BR112018010766A8 - proteínas de ligação ao cd131 e usos das mesmas - Google Patents
proteínas de ligação ao cd131 e usos das mesmasInfo
- Publication number
- BR112018010766A8 BR112018010766A8 BR112018010766A BR112018010766A BR112018010766A8 BR 112018010766 A8 BR112018010766 A8 BR 112018010766A8 BR 112018010766 A BR112018010766 A BR 112018010766A BR 112018010766 A BR112018010766 A BR 112018010766A BR 112018010766 A8 BR112018010766 A8 BR 112018010766A8
- Authority
- BR
- Brazil
- Prior art keywords
- binding proteins
- antigen
- binding domain
- binds
- binding
- Prior art date
Links
- 108091008324 binding proteins Proteins 0.000 title abstract 2
- 102000014914 Carrier Proteins Human genes 0.000 title 1
- 239000000427 antigen Substances 0.000 abstract 2
- 102000036639 antigens Human genes 0.000 abstract 2
- 108091007433 antigens Proteins 0.000 abstract 2
- 102000004269 Granulocyte Colony-Stimulating Factor Human genes 0.000 abstract 1
- 108010017080 Granulocyte Colony-Stimulating Factor Proteins 0.000 abstract 1
- 102000004457 Granulocyte-Macrophage Colony-Stimulating Factor Human genes 0.000 abstract 1
- 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 abstract 1
- 102000015696 Interleukins Human genes 0.000 abstract 1
- 108010063738 Interleukins Proteins 0.000 abstract 1
- 102000007651 Macrophage Colony-Stimulating Factor Human genes 0.000 abstract 1
- 108010046938 Macrophage Colony-Stimulating Factor Proteins 0.000 abstract 1
- 102000023732 binding proteins Human genes 0.000 abstract 1
- 210000003714 granulocyte Anatomy 0.000 abstract 1
- 230000011664 signaling Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/577—Immunoassay; Biospecific binding assay; Materials therefor involving monoclonal antibodies binding reaction mechanisms characterised by the use of monoclonal antibodies; monoclonal antibodies per se are classified with their corresponding antigens
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
- A61K2039/541—Mucosal route
- A61K2039/543—Mucosal route intranasal
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/70596—Molecules with a "CD"-designation not provided for elsewhere in G01N2333/705
Abstract
a presente divulgação fornece uma proteína de ligação à cd131 que compreende um domínio de ligação ao antígeno de um anticorpo, em que o domínio de ligação ao antígeno se liga a ou se liga especificamente ao cd131 e neutraliza a sinalização por interleucina il-3 (il) 3, il-5 e fator estimulante de colônia de granulócitos e macrófagos (gm- csf), e usos dos mesmos.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2015904924 | 2015-11-27 | ||
AU2015904924A AU2015904924A0 (en) | 2015-11-27 | Cd131 binding proteins and uses thereof | |
PCT/AU2016/051158 WO2017088028A1 (en) | 2015-11-27 | 2016-11-25 | Cd131 binding proteins and uses thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
BR112018010766A2 BR112018010766A2 (pt) | 2018-11-21 |
BR112018010766A8 true BR112018010766A8 (pt) | 2019-02-26 |
Family
ID=58762858
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112018010766A BR112018010766A8 (pt) | 2015-11-27 | 2016-11-25 | proteínas de ligação ao cd131 e usos das mesmas |
Country Status (13)
Country | Link |
---|---|
US (2) | US10894834B2 (pt) |
EP (1) | EP3380514A4 (pt) |
JP (1) | JP6882287B2 (pt) |
KR (1) | KR20180084134A (pt) |
CN (2) | CN108368167B (pt) |
AU (1) | AU2016361462B2 (pt) |
BR (1) | BR112018010766A8 (pt) |
CA (1) | CA3003200A1 (pt) |
HK (1) | HK1253533A1 (pt) |
IL (1) | IL259519B (pt) |
MX (1) | MX2018006410A (pt) |
SG (2) | SG10201912051TA (pt) |
WO (1) | WO2017088028A1 (pt) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP6882287B2 (ja) * | 2015-11-27 | 2021-06-02 | シーエスエル リミティド | Cd131結合タンパク質とその利用 |
CN108586606A (zh) * | 2018-04-24 | 2018-09-28 | 上海药明生物技术有限公司 | 一种用于去除抗体蛋白中内毒素的方法 |
US20230406943A1 (en) * | 2020-12-04 | 2023-12-21 | CSL Innovation Pty Ltd | Methods for treating inflammatory skin conditions |
WO2022133519A1 (en) * | 2020-12-21 | 2022-06-30 | CSL Innovation Pty Ltd | Methods for treating or preventing acute respiratory distress syndrome |
CN117836326A (zh) * | 2021-08-26 | 2024-04-05 | 协和麒麟株式会社 | 与cd116和cd131结合的双特异性抗体 |
WO2023173173A1 (en) * | 2022-03-16 | 2023-09-21 | CSL Innovation Pty Ltd | Method of treating an eosinophil-associated disease |
WO2023192944A1 (en) * | 2022-04-01 | 2023-10-05 | The Jackson Laboratory | Combination immune checkpoint inhibitor therapies |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AUPP525198A0 (en) * | 1998-08-13 | 1998-09-03 | Medvet Science Pty. Ltd. | Monoclonal antibody inhibitor of GM-CSF, IL-3 and IL-5 and other cytokines and uses thereof |
CA2362264C (en) * | 1999-02-08 | 2012-05-08 | Medvet Science Pty. Ltd. | Cytokine-binding domain |
AU2002351208A1 (en) | 2001-12-03 | 2003-06-17 | Abgenix, Inc. | Antibodies against carbonic anhydrase IX (CA IX) tumor antigen |
EP1467757B1 (en) | 2001-12-28 | 2008-05-07 | Amgen Fremont Inc. | Use of antibodies against the muc18 antigen |
BRPI0510885A (pt) | 2004-06-04 | 2007-12-26 | Genentech Inc | método de tratamento de lúpus e artigo industrializado |
US7329737B2 (en) | 2004-08-03 | 2008-02-12 | Dyax Corp. | Antibodies that bind hK-1 |
US7790862B2 (en) * | 2006-06-13 | 2010-09-07 | Zymogenetics, Inc. | IL-17 and IL-23 antagonists and methods of using the same |
WO2013090989A1 (en) | 2011-12-22 | 2013-06-27 | Csl Limited | Method of treating inflammatory bowel disease |
JP6882287B2 (ja) * | 2015-11-27 | 2021-06-02 | シーエスエル リミティド | Cd131結合タンパク質とその利用 |
-
2016
- 2016-11-25 JP JP2018526904A patent/JP6882287B2/ja active Active
- 2016-11-25 SG SG10201912051TA patent/SG10201912051TA/en unknown
- 2016-11-25 AU AU2016361462A patent/AU2016361462B2/en active Active
- 2016-11-25 EP EP16867461.2A patent/EP3380514A4/en active Pending
- 2016-11-25 CA CA3003200A patent/CA3003200A1/en active Pending
- 2016-11-25 WO PCT/AU2016/051158 patent/WO2017088028A1/en active Application Filing
- 2016-11-25 SG SG11201803565UA patent/SG11201803565UA/en unknown
- 2016-11-25 BR BR112018010766A patent/BR112018010766A8/pt active Search and Examination
- 2016-11-25 CN CN201680069441.4A patent/CN108368167B/zh active Active
- 2016-11-25 CN CN202311005982.9A patent/CN116987190A/zh active Pending
- 2016-11-25 MX MX2018006410A patent/MX2018006410A/es unknown
- 2016-11-25 KR KR1020187017798A patent/KR20180084134A/ko not_active Application Discontinuation
- 2016-11-25 US US15/779,252 patent/US10894834B2/en active Active
-
2018
- 2018-05-22 IL IL259519A patent/IL259519B/en unknown
- 2018-10-05 HK HK18112733.7A patent/HK1253533A1/zh unknown
-
2020
- 2020-11-20 US US16/953,499 patent/US11840573B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
US20190062438A1 (en) | 2019-02-28 |
AU2016361462B2 (en) | 2023-09-21 |
IL259519A (en) | 2018-07-31 |
US11840573B2 (en) | 2023-12-12 |
US10894834B2 (en) | 2021-01-19 |
EP3380514A4 (en) | 2019-05-22 |
JP2019500859A (ja) | 2019-01-17 |
CA3003200A1 (en) | 2017-06-01 |
HK1253533A1 (zh) | 2019-06-21 |
CN116987190A (zh) | 2023-11-03 |
EP3380514A1 (en) | 2018-10-03 |
SG10201912051TA (en) | 2020-02-27 |
BR112018010766A2 (pt) | 2018-11-21 |
CN108368167A (zh) | 2018-08-03 |
SG11201803565UA (en) | 2018-06-28 |
CN108368167B (zh) | 2023-09-05 |
MX2018006410A (es) | 2019-01-31 |
US20210324091A1 (en) | 2021-10-21 |
KR20180084134A (ko) | 2018-07-24 |
WO2017088028A1 (en) | 2017-06-01 |
IL259519B (en) | 2022-06-01 |
RU2018123349A3 (pt) | 2020-05-26 |
JP6882287B2 (ja) | 2021-06-02 |
AU2016361462A1 (en) | 2018-05-10 |
RU2018123349A (ru) | 2019-12-27 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BR112018010766A2 (pt) | proteínas de ligação ao cd131 e usos das mesmas | |
BR112018014150A2 (pt) | anticorpos monoclonais humanizados imunoestimulantes contra interleucina-2 humana, e proteínas de fusão dos mesmos | |
CY1123163T1 (el) | Αντισωματα που δεσμευουν beta klotho επικρατεια 2 και μεθοδοι χρησης αυτων | |
BR112016030670A2 (pt) | "imunocitoquina" | |
BR112018076260A2 (pt) | anticorpo ou fragmento do mesmo que se liga especificamente a hpd-l1, anticorpo biespecífico ou proteína de fusão, uso de um anticorpo ou fragmento, método, composição farmacêutica, método de modulação, método de inibição, método de tratamento, ácido nucleico, vetor, hospedeiro e imunocitocina | |
BR112017028353A2 (pt) | anticorpos para cd40 com atividade agonista melhorada | |
BR112019004998A2 (pt) | anticorpos anti-pd-1(cd279) | |
AR105767A1 (es) | Proteínas de fusión de unión a gitr multivalentes y multiespecíficas | |
BR112018010084A2 (pt) | ligantes de pd1 e/ou lag3 | |
BR112018074468A2 (pt) | anticorpos anti-cd40 e suas utilizações | |
BR112018071307A2 (pt) | anticorpos agonistas que ligam cd40 humana e usos dos mesmos | |
BR112016014022A2 (pt) | anticorpos anti-cd3, ácido nucleico isolado, vetor, célula hospedeira, método de produção do anticorpo anti-cd3, imunoconjugado, composição, uso do anticorpo anti-cd3, métodos de tratamento, métodos de intensificação da função imune e kit | |
CR20180031A (es) | Anticuerpos madurados por afinidad y humanizados para fcrh5 y métodos para su uso | |
BR112018000475A2 (pt) | construtos de anticorpo biespecíficos que se ligam a dll3 e a cd3 | |
BR112017017025A2 (pt) | métodos e composições para analizar componentes celulares | |
EA201591376A1 (ru) | Конструкции антител к cdh19 и cd3 | |
MA53742A (fr) | Molécules de liaison à l'antigène capables de se lier à cd3 et cd137 mais pas simultanément | |
BR112017016636A2 (pt) | formulação líquida estável para anticorpos monoclonais | |
BR112016001977A2 (pt) | septo acústico de vários segmentos | |
BR112019023990A2 (pt) | Bis-octa-hidrofenantreno carboxamidas e conjugados de proteína das mesmas | |
BR112013027829A2 (pt) | anticorpos anti-cd40 e método de uso | |
UY33983A (es) | Proteínas de Unión de Tipo Anticuerpo con Región Variable Dual que Tienen Orientación de la Región de Unión con Entrecruzamiento. | |
BR112018068678A2 (pt) | anticorpos anti-mica | |
BR112019004990A2 (pt) | anticorpo que se liga especificamente a il-17a e fragmento funcional do mesmo | |
BR112017013956B8 (pt) | Proteínas de fusão de citocinas |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] |
Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS. |
|
B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
B350 | Update of information on the portal [chapter 15.35 patent gazette] |