CN101422177B - Matrine chlorpyrifos water agent - Google Patents
Matrine chlorpyrifos water agent Download PDFInfo
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- CN101422177B CN101422177B CN2008101821541A CN200810182154A CN101422177B CN 101422177 B CN101422177 B CN 101422177B CN 2008101821541 A CN2008101821541 A CN 2008101821541A CN 200810182154 A CN200810182154 A CN 200810182154A CN 101422177 B CN101422177 B CN 101422177B
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- Prior art keywords
- matrine
- chlorpyrifos
- vegetable extract
- chlopyrifos
- aqua
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention relates to a matrine chlorpyrifos aqua which is characterized in that chlorpyrifos and matrine plant extract are composed into the aqua, wherein, the content of the chlorpyrifos is 1mg/L to 2mg/L and the content of the matrine plant extract is 2mg/L to 5mg/L. The matrine chlorpyrifos aqua, by composing two kinds of pesticides with different mechanisms of action, not only can be favorable to solving the drug resistance of pests but also can improve the property of each drug, i.e. the dosage of the chlorpyrifos is greatly reduced, while the toxicity of the chlorpyrifos against the pests and the control of the matrine plant extract over the pests are improved; simultaneously, the aqua takes water as basic material, thus solving the problems of flammability and hazard caused by organic solvents and avoiding poisoning people and livestock and polluting environment.
Description
Technical field
The invention belongs to pesticide production technology field, particularly relate to a kind of matrine chlorpyrifos water agent.
Background technology
Matrine is the chemical composition in the traditional Chinese medicine leguminous plant kuh-seng, belongs to the quinolizine pyridine class in the alkaloid, and molecular formula is C
15H
24N
2O, structure is as follows:
Verified at present: matrine has insecticidal action, and the mechanism of action makes the polypide protein coagulating then for paralysis insect nerve center, blocks the polypide pore, and insect is choked to death.The existing many reports of matrine control agricultural and sanitary insect pest have toxic action to various pests, as cabbage caterpillar, elm fleautiauxia armata black peach aphid, radish aphid, diamond-back moth, wheat aphid etc.Prove that simultaneously Banlangen is better than matrine list alkali control efficiency, the matrine mixture is better than matrine list agent control efficiency.
Matrine is a kind of quality raw materials composition that can be used to make botanical biological pesticide.But because single agent quick-acting of botanical biological pesticide is relatively poor in producing, thereby exist the insect drug effect slowly, field efficacy is poor, the spray medicine often, defective such as extension rate is lower.
The English common name chlorpyrifos of chlopyrifos, chemical name is O, O-diethyl-O-3,5,6-trichloro-2-pyridyl phosphorothionate.Its chemical structural formula is as follows:
Chlopyrifos is a kind of broad-spectrum organic insecticide, miticide, its mechanism of action is by suppressing the insect acetylcholine esterase active, make a large amount of acetylcholine accumulation in nerve synapse position, cause postsynaptic membrane constantly to activate, nerve fibre is in the state of being overexcited for a long time, and death spasm appears and in middle kissing bug.Chlopyrifos have tag, stomach poison function, residual life on blade, is not long, belongs to medium insecticide, is one of maximum insecticide variety of present produced worldwide and sale, also be the organic phosphor kind of World Health Organization's permission, active constituent content is 40～48%.But formulation in the market mostly is missible oil, owing to contain organic solvent in the missible oil more, and big to environmental hazard.
Do not see at present the complex preparation of matrine and chlopyrifos.
Summary of the invention
Purpose of the present invention just is to provide a kind of matrine chlorpyrifos water agent.
The present invention is achieved through the following technical solutions:
A kind of matrine chlorpyrifos water agent is characterized in that it being to be re-dubbed aqua by chlopyrifos and matrine vegetable extract, and wherein the content of chlopyrifos is 1～2mg/L, and the content of matrine vegetable extract is 2～5mg/L.
Above-mentioned matrine vegetable extract is for pressing the mixed aqueous extract of parts by weight of 1～2 part of 2～4 parts of kuh-sengs, 1～2 part of China tree, 1～2 part of golden cypress and castor-oil plant, and wherein every milliliter contains the jamaicin plant extraction liquid and is equivalent to contain the 1g crude drug;
The preparation technology of above-mentioned matrine vegetable extract is: take by weighing kuh-seng, China tree, golden cypress and castor-oil plant by weight it is pulverized, soaked 12～24 hours with clear water, the clear water addition is as the criterion to cover medicine, stir between soak period 2～3 times, be heated to 100 ℃ then, kept slight boiling condition 1 hour, squeeze and filter, filtrate is carried out centrifugal or is placed precipitation.Then, the dregs of a decoction after the filter were soaked 3～4 hours again, boiled after 1 hour and refilter, twice filtered fluid mixed, the filtrate cryogenic vacuum is concentrated into every milliliter of soup and is equivalent to contain the 1g crude drug, obtains the matrine vegetable extract.
Active insecticidal components mainly is a secondary metabolites in the above-mentioned matrine vegetable extract, is the result of the adaptation differentiation coevolution of plant self-defense and insect, and insect is difficult for developing immunity to drugs to it.The Secondary Metabolism of Plant material is to the effect uniqueness of insect, mode of action variation, and mechanism of action more complicated is concluded and is got up to mainly contain toxic action, food refusal and deterrent effect.And this medicine component is natural materials, rather than the chemical substance of synthetic, and using the back has its degradation pathway smoothly at natural world, and environmental pollution is little; Selectivity is strong, and is low to people, animal and natural enemy toxicity, and exploitation and use cost are relatively low.
The present invention is based on above-mentioned plant extraction liquid---and the matrine vegetable extract, composite chlopyrifos is made matrine chlorpyrifos water agent.The present invention is with two kinds of pesticide compositionals of mechanism of action inequality, not only help overcoming pest resistance to insecticide, and can improve the characteristic of single medicine, as greatly reducing the consumption of chlopyrifos, improved the virulence of chlopyrifos, improved the preventive effect of matrine vegetable extract insect to insect; Simultaneously, the present invention is a matrix with water, has solved the inflammable and drug injury problem that organic solvent produces, and can avoid people, animal to poison and environmental pollution.
The present invention makes the Chinese herbal medicine pesticide technology that new breakthrough arranged, and has captured the difficult problem of the quick-acting difference of current Chinese herbal medicine agricultural chemicals, has brought into play Chinese herbal medicine agricultural chemicals low toxicity, noresidue, nuisanceless, characteristics such as the soup absorption affinity is strong, duration of efficacy length.And raw material sources of the present invention are wide, production cost is low, have anesthesia concurrently, tag, multi-efficiency such as stomach toxicity, interior suction, desinsection, antibacterial integrated control effect are good, can be particularly useful for the production of traditional Chinese medicine, organic food, pollution-free food and pollution-free food in a plurality of fields extensive uses such as agricultural, forestry, animal husbandry.
Below for the virulence test of matrine chlorpyrifos water agent of the present invention:
Infusion process is adopted in test, get fresh and tender Radix Glycyrrhizae leaf, blade is immersed supplying in the reagent liquid of having prepared respectively, take out behind the dipping 5s, blot the soup on the blade and dry with blotting paper, put into and have the culture dish that filter paper is preserved moisture, it is chrysomelid to put into ten Radix Glycyrrhizae fireflies then, and indoor temperature remains on (26 ± 1) ℃ scope.Dead, the borer population of living of 48h " Invest, Then Investigate ", death standard does not have any reaction and then is considered as death for to touch polypide and appendage with writing brush.The calculation correction lethality.
The result shows: the former medicine of chlopyrifos is y=2.083x+2.099 to the chrysomelid virulence regression equation of Radix Glycyrrhizae firefly, LD
50(lethal dose of 50) is 24.6879ug/ml; The virulence regression equation y=1.9756x+3.9545 of matrine chlorpyrifos water agent, LD
50(lethal dose of 50) is 3.3820ug/ml.The result shows: the matrine vegetable extract has obvious synergistic effect to chlopyrifos, and matrine chlorpyrifos water agent is 4.11 times of chlopyrifos to the chrysomelid virulence of Radix Glycyrrhizae firefly.
The matrine chlorpyrifos water agent field trial
Experimental field be located at Yinchuan City Vegetable Research Institute matrimony vine experimental field, No. 1, the peaceful Qi of life in 2 years, and experimental field management is strict, and water and fertilizer condition is good.Result of the test shows that 2000 times of matrine chlorpyrifos water agents can reach more than 90% the chrysomelid control of Radix Glycyrrhizae firefly, with 2000 times of 48% chlopyrifos dilutions the chrysomelid control efficiency of Radix Glycyrrhizae firefly is not had marked difference.
A large number of experiments show that chlopyrifos and described matrine vegetable agricultural chemicals the composite aqua of making of quality volume (mg/L) ratio through Plant Protection Research Inst. of Ningxia Academy of Agriculture and Forest Sci in the period of 2007～2008 liang in 1:3, can reduce the chlopyrifos consumption, improve the virulence of chlopyrifos simultaneously insect; And it is not very good to have overcome the performance of matrine vegetable extract drug effect, and control efficiency is subjected to environmental factor (temperature, humidity) influence bigger, the defective that quick-acting is not enough.
Present wild Radix Glycyrrhizae resource has faced extinction, the Radix Glycyrrhizae artificial planting takes shape gradually, behind the medicinal material artificial cultivation, break the ecological balance of original biology, perhaps changed original growing environment, it is serious that medicinal material disease, worm, crop smothering are taken place, new sick worm constantly occurs, and is chrysomelid as the Radix Glycyrrhizae firefly, generation overlap, food Radix Glycyrrhizae tender leaf, spray are got in happiness, and a large amount of generations easily cause Radix Glycyrrhizae death.The control of at present general directly use chlopyrifos does not also have the environmental protection of the chrysomelid special use of Radix Glycyrrhizae firefly to prevent and treat medicament.Above evidence the present invention has toxicity preferably to the Radix Glycyrrhizae firefly is chrysomelid, can be used as chrysomelid preventing and curing medicament dedicated of Radix Glycyrrhizae firefly.
Embodiment
The preparation of 1 matrine vegetable extract
The matrine vegetable extract is according to the mixed aqueous extract of following portions by weight with 1～2 part of 2～4 parts of kuh-sengs, 1～2 part of China tree, 1～2 part of golden cypress and castor-oil plant, and wherein every milliliter contains the jamaicin plant extraction liquid and is equivalent to contain the 1g crude drug.Its concrete extraction process is: take by weighing kuh-seng, China tree, golden cypress and castor-oil plant by weight respectively it is pulverized, soaked 12～24 hours with clear water, the clear water addition is as the criterion to cover medicine, stir between soak period 2～3 times, be heated to 100 ℃ then, kept slight boiling condition 1 hour, squeeze and filter, filtrate is carried out centrifugal or is placed precipitation.Then, the dregs of a decoction after the filter were soaked 3～4 hours again, boiled after 1 hour and refilter, twice filtered fluid mixed, the filtrate cryogenic vacuum is concentrated into every milliliter of soup and is equivalent to contain the 1g crude drug, obtains the matrine vegetable extract.
The preparation of 2 matrine chlorpyrifos water agents
Chlopyrifos is dissolved in acetone is made into the full solution that closes, by 1～2 part of chlopyrifos saturated solution, the volume ratio that the matrine extract is 2～5 parts is mixed, the surfactant dodecyl sodium sulfate, alkylphenol polyoxyethylene or the fatty alcohol-polyoxyethylene ether that add 15～30 parts then, it plays the wetting osmosis of opening up in aqua.60～70 parts of moisturizings.The content of aqua death by poisoning tick of being mixed is 1～2mg/L, and the content of matrine vegetable extract is 2～5mg/L.
Claims (2)
1. matrine chlorpyrifos water agent, it is characterized in that it being to be re-dubbed aqua by chlopyrifos and matrine vegetable extract, wherein the content of chlopyrifos is 1～2mg/L, the content of matrine vegetable extract is 2～5mg/L, described matrine vegetable extract is for pressing the mixed aqueous extract of parts by weight of 1～2 part of 2～4 parts of kuh-sengs, 1～2 part of China tree, 1～2 part of golden cypress and castor-oil plant, and wherein every milliliter of matrine vegetable extract is equivalent to contain the 1g crude drug.
2. according to the described matrine chlorpyrifos water agent of claim 1, the preparation technology who it is characterized in that above-mentioned matrine vegetable extract is: take by weighing kuh-seng, China tree, golden cypress and castor-oil plant by weight it is pulverized, soaked 12～24 hours with clear water, the clear water addition is as the criterion to cover medicine, stir between soak period 2～3 times, be heated to 100 ℃ then, kept slight boiling condition 1 hour, squeeze and filter, filtrate carry out centrifugal or place precipitation; Then, the dregs of a decoction after the filter were soaked 3～4 hours again, boiled after 1 hour and refilter, twice filtered fluid mixed, the filtrate cryogenic vacuum is concentrated into every milliliter of soup and is equivalent to contain the 1g crude drug, obtains the matrine vegetable extract.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2008101821541A CN101422177B (en) | 2008-11-14 | 2008-11-14 | Matrine chlorpyrifos water agent |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2008101821541A CN101422177B (en) | 2008-11-14 | 2008-11-14 | Matrine chlorpyrifos water agent |
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| CN101422177A CN101422177A (en) | 2009-05-06 |
| CN101422177B true CN101422177B (en) | 2011-02-09 |
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| CN2008101821541A Expired - Fee Related CN101422177B (en) | 2008-11-14 | 2008-11-14 | Matrine chlorpyrifos water agent |
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Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104012583A (en) * | 2014-06-30 | 2014-09-03 | 济南东泽生物科技有限公司 | Chlorpyrifos-traditional Chinese medicine compound insecticide |
| CN104757039A (en) * | 2014-09-26 | 2015-07-08 | 刘宁 | Biological pesticide for killing longicorn |
| CN107018998B (en) * | 2016-02-01 | 2020-08-18 | 武汉木兰金秋农业科技发展有限公司 | Plant compound type special pesticide for killing pests, removing bacteria and increasing yield of strawberries |
| CN110679589A (en) * | 2019-10-10 | 2020-01-14 | 南京华洲药业有限公司 | Nanometer water agent containing chlorpyrifos and processing method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1308871A (en) * | 2000-11-23 | 2001-08-22 | 刘茂萱 | Agricultural chemical prepared from avermectin and alkaloid extracted from plant and its preparing process |
| CN1401235A (en) * | 2001-08-15 | 2003-03-12 | 北京阳光露雨生物科技有限公司 | Aqueous berberine-matrine fungicidal and insecticidal solution |
-
2008
- 2008-11-14 CN CN2008101821541A patent/CN101422177B/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1308871A (en) * | 2000-11-23 | 2001-08-22 | 刘茂萱 | Agricultural chemical prepared from avermectin and alkaloid extracted from plant and its preparing process |
| CN1401235A (en) * | 2001-08-15 | 2003-03-12 | 北京阳光露雨生物科技有限公司 | Aqueous berberine-matrine fungicidal and insecticidal solution |
Non-Patent Citations (2)
| Title |
|---|
| 南宁丽,等.8种药剂对甘草胭脂蚧的田间防效评价.《农药》.2008,第47卷(第10期),775-776. |
| 南宁丽等.8种药剂对甘草胭脂蚧的田间防效评价.《农药》.2008,第47卷(第10期),775-776. * |
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