BRPI0708813A2 - composto; composição; método de tratamento, inibição do crescimento ou erradicaçõ de neoplasias em um mamìfero necessitado; método de tratamento dse cáncer em um mamìfero necessitado; e mistura - Google Patents

composto; composição; método de tratamento, inibição do crescimento ou erradicaçõ de neoplasias em um mamìfero necessitado; método de tratamento dse cáncer em um mamìfero necessitado; e mistura Download PDF

Info

Publication number
BRPI0708813A2
BRPI0708813A2 BRPI0708813-2A BRPI0708813A BRPI0708813A2 BR PI0708813 A2 BRPI0708813 A2 BR PI0708813A2 BR PI0708813 A BRPI0708813 A BR PI0708813A BR PI0708813 A2 BRPI0708813 A2 BR PI0708813A2
Authority
BR
Brazil
Prior art keywords
phenyl
trifluoromethyl
pyrazolo
pyrimidin
amino
Prior art date
Application number
BRPI0708813-2A
Other languages
English (en)
Portuguese (pt)
Inventor
Ariamala Gopalsamy
Gregory M Ciszewski
Mengxiao Shi
Dan Maarten Berger
Nancy Torres
Jeremy I Levin
Dennis William Powell
Kyung-Hee Kim
Zhong Li
George Diamantidis
Darrin William Hopper
Edward James Salaski
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of BRPI0708813A2 publication Critical patent/BRPI0708813A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
BRPI0708813-2A 2006-03-17 2007-03-15 composto; composição; método de tratamento, inibição do crescimento ou erradicaçõ de neoplasias em um mamìfero necessitado; método de tratamento dse cáncer em um mamìfero necessitado; e mistura BRPI0708813A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US78363106P 2006-03-17 2006-03-17
US783,631 2006-03-17
PCT/US2007/006539 WO2007109093A2 (en) 2006-03-17 2007-03-15 Pyrazolo[1,5-a]pyrimidine derivatives and methods of use thereof

Publications (1)

Publication Number Publication Date
BRPI0708813A2 true BRPI0708813A2 (pt) 2011-05-24

Family

ID=38522947

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0708813-2A BRPI0708813A2 (pt) 2006-03-17 2007-03-15 composto; composição; método de tratamento, inibição do crescimento ou erradicaçõ de neoplasias em um mamìfero necessitado; método de tratamento dse cáncer em um mamìfero necessitado; e mistura

Country Status (9)

Country Link
US (1) US20070219186A1 (https=)
EP (1) EP1996594A2 (https=)
JP (1) JP2009530296A (https=)
CN (1) CN101405289A (https=)
AU (1) AU2007227557A1 (https=)
BR (1) BRPI0708813A2 (https=)
CA (1) CA2643968A1 (https=)
MX (1) MX2008011853A (https=)
WO (1) WO2007109093A2 (https=)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100029657A1 (en) * 2008-02-29 2010-02-04 Wyeth Bridged, Bicyclic Heterocyclic or Spiro Bicyclic Heterocyclic Derivatives of Pyrazolo[1, 5-A]Pyrimidines, Methods for Preparation and Uses Thereof
WO2009108827A1 (en) * 2008-02-29 2009-09-03 Wyeth Fused tricyclic pyrazolo[1, 5-a]pyrimidines, methods for preparation and uses thereof
CN102223798A (zh) * 2008-09-24 2011-10-19 巴斯夫欧洲公司 用于防治无脊椎动物害虫的吡唑化合物
WO2010138820A2 (en) * 2009-05-28 2010-12-02 President And Fellows Of Harvard College N,n-diarylurea compounds and n,n'-diarylthiourea compounds as inhibitors of translation initiation
US9745320B2 (en) 2013-01-18 2017-08-29 Guangzhou Maxinovel Pharmaceuticals Co., Ltd. Five-and-six-membered heterocyclic compound, and preparation method, pharmaceutical composition and use thereof
US9242969B2 (en) * 2013-03-14 2016-01-26 Novartis Ag Biaryl amide compounds as kinase inhibitors
CR20190157A (es) 2016-08-31 2019-08-13 Agios Pharmaceuticals Inc Inhibidores de procesos metabólicos celulares
CN117659025A (zh) * 2017-10-30 2024-03-08 科罗拉多州立大学董事会法人团体 Toll样受体8（tlr8）特异性拮抗剂及其制备方法和用途

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4626538A (en) * 1983-06-23 1986-12-02 American Cyanamid Company [7-(3-disubstituted amino)phenyl]pyrazolo[1,5-a]pyrimidines
US5219857A (en) * 1986-10-16 1993-06-15 American Cyanamid Company Method of treating cognitive and related neural behavioral problems
US4847256A (en) * 1986-10-16 1989-07-11 American Cyanamid Company 4,5-dihydro and 4,5,6,7-tetrahydropyrazolo(1,5-A)-pyrimidines
US5126340A (en) * 1986-10-16 1992-06-30 American Cyanamid Company 4-[(substituted)alkylcarbonyl]-4,5-dihydro and -4,5,6,7-tetrahydro-7-[(substituted)-phenyl]pyrazolo[1,5-a]pyrimidine-3-carbonitriles
US4963553A (en) * 1986-10-16 1990-10-16 American Cyanamid Co. 4-[(substituted) alkylcarbonyl]-4,5-dihydro- and -4,5,6,7-tetrahydro-7-[(substituted)phenyl]pyrazolo[1,5-a]pyrimidines
US5013737A (en) * 1988-02-22 1991-05-07 American Cyanamid Company 2,4,8-Trisubstituted-3H,6H-1,4,5A,8A-tetraazaacenaphtylene-3,5-(4H)-diones and 2,4-8-trisubstituted-4,5-dihydro-5-thioxo-3H,6H-1,4,5A,8A-tetrazaacenaphthylen-3-ones
US4916137A (en) * 1988-02-22 1990-04-10 American Cyanamid Company 5-(Substituted-amino)-8-(phenyl or substituted-phenyl)-3H,6H-1,4,5A,8A-tetraazaacenaphthylen-3-ones and treatment of neural behavior disorders
US20070179161A1 (en) * 2003-03-31 2007-08-02 Vernalis (Cambridge) Limited. Pyrazolopyrimidine compounds and their use in medicine
ES2222813B1 (es) * 2003-07-24 2005-12-16 Ferrer Internacional, S.A. N-(3-(3-sustituidas-pirazolo(1,5-a)pirimidin-7-il)-fenil)-sulfonamidas y composiciones y metodos relacionados.
WO2006033795A2 (en) * 2004-09-17 2006-03-30 Wyeth Substituted pyrazolo [1, 5-a] pyrimidines for inhibiting abnormal cell growth
WO2006033796A1 (en) * 2004-09-17 2006-03-30 Wyeth SUBSTITUTED PYRAZOLO [1,5-a] PYRIMIDINES AND PROCESS FOR MAKING SAME
EP1736475A1 (en) * 2005-06-21 2006-12-27 Ferrer Internacional, S.A. Halogenated pyrazolo[1,5-a]pyrimidines, processes, uses, compositions and intermediates

Also Published As

Publication number Publication date
WO2007109093A2 (en) 2007-09-27
EP1996594A2 (en) 2008-12-03
JP2009530296A (ja) 2009-08-27
WO2007109093A3 (en) 2008-01-24
MX2008011853A (es) 2008-09-29
US20070219186A1 (en) 2007-09-20
AU2007227557A1 (en) 2007-09-27
CA2643968A1 (en) 2007-09-27
CN101405289A (zh) 2009-04-08

Similar Documents

Publication Publication Date Title
ES2426951T3 (es) Imidazopiridazinacarbonitrilos útiles como inhibidores de quinasa
JP6759514B2 (ja) ブロモドメインに対して活性な化合物
EP3016932B1 (en) Ido inhibitors
ES2297498T3 (es) Composiciones utiles como inhibidores de proteina quinasas.
US9556179B2 (en) Substituted imidazoles as casein kinase 1 D/E inhibitors
US9956220B2 (en) Imidazo-pyridazine derivatives as casein kinase 1 δ/ϵ inhibitors
BRPI0708813A2 (pt) composto; composição; método de tratamento, inibição do crescimento ou erradicaçõ de neoplasias em um mamìfero necessitado; método de tratamento dse cáncer em um mamìfero necessitado; e mistura
BRPI0713328A2 (pt) derivados de piridina e pirazina como inibidores de cinase mnk
CA2917964A1 (en) Ido inhibitors
AU2007336011A1 (en) Acylaminopyrazoles as FGFR inhibitors
KR20130073876A (ko) Ｎ-(이미다조피리미딘-7-일)-헤테로아릴아마이드 유도체 및 ｐｄｅ10ａ 억제제로서의 그의 용도
JP2011529073A (ja) キナーゼ調節因子として有用な縮合ヘテロ環化合物
JP2021505684A (ja) ヒストンデアセチラーゼ６阻害剤としての１，２，４−オキサジアゾール誘導体
JP2010522241A (ja) 増殖性疾患、アレルギー性疾患、自己免疫疾患または炎症性疾患として有用な縮合ヘテロ環化合物
US9475817B2 (en) Pyrazole substituted imidazopyrazines as casein kinase 1 d/e inhibitors
JP2021536436A (ja) キノリン誘導体から調製される新規な阻害剤
CN110494433A (zh) 布鲁顿酪氨酸激酶抑制剂
JP2026021463A (ja) スルホンアミド化合物
WO2014014314A1 (ko) 이중 저해 활성을 갖는 헤테로고리 유도체
US20180057465A1 (en) Inhibitors of Necroptosis
AU2021398704A1 (en) Heterocyclic jak inhibitor
CN115843296B (zh) Cdk9抑制剂及其用途
CN121517411A (zh) Cdk2降解剂及其制备方法和应用
CN120398829A (zh) 2-胺基取代氮杂芳环类化合物及其药物组合物和应用

Legal Events

Date Code Title Description
B06G Technical and formal requirements: other requirements [chapter 6.7 patent gazette]

Free format text: PARA QUE A PETICAO NO 20090072505/RJ DE 28.07.09 SEJA ATENDIDA, APRESENTAR PROCURACAO ORIGINAL, OUCOPIA AUTENTICADA, DANDO PODERES PARA DESISTIR DO PEDIDO.

B15G Petition not considered as such [chapter 15.7 patent gazette]

Free format text: NAO CONHECIDA A PETICAO NO 20090072505/RJ DE 28.07.2009, EM VIRTUDE DO DISPOSTO NO ART. 219 INCISOII DA LPI, UMA VEZ QUE NAO FOI CUMPRIDA A EXIGENCIA 6.7 PUBLICADA NA RPI 2032 DE 15.12.2009.

B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]