CN101405289A - 吡唑并[1,5-a]嘧啶衍生物和其使用方法 - Google Patents

吡唑并[1,5-a]嘧啶衍生物和其使用方法 Download PDF

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Publication number
CN101405289A
CN101405289A CNA2007800095014A CN200780009501A CN101405289A CN 101405289 A CN101405289 A CN 101405289A CN A2007800095014 A CNA2007800095014 A CN A2007800095014A CN 200780009501 A CN200780009501 A CN 200780009501A CN 101405289 A CN101405289 A CN 101405289A
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CN
China
Prior art keywords
phenyl
pyrazolo
trifluoromethyl
amino
pyrimidin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CNA2007800095014A
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English (en)
Chinese (zh)
Inventor
阿里亚马拉·戈帕尔萨米
格雷戈里·M·齐谢夫斯基
石孟晓
达恩·马尔滕·贝格尔
南希·托里斯
杰里米·I·莱温
丹尼斯·威廉·鲍威尔
金耿义
李忠
乔治·迪亚曼迪斯
达林·威廉姆·霍伯
爱德华·詹姆斯·萨拉斯基
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Wyeth LLC
Original Assignee
Wyeth LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth LLC filed Critical Wyeth LLC
Publication of CN101405289A publication Critical patent/CN101405289A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CNA2007800095014A 2006-03-17 2007-03-15 吡唑并[1,5-a]嘧啶衍生物和其使用方法 Pending CN101405289A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US78363106P 2006-03-17 2006-03-17
US60/783,631 2006-03-17

Publications (1)

Publication Number Publication Date
CN101405289A true CN101405289A (zh) 2009-04-08

Family

ID=38522947

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA2007800095014A Pending CN101405289A (zh) 2006-03-17 2007-03-15 吡唑并[1,5-a]嘧啶衍生物和其使用方法

Country Status (9)

Country Link
US (1) US20070219186A1 (https=)
EP (1) EP1996594A2 (https=)
JP (1) JP2009530296A (https=)
CN (1) CN101405289A (https=)
AU (1) AU2007227557A1 (https=)
BR (1) BRPI0708813A2 (https=)
CA (1) CA2643968A1 (https=)
MX (1) MX2008011853A (https=)
WO (1) WO2007109093A2 (https=)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103936757A (zh) * 2013-01-18 2014-07-23 上海昀怡健康管理咨询有限公司 五元并六元杂环化合物、其制备方法、药物组合物和应用
CN108467369A (zh) * 2013-03-14 2018-08-31 诺华股份有限公司 作为激酶抑制剂的联芳基酰胺化合物
CN117659025A (zh) * 2017-10-30 2024-03-08 科罗拉多州立大学董事会法人团体 Toll样受体8（tlr8）特异性拮抗剂及其制备方法和用途

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100029657A1 (en) * 2008-02-29 2010-02-04 Wyeth Bridged, Bicyclic Heterocyclic or Spiro Bicyclic Heterocyclic Derivatives of Pyrazolo[1, 5-A]Pyrimidines, Methods for Preparation and Uses Thereof
WO2009108827A1 (en) * 2008-02-29 2009-09-03 Wyeth Fused tricyclic pyrazolo[1, 5-a]pyrimidines, methods for preparation and uses thereof
CN102223798A (zh) * 2008-09-24 2011-10-19 巴斯夫欧洲公司 用于防治无脊椎动物害虫的吡唑化合物
WO2010138820A2 (en) * 2009-05-28 2010-12-02 President And Fellows Of Harvard College N,n-diarylurea compounds and n,n'-diarylthiourea compounds as inhibitors of translation initiation
CR20190157A (es) 2016-08-31 2019-08-13 Agios Pharmaceuticals Inc Inhibidores de procesos metabólicos celulares

Family Cites Families (12)

* Cited by examiner, † Cited by third party
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US4626538A (en) * 1983-06-23 1986-12-02 American Cyanamid Company [7-(3-disubstituted amino)phenyl]pyrazolo[1,5-a]pyrimidines
US5219857A (en) * 1986-10-16 1993-06-15 American Cyanamid Company Method of treating cognitive and related neural behavioral problems
US4847256A (en) * 1986-10-16 1989-07-11 American Cyanamid Company 4,5-dihydro and 4,5,6,7-tetrahydropyrazolo(1,5-A)-pyrimidines
US5126340A (en) * 1986-10-16 1992-06-30 American Cyanamid Company 4-[(substituted)alkylcarbonyl]-4,5-dihydro and -4,5,6,7-tetrahydro-7-[(substituted)-phenyl]pyrazolo[1,5-a]pyrimidine-3-carbonitriles
US4963553A (en) * 1986-10-16 1990-10-16 American Cyanamid Co. 4-[(substituted) alkylcarbonyl]-4,5-dihydro- and -4,5,6,7-tetrahydro-7-[(substituted)phenyl]pyrazolo[1,5-a]pyrimidines
US5013737A (en) * 1988-02-22 1991-05-07 American Cyanamid Company 2,4,8-Trisubstituted-3H,6H-1,4,5A,8A-tetraazaacenaphtylene-3,5-(4H)-diones and 2,4-8-trisubstituted-4,5-dihydro-5-thioxo-3H,6H-1,4,5A,8A-tetrazaacenaphthylen-3-ones
US4916137A (en) * 1988-02-22 1990-04-10 American Cyanamid Company 5-(Substituted-amino)-8-(phenyl or substituted-phenyl)-3H,6H-1,4,5A,8A-tetraazaacenaphthylen-3-ones and treatment of neural behavior disorders
US20070179161A1 (en) * 2003-03-31 2007-08-02 Vernalis (Cambridge) Limited. Pyrazolopyrimidine compounds and their use in medicine
ES2222813B1 (es) * 2003-07-24 2005-12-16 Ferrer Internacional, S.A. N-(3-(3-sustituidas-pirazolo(1,5-a)pirimidin-7-il)-fenil)-sulfonamidas y composiciones y metodos relacionados.
WO2006033795A2 (en) * 2004-09-17 2006-03-30 Wyeth Substituted pyrazolo [1, 5-a] pyrimidines for inhibiting abnormal cell growth
WO2006033796A1 (en) * 2004-09-17 2006-03-30 Wyeth SUBSTITUTED PYRAZOLO [1,5-a] PYRIMIDINES AND PROCESS FOR MAKING SAME
EP1736475A1 (en) * 2005-06-21 2006-12-27 Ferrer Internacional, S.A. Halogenated pyrazolo[1,5-a]pyrimidines, processes, uses, compositions and intermediates

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103936757A (zh) * 2013-01-18 2014-07-23 上海昀怡健康管理咨询有限公司 五元并六元杂环化合物、其制备方法、药物组合物和应用
WO2014111037A1 (zh) * 2013-01-18 2014-07-24 上海昀怡健康管理咨询有限公司 五元并六元杂环化合物、其制备方法、药物组合物和应用
US9745320B2 (en) 2013-01-18 2017-08-29 Guangzhou Maxinovel Pharmaceuticals Co., Ltd. Five-and-six-membered heterocyclic compound, and preparation method, pharmaceutical composition and use thereof
CN103936757B (zh) * 2013-01-18 2019-09-13 广州再极医药科技有限公司 五元并六元杂环化合物、其制备方法、药物组合物和应用
CN108467369A (zh) * 2013-03-14 2018-08-31 诺华股份有限公司 作为激酶抑制剂的联芳基酰胺化合物
CN108467369B (zh) * 2013-03-14 2021-08-20 诺华股份有限公司 作为激酶抑制剂的联芳基酰胺化合物
CN117659025A (zh) * 2017-10-30 2024-03-08 科罗拉多州立大学董事会法人团体 Toll样受体8（tlr8）特异性拮抗剂及其制备方法和用途

Also Published As

Publication number Publication date
BRPI0708813A2 (pt) 2011-05-24
WO2007109093A2 (en) 2007-09-27
EP1996594A2 (en) 2008-12-03
JP2009530296A (ja) 2009-08-27
WO2007109093A3 (en) 2008-01-24
MX2008011853A (es) 2008-09-29
US20070219186A1 (en) 2007-09-20
AU2007227557A1 (en) 2007-09-27
CA2643968A1 (en) 2007-09-27

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Open date: 20090408