CN101415498B - 从含磁性微粒的液体分离所述微粒的设备和适于与之一起使用的容器阵列 - Google Patents

从含磁性微粒的液体分离所述微粒的设备和适于与之一起使用的容器阵列 Download PDF

Info

Publication number
CN101415498B
CN101415498B CN2007800122011A CN200780012201A CN101415498B CN 101415498 B CN101415498 B CN 101415498B CN 2007800122011 A CN2007800122011 A CN 2007800122011A CN 200780012201 A CN200780012201 A CN 200780012201A CN 101415498 B CN101415498 B CN 101415498B
Authority
CN
China
Prior art keywords
container
containers
magnet
array
row
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN2007800122011A
Other languages
English (en)
Chinese (zh)
Other versions
CN101415498A (zh
Inventor
T·霍伦斯坦
R·施尼贝利
R·贝尔茨
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of CN101415498A publication Critical patent/CN101415498A/zh
Application granted granted Critical
Publication of CN101415498B publication Critical patent/CN101415498B/zh
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B03SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03CMAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C1/00Magnetic separation
    • B03C1/02Magnetic separation acting directly on the substance being separated
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508Rigid containers without fluid transport within
    • B01L3/5085Rigid containers without fluid transport within for multiple samples, e.g. microtitration plates
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L9/00Supporting devices; Holding devices
    • B01L9/54Supports specially adapted for pipettes and burettes
    • B01L9/543Supports specially adapted for pipettes and burettes for disposable pipette tips, e.g. racks or cassettes
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B03SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03CMAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C1/00Magnetic separation
    • B03C1/005Pretreatment specially adapted for magnetic separation
    • B03C1/01Pretreatment specially adapted for magnetic separation by addition of magnetic adjuvants
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B03SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03CMAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C1/00Magnetic separation
    • B03C1/02Magnetic separation acting directly on the substance being separated
    • B03C1/025High gradient magnetic separators
    • B03C1/031Component parts; Auxiliary operations
    • B03C1/033Component parts; Auxiliary operations characterised by the magnetic circuit
    • B03C1/0332Component parts; Auxiliary operations characterised by the magnetic circuit using permanent magnets
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B03SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03CMAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C1/00Magnetic separation
    • B03C1/02Magnetic separation acting directly on the substance being separated
    • B03C1/10Magnetic separation acting directly on the substance being separated with cylindrical material carriers
    • B03C1/12Magnetic separation acting directly on the substance being separated with cylindrical material carriers with magnets moving during operation; with movable pole pieces
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B03SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03CMAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C1/00Magnetic separation
    • B03C1/02Magnetic separation acting directly on the substance being separated
    • B03C1/28Magnetic plugs and dipsticks
    • B03C1/288Magnetic plugs and dipsticks disposed at the outer circumference of a recipient
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B03SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03CMAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C2201/00Details of magnetic or electrostatic separation
    • B03C2201/18Magnetic separation whereby the particles are suspended in a liquid
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/0098Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor involving analyte bound to insoluble magnetic carrier, e.g. using magnetic separation

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Separation Of Solids By Using Liquids Or Pneumatic Power (AREA)
  • Sampling And Sample Adjustment (AREA)
CN2007800122011A 2006-03-31 2007-03-21 从含磁性微粒的液体分离所述微粒的设备和适于与之一起使用的容器阵列 Expired - Fee Related CN101415498B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP06075785A EP1839756A1 (en) 2006-03-31 2006-03-31 Apparatus for separating magnetic particles from liquids containing said particles, and an array of vessels suitable for use with such an apparatus
EP06075785.3 2006-03-31
PCT/EP2007/002491 WO2007112862A2 (en) 2006-03-31 2007-03-21 Apparatus for separating magnetic particles from liquids containing said particles, and an array of vessels suitable for use with such an apparatus

Publications (2)

Publication Number Publication Date
CN101415498A CN101415498A (zh) 2009-04-22
CN101415498B true CN101415498B (zh) 2012-11-07

Family

ID=36910803

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2007800122011A Expired - Fee Related CN101415498B (zh) 2006-03-31 2007-03-21 从含磁性微粒的液体分离所述微粒的设备和适于与之一起使用的容器阵列

Country Status (6)

Country Link
US (2) US8470267B2 (https=)
EP (2) EP1839756A1 (https=)
JP (1) JP4861468B2 (https=)
CN (1) CN101415498B (https=)
CA (1) CA2646670C (https=)
WO (1) WO2007112862A2 (https=)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6692700B2 (en) 2001-02-14 2004-02-17 Handylab, Inc. Heat-reduction methods and systems related to microfluidic devices
US7829025B2 (en) 2001-03-28 2010-11-09 Venture Lending & Leasing Iv, Inc. Systems and methods for thermal actuation of microfluidic devices
US8895311B1 (en) 2001-03-28 2014-11-25 Handylab, Inc. Methods and systems for control of general purpose microfluidic devices
EP3718635A1 (en) 2003-07-31 2020-10-07 Handylab, Inc. Processing particle-containing samples
US8852862B2 (en) 2004-05-03 2014-10-07 Handylab, Inc. Method for processing polynucleotide-containing samples
US7998708B2 (en) 2006-03-24 2011-08-16 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
ES2692380T3 (es) 2006-03-24 2018-12-03 Handylab, Inc. Método para realizar PCR con un cartucho con varias pistas
US11806718B2 (en) 2006-03-24 2023-11-07 Handylab, Inc. Fluorescence detector for microfluidic diagnostic system
US10900066B2 (en) 2006-03-24 2021-01-26 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
EP1839756A1 (en) 2006-03-31 2007-10-03 F.Hoffmann-La Roche Ag Apparatus for separating magnetic particles from liquids containing said particles, and an array of vessels suitable for use with such an apparatus
US8765076B2 (en) 2006-11-14 2014-07-01 Handylab, Inc. Microfluidic valve and method of making same
WO2008060604A2 (en) 2006-11-14 2008-05-22 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
US9186677B2 (en) 2007-07-13 2015-11-17 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
US8105783B2 (en) 2007-07-13 2012-01-31 Handylab, Inc. Microfluidic cartridge
US9618139B2 (en) 2007-07-13 2017-04-11 Handylab, Inc. Integrated heater and magnetic separator
AU2008276211B2 (en) 2007-07-13 2015-01-22 Handylab, Inc. Polynucleotide capture materials, and methods of using same
US8287820B2 (en) 2007-07-13 2012-10-16 Handylab, Inc. Automated pipetting apparatus having a combined liquid pump and pipette head system
US8182763B2 (en) 2007-07-13 2012-05-22 Handylab, Inc. Rack for sample tubes and reagent holders
USD787087S1 (en) 2008-07-14 2017-05-16 Handylab, Inc. Housing
EP3663004B1 (en) 2009-05-15 2022-01-26 Gen-Probe Incorporated Method and apparatus for performing a magnetic separation procedure
JP5623888B2 (ja) 2009-12-10 2014-11-12 エフ.ホフマン−ラ ロシュアーゲーF.Hoffmann−La Roche Aktiengesellschaft 分析対象物を分離して検出する方法
SE535983C2 (sv) * 2010-04-20 2013-03-19 Noviscens Ab Spruta
JP6088487B2 (ja) 2011-04-15 2017-03-01 ベクトン・ディキンソン・アンド・カンパニーBecton, Dickinson And Company 走査リアルタイムマイクロ流体熱サイクラーと同期熱サイクリング及び走査光学検出の方法
USD692162S1 (en) 2011-09-30 2013-10-22 Becton, Dickinson And Company Single piece reagent holder
RU2622432C2 (ru) 2011-09-30 2017-06-15 Бектон, Дикинсон Энд Компани Унифицированная полоска для реактивов
WO2013067202A1 (en) 2011-11-04 2013-05-10 Handylab, Inc. Polynucleotide sample preparation device
EP2607904B1 (en) 2011-12-21 2020-01-15 Roche Diagnostics GmbH Method for disposing of a liquid within an automated analytical system, tip rack assembly and analytical system
JP2013134069A (ja) * 2011-12-26 2013-07-08 Hitachi High-Technologies Corp 自動分析装置
AU2013214849B2 (en) 2012-02-03 2016-09-01 Becton, Dickinson And Company External files for distribution of molecular diagnostic tests and determination of compatibility between tests
US20130327695A1 (en) * 2012-06-08 2013-12-12 Massachusetts Institute Of Technology Magnet Configurations For Improved Separations Of Magnetic And Non-Magnetic Materials
US10220392B2 (en) 2013-03-15 2019-03-05 Becton, Dickinson And Company Process tube and carrier tray
US11865544B2 (en) 2013-03-15 2024-01-09 Becton, Dickinson And Company Process tube and carrier tray
AU2013381879B2 (en) 2013-03-15 2018-08-16 Becton, Dickinson And Company Process tube and carrier tray
CN203866294U (zh) * 2013-11-01 2014-10-08 艾康生物技术(杭州)有限公司 核酸提取仪
US9656267B2 (en) * 2015-09-17 2017-05-23 Nvigen, Inc. Magnetic rack
JP6771903B2 (ja) * 2016-02-29 2020-10-21 シスメックス株式会社 検体前処理装置、検体前処理カートリッジおよび検体前処理方法
EP3213819B1 (en) 2016-03-02 2021-09-29 F. Hoffmann-La Roche AG Device and method for separation
SG11201811781XA (en) * 2016-06-30 2019-01-30 General Automation Lab Technologies Inc High resolution systems, kits, apparatus, and methods using magnetic beads for high throughput microbiology applications
US9753044B1 (en) 2016-07-13 2017-09-05 William J. Palin Apparatus and method for detecting paramagnetic and superparamagnetic biomarkers
JP6995090B2 (ja) * 2019-07-11 2022-01-14 日本電子株式会社 自動分析装置および自動分析装置の制御方法
EP3834939A1 (en) * 2019-12-12 2021-06-16 TTP plc Sample preparation system
US11327087B2 (en) * 2020-04-13 2022-05-10 Brevitest Technologies, Llc Automated driving of an assay with spaced magnets
US20230136755A1 (en) * 2021-11-03 2023-05-04 Fluent Biosciences Inc. Devices for improving sample preparation and processing
WO2025196474A1 (en) * 2024-03-17 2025-09-25 Askari Mehdi Magnetic filter system in the electromechanical equipment of the refineries

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1295669A (zh) * 1998-02-06 2001-05-16 生物磁性有限公司 转移材料的装置和系统
DE10063984A1 (de) * 2000-12-19 2002-06-20 Bilatec Ges Zur Entwicklung Bi Vorrichtungen zur magnetischen Abtrennung von Magnetpartikeln
US6579453B1 (en) * 1997-09-29 2003-06-17 Roche Diagnostics Corporation Apparatus for separating magnetic particles
EP1441225A1 (en) * 2003-01-27 2004-07-28 Iqbal W. Dr. Siddiqi Apparatus and method for processing magnetic particles

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10219541C1 (de) 2002-05-02 2003-12-11 Koenig & Bauer Ag Vorrichtung zum Erfassen eines Bahnbruckes an einer eine Bahn verarbeitenden Maschine
JPS6484151A (en) * 1987-09-26 1989-03-29 Olympus Optical Co Dilution plate for liquid analyzing device
DE9006918U1 (de) * 1990-06-20 1990-08-23 Walter Sarstedt Geräte und Verbrauchsmaterial für Medizin und Wissenschaft, 5223 Nümbrecht Pipettenspitzenbehälter
DE4301084A1 (de) 1993-01-16 1994-07-21 Claas Saulgau Gmbh Kreiselheumaschine
DE59410037D1 (de) * 1993-09-17 2002-03-14 Hoffmann La Roche Analysengerät mit einer Vorrichtung zum Abtrennen magnetischer Mikropartikel
DE4423878A1 (de) 1994-07-07 1996-01-11 Boehringer Mannheim Gmbh Vorrichtung und Verfahren zum Abscheiden von magnetischen Mikropartikeln
JP3962789B2 (ja) * 1995-02-21 2007-08-22 ダブリュー. シディキー,イクバール 磁性粒子を利用した混合/分離装置及びその方法
JP3914552B2 (ja) * 1995-07-31 2007-05-16 プレシジョン・システム・サイエンス株式会社 容器
JP3985872B2 (ja) * 1995-07-31 2007-10-03 プレシジョン・システム・サイエンス株式会社 容器
US6065617A (en) * 1998-06-15 2000-05-23 Bayer Corporation Sample tube rack
DE19963032A1 (de) * 1999-12-24 2001-06-28 Roche Diagnostics Gmbh System zur Bearbeitung von Proben in einer Mehrkammeranordnung
DE10156790A1 (de) * 2001-11-19 2003-06-18 Chemagen Biopolymer Technologi Vorrichtung und Verfahren zum Behandeln von Magnetpartikeln
AU2003239485B2 (en) * 2002-05-17 2008-11-20 Gen-Probe Incorporated Sample carrier having sample tube blocking means and drip shield for use therewith
DE60336627D1 (de) * 2003-02-24 2011-05-19 Becton Dickinson France Vorrichtung zur Gruppierung von Spritzen
US7000785B2 (en) * 2003-04-03 2006-02-21 Bio-Rad Laboratories, Inc. Tube rack accommodating a range of tube diameters
US8211386B2 (en) * 2004-06-08 2012-07-03 Biokit, S.A. Tapered cuvette and method of collecting magnetic particles
EP1839756A1 (en) 2006-03-31 2007-10-03 F.Hoffmann-La Roche Ag Apparatus for separating magnetic particles from liquids containing said particles, and an array of vessels suitable for use with such an apparatus

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6579453B1 (en) * 1997-09-29 2003-06-17 Roche Diagnostics Corporation Apparatus for separating magnetic particles
CN1295669A (zh) * 1998-02-06 2001-05-16 生物磁性有限公司 转移材料的装置和系统
DE10063984A1 (de) * 2000-12-19 2002-06-20 Bilatec Ges Zur Entwicklung Bi Vorrichtungen zur magnetischen Abtrennung von Magnetpartikeln
EP1441225A1 (en) * 2003-01-27 2004-07-28 Iqbal W. Dr. Siddiqi Apparatus and method for processing magnetic particles

Also Published As

Publication number Publication date
US20130256205A1 (en) 2013-10-03
CA2646670C (en) 2011-09-20
JP4861468B2 (ja) 2012-01-25
WO2007112862A2 (en) 2007-10-11
US8470267B2 (en) 2013-06-25
CN101415498A (zh) 2009-04-22
JP2009531676A (ja) 2009-09-03
WO2007112862A3 (en) 2007-12-27
EP1839756A1 (en) 2007-10-03
EP2001597A2 (en) 2008-12-17
US9381519B2 (en) 2016-07-05
CA2646670A1 (en) 2007-10-11
US20100284864A1 (en) 2010-11-11

Similar Documents

Publication Publication Date Title
CN101415498B (zh) 从含磁性微粒的液体分离所述微粒的设备和适于与之一起使用的容器阵列
JP2009531676A5 (https=)
CN106537138B (zh) 预处理组件、使用该预处理组件进行试样的预处理的预处理装置及包括该预处理装置的分析系统
US8357543B2 (en) Apparatus and method for handling fluids for analysis
CN1967195B (zh) 提取涂抹试样的设备和方法
JP4901035B2 (ja) パーツの送給装置
JPH08248035A (ja) 分析装置に用いる探針洗浄装置
JP2024531316A (ja) 分注デバイス、そのような分注デバイスを有する遠心分離機、及び分注ノズルを洗浄するための方法
KR20170039288A (ko) 시약운반부, 어댑터 및 시약운반부 취급방법
KR100989710B1 (ko) 담체수용처리장치 및 담체수용처리방법
WO2006016528A1 (ja) ピペットチップ
JP3720461B2 (ja) 移送装置
CN116829263A (zh) 用于分离物体的微流体装置和方法
CN107153024A (zh) 用于分离的装置
CN110305767A (zh) 试剂盒、核酸提取组件及溶液废弃方法
US20140023569A1 (en) Suction Device for a Matrix Array of Pipette Tips
JP4250641B2 (ja) ピペットチップの収納方法
EP1681570A2 (en) Apparatus and method for handling fluids for analysis
JP3347179B2 (ja) 試料採取用プローブの供給装置
CN112639487A (zh) 自动分析装置和清洗方法
CN120651621A (zh) 检体处理装置
JP2023026306A (ja) 自動分析装置および自動分析方法
JP2007046956A (ja) 分注装置
CN105142532A (zh) 用于固体生物样品的分析的样品支架
JP2001343359A (ja) ゲル処理プレート

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
CF01 Termination of patent right due to non-payment of annual fee
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20121107

Termination date: 20170321