CN101356916A - Anticoagulation rodenticide synergist, preparation method and use thereof - Google Patents
Anticoagulation rodenticide synergist, preparation method and use thereof Download PDFInfo
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- CN101356916A CN101356916A CNA2008100303456A CN200810030345A CN101356916A CN 101356916 A CN101356916 A CN 101356916A CN A2008100303456 A CNA2008100303456 A CN A2008100303456A CN 200810030345 A CN200810030345 A CN 200810030345A CN 101356916 A CN101356916 A CN 101356916A
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Abstract
The invention discloses an anticoagulant rodenticide synergist which comprises the following raw materials with the parts by weight: 2.4-3.1 parts of industrial salicylic acid, 0.9-1.1 parts of sodium bicarbonate and 2.5-3.5 parts of water. The invention further discloses a preparation method of the anticoagulant rodenticide synergist, and the preparation method comprises the following steps: (1) 0.9-1.1 parts of the sodium bicarbonate are dissolved into 2.5-3.5 parts of the water to obtain a mixture, and the water temperature is 20-100 DEG C; (2) 2.4-3.1 parts of the industrial salicylic acid is added to the mixture and stirred to be completely dissolved, therefore, the anticoagulant rodenticide synergist is prepared. The invention further discloses the application of the anticoagulant rodenticide synergist for preparing a synergistic anticoagulant rodenticide. The anticoagulant rodenticide synergist has the advantages of reducing the dosage of the anticoagulant rodenticide by about 50%, lowering cost, lowering the pharmic residue in environment and reducing the danger to other non-target organisms, and obviously improving the control effect.
Description
Technical field
The present invention relates to the compound medicine synergist, particularly a kind of anticoagulation rodenticide synergist and preparation method thereof and application.
Background technology
At present, use anticoagulation rodenticide to kill mouse to be the domestic and international application means that kill mouse the most widely, have advantage effective, that effect is fast.The usage amount of anticoagulation rodenticide accounts for 90%～95% of rat-bane total amount, but the kind of anticoagulation rodenticide very little, passes through nearly 60 years effort both at home and abroad, and present anticoagulation rodenticide has only two a Dai Jinshi kind.And present home mouse both domestic and external and vole have produced pesticide resistance to a certain degree to such medicine, cause the usage amount of rat-bane to increase considerably, and deratization effect descends year by year, and some areas face the passive situation that no medicine can be used.For this reason, synergist to anticoagulation rodenticide has carried out some explorations and research both at home and abroad, preliminary clearer and more definite chemical compositions have synergistic effect to anticoagulation rodenticide, as some bactericide, salicylic acid material etc., but aspects such as the mechanism of action of the composition of these materials and application technology are not seen the research report as yet.
Salicylic acid is a white crystalline powder, odorless, and raw meat is changeed in the earlier little bitter back of flavor.157～159 ℃ of fusing points, variable color gradually under illumination, relative density 1.44, the about 211 ℃/2.67kPa of boiling point, 76 ℃ of distillations.The rapid down heating of normal pressure is decomposed into phenol and carbonic acid gas.The 1g salicylic acid can be dissolved in respectively in 460ml water, 15ml boiling water, 2.7ml ethanol, 3ml acetone, 3ml ether, 42ml chloroform, 135ml benzene, 52ml turpentine oil, about 60ml glycerine and the 80ml benzinum.Salicylic acid is important fine chemical material.In medical industry, salicylic acid itself is exactly the extremely wide disinfection preservative of a kind of purposes.As medicine intermediate, it can be used for the synthetic nitrogen sulfanilamide (SN) (Salazosulfanilamidum) that presses down, Azudimidine (Salazosulfdimidine), antipyretic analgesic medicine aspirin (Aspirin), sodium salicylate (Natrii salicylas), salicylamide (Salicylamide), ethoxy acyl phenylamino (Ethoxybenzamidum), benoral (Benorylatum), diflunisal (Diflunisal), naphthalol (Salinaphtol), ethrisin (Salacetamide), lopirin (Lopirin), Fenamifuril (Fenamifuril), Saliphen (Saliphen), salicylamid-o-essigsaure (Salicylamid-o-Essigsaure), as ruvazone (Ruvazone), [Salicylic acid is called B hydroxylic acid (BHA) again to the anilamate salicylic acid, the B skin tartaric acid that softens].
Sodium salicylate is the main effect composition in the synergist, derives from the pharmacy experience, but its proportioning and application technology do not see that as yet report is arranged.Sodium salicylate and bicoumarin class anti-freezing medicine, first sulphur fourth material class hypoglycemic agent share, and can improve free concentration in their blood, strengthen its toxicity.Its principle is: phosphatide is converted into arachidonic acid (AA) in vivo, and further by suppressing Cycloxygenase (COX) or suppress peroxidase to generate various metabolites, COX has two kinds of isoenzymes, i.e. COX-1 and COX-2.Salicylate acts on the serine-350 (S-350) on the COX-1, suppresses AA generation TXTA2 on the platelet cell film.TXTA2 is a kind of strong platelet aggregation thing, and stronger short hemagglutinative function is arranged, and also is a kind of vasoconstrictor substance simultaneously, can make vessel retraction, causes hypercoagulative state, and thrombus is easy to form.Reduce because salicylate makes TXTA2 generate, suppressed blood platelet and discharged adenosine diphosphate (ADP) and gathering, cause platelet thrombus to form and be obstructed, produce blood coagulation resisting function.Acellular nuclear in the blood platelet, can not generate new COX, so salicylate is irreversible for this inhibitory action of COX, generate (Jams Ferguson III until new blood platelet, Nicolas AFChronos, Robert A Harrington.Antiplatelet therapy in clinical pratice.MartinDunitz Ltd 2000).
In the practical application of synergist, the prostatitis in the world is walked in domestic research work, and subtropics Agricultural Research Institute of the Chinese Academy of Sciences researchs and develops out a kind of synergy rat-bane and Preliminary Applications in production.The patent No. be " 98112818.1 " disclosure of the Invention a kind of " anti-hemagglutination rat eradication agent without environment pollution ", it is a kind of anti-hemagglutination rat eradication agent without environment pollution that can be used for preventing and treating all kinds of bandicoots such as zokor, vole, home mouse, being a kind of rat-bane of developing at muroid individual character and feeding habit again simultaneously according to the muroid general character, is the base substance prescription with Bromadiolone, attractant, synergist, emetic and base-material.The patent No. be " 98121737.0 " disclosure of the Invention a kind of " compound rat-killing agent ", be a kind of anticoagulation compound rat-killing agent, by diphacinone-Na, warfarin or Bromadiolone, synergy, increase lure and form, add compositions such as hydrotropy, emulsification in proportion.
But existing rat-bane is all owing to factors such as technology and costs, and the practical application area is very little, is difficult to realize commercial application.
Summary of the invention
The present invention is in order to overcome the deficiency that above prior art exists, for production practices provide a kind of anticoagulation class rodenticide synergist.
Another object of the present invention provides a kind of preparation method of anticoagulation class rodenticide synergist.
A further object of the present invention is: anticoagulation rodenticide synergist, and as the application of preparation synergy anticoagulation class mouse killing medicine.
Purpose of the present invention realizes by following technical scheme: this anticoagulation rodenticide synergist is characterized in that: comprise the following raw material of part by weight: 2.4～3.1 parts of sublimed salicylic acids, 0.9～1.1 part of sodium bicarbonate, 2.5～3.5 parts in water.
Preferable range is: 2.4～2.7 parts of described sublimed salicylic acids, 1 part of sodium bicarbonate, 2.5～3.5 parts in water.
The preparation method of above-mentioned anticoagulation rodenticide synergist is characterized in that: may further comprise the steps:
(1) with 2.5～3.5 parts of dissolvings of 0.9～1.1 portion of water of sodium bicarbonate, 20～100 ℃ of water temperature;
(2) in above-mentioned solution, add 2.4～3.1 parts of sublimed salicylic acids, be stirred to dissolving fully, make anticoagulation rodenticide synergist.
Above-mentioned anticoagulation rodenticide synergist is used to prepare synergy anticoagulation class mouse killing medicine.
The concrete application may further comprise the steps:
(1) in 0.9～1.1 part of anticoagulation rodenticide synergist, adds 0.9～1.1 part of anticoagulation rodenticide, be stirred to evenly;
(2) add 390～410 parts of bait material, stir, dry or dry.
The anticoagulation rodenticide of described step (1) is coumatetralyl or diphacinone-Na.
The bait material of described step (2) is paddy, wheat, Chinese sorghum or its any mixture.
The present invention has following advantage with respect to prior art:
1, qualitative main synergistic component: qualitative sublimed salicylic acid cooperates pharmaceutically-active sodium bicarbonate as a kind of main synergistic component, handles through quantitative multistep, realizes the preparation and the application of synergist, and program is simple, easy operating;
2, filled up the blank of existing anticoagulation rodenticide synergist practical application area;
3, reduced about 50% of anticoagulation rodenticide consumption, saved cost and reduced the environment of medicine residual and reduce danger other non-target organisms;
4, improve the palatability of synergy anticoagulation class mouse killing medicine, accelerated the dead speed of material bandicoot, and then significantly improved the control efficiency of medicine.
Embodiment
The invention will be further described for the following examples.
Embodiment 1:
Take by weighing the 0.9kg sodium bicarbonate, add 20 ℃ of water 2.5kg, after stirring is treated to dissolve fully, add sublimed salicylic acid 2.4kg, be stirred to dissolving; Take by weighing the synergist solution 0.9kg after dissolving fully, adding concentration is 7.35% coumatetralyl mother liquor 0.9kg, is stirred to evenly.Take by weighing fresh paddy 390kg, add the synergy coumatetralyl solution 1.8kg for preparing, be stirred to evenly, dry, make synergy coumatetralyl poison grain.
Wherein containing the synergist composition is: [2.4/ (0.9+2.5+2.4)] * 0.9/390=9/10000,
Containing coumatetralyl is: 0.0735 * 0.9/390=1.7/10000.
Get the synergy coumatetralyl poison grain for preparing feed small white mouse and Rattus losea, the exponential sum of ingesting lethality is compared as follows:
Embodiment 2:
Take by weighing the 1.1kg sodium bicarbonate, add 100 ℃ of water 3.5kg, be stirred to fully dissolving after, add sublimed salicylic acid 3.1kg, be stirred to dissolving fully; Take by weighing consoluet synergist solution 1.1kg, adding concentration is 5% diphacinone-Na mother liquor 1.1kg, is stirred to evenly.Take by weighing fresh wheat 410kg, add the synergy diphacinone-Na solution 2.2kg for preparing, be stirred to evenly, dry, make synergy diphacinone-Na poison wheat.
Wherein containing the synergist composition is: 3.1/ (1.1+3.5+3.1) * 1.1/410=1/1000,
Containing diphacinone-Na is: 0.05 * 1.1/410=1.34/10000.
Embodiment 3:
Take by weighing the 1kg sodium bicarbonate, add 60 ℃ of water 3kg, be stirred to fully dissolving after, add the 2.7kg sublimed salicylic acid, be stirred to dissolving fully; Take by weighing consoluet synergist solution 1kg, adding concentration is 5% diphacinone-Na mother liquor 1kg, is stirred to evenly.Take by weighing fresh Chinese sorghum 400kg,, add the synergy diphacinone-Na solution 2kg for preparing, be stirred to evenly, dry, make synergy diphacinone-Na poison jowar.
Wherein containing the synergist composition is: 2.7/ (1+3+2.7) * 1/400=1/1000,
Containing diphacinone-Na is: 0.05 * 1/400=1.25/10000 only is half of traditional diphacinone-Na concentration (2.5/10000).
Above-mentioned embodiment is the preferred embodiments of the present invention; can not limit claim of the present invention; other any change or other equivalent substitute mode that does not deviate from technical scheme of the present invention and made is included within protection scope of the present invention.
Claims (7)
1, anticoagulation rodenticide synergist is characterized in that: comprise the following raw material of part by weight: 2.4～3.1 parts of sublimed salicylic acids, 0.9～1.1 part of sodium bicarbonate, 2.5～3.5 parts in water.
2, anticoagulation rodenticide synergist according to claim 1 is characterized in that: 2.4～2.7 parts of described sublimed salicylic acids, 1 part of sodium bicarbonate, 2.5～3.5 parts in water.
3, the preparation method of anticoagulation rodenticide synergist according to claim 1 is characterized in that: may further comprise the steps:
(1) with 2.5～3.5 parts of dissolvings of 0.9～1.1 portion of water of sodium bicarbonate, 20～100 ℃ of water temperature;
(2) in above-mentioned solution, add 2.4～3.1 parts of sublimed salicylic acids, be stirred to dissolving fully, make anticoagulation rodenticide synergist.
4, the application of anticoagulation rodenticide synergist according to claim 1 is characterized in that: be used to prepare synergy anticoagulation class mouse killing medicine.
5, the application of anticoagulation rodenticide synergist according to claim 4 is characterized in that: may further comprise the steps:
(1) in 0.9～1.1 part of anticoagulation rodenticide synergist, adds 0.9～1.1 part of anticoagulation rodenticide, be stirred to evenly;
(2) add 390～410 parts of bait material, stir, dry or dry.
6, the application of anticoagulation rodenticide synergist according to claim 5 is characterized in that: the anticoagulation rodenticide of described step (1) is coumatetralyl or diphacinone-Na.
7, the application of anticoagulation rodenticide synergist according to claim 5 is characterized in that: the bait material of described step (2) is paddy, wheat, Chinese sorghum or its any mixture.
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| Application Number | Priority Date | Filing Date | Title |
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| CNA2008100303456A CN101356916A (en) | 2008-08-22 | 2008-08-22 | Anticoagulation rodenticide synergist, preparation method and use thereof |
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| CNA2008100303456A CN101356916A (en) | 2008-08-22 | 2008-08-22 | Anticoagulation rodenticide synergist, preparation method and use thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103329901A (en) * | 2013-07-18 | 2013-10-02 | 广东省农业科学院植物保护研究所 | Anticoagulative rodenticide enhancer and preparation method and application thereof |
| CN103340198A (en) * | 2013-07-25 | 2013-10-09 | 广东省农业科学院植物保护研究所 | Anticoagulant rodenticide penetrant as well as preparation method and application thereof |
| US20140259879A1 (en) * | 2013-03-12 | 2014-09-18 | Joseph Benedict Logsdon | Badder than a Bed Bug Strategically Designed Modular Moat Systems for Control of Target Pests |
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2008
- 2008-08-22 CN CNA2008100303456A patent/CN101356916A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20140259879A1 (en) * | 2013-03-12 | 2014-09-18 | Joseph Benedict Logsdon | Badder than a Bed Bug Strategically Designed Modular Moat Systems for Control of Target Pests |
| CN103329901A (en) * | 2013-07-18 | 2013-10-02 | 广东省农业科学院植物保护研究所 | Anticoagulative rodenticide enhancer and preparation method and application thereof |
| CN103340198A (en) * | 2013-07-25 | 2013-10-09 | 广东省农业科学院植物保护研究所 | Anticoagulant rodenticide penetrant as well as preparation method and application thereof |
| CN103340198B (en) * | 2013-07-25 | 2015-05-06 | 广东省农业科学院植物保护研究所 | Anticoagulant rodenticide penetrant as well as preparation method and application thereof |
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Open date: 20090204 |