in field of medicaments.
Background technology
Asthma is universally acknowledged difficult medical problem, is classified as one of four big pertinacious diseases in the disease by World Health Organization (WHO).Asthma is by various kinds of cell, the chronic airway inflammation that participates in of mastocyte, eosinophilic granulocyte and T lymphocyte particularly, and this kind inflammation can cause symptoms such as the panting of outbreak repeatedly, tachypnea, uncomfortable in chest and cough in the susceptible person, how to take place at night or morning.This type of symptom is often limited with extensive and changeable exhalation flow rate, but natural remission or alleviate through treatment partly; This kind symptom also increases multiple stimulating factor reactivity with air flue.
Asthma in acute attack stage generally adopts the albuterol aerosol relief of symptoms, catabasis AudioCodes commonly used this all precious (formoterol fumarate powder inhalant) and Pumi's gram all precious (budesonide powder inhalant) keep, also have report can adopt the auxilliary ketone (fluticasone propionate) that relaxes to treat.
Can be used for treating asthma in the tcm field also has report more, as: CN101301338A relates to a kind of Chinese medicine preparation, promptly a kind of Chinese medicine for oral administration for the treatment of asthma and cough.Its medicine is to be made by the raw material of following weight parts: Herba Ephedrae, each 13-15 gram of Flos Gomphrenae, Herba Turczaninowiae Fastigiatae, each 9-12 gram of Folium Rhododendri Anthopogonoidis, Ganoderma 6-7 gram, fluorite 18-20 gram.It has, and cost is low, preparation is easy, toxic and side effects characteristics little, evident in efficacy.
Also see the report that independent application Ganoderma treatment asthma is arranged, as Chinese patent application CN101647567A, a kind of nutrient and healthcare products and preparation method thereof are provided, especially refer to a kind of liquid dosage form nutritional solution that natural wild Ganoderma extract makes for raw material and preparation method thereof that utilizes.Lucidum liquid mainly is that raw material is made with the wild Ganoderma, and its purpose is exactly to cause a large amount of nutrient loss of Ganoderma or destruction in order to solve existing Ganoderma processing and methods for using them, and human body such as can not make full use of at the problem that the aspect exists.Ganoderma lucidum liquid preparation of the present invention improves significantly to symptoms such as chronic bronchitis, bronchial asthma, leukopenia, coronary heart disease, arrhythmia, acute viral hepatitis, neurasthenia, diabetes.
But, still do not contain Ganoderma in the medicine that has gone on the market, and clear and definite its has the medicine of treatment asthma effect.Treatment cough with asthma aspect, as seen standard for traditional Chinese medicines WS3-195 (X-185)-2000 (Z) GUILONG KECHUANNING granule, prescription is Ramulus Cinnamomi, Os Draconis, the Radix Paeoniae Alba, Rhizoma Zingiberis Recens, Fructus Jujubae, Radix Glycyrrhizae Preparata, Concha Ostreae, Rhizoma Coptidis, the Rhizoma Pinelliae (method), Pericarpium Trichosanthis, Semen Armeniacae Amarum (stir-fry), relieving cough and resolving phlegm, lowering the adverse-rising QI to subdue asthma.Be used for the cough that wind and cold or accumulation of phlegm-damp in the lung cause, asthma, disease and acute and chronic bronchitis such as accumulation and obstruction of sputum.The most valuable treasure Lucid Ganoderma wine that also has the Central Asia, Yantai Pharmaceutical Co., Ltd to produce, writing out a prescription is Ganoderma 120g, Radix Ginseng 60g, Rhizoma Atractylodis Macrocephalae 100g, Poria 100g, Cortex Cinnamomi 60g, Pericarpium Citri Reticulatae 30g, Radix Angelicae Sinensis (stir-fry) 100g, Radix Paeoniae Alba 100g, Radix Rehmanniae Preparata 150g, Radix Astragali 150g, Fructus Schisandrae Chinensis 30g, Radix Polygalae 30g, Radix Glycyrrhizae 30g.Function cures mainly and is benefiting qi and nourishing blood, the Zhichuan of calming the nerves; Be used for deficiency of both QI and blood, pale or sallow complexion, the cough with asthma of breathing hard has expectorant, the extremity asthenia, inappetence, severe palpitation is had a dizzy spell, and is weak after being ill.The indication of said medicine does not spell out its effect with treatment asthma
Summary of the invention
Technical problem solved by the invention provides a kind of brand-new medicinal composition and is used for the treatment of asthma.
Pharmaceutical composition of the present invention is to be prepared from by following materials of weight proportions medicine: Ganoderma 6-12 part, Radix Notoginseng 1-3 part, Semen Armeniacae Amarum 4.5-9 part.The curative effect of this medicine composite for curing asthma is clear and definite.
The curative effect of determining 6 parts of Ganodermas, 1 part of Radix Notoginseng, 5 parts of Semen Armeniacae Amarums through the inventor for a long time is clearer and more definite, more stable.
Second technical problem solved by the invention provides the preparation method of aforementioned pharmaceutical compositions, and step is as follows:
A, take by weighing Ganoderma 6-12 part, Radix Notoginseng 1-3 part, Semen Armeniacae Amarum 4.5-9 part;
B, get Ganoderma, Semen Armeniacae Amarum decocts with water three times, collecting decoction filters, filtrate is concentrated into the thick paste shape;
C, get Radix Notoginseng powder and be broken into fine powder;
D, step B gained thick paste, step C gained fine powder are mixed, add acceptable accessories and make medicament.
Said method all is the process routes according to the characteristics design of crude drug, adopts rational preparation method to use its main active, makes therapeutic effect more stable, controlled.
The specific embodiment
Below by specific description of embodiments of the present invention the explanation but do not limit the present invention.
Pharmaceutical composition of the present invention is to be prepared from by following materials of weight proportions medicine: Ganoderma 6-12 part, Radix Notoginseng 1-3 part, Semen Armeniacae Amarum 4.5-9 part.Crude drug floats in this amount ranges all can realize the purpose of asthma, and curative effect is clear and definite.
The effect of determining 6 parts of Ganodermas, 1 part of Radix Notoginseng, 5 parts of Semen Armeniacae Amarums through the inventor for a long time is clearer and more definite, more stable.
For the ease of taking, be that crude drug adding acceptable accessories is made common dosage forms with Ganoderma, Radix Notoginseng, Semen Armeniacae Amarum, as capsule, granule, powder, tablet, pill, soft extract, syrup or oral liquid etc.
Below beneficial effect by pharmaceutical test and clinical statistics digital proof pharmaceutical composition of the present invention.
1, medicine and drugs compared:
(1) pharmaceutical composition of the present invention is the ratio preparation of adopting 6 parts of Ganodermas, 1 part of Radix Notoginseng, 5 parts of Semen Armeniacae Amarums, and preparation method is for to decoct with water Ganoderma, Semen Armeniacae Amarum three times, and collecting decoction filters, and filtrate is concentrated into the thick paste shape; Radix Notoginseng powder is broken into fine powder.Thick paste is mixed with the Radix Notoginseng fine powder, granulate, encapsulated, promptly.(every capsules is equivalent to crude drug 15g)
(2) matched group 1: LINGZHI JIAONANG, preparation method are for to decoct with water Ganoderma three times, and collecting decoction filters, and filtrate is concentrated into the thick paste shape, granulates, and is encapsulated, promptly.
(3) matched group 2: the most valuable treasure Lucid Ganoderma wine.
2, clinical practice statistics:
Through clinical practice statistics, to use the effective dose that pharmaceutical composition of the present invention is applied to treat asthma and can reach more than 90%, cure rate can reach 81.7%.Major advantage is embodied in and takes the symptom of not having recurrence in the 1-2 of back for a long time.
Also the medicine of medicine of the present invention with existing treatment asthma compared during clinical practice, the clinical statistics data as follows:
(1) patient's situation:
Be diagnosed as the patient of asthma, every group 60 example, wherein every group man 30 examples, women 30 examples, totally 180 examples; Age bracket 18-60 does not wait.
(2) therapeutic process:
Medicine of the present invention is taken three times every day, and each one, be two weeks the course of treatment.
(3) the clinical statistics evaluation criterion is:
Recovery from illness clinical symptoms, sign disappear or basic the disappearance.
Effectively clinical symptoms, sign all take a favorable turn.
Invalid clinical symptoms, sign do not have obvious improvement.
(4) clinical statistics data: see Table 1:
Table 1
Number Healing number/cure rate Effective number/effective percentage Invalid number/inefficiency
This prescription 60 49/81.7% 55/91.7% 5/8.3%
Matched group 1 60 38/63.3% 42/70% 18/30%
Matched group 2 60 43/71.7% 54/90% 6/10%
Asthmatic patient can obviously reduce the relapse rate of asthma when adopting Drug therapy of the present invention; The patient can feel all that after taking body constitution obtains enhancing to a certain degree, and paresthesia alleviateding time is very fast, and quality of life is improved; Moving then pant tangible patient after taking this product, do not influence basically and have a rest or movable.

Claims (5)

1. treat the pharmaceutical composition of asthma, it is characterized in that: it is to be prepared from by following materials of weight proportions medicine: Ganoderma 6-12 part, Radix Notoginseng 1-3 part, Semen Armeniacae Amarum 4.5-9 part.
2. the pharmaceutical composition of treatment asthma according to claim 1 is characterized in that: it is to be prepared from by following materials of weight proportions medicine:
6 parts of Ganodermas, 1 part of Radix Notoginseng, 5 parts of Semen Armeniacae Amarums.
3. the pharmaceutical composition of treatment asthma according to claim 1 is characterized in that: it is to be crude drug with Ganoderma, Radix Notoginseng, Semen Armeniacae Amarum, adds the medicament that acceptable accessories is prepared from.
4. the pharmaceutical composition of treatment asthma according to claim 3 is characterized in that: described medicament is capsule, granule, powder, tablet, pill, soft extract, syrup or oral liquid.
5. the preparation of drug combination method of the described treatment asthma of claim 1 is characterized in that its step is as follows:
A, take by weighing Ganoderma 6-12 part, Radix Notoginseng 1-3 part, Semen Armeniacae Amarum 4.5-9 part;
B, get Ganoderma, Semen Armeniacae Amarum decocts with water three times, collecting decoction filters, filtrate is concentrated into the thick paste shape;
C, get Radix Notoginseng powder and be broken into fine powder;
D, step B gained thick paste, step C gained fine powder are mixed, add acceptable accessories and make medicament.
CN201010199027XA 2010-06-12 2010-06-12 Medicine composition for treating asthma and preparation method thereof Active CN101829213B (en)

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Application Number Priority Date Filing Date Title
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CN101829213B true CN101829213B (en) 2011-05-18

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CN105412200A (en) * 2015-12-11 2016-03-23 普洱淞茂制药股份有限公司 Medicine composition, preparation method thereof, preparation and application

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CN1370596A (en) * 2001-02-27 2002-09-25 吴戌 Mass dissipating and swelling eliminating health beverage
CN101564505B (en) * 2008-04-23 2010-12-15 北京绿源求证科技发展有限责任公司 Chinese medicament for treating pulmonary heart disease

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