CN101422176B - Berberine avermectin water agent - Google Patents
Berberine avermectin water agent Download PDFInfo
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- CN101422176B CN101422176B CN2008101821448A CN200810182144A CN101422176B CN 101422176 B CN101422176 B CN 101422176B CN 2008101821448 A CN2008101821448 A CN 2008101821448A CN 200810182144 A CN200810182144 A CN 200810182144A CN 101422176 B CN101422176 B CN 101422176B
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- Prior art keywords
- jamaicin
- avermectin
- berberine
- extraction liquid
- plant extraction
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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Abstract
The invention relates to a berberine abamectin aqua which is characterized in that abamectin and berberine plant extract are composed into the aqua, wherein, the content of the abamectin is 1mg/L to 2mg/L and the content of the berberine plant extract is 45mg/L to 55mg/L. The berberine abamectin aqua, by composing two kinds of pesticides with different mechanisms of action, not only can be favorable to solving the drug resistance of pests but also can improve the property of each drug, i.e. the content of the abamectin is greatly reduced, while the toxicity of the abamectin against the pests and the control of the berberine plant extract over the pests are improved; simultaneously, the aqua takes water as basic material, thus solving the problems of flammability and hazard caused by organic solvents and avoiding poisoning people and livestock and polluting environment.
Description
Technical field
The invention belongs to pesticide production technology field, particularly relate to a kind of berberine avermectin water agent.
Background technology
Jamaicin is the active ingredient in medicinal plant barberry, the golden cypress, belong to the different quinoline of benzyl in the alkaloid (benzyl-isoquinoline) class of giving repeated exhortations, chemical formula is: 5,6-Dihydro-9,10-dimethoxybenzo[g]-1,3-benzodioxzolo[5,6-a] quinolizinium, structure is as follows:
Jamaicin is a kind of active insecticidal components, and insect is had photoactivation toxicity, and promptly the lethality to insect can improve several times even thousands of times under illumination, can be used to make the quality raw materials composition of botanical biological pesticide.But because single agent quick-acting of botanical biological pesticide is relatively poor in producing, thereby exist the insect drug effect slowly, field efficacy is poor, the spray medicine often, defective such as extension rate is lower.
Avermectin is the microbial pesticide farm antibiotics---the macrolides antiinsect antibiotic, and its chemical constitution is as follows:
The effect target body of Avermectin is the release of the interior γ-An Jidingsuan of insect peripheral neverous system from nerve endings, strengthen combining of acceptor on γ-An Jidingsuan and the cell, thereby the chlorion that enters cell is increased, and the cell membrane hyperpolarization causes the nerve signal transmission to be subjected to press down.The avermitilis strain prime system plays its desinsection, acaricidal action by insect cuticle and intestines and stomach.With the dosage of every mu of 0.1～0.5g (active ingredient), can kill various pests effectively.
Although the acute oral toxicity of Avermectin is higher, because its content is low relatively, so to people and animals, all fool proof to environment.Avermectin has become one of desirable agricultural chemicals that substitutes highly toxic pesticide such as acephatemet.
The complex preparation of not seeing at present jamaicin and Avermectin exists.
Summary of the invention
Purpose of the present invention just is to provide a kind of berberine avermectin water agent.
The present invention is achieved through the following technical solutions:
A kind of berberine avermectin water agent is characterized in that it being to be re-dubbed aqua by Avermectin and jamaicin plant extraction liquid, and wherein the content of Avermectin is 1～2mg/L, and the content of jamaicin plant extraction liquid is 45～55mg/L.
Above-mentioned jamaicin plant extraction liquid is for by weight to be the aqueous extract of raw material after 40～50 parts of barberries, 1～2 part of golden cypress, 45～50 parts of purple perillas and 2～3 parts of mixing of castor-oil plant, and wherein every milliliter contains the jamaicin plant extraction liquid and is equivalent to contain the 1g crude drug;
The preparation technology of above-mentioned jamaicin plant extraction liquid is: take by weighing barberry, golden cypress, purple perilla and castor-oil plant by weight, with its pulverizing, soaked 12～24 hours with clear water, the clear water addition is as the criterion to cover medicine, stir between soak period 2～3 times, be heated to 100 ℃ then, kept slight boiling condition 1 hour, squeeze and filter, filtrate carry out centrifugal or place precipitation; Then, the dregs of a decoction after the filter were soaked 3～4 hours again, boiled after 1 hour and refilter, twice filtered fluid mixed, the filtrate cryogenic vacuum is concentrated into every milliliter of soup and is equivalent to contain the 1g crude drug, obtains the jamaicin plant extraction liquid.
Above-mentioned jamaicin plant extraction liquid promptly is the alkaloids plant pesticide of insecticidal active ingredient with the jamaicin.Because jamaicin has photoactivation toxicity to insect, the jamaicin plant extraction liquid is subjected to after the optical excitation that the toxicity to insect increases in degraded, therefore not only improve the drug effect of insecticide, and avoided residual lastingly in environment, met the desired environment concordance of public nuisance-free agricultural chemicals; Secondly, it has selectivity preferably, and is extremely low to the toxicity of non-target organism; The 3rd, resistance development slows down.
The present invention is based on above-mentioned plant extraction liquid---and the jamaicin plant extraction liquid, composite Avermectin is made berberine avermectin water agent.The present invention is with two kinds of pesticide compositionals of mechanism of action inequality, not only help overcoming pest resistance to insecticide, and can improve the characteristic of single medicine, greatly reduce the content of Avermectin, improved the virulence of Avermectin, improved the preventive effect of jamaicin plant extraction liquid insect to insect; Simultaneously, the present invention is a matrix with water, has solved the inflammable and drug injury problem that organic solvent produces, and can avoid people, animal to poison and environmental pollution.
The present invention makes the Chinese herbal medicine pesticide technology that new breakthrough arranged, and has captured the difficult problem of the quick-acting difference of current Chinese herbal medicine agricultural chemicals, has brought into play Chinese medicine low toxicity, noresidue, nuisanceless, characteristics such as the soup absorption affinity is strong, duration of efficacy length.And raw material sources of the present invention are wide, production cost is low, have anesthesia concurrently, tag, multi-efficiencies such as stomach toxicity, neural poisoning, desinsection, antibacterial integrated control effect are good, can be particularly useful for the production of traditional Chinese medicine, organic food, pollution-free food and pollution-free food in a plurality of fields extensive uses such as agricultural, forestry, animal husbandry.
Below for the test of pesticide effectiveness of berberine avermectin water agent of the present invention:
Virulence experiment:
Infusion process is adopted in test, and the matrimony vine blade that will have the matrimony vine blade of goitre acarocecidium or have an aphid is dipped in the medicament, observes examination worm mortality then, and calculates lethality.
The result shows: the former medicine of Avermectin is y=1.3091x+1.9249 to the virulence regression equation of matrimony vine goitre mite, L D
50(lethal dose of 50) is 223.3622ug/ml; The former medicine of Avermectin is y=1.3751x+2.4917 to the virulence regression equation of matrimony vine aphid, and L D50 (lethal dose of 50) is 69.9793ug/ml; Berberine avermectin water agent is y=0.7531x+4.5431 to the virulence regression equation of matrimony vine goitre mite, LD
50(lethal dose of 50) is 4.0420ug/ml; Berberine avermectin water agent is y=2.5023x+5.1156 to the virulence regression equation of matrimony vine aphid, LD
50(lethal dose of 50) is 0.8990ug/ml; The above results shows that the jamaicin plant extraction liquid has obvious synergistic effect to Avermectin, and berberine avermectin water agent is 46.43 times of Avermectin to the virulence of goitre mite, is 77.84 times of Avermectin to the virulence of aphid.
The berberine avermectin water agent field trial
Experimental field be located at Yinchuan City Vegetable Research Institute matrimony vine experimental field, No. 1, the peaceful Qi of life in 2 years, and experimental field management is strict, and water and fertilizer condition is good.Result of the test shows that 2000 times of controls to matrimony vine goitre mite of berberine avermectin water agent can reach about 70%, control efficiency to the matrimony vine aphid can reach more than 95%, does not have marked difference with 3000 times of control efficiency to matrimony vine goitre mite, matrimony vine aphid of 2.0% Avermectin dilution.
A large number of experiments show that through Plant Protection Research Inst. of Ningxia Academy of Agriculture and Forest Sci jamaicin plant extraction liquid and Avermectin are in the composite aqua of making of the ratio of 52:1 in the period of the 2007-2008 two, can reduce Avermectin content, improve the virulence of Avermectin simultaneously insect; And it is slow to the insect drug effect to have solved the jamaicin plant extraction liquid, and field efficacy is poor, sprays medicine often, the defective that extension rate is low.
Agricultural chemicals makes content very big on the matrimony vine at present.Insect pest took place very seriously during matrimony vine produced, and was mainly aphid, goitre mite etc., and the pesticide variety of use is very many, comprises Imidacloprid, Acetamiprid, chlopyrifos, A Wei diesel oil, beta-cypermethrin and Amitraz etc.; Pesticide application uses with the matrimony vine plucking time and is difficult to stagger, and matrimony vine belongs to the season of growth repeatedly plucks, and adopts once in 7 days, and a growth can be adopted 14-18 time in season, easily causes harvesting very near with the pesticide application time interval even overlap, and residue of pesticide are serious.Therefore the utmost point lacks the special-purpose non-toxic environment-protection pesticide on the matrimony vine.
Above evidence the present invention has good control efficiency to the insect on the matrimony vine, especially to the goitre mite, can be used as the specialized acaricide of matrimony vine.2000 times of sprayings of general dilution are used has good control efficiency to matrimony vine goitre mite, aphid.Also can be used for simultaneously the insect on other traditional Chinese medicines, vegetables, the crops, as rust mite, citrus red mite, citrus bud mite, tangerine short hairs mite, spot true leaf mite, tea half furan mite, unaspis shield kuwana and the real hard thrips of oranges and tangerines; Control various mite classes of cotton and lyonetid, cotton leaf noctuid; The leaf miner of ornamental plants, alfalfa thrips, little Macrosiphus spp class, black peach aphid, vegetables liriomyza bryoniae larva, cauline leaf moth, black peach aphid; Colorado potato beetles; Fruit tree mites, Aspidiotus and cigarette beetle, hawkmoth etc.
Embodiment
The preparation of 1 jamaicin plant extraction liquid
Take by weighing 40～50 parts of barberries by weight, 1～2 part of golden cypress, 2～3 parts of 45～50 parts of purple perillas and castor-oil plants, pulverizing the back soaked 12～24 hours with clear water, the clear water addition is as the criterion to cover medicine, stir between soak period 2～3 times, be heated to 100 ℃ then, maintenance slight boiling condition squeeze and filter after 1 hour, filtrate is carried out centrifugal or is placed precipitation, simultaneously the dregs of a decoction after the filter were soaked 3～4 hours again, boil after 1 hour and filter, twice filtered fluid mixed, and the filtrate cryogenic vacuum is concentrated into every milliliter of soup and is equivalent to contain the 1g crude drug, obtains the jamaicin plant extraction liquid.
2. the preparation of berberine avermectin water agent
Avermectin is dissolved in acetone is made into the full solution that closes, be mixed even with 45～55 parts of jamaicin plant extraction liquids for 1～2 part by the full solution that closes of Avermectin, the surfactant dodecyl sodium sulfate, alkylphenol polyoxyethylene or the fatty alcohol-polyoxyethylene ether that add 15～30 parts then, it plays the wetting osmosis of opening up in aqua.15～40 parts of moisturizings, the content of Avermectin is that the content of 45～50mg/L, jamaicin plant extraction liquid is 1～2mg/L in the feasible aqua that is mixed.
Claims (2)
1. berberine avermectin water agent, it is characterized in that it being to be re-dubbed aqua by Avermectin and jamaicin plant extraction liquid, wherein the content of Avermectin is 1～2mg/L, the content of jamaicin plant extraction liquid is 45～55mg/L, described jamaicin plant extraction liquid is that wherein every milliliter of jamaicin plant extraction liquid is equivalent to contain the 1g crude drug by weight to be the aqueous extract of raw material after 40～50 parts of barberries, 1～2 part of golden cypress, 45～50 parts of purple perillas and 2～3 parts of mixing of castor-oil plant.
2. according to the described berberine avermectin water agent of claim 1, the preparation technology who it is characterized in that above-mentioned jamaicin plant extraction liquid is: take by weighing barberry, golden cypress, purple perilla and castor-oil plant by weight, with its pulverizing, soaked 12～24 hours with clear water, the clear water addition is as the criterion to cover medicine, stirs between soak period 2～3 times, be heated to 100 ℃ then, kept slight boiling condition 1 hour, squeeze and filter, filtrate is carried out centrifugal or is placed precipitation; Then, the dregs of a decoction after the filter were soaked 3～4 hours again, boiled after 1 hour and refilter, twice filtered fluid mixed, the filtrate cryogenic vacuum is concentrated into every milliliter of soup and is equivalent to contain the 1g crude drug, obtains the jamaicin plant extraction liquid.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2008101821448A CN101422176B (en) | 2008-11-14 | 2008-11-14 | Berberine avermectin water agent |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2008101821448A CN101422176B (en) | 2008-11-14 | 2008-11-14 | Berberine avermectin water agent |
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| CN101422176A CN101422176A (en) | 2009-05-06 |
| CN101422176B true CN101422176B (en) | 2011-02-09 |
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| CN2008101821448A Expired - Fee Related CN101422176B (en) | 2008-11-14 | 2008-11-14 | Berberine avermectin water agent |
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Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101731292B (en) * | 2009-11-23 | 2013-03-27 | 李远林 | Production method of biopesticide |
| CN103548852B (en) * | 2013-10-31 | 2016-04-13 | 浙江农林大学天目学院 | A kind of containing alkaloidal insecticides and uses thereof |
| CN107006496A (en) * | 2017-04-14 | 2017-08-04 | 田德远 | A kind of bactericidal composition containing kasugarnycin and jamaicin |
| CN108041037B (en) * | 2018-01-26 | 2019-02-19 | 上海交通大学 | A kind of complex biological pesticide and its application |
| CN113498794A (en) * | 2018-03-02 | 2021-10-15 | 中国农业科学院棉花研究所 | Method for extracting castor-containing insecticidal active substance and combined application of castor-containing insecticidal active substance and carbamate insecticide |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1308871A (en) * | 2000-11-23 | 2001-08-22 | 刘茂萱 | Agricultural chemical prepared from avermectin and alkaloid extracted from plant and its preparing process |
| CN1401235A (en) * | 2001-08-15 | 2003-03-12 | 北京阳光露雨生物科技有限公司 | Aqueous berberine-matrine fungicidal and insecticidal solution |
-
2008
- 2008-11-14 CN CN2008101821448A patent/CN101422176B/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1308871A (en) * | 2000-11-23 | 2001-08-22 | 刘茂萱 | Agricultural chemical prepared from avermectin and alkaloid extracted from plant and its preparing process |
| CN1401235A (en) * | 2001-08-15 | 2003-03-12 | 北京阳光露雨生物科技有限公司 | Aqueous berberine-matrine fungicidal and insecticidal solution |
Non-Patent Citations (2)
| Title |
|---|
| 南宁丽,等.6种杀虫剂对枸杞蚜虫的毒力测定结果.《甘肃农业科技》.2003,(第12期),41-42. |
| 南宁丽等.6种杀虫剂对枸杞蚜虫的毒力测定结果.《甘肃农业科技》.2003,(第12期),41-42. * |
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| CN101422176A (en) | 2009-05-06 |
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