CN101367877A - 人b7.1和/或b7.2特异的猴源单克隆抗体的灵长动物化形式,药用组合物 - Google Patents
人b7.1和/或b7.2特异的猴源单克隆抗体的灵长动物化形式,药用组合物 Download PDFInfo
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| US08/487550 | 1995-06-07 | ||
| US08/487,550 US6113898A (en) | 1995-06-07 | 1995-06-07 | Human B7.1-specific primatized antibodies and transfectomas expressing said antibodies |
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| CNB961961457A Division CN100379855C (zh) | 1995-06-07 | 1996-06-06 | 人b7.1和/或b7.2特异的猴源单克隆抗体灵长动物化形式,药用组合物 |
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| CN101367877A true CN101367877A (zh) | 2009-02-18 |
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| CNA2008100058558A Pending CN101367877A (zh) | 1995-06-07 | 1996-06-06 | 人b7.1和/或b7.2特异的猴源单克隆抗体的灵长动物化形式,药用组合物 |
| CNB961961457A Expired - Fee Related CN100379855C (zh) | 1995-06-07 | 1996-06-06 | 人b7.1和/或b7.2特异的猴源单克隆抗体灵长动物化形式,药用组合物 |
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| CNB961961457A Expired - Fee Related CN100379855C (zh) | 1995-06-07 | 1996-06-06 | 人b7.1和/或b7.2特异的猴源单克隆抗体灵长动物化形式,药用组合物 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI854983B (zh) * | 2018-06-22 | 2024-09-11 | 日商順天生化股份有限公司 | 誘導免疫耐受之抗體、被誘導之淋巴球、及使用被誘導之淋巴球之細胞治療劑治療方法 |
Families Citing this family (114)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7153508B2 (en) * | 1995-06-07 | 2006-12-26 | Biogen Idec Inc. | Treatment of B cell lymphoma using anti-CD80 antibodies that do not inhibit the binding of CD80 to CTLA-4 |
| US20030180290A1 (en) * | 1995-06-07 | 2003-09-25 | Idec Pharmaceuticals Corporation | Anti-CD80 antibody having ADCC activity for ADCC mediated killing of B cell lymphoma cells alone or in combination with other therapies |
| US6113898A (en) * | 1995-06-07 | 2000-09-05 | Idec Pharmaceuticals Corporation | Human B7.1-specific primatized antibodies and transfectomas expressing said antibodies |
| US7175847B1 (en) * | 1995-06-07 | 2007-02-13 | Biogen Idec Inc. | Treating intestinal inflammation with anti-CD80 antibodies that do not inhibit CD80 binding to CTLA-4 |
| US6090382A (en) * | 1996-02-09 | 2000-07-18 | Basf Aktiengesellschaft | Human antibodies that bind human TNFα |
| BRPI9707379C8 (pt) | 1996-02-09 | 2017-12-12 | Abbott Biotech Ltd | composições farmacêuticas compreendendo anticorpo humano recombinante geneticamente engenheirado, e anticorpo humano recombinante geneticamente engenheirado. |
| PT892643E (pt) * | 1996-03-20 | 2002-09-30 | Univ Emory | Metodos para inibir uma resposta imunitaria bloqueando os circuitos de gp39/cd40 e ctla4/cd28/b7 e composicoes utilizaveis para o efeito |
| EP1007090B1 (en) * | 1996-11-08 | 2009-12-30 | Biogen Idec Inc. | Identification of unique binding interactions between certain antibodies and the human b7.1 (cd80) and b7.2 (cd28) co-stimulatory antigens |
| WO1998058965A2 (en) * | 1997-06-20 | 1998-12-30 | Innogenetics N.V. | B7-binding molecules for treating immune diseases |
| IT1293795B1 (it) * | 1997-07-28 | 1999-03-10 | Angelini Ricerche Spa | Farmaco attivo nel ridurre la produzione di proteina mcp-1 |
| IL146005A0 (en) | 1999-05-07 | 2002-07-25 | Genentech Inc | Treatment of autoimmune diseases with antagonists which bind to b cell surface markers |
| KR20020027490A (ko) * | 1999-07-12 | 2002-04-13 | 제넨테크, 인크. | Ｃｄ20에 결합하는 길항제를 사용한 외래 항원에 대한면역 반응 차단 방법 |
| US6451284B1 (en) * | 1999-08-11 | 2002-09-17 | Idec Pharmaceuticals Corporation | Clinical parameters for determining hematologic toxicity prior to radioimmunotheraphy |
| SE9903895D0 (sv) * | 1999-10-28 | 1999-10-28 | Active Biotech Ab | Novel compounds |
| US20020028178A1 (en) * | 2000-07-12 | 2002-03-07 | Nabil Hanna | Treatment of B cell malignancies using combination of B cell depleting antibody and immune modulating antibody related applications |
| US20010055593A1 (en) * | 2000-03-14 | 2001-12-27 | Joseph Sypek | Use of rapamycin and agents that inhibit B7 activity in immunomodulation |
| CN1981868A (zh) | 2000-03-31 | 2007-06-20 | 拜奥根Idec公司 | 抗细胞因子抗体或拮抗剂与抗－cd20在b细胞淋巴瘤治疗中的联合应用 |
| US6379900B1 (en) | 2000-05-09 | 2002-04-30 | Conceptual Mindworks, Inc. | Compositions and methods of use of 8-nitroguanine |
| MXPA02012157A (es) * | 2000-06-09 | 2003-06-06 | Bristol Myers Squibb Co | Metodos para regular una respuesta inmune mediada por celulas al bloquear se°ales linfociticas y al bloquear la adhesion mediada por el antigeno 1 asociado con la funcion de linfocitos. |
| JP2004512262A (ja) | 2000-06-20 | 2004-04-22 | アイデック ファーマスーティカルズ コーポレイション | 非放射性抗ｃｄ２０抗体／放射標識抗ｃｄ２２抗体の組合せ |
| US20040022787A1 (en) | 2000-07-03 | 2004-02-05 | Robert Cohen | Methods for treating an autoimmune disease using a soluble CTLA4 molecule and a DMARD or NSAID |
| PL212205B1 (pl) | 2000-07-03 | 2012-08-31 | Bristol Myers Squibb Co | Zastosowanie rozpuszczalnej zmutowanej cząsteczki CTLA4 |
| US8568766B2 (en) | 2000-08-24 | 2013-10-29 | Gattadahalli M. Anantharamaiah | Peptides and peptide mimetics to treat pathologies associated with eye disease |
| KR20040023565A (ko) * | 2000-09-18 | 2004-03-18 | 아이덱 파마슈티칼즈 코포레이션 | Ｂ 세포 고갈/면역조절 항체 조합을 이용한 자가면역질환의 치료를 위한 조합 요법 |
| AU2002243905B2 (en) * | 2001-01-26 | 2007-11-08 | Emory University | Methods of inducing organ transplant tolerance and correcting hemoglobinopathies |
| US20030211107A1 (en) * | 2002-01-31 | 2003-11-13 | Kandasamy Hariharan | Use of CD23 antagonists for the treatment of neoplastic disorders |
| US20020159996A1 (en) * | 2001-01-31 | 2002-10-31 | Kandasamy Hariharan | Use of CD23 antagonists for the treatment of neoplastic disorders |
| US20030103971A1 (en) * | 2001-11-09 | 2003-06-05 | Kandasamy Hariharan | Immunoregulatory antibodies and uses thereof |
| US20070065436A1 (en) * | 2001-01-31 | 2007-03-22 | Biogen Idec Inc. | Anti-cd80 antibody having adcc activity for adcc mediated killing of b cell lymphoma cells alone or in combination with other therapies |
| WO2002102303A2 (en) * | 2001-05-01 | 2002-12-27 | Medimmune, Inc. | Crystals and structure of synagis fab |
| PL204899B1 (pl) * | 2001-05-23 | 2010-02-26 | Bristol Myers Squibb Co | Zastosowanie rozpuszczalnej zmutowanej cząsteczki CTLA4 |
| CN1585822A (zh) | 2001-11-16 | 2005-02-23 | 拜奥根Idec公司 | 抗体的多顺反子表达 |
| SI1485127T1 (sl) | 2002-02-25 | 2011-09-30 | Elan Pharm Inc | Dajanje aktivne snovi za zdravljenje vnetja |
| US20030180292A1 (en) * | 2002-03-14 | 2003-09-25 | Idec Pharmaceuticals | Treatment of B cell malignancies using anti-CD40L antibodies in combination with anti-CD20 antibodies and/or chemotherapeutics and radiotherapy |
| EP3254673A1 (en) | 2002-11-13 | 2017-12-13 | The UAB Research Foundation | Synthetic single domain polypeptides mimicking apolipoprotein e and methods of use |
| CA2762015A1 (en) * | 2003-08-04 | 2005-02-24 | Bristol-Myers Squibb Company | Methods for treating cardiovascular disease using a soluble ctla4 molecule |
| AU2004284243B2 (en) * | 2003-10-21 | 2010-11-04 | Merck Serono Sa | Minimal DNA sequence acting as a chromatin insulator and its use in protein expression |
| CA2543631A1 (en) * | 2003-11-07 | 2005-05-26 | Amgen Inc. | Monkey immunoglobulin sequences |
| US8029783B2 (en) * | 2005-02-02 | 2011-10-04 | Genentech, Inc. | DR5 antibodies and articles of manufacture containing same |
| CN100369931C (zh) * | 2005-04-07 | 2008-02-20 | 苏州大学 | 抗人b7-1分子单克隆抗体及其应用 |
| WO2008118324A2 (en) | 2007-03-26 | 2008-10-02 | Macrogenics, Inc. | Composition and method of treating cancer with an anti-uroplakin ib antibody |
| CA2704729C (en) | 2007-08-28 | 2020-06-23 | Uab Research Foundation | Synthetic apolipoprotein e mimicking polypeptides and methods of use |
| CA2697957A1 (en) | 2007-08-28 | 2009-03-12 | Uab Research Foundation | Synthetic apolipoprotein e mimicking polypeptides and methods of use |
| ES2719728T3 (es) | 2007-09-04 | 2019-07-12 | Compugen Ltd | Polipéptidos y polinucleótidos, y usos de los mismos como una diana farmacológica para producir fármacos y agentes biológicos |
| EP3062106B1 (en) | 2008-04-16 | 2020-11-11 | The Johns Hopkins University | Method for determining androgen receptor variants in prostate cancer |
| HUE029197T2 (en) | 2009-09-29 | 2017-02-28 | Hoffmann La Roche | Adjustment of dissolved buffer by pre-filtration to a high concentration immunoglobulin formulation |
| US9540426B2 (en) | 2009-10-06 | 2017-01-10 | Bristol-Myers Squibb Company | Mammalian cell culture processes for protein production |
| EP2322149A1 (en) | 2009-11-03 | 2011-05-18 | Universidad del Pais Vasco | Methods and compositions for the treatment of ischemia |
| EP2338492A1 (en) | 2009-12-24 | 2011-06-29 | Universidad del Pais Vasco | Methods and compositions for the treatment of alzheimer |
| CN102844050B (zh) | 2010-02-19 | 2019-02-05 | 康奈尔大学 | 自身免疫性脱髓鞘疾病及其它自身免疫疾病或炎性疾病的治疗方法 |
| SG10201604336VA (en) | 2010-03-04 | 2016-07-28 | Macrogenics Inc | Antibodies Reactive With B7-H3, Immunologically Active Fragments Thereof And Uses Thereof |
| PH12012501751A1 (en) | 2010-03-04 | 2012-11-12 | Macrogenics Inc | Antibodies reactive with b7-h3, immunologically active fragments thereof and uses thereof |
| EA031737B1 (ru) | 2010-06-03 | 2019-02-28 | Фармасайкликс, Инк. | Применение ингибиторов тирозинкиназы брутона (btk) для лечения лейкоза и лимфомы |
| AU2011267089B2 (en) | 2010-06-14 | 2017-02-16 | Lykera Biomed Sa | S100A4 antibodies and therapeutic uses thereof |
| EP2596022A4 (en) | 2010-07-20 | 2014-11-05 | Cephalon Australia Pty Ltd | SPECIFIC ANTIBODIES ANTI-HETERODIMER IL-23 |
| LT3722808T (lt) | 2010-10-25 | 2024-12-27 | Biogen Ma Inc. | Alfa-4 integrino aktyvumo skirtumo, koreliuojančio su skirtumais svcam ir/arba smadcam lygiuose, nustatymo būdai |
| CA2817418A1 (en) | 2010-11-10 | 2012-05-18 | Laboratorios Del Dr. Esteve, S.A. | Highly immunogenic hiv p24 sequences |
| DK2665746T3 (en) | 2011-01-17 | 2021-02-01 | Lykera Biomed S A | Antibodies against the s100p protein for the treatment and diagnosis of cancer |
| WO2012100835A1 (en) | 2011-01-28 | 2012-08-02 | Laboratorios Del Dr. Esteve, S.A. | Methods and compositions for the treatment of aids |
| EP2702077A2 (en) | 2011-04-27 | 2014-03-05 | AbbVie Inc. | Methods for controlling the galactosylation profile of recombinantly-expressed proteins |
| JP6305919B2 (ja) | 2011-06-06 | 2018-04-04 | プロセナ バイオサイエンシーズ リミテッド | Ｍｃａｍアンタゴニスト及び治療の方法 |
| US9428574B2 (en) | 2011-06-30 | 2016-08-30 | Compugen Ltd. | Polypeptides and uses thereof for treatment of autoimmune disorders and infection |
| MX2014003689A (es) | 2011-09-30 | 2014-12-05 | Teva Pharmaceuticals Australia Pty Ltd | Anticuerpos contra tl1a y sus usos. |
| JP2015504413A (ja) | 2011-10-28 | 2015-02-12 | パトリス リミテッド | Ｐａｔ−ｌｍ１エピトープおよびそれを使用するための方法 |
| KR20140126357A (ko) | 2012-02-01 | 2014-10-30 | 컴퓨젠 엘티디. | C1orf32 항체 및 이의 암 치료를 위한 용도 |
| WO2013158273A1 (en) | 2012-04-20 | 2013-10-24 | Abbvie Inc. | Methods to modulate c-terminal lysine variant distribution |
| US9150645B2 (en) | 2012-04-20 | 2015-10-06 | Abbvie, Inc. | Cell culture methods to reduce acidic species |
| US9067990B2 (en) | 2013-03-14 | 2015-06-30 | Abbvie, Inc. | Protein purification using displacement chromatography |
| US9249182B2 (en) | 2012-05-24 | 2016-02-02 | Abbvie, Inc. | Purification of antibodies using hydrophobic interaction chromatography |
| EP3550031A1 (en) | 2012-07-24 | 2019-10-09 | Pharmacyclics, LLC | Mutations associated with resistance to inhibitors of bruton's tyrosine kinase (btk) |
| AU2013309506A1 (en) | 2012-09-02 | 2015-03-12 | Abbvie Inc. | Methods to control protein heterogeneity |
| US9512214B2 (en) | 2012-09-02 | 2016-12-06 | Abbvie, Inc. | Methods to control protein heterogeneity |
| TWI660972B (zh) | 2012-09-10 | 2019-06-01 | 愛爾蘭商尼歐托普生物科學公司 | 抗ｍｃａｍ抗體及相關使用方法 |
| AU2014213009B2 (en) | 2013-02-01 | 2019-01-03 | Kira Biotech Pty Limited | Anti-CD83 antibodies and use thereof |
| AU2014214530B2 (en) | 2013-02-07 | 2014-10-16 | Csl Limited | IL-11R binding proteins and uses thereof |
| US9487587B2 (en) | 2013-03-05 | 2016-11-08 | Macrogenics, Inc. | Bispecific molecules that are immunoreactive with immune effector cells of a companion animal that express an activating receptor and cells that express B7-H3 and uses thereof |
| EP2830651A4 (en) | 2013-03-12 | 2015-09-02 | Abbvie Inc | HUMAN ANTIBODIES THAT BIND TNF-ALPHA AND PREPARATION METHODS |
| US9017687B1 (en) | 2013-10-18 | 2015-04-28 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same using displacement chromatography |
| US9499614B2 (en) | 2013-03-14 | 2016-11-22 | Abbvie Inc. | Methods for modulating protein glycosylation profiles of recombinant protein therapeutics using monosaccharides and oligosaccharides |
| RU2015137617A (ru) | 2013-03-14 | 2017-04-18 | Юниверсити Оф Мэриленд, Балтимор Офис Оф Текнолоджи Трансфер | Агенты, подавляющие андрогенные рецепторы, и их применение |
| WO2014159579A1 (en) | 2013-03-14 | 2014-10-02 | Abbvie Inc. | MUTATED ANTI-TNFα ANTIBODIES AND METHODS OF THEIR USE |
| PL2984108T3 (pl) | 2013-04-09 | 2017-12-29 | Lykera Biomed, S.A. | Przeciwciała anty s100a7 do leczenia i diagnozowania nowotworu |
| KR20160058774A (ko) | 2013-08-12 | 2016-05-25 | 토카이 파마슈티컬, 아이엔씨. | 안드로겐-표적 치료제를 이용하는 종양 질환 치료를 위한 바이오마커 |
| EP3052640A2 (en) | 2013-10-04 | 2016-08-10 | AbbVie Inc. | Use of metal ions for modulation of protein glycosylation profiles of recombinant proteins |
| US9085618B2 (en) | 2013-10-18 | 2015-07-21 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same |
| US9181337B2 (en) | 2013-10-18 | 2015-11-10 | Abbvie, Inc. | Modulated lysine variant species compositions and methods for producing and using the same |
| US8946395B1 (en) | 2013-10-18 | 2015-02-03 | Abbvie Inc. | Purification of proteins using hydrophobic interaction chromatography |
| US20150139988A1 (en) | 2013-11-15 | 2015-05-21 | Abbvie, Inc. | Glycoengineered binding protein compositions |
| EP2876114A1 (en) | 2013-11-25 | 2015-05-27 | Consejo Superior De Investigaciones Científicas | Antibodies against CCR9 and applications thereof |
| CA2931357C (en) | 2013-11-28 | 2022-07-12 | Csl Limited | Method of treating nephropathy |
| EP2883883A1 (en) | 2013-12-16 | 2015-06-17 | Cardio3 Biosciences S.A. | Therapeutic targets and agents useful in treating ischemia reperfusion injury |
| CA2932465C (en) | 2013-12-18 | 2023-08-22 | Csl Limited | Methods of treating wounds in a diabetic subject |
| EP3119910A4 (en) | 2014-03-20 | 2018-02-21 | Pharmacyclics LLC | Phospholipase c gamma 2 and resistance associated mutations |
| EP3146081B1 (en) | 2014-05-19 | 2020-10-28 | The Johns Hopkins University | Methods for identifying androgen receptor splice variants in subjects having castration resistant prostate cancer |
| BR112017001860A2 (pt) | 2014-07-31 | 2018-02-27 | Uab Research Foundation | peptídeo sintético, composição farmacêutica, métodos, regime de dosagem, e, anticorpo monoclonal |
| JP2017523207A (ja) * | 2014-08-08 | 2017-08-17 | ファーマサイクリックス エルエルシー | ブルトン型チロシンキナーゼ阻害薬の組み合わせ及びそれらの使用 |
| CA2959336A1 (en) | 2014-08-25 | 2016-03-03 | The Johns Hopkins University | Methods and compositions related to prostate cancer therapeutics |
| EP3209695A4 (en) | 2014-10-23 | 2018-05-30 | DendroCyte BioTech Pty Ltd | Cd83 binding proteins and uses thereof |
| WO2016094962A1 (en) | 2014-12-19 | 2016-06-23 | Monash University | Il-21 antibodies |
| CN108368167B (zh) | 2015-11-27 | 2023-09-05 | 杰特有限公司 | Cd131结合蛋白及其应用 |
| CN105628935A (zh) * | 2016-03-01 | 2016-06-01 | 广东医学院附属医院 | 一种检测人尿中cd80的试剂盒 |
| US10961311B2 (en) | 2016-04-15 | 2021-03-30 | Macrogenics, Inc. | B7-H3 binding molecules, antibody drug conjugates thereof and methods of use thereof |
| CA3034105A1 (en) | 2016-09-23 | 2018-03-29 | Csl Limited | Coagulation factor binding proteins and uses thereof |
| KR101926834B1 (ko) | 2017-03-21 | 2018-12-07 | 동아에스티 주식회사 | 항-dr5 항체 및 그의 용도 |
| CA3058290A1 (en) | 2017-04-18 | 2018-10-25 | Universite Libre De Bruxelles | Biomarkers and targets for proliferative diseases |
| IL273202B2 (en) | 2017-09-11 | 2024-08-01 | Univ Monash | Binding proteins to the human thrombin receptor, par4 |
| US11466073B2 (en) | 2017-10-18 | 2022-10-11 | Csl Limited | Human serum albumin variants and uses thereof |
| KR102879500B1 (ko) | 2018-03-23 | 2025-10-31 | 유니베르시테 리브레 드 브룩크젤즈 | Wnt 시그널링 작용제 분자 |
| KR102854142B1 (ko) | 2018-05-16 | 2025-09-04 | 시에스엘 리미티드 | 가용성 보체 수용체 1형 변이체 및 이의 용도 |
| WO2020116636A1 (ja) * | 2018-12-07 | 2020-06-11 | 小野薬品工業株式会社 | 免疫抑制剤 |
| EP4182475A2 (en) | 2020-07-17 | 2023-05-24 | Onena Medicines S.L. | Antibodies against lefty proteins |
| EP4433084A1 (en) | 2021-11-19 | 2024-09-25 | Lykera Biomed, S.A. | Treatment and diagnosis of diseases associated to pathogenic fibrosis |
| WO2025149667A1 (en) | 2024-01-12 | 2025-07-17 | Pheon Therapeutics Ltd | Antibody drug conjugates and uses thereof |
| WO2025171411A1 (en) | 2024-02-09 | 2025-08-14 | Herophilus, Inc. | Compositions and methods related to modulating macrophage migration inhibitory factor (mif)-cd74 signaling and related treatments for neuroinflammatory conditions |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8308235D0 (en) | 1983-03-25 | 1983-05-05 | Celltech Ltd | Polypeptides |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US4777245A (en) * | 1984-01-06 | 1988-10-11 | Genelabs Incorporated | Non-human primate monoclonal antibodies and methods |
| JPS6147500A (ja) | 1984-08-15 | 1986-03-07 | Res Dev Corp Of Japan | キメラモノクロ−ナル抗体及びその製造法 |
| EP0173494A3 (en) | 1984-08-27 | 1987-11-25 | The Board Of Trustees Of The Leland Stanford Junior University | Chimeric receptors by dna splicing and expression |
| GB8422238D0 (en) | 1984-09-03 | 1984-10-10 | Neuberger M S | Chimeric proteins |
| GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
| US5045469A (en) * | 1988-10-27 | 1991-09-03 | Mycogen Corporation | Novel bacillus thuringiensis isolate denoted B. T. PS81F, active against lepidopteran pests, and a gene encoding a lepidopteran-active toxin |
| IL162181A (en) * | 1988-12-28 | 2006-04-10 | Pdl Biopharma Inc | A method of producing humanized immunoglubulin, and polynucleotides encoding the same |
| US5116964A (en) | 1989-02-23 | 1992-05-26 | Genentech, Inc. | Hybrid immunoglobulins |
| US5304635A (en) * | 1990-03-12 | 1994-04-19 | University Of Southern California | Antigen specifically expressed on the surface of B cells and Hodgkin's cells |
| US6641809B1 (en) * | 1990-03-26 | 2003-11-04 | Bristol-Myers Squibb Company | Method of regulating cellular processes mediated by B7 and CD28 |
| GB9021679D0 (en) | 1990-10-05 | 1990-11-21 | Gorman Scott David | Antibody preparation |
| US5851795A (en) * | 1991-06-27 | 1998-12-22 | Bristol-Myers Squibb Company | Soluble CTLA4 molecules and uses thereof |
| US5844095A (en) * | 1991-06-27 | 1998-12-01 | Bristol-Myers Squibb Company | CTLA4 Ig fusion proteins |
| ES2123001T5 (es) * | 1991-06-27 | 2009-04-16 | Bristol-Myers Squibb Company | Receptor ctl4a, proteinas de fusion que lo contienen y sus usos. |
| MX9204374A (es) | 1991-07-25 | 1993-03-01 | Idec Pharma Corp | Anticuerpo recombinante y metodo para su produccion. |
| EP0605442B1 (en) | 1991-07-25 | 2003-04-16 | Idec Pharmaceuticals Corporation | Recombinant antibodies for human therapy |
| US6162432A (en) * | 1991-10-07 | 2000-12-19 | Biogen, Inc. | Method of prophylaxis or treatment of antigen presenting cell driven skin conditions using inhibitors of the CD2/LFA-3 interaction |
| US5474771A (en) | 1991-11-15 | 1995-12-12 | The Trustees Of Columbia University In The City Of New York | Murine monoclonal antibody (5c8) recognizes a human glycoprotein on the surface of T-lymphocytes, compositions containing same |
| IL104684A0 (en) | 1992-02-14 | 1993-06-10 | Bristol Myers Squibb Co | The cd40cr receptor and ligands therefor |
| US5747034A (en) * | 1992-07-09 | 1998-05-05 | Chiron Corporation | Methods and materials for the induction of T cell anergy |
| WO1994028912A1 (en) | 1993-06-10 | 1994-12-22 | The Regents Of The University Of Michigan | Cd28 pathway immunosuppression |
| ATE188487T1 (de) | 1993-09-02 | 2000-01-15 | Dartmouth College | Anti-gp39 antikoerper und deren verwendungen |
| US7175847B1 (en) * | 1995-06-07 | 2007-02-13 | Biogen Idec Inc. | Treating intestinal inflammation with anti-CD80 antibodies that do not inhibit CD80 binding to CTLA-4 |
| US6113898A (en) * | 1995-06-07 | 2000-09-05 | Idec Pharmaceuticals Corporation | Human B7.1-specific primatized antibodies and transfectomas expressing said antibodies |
| EP1007090B1 (en) | 1996-11-08 | 2009-12-30 | Biogen Idec Inc. | Identification of unique binding interactions between certain antibodies and the human b7.1 (cd80) and b7.2 (cd28) co-stimulatory antigens |
| US6051228A (en) * | 1998-02-19 | 2000-04-18 | Bristol-Myers Squibb Co. | Antibodies against human CD40 |
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1995
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI854983B (zh) * | 2018-06-22 | 2024-09-11 | 日商順天生化股份有限公司 | 誘導免疫耐受之抗體、被誘導之淋巴球、及使用被誘導之淋巴球之細胞治療劑治療方法 |
| US12139537B2 (en) | 2018-06-22 | 2024-11-12 | Junten Bio Co., Ltd. | Antibody inducing immune tolerance, induced lymphocyte, and cell therapy agent therapeutic method using induced lymphocyte |
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