CN101417077B - Compound buckwheat flower and leaf flavones preparation for controlling diabetes and complicating disease thereof and preparation method thereof - Google Patents
Compound buckwheat flower and leaf flavones preparation for controlling diabetes and complicating disease thereof and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a drug for preventing and curing diabetes and complicating diseases and a preparation method thereof, in particular to a compound buckwheat flower leaf flavones preparation for preventing and curing diabetes and complicating diseases and a preparation method thereof. The technical proposal is that: the drug contains buckwheat flavones and other extracts from Chinese traditional drugs which comprise kudzu root, root of Chinese trichosannthes, dwarf lilyturf root, scrophulariaceae canaria and edestan; the weight percentage between the buckwheat flavones and the other extracts from Chinese traditional drugs is: 10 percent to 20 percent of the buckwheat flavones and 80 percent to 90 percent of the other extracts from Chinese traditional drugs, wherein, the weight percentage of every crude drug in the other extracts from Chinese traditional drugs is: 15 percent to 25 percent of kudzu root, 15 percent to 25 percent of root of Chinese trichosannthes, 15 percent to 25 percent of dwarf lilyturf root, 10 percent to 20 percent of scrophulariaceae canaria and 10 percent to 20 percent of edestan. The drug is applied to the cure of animal model of diabetes, showing obvious functions of blood sugar and blood fat reduction, improvement of the insulin resistance and reduction of such symptoms of diabetes as more blood sugar, more blood fat, more blood plasma and less insulin. The drug has obvious advantages of the reduction and delay of the occurrence and development of complicating diseases of diabetes, showing that the compound buckwheat flower leaf flavones preparation has great prevention and cure effects on the diabetes and the complicating diseases thereof.
Description
Affiliated technical field:
The present invention relates to a kind of be used to prevent and treat diabetes and complication medicine and preparation method thereof, particularly prevent and treat compound buckwheat floral leaf flavones preparation of diabetes and complication and preparation method thereof.
Background technology:
Diabetes have become one of the world's three big diseases, and along with the raising of people's living standard, the sickness rate of aged tendency of population, diabetes and obesity increases year by year, and especially the type 2 diabetes mellitus sickness rate is higher, has become the chronic disease of serious threat human health.Diabetes are not only the sickness rate height, the more important thing is the complication that causes by diabetes, prolongation along with diabetic duration, can cause losing one's sight, multiple complications such as cardiovascular and cerebrovascular disease, liver dysfunction, renal failure, neuropathy, extremity gangrene so that amputation, stupor, finally be directed at death.Treatment of diabetes mainly based on medicine, mostly is long-term even lifelong medication, and present medicine prolonged application has problems such as compliance is poor, financial burden weight, untoward reaction.Because the truly specific medicine of preventing and treating diabetes and complication of neither one, thereby the sickness rate of diabetes and medical expense still are the trend of rising.Clinical practice Chinese medicine has its special advantages aspect treating diabetes.But clinical Chinese medicine selection face limits to, and there are shortcomings such as taking dose is big, application inconvenience, price comparison costliness in outer tens kinds of using always, the Chinese medicine majority of clinical practice simultaneously.
Summary of the invention:
The object of the invention provides a kind of compound buckwheat floral leaf flavones preparation of preventing and treating diabetes and complication and preparation method thereof, and curative effect is clear and definite, with low cost, taking convenience, consumption are little, solves the problems referred to above that exist in the background technology.
Technical scheme of the present invention is: the compound buckwheat floral leaf flavones preparation of preventing and treating diabetes and complication comprises buckwheat flavonoids and other Chinese medicine extract, and other Chinese medicine extract comprises Radix Puerariae, Radix Trichosanthis, Radix Ophiopogonis, Radix Scrophulariae, Fructus Cannabis; Percentage by weight between buckwheat flavonoids and other Chinese medicine extract is: buckwheat flavonoids 10-20%, Chinese medicine extract 80-90%;
The percentage by weight of each crude drug is in other Chinese medicine extract:
Radix Puerariae 15-25%, Radix Trichosanthis 15-25%, Radix Ophiopogonis 15-25%, Radix Scrophulariae 10-20%, Fructus Cannabis 10-20%.
The preparation method of compound buckwheat floral leaf flavones preparation comprises following technical process:
1. answer the water bonus point to extract total flavones, make Flavonoid substances purity height from the method for agent extraction separation flowers and leaves of buckwheat flavone;
2. other Chinese medicine ingredients in the prescription is mixed, percentage by weight is Radix Puerariae 15-25%, Radix Trichosanthis 15-25%, Radix Ophiopogonis 15-25%, Radix Scrophulariae 10-20%, Fructus Cannabis 10-20% carries out extracts active ingredients and processing, the Chinese medicine medical material is mixed decoction, kept effective ingredient, remove invalid medicinal residues;
3. it is even flowers and leaves of buckwheat flavone and Chinese medicine extract to be pressed prescription content requirement mixed, and percentage by weight is buckwheat flavonoids 10-20%, and Chinese medicine extract 80-90% makes preparation.
Compound buckwheat floral leaf flavones preparation can be made capsule, tablet, powder or the like as required.
Said separating medium is acid chitosan, preferably with concentration be 1% acid chitosan as separating medium, impurity in the flowers and leaves of buckwheat water extract is combined with chitosan form macromolecular substances to be filtered removing easily, improve the content and the purity of flavone.
Side's medicine of the present invention is formed buckwheat flavonoids, Radix Puerariae, Radix Trichosanthis, Radix Ophiopogonis, Radix Scrophulariae, Fructus Cannabis.
Buckwheat flavonoids: the total flavones for extracting in the sweet Buckwheat Flower of polygonaceae plant, the leaf, mainly contain rutin and Quercetin.Studies show that in a large number buckwheat flavonoids has many pharmacologically actives such as blood sugar lowering, blood fat reducing, antioxidation and anticoagulant, particularly has good preventive and therapeutic effect to diabetes, hyperlipemia and cardiovascular diseases etc.
Radix Puerariae: main component has total flavones, puerarin, daidzein etc.Have the yang invigorating expelling pathogenic factors from muscles, relieving restlessness is quenched the thirst, rash antidiarrheal effect.Modern study finds that Radix Puerariae extract can improve multiple pharmacological effect such as cerebral circulation, cerebral blood flow increasing amount, anticoagulant, blood sugar lowering blood fat and adjusting immunologic function.
Radix Trichosanthis: mainly contain trichosanthin, several amino acids, Saponin.Clearing away heat and promoting production of body fluid is arranged, detumescence and apocenosis, clearing away lung-heat and moistening for dryness, the effect of promoting the production of body fluid and quenching one's thirst.Pharmacological research finds that Radix Trichosanthis extract has effects such as blood sugar lowering, anticancer, antibiotic, antiviral.
Radix Ophiopogonis: contain Radix Ophiopogonis such as multiple steroidal saponin, cupreol, stigmasterol etc.The energy yin nourishing is quenched one's thirst and is promoted the production of body fluid, and lung moistening clears away heart-fire, and relieving restlessness clears away heart-fire.Pharmacological action mainly contains the coordination insulin function, can blood sugar lowering, and impel islet cells to recover normal, and effects such as protection ischemic myocardium, antithrombotic and microcirculation improvement, antibiotic, human body immunity improving function are arranged.
Radix Scrophulariae: contain alkaloid, saccharide, sterol, aminoacid, micro-volatile oil, carotene etc.YIN nourishing is arranged, pathogenic fire reducing, relieving restlessness, antidotal effect.Pharmacological action has effects such as blood pressure lowering, blood sugar lowering, analgesic, function of gallbladder promoting.
Fructus Cannabis: contain trigonelline, isoleucine betanin, Fructus Cannabis globulin enzyme, linolenic acid, linoleic acid etc.The laxation of moisturizing relieving constipation effect is arranged.There are blood pressure lowering, enterokinesia to accelerate, reduce effects such as serum cholesterol.
According to the effect characteristics of the medicine of respectively distinguishing the flavor of among the above-mentioned side, show that full side acts on a plurality of internal organs of whole body, system, be not single blood sugar lowering, but bring into play the comprehensive function that integrally-regulated effect reaches treatment type 2 diabetes mellitus and complication.The present invention is applied to the treatment of diabetes animal model, show obvious functions of blood sugar, blood fat, improve insulin resistant, reduce the symptoms such as " three-many-one-littles " of diabetes, reduce and the generation of delaying complications of diabetes, development aspect have remarkable advantages, show that compound buckwheat floral leaf flavone capsule has good preventive and therapeutic effect to diabetes and complication.
The invention has the beneficial effects as follows:
Scientific formulation: compound buckwheat floral leaf flavones preparation carries out prescription according to modern medicine and pharmacology theory and Chinese medicine traditional theory, and the present invention combines active ingredient of natural plant with Chinese medicine, make the modern Chinese medicine preparation.The flowers and leaves of buckwheat of selecting for use aboundresources, economy to be easy to get is a raw material, extract effective active component-flavone, and the flavone component that extracts based on flowers and leaves of buckwheat, the blended extract of compatibility Radix Puerariae, Radix Trichosanthis, Radix Ophiopogonis, Radix Scrophulariae and Fructus Cannabis is made modern compound buckwheat floral leaf flavones preparation.
Preparation technology is simple: this method technological process is simple, and cost is low, flavone extraction ratio and purity height.Extracts active ingredients and processing have been carried out in other Chinese medicine ingredients mixing in the prescription, kept effective ingredient.
It is convenient to use, effect is obvious: be applied to the treatment of diabetes animal model, show obvious functions of blood sugar, blood fat, improve insulin resistant, reduce the symptoms such as " three-many-one-littles " of diabetes, reduce and the generation of delaying complications of diabetes, development aspect have remarkable advantages.Show that compound buckwheat floral leaf flavones preparation has good preventive and therapeutic effect to diabetes and complication.
Preparation process of the present invention is simple, does not need specific apparatus and equipment, can be applicable.Said preparation meets the modern Chinese medicine requirement of " triple effect, three little, three convenience ", has embodied the road of " innovation, succession, modernization ".
The specific embodiment:
Below in conjunction with embodiment, the invention will be further described.
Embodiment one:
(percentage by weight) buckwheat flavonoids: 10%, Chinese medicine extract such as Radix Puerariae: 90%, each crude drug ratio is in the Chinese medicine extract such as Radix Puerariae: Radix Puerariae 25%, Radix Trichosanthis 15%, Radix Ophiopogonis 25%, Radix Scrophulariae 15%, Fructus Cannabis 20%.
Embodiment two:
(percentage by weight) buckwheat flavonoids: 15%, Chinese medicine extract such as Radix Puerariae: 85%, each crude drug ratio is in the Chinese medicine extract such as Radix Puerariae: Radix Puerariae 15%, Radix Trichosanthis 25%, Radix Ophiopogonis 25%, Radix Scrophulariae 15%, Fructus Cannabis 20%.
Embodiment three:
(percentage by weight) buckwheat flavonoids: 20%, Chinese medicine extract such as Radix Puerariae: 80%, each crude drug ratio is in the Chinese medicine extract such as Radix Puerariae: Radix Puerariae 25%, Radix Trichosanthis 25%, Radix Ophiopogonis 15%, Radix Scrophulariae 20%, Fructus Cannabis 15%.
The preparation technology of each embodiment is as follows:
1. the preparation of flowers and leaves of buckwheat flavone: flowers and leaves of buckwheat be the sweet Semen Fagopyri Esculenti of polygonaceae plant (the cereal crops Semen Fagopyri Esculenti, buckwheat) the natural drying thing of floral leaf contains abundant flavonoids, the extraction process flow process of its flavone is:
Buckwheat Flower, leaf add deionized water heating and refluxing extraction secondary, each 1 hour, merge 2 times filtrate, be concentrated into 1/4-1/5 of former liquid measure, with separating medium, accent PH is 4-6,70-80 ℃ of heated and stirred 30 minutes, and filtered while hot, filtrate staticly settles, filter yellow mercury oxide, dry through 70 ℃, dry thing is ground to form fine powder, be the flowers and leaves of buckwheat flavone by 60 mesh sieves, general flavone content can reach 95%.
2. the preparation of other Chinese medicine extract:
(1) material choice and percentage by weight: Radix Puerariae 15-25%, Radix Trichosanthis 15-25%, Radix Ophiopogonis 15-25%, Radix Scrophulariae 10-20% and Fructus Cannabis 10-20%;
(2) preparation of extract: measure Radix Puerariae, Radix Trichosanthis, Radix Ophiopogonis, Radix Scrophulariae and Fructus Cannabis by above-mentioned percentage ratio requirement, decoct with water secondary, decocted 1 hour at every turn, merge 2 times filtrate, stir in the 80-90 ℃ of water-bath, be condensed into paste, put on the plate glass, dry in 80 ℃ of baking boxs.Dry thing is ground to form fine powder, by 60 mesh sieves;
3. formulation preparation: get the flowers and leaves of buckwheat flavone, ratio is 10-20%, other Chinese medicine extract, and ratio is 80-90%, fully stirs to be mixed and makes compound buckwheat floral leaf flavones preparation.
Embodiment one makes capsule, and embodiment two makes tablet, and embodiment three makes powder.
In the preparation of flowers and leaves of buckwheat flavone, Buckwheat Flower, leaf add deionized water heating and refluxing extraction secondary, add 12 times of water gagings for the first time, add 8 times of water gagings for the second time; Said separating medium is acid chitosan, preferably with concentration be 1% acid chitosan as separating medium, impurity in the flowers and leaves of buckwheat water extract is combined with chitosan form macromolecular substances to be filtered removing easily, improve the content and the purity of flavone.
In the preparation of other Chinese medicine extract, Radix Puerariae, Radix Trichosanthis, Radix Ophiopogonis, Radix Scrophulariae and Fructus Cannabis decoct with water secondary, add 12 times of water gagings for the first time, add 8 times of water gagings for the second time.
The present invention studies by rat experiment, has obtained fine result for the treatment of, draws to draw a conclusion:
1. the present invention can significantly reduce blood sugar, the blood fat level of diabetes rat, improves sugar tolerance, improves insulin sensitivity.
2. the present invention can significantly improve the symptoms such as diabetes rat general state and three-many-one-little, and the effect of high dose group is more obvious.
3. the present invention has protective effect to the damage of the histoorgans such as diabetes rat liver, kidney, heart and eye, can reduce the sensitiveness that the diabetes body infects bacterium.
4. the present invention has good preventive and therapeutic effect to diabetes and complication thereof.
Claims (4)
1. a compound buckwheat floral leaf flavones preparation of preventing and treating diabetes and complication is characterized in that being made up of buckwheat floral leaf flavone and other Chinese medicine extract, and other Chinese medicine extract is the extract of Radix Puerariae, Radix Trichosanthis, Radix Ophiopogonis, Radix Scrophulariae, Fructus Cannabis; Percentage by weight between buckwheat floral leaf flavone and other Chinese medicine extract is: buckwheat floral leaf flavone 10-20%, other Chinese medicine extract 80-90%;
The crude drug percentage by weight of other Chinese medicine extract is: Radix Puerariae 15-25%, Radix Trichosanthis 15-25%, Radix Ophiopogonis 15-25%, Radix Scrophulariae 10-20%, Fructus Cannabis 10-20%, preparation method is: the Chinese medicine medical material mix is decocted, kept effective ingredient, remove invalid medicinal residues.
2. preparation method of preventing and treating the compound buckwheat floral leaf flavones preparation of diabetes and complication is characterized in that technical process is as follows:
1. answer the water bonus point to extract total flavones from the method for agent extraction separation buckwheat floral leaf flavone, make Flavonoid substances purity height, separating medium is acid chitosan;
2. other Chinese crude drug in the prescription is mixed, percentage by weight is a Radix Puerariae 15～25%, Radix Trichosanthis 15-25%, Radix Ophiopogonis 15-25%, Radix Scrophulariae 10-20%, Fructus Cannabis 10-20% mixes the Chinese medicine medical material decocting, and has kept effective ingredient, removes invalid medicinal residues;
3. it is even buckwheat floral leaf flavone and other Chinese medicine extract to be pressed prescription content requirement mixed, and percentage by weight is buckwheat floral leaf flavone 10-20%, and other Chinese medicine extract 80-90% makes preparation.
3. preparation method of preventing and treating the compound buckwheat floral leaf flavones preparation of diabetes and complication according to claim 2 is characterized in that concrete technology is as follows:
1. the preparation of buckwheat floral leaf flavone: Buckwheat Flower, leaf add deionized water heating and refluxing extraction secondary, each 1 hour, merge 2 times filtrate, be concentrated into the 1/4-1/5 of former liquid measure, with separating medium, separating medium is acid chitosan, accent PH is 4-6,70-80 ℃ of heated and stirred 30 minutes, and filtered while hot, filtrate staticly settles, filter yellow mercury oxide, dry through 70 ℃, dry thing is ground to form fine powder, be buckwheat floral leaf flavone by 60 mesh sieves, general flavone content can reach 95%;
2. the preparation of other Chinese medicine extract:
(1) crude drug is selected and percentage by weight: Radix Puerariae 15-20%, Radix Trichosanthis 15-20%, Radix Ophiopogonis 15-20%, Radix Scrophulariae 10-15% and Fructus Cannabis 10-15%;
(2) preparation of extract: measure Radix Puerariae, Radix Trichosanthis, Radix Ophiopogonis, Radix Scrophulariae and Fructus Cannabis by above-mentioned percentage ratio requirement, decoct with water secondary, the each decoction 1 hour, merge 2 times filtrate, stir in the 80-90 ℃ of water-bath, be condensed into paste, put on the plate glass, dry in 80 ℃ of baking boxs, dry thing is ground to form fine powder, by 60 mesh sieves;
3. formulation preparation: get buckwheat floral leaf flavone, ratio is 10-20%, other Chinese medicine extract, and ratio is 80-90%, fully stirs to be mixed, and makes compound buckwheat floral leaf flavones preparation.
4. according to claim 2 or 3 described preparation methoies of preventing and treating the compound buckwheat floral leaf flavones preparation of diabetes and complication, it is characterized in that with concentration being that 1% acid chitosan is as separating medium.
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| Application Number | Priority Date | Filing Date | Title |
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| CN2008101832103A CN101417077B (en) | 2008-12-16 | 2008-12-16 | Compound buckwheat flower and leaf flavones preparation for controlling diabetes and complicating disease thereof and preparation method thereof |
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| CN2008101832103A CN101417077B (en) | 2008-12-16 | 2008-12-16 | Compound buckwheat flower and leaf flavones preparation for controlling diabetes and complicating disease thereof and preparation method thereof |
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| CN101417077A CN101417077A (en) | 2009-04-29 |
| CN101417077B true CN101417077B (en) | 2011-01-05 |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1212134A (en) * | 1997-09-24 | 1999-03-31 | 肖克佑 | Food with function for preventing and curing diabets |
| CN1690055A (en) * | 2004-04-22 | 2005-11-02 | 韩淑英 | Process for extracting total flavones from sweet buckwheat flower and leaf by using water and separating agent |
| CN101134083A (en) * | 2007-09-18 | 2008-03-05 | 王平 | Chinese medicinal herb capsule for treating diabetes and its complication and method for preparing the same |
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2008
- 2008-12-16 CN CN2008101832103A patent/CN101417077B/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1212134A (en) * | 1997-09-24 | 1999-03-31 | 肖克佑 | Food with function for preventing and curing diabets |
| CN1690055A (en) * | 2004-04-22 | 2005-11-02 | 韩淑英 | Process for extracting total flavones from sweet buckwheat flower and leaf by using water and separating agent |
| CN101134083A (en) * | 2007-09-18 | 2008-03-05 | 王平 | Chinese medicinal herb capsule for treating diabetes and its complication and method for preparing the same |
Non-Patent Citations (3)
| Title |
|---|
| 刘淑梅等.甜荞麦叶总黄酮降糖、降脂作用及机制.《第四军医大学学报》.2003,第24卷(第19期), * |
| 韩淑英等.荞麦花总黄酮对体内外蛋白质非酶糖基化的抑制作用.《中国药理学通报》.2004,第20卷(第11期), * |
| 韩淑英等.荞麦花总黄酮对实验性大鼠Ⅱ型糖尿病高脂血症的防治作用.《中国药理学通报》.2003,第19卷(第4期), * |
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