CN106818723A - Composition containing benziothiazolinone and preparation method thereof - Google Patents
Composition containing benziothiazolinone and preparation method thereof Download PDFInfo
- Publication number
- CN106818723A CN106818723A CN201611078467.3A CN201611078467A CN106818723A CN 106818723 A CN106818723 A CN 106818723A CN 201611078467 A CN201611078467 A CN 201611078467A CN 106818723 A CN106818723 A CN 106818723A
- Authority
- CN
- China
- Prior art keywords
- benziothiazolinone
- microemulsion
- composition containing
- agent
- containing benziothiazolinone
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/02—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
- A01N25/04—Dispersions, emulsions, suspoemulsions, suspension concentrates or gels
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
- A01N43/80—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,2
Abstract
The present invention relates to a kind of composition containing benziothiazolinone and preparation method thereof, it is the microemulsion with benziothiazolinone as active material, and described microemulsion includes following composition：Benziothiazolinone, emulsifying agent, organic solvent, cosolvent, antifreezing agent, bleeding agent and softened water.Benziothiazolinone microemulsion（ME）With benziothiazolinone wettable powder（WP）Toxicity Determination contrast test shows, the drug effect of benziothiazolinone microemulsion is apparently higher than benziothiazolinone wettable powder.
Description
The application is the divisional application of the application for a patent for invention of Application No. 2015108811733；
The applying date of original application：2015-12-04；
The application number of original application：2015108811733；
The title of original application：Composition containing benziothiazolinone and preparation method thereof.
Technical field
The invention belongs to formulations of pesticide field, it is related to pesticide new product benziothiazolinone microemulsion and preparation method thereof
Background technology
Benziothiazolinone (Benziothiazolinone) belongs to isothiazole heterocyclic compound, is that a kind of efficient, low toxicity, broad spectrum activity are killed
Microbial inoculum, its mechanism of action is：Reacted with bacterium, the anion binding of the surface of cell membrane of mould or with sulfydryl, destroy protein
With the synthesis system of cell membrane, so as to suppress bacterium, mould breeding, pathogen cell metabolism is disturbed, makes its physiologic derangement,
Cause pathogen dead.The benziothiazolinone of Shaanxi Xida Huate Science ＆ Technology Industrial Co., Ltd.'s development and production obtains agriculture radical for 2008
Family's agricultural chemicals formal registration, and wide popularization and application.The compound has good preventing and treating effect to bacterium, fungus-caused corps diseases
Really, it is and fool proof to crops.At present, the formulation of benziothiazolinone is generally pulvis, wettable powder, suspending agent, moisture and dissipates
Granula.
The content of the invention
It is an object of the invention to provide a kind of composition containing benziothiazolinone, a kind of novel form is provided with to benziothiazolinone.Therefore,
The present invention uses following technical scheme：
Composition containing benziothiazolinone, it is characterised in that it is the microemulsion with benziothiazolinone as active material.
Further, 2-8% containing benziothiazolinone in the combination, by mass percentage.
Further, the microemulsion includes following component and content range, by mass percentage：
Further, emulsifying agent is selected from nonionic surfactant and anion surfactant in the microemulsion
One or more, nonionic surfactant is selected from APES, APES phosphate, alkyl phenol
APEO formaldehyde condensation products, benzylbiphenyl phenol polyethenoxy ether；Anion surfactant be selected from alkylbenzenesulfonate,
C8- 20 sodium alkyl sulfates, styrene polyoxyethylene ether ammonium sulfate salt；Preferably nonionic surfactant and anionic surface
The mixture of activating agent.
Further, organic solvent is selected from water miscible cyclohexanone, cyclohexanol, dimethylformamide in the microemulsion；
Cosolvent is selected from water miscible methyl alcohol, ethanol, isopropanol.
Further, antifreezing agent is selected from ethylene glycol, propane diols, glycerine in the microemulsion；Bleeding agent is selected from laruyl alcohol
Ether sodium sulfate, JFC, sodium lignin sulfonate.
The processing technology of microemulsion：First benziothiazolinone is dissolved in organic solvent and helped in the dissolution kettle with agitating device
In the mixed liquor of solvent, the solution is put into the emulsifying kettle with high shear machine, then sequentially adds antifreezing agent, bleeding agent, breast
Simultaneously after softening water, to 100%, starts high-shear impeller and stirs 30-50 minutes agent, and the prepared benziothiazolinone for meeting mark Cui is micro-
Emulsion, through being packed after the assay was approved, being put in storage.
The benziothiazolinone microemulsion (Microemulsion) that the present invention is provided is with water as matrix, less with organic solvent (as far as possible
Without benzene class organic solvent) eco-friendly pesticide novel formulation.Using physicochemical liquid-liquid dispersion system theory and method system
For the polymolecularity emulsion for going out, its oil, globule particle diameter are 10-100nm.
The experiment proved that, the drug effect 10%-30% higher than missible oil of benziothiazolinone microemulsion of the present invention, with wettable powder phase
Compare, drug effect is improved significantly, belong to efficient, the low benziothiazolinone novel form for staining, storing and transporting safety.
Specific embodiment
Benziothiazolinone microemulsion prepares embodiment
The present invention is illustrated with following examples, but does not limit the present invention.
Prepare embodiment one：3% benziothiazolinone microemulsion
During benziothiazolinone to be first dissolved in the mixed liquor of cyclohexanone and ethanol in the dissolution kettle with agitating device, then will
The solution is put into the emulsifying kettle with high shear machine, sequentially adds ethylene glycol, JFC, APES, alkyl benzene sulphonate
Sodium and softened water, start high-shear impeller and stir 30-50 minutes, are obtained and meet 3% benziothiazolinone microemulsion of standard, through inspection
Test it is qualified after packed, be put in storage.
Taking benziothiazolinone microemulsion manufactured in the present embodiment carries out physicochemical property test, as a result as follows：
Outward appearance：As clear as crystal single-phase liquid；
Transparency temperature region：- 5 degree are to more than 60 degree；
Low-temperature stability：Layering is occurred without within 2 weeks under being spent -5, is crystallized；
Thermodynamic stability：2 weeks active ingredient resolution ratios are less than 3% under (54=2) degree；
Stability of emulsion：Water-reducible emulsion-stabilizing in any proportion；
Ageing stability：Stabilization under normal temperature.
Prepare embodiment two：8% benziothiazolinone microemulsion
Benziothiazolinone is first dissolved in cyclohexanone, ring alcohol and dimethylformamide in the dissolution kettle with agitating device
In mixed liquor, then the solution is put into the mixing emulsifying kettle with high shear machine, sequentially adds addition propane diols, lauryl alcohol
Sodium sulphate, APES phosphate, lauryl sodium sulfate and softened water, start high-shear impeller stirring 30-
50 minutes, standard compliant 8% benziothiazolinone microemulsion is obtained, through being packed after the assay was approved, being put in storage.
Taking benziothiazolinone microemulsion manufactured in the present embodiment carries out physicochemical property test, as a result as follows：
Outward appearance：As clear as crystal single-phase liquid；
Transparency temperature region：- 5 degree are to more than 60 degree；
Low-temperature stability：Layering is occurred without within 2 weeks under being spent -5, is crystallized；
Thermodynamic stability：2 weeks active ingredient resolution ratios are less than 3% under (54=2) degree；
Stability of emulsion：Water-reducible emulsion-stabilizing in any proportion；
Ageing stability：Stabilization under normal temperature.
Benziothiazolinone microemulsion indoor biometricses embodiment
Experiment is carried out with reference to ＜ agricultural chemicals room Inner bioassay test criterion bactericide ＞.
Mycelial growth inhibition rate is calculated by mycelium morphology factor test measurements, then is calculated by virulence regression equation y=a+bX
Go out the EC of every kind of medicament50, while calculating relative virus force index according to Wadlcy methods.
The raw benziothiazolinone microemulsion of embodiment one 3% of surveying the results are shown in Table 1 to cucumber bacterial angular leaf spot Toxicity Determination,
Wherein WP represents wettable powder, and ME represents microemulsion
The benziothiazolinone microemulsion of table 1 3% is to cucumber bacterial angular leaf spot Toxicity Determination
The result of table 1 shows that benziothiazolinone microemulsion and benziothiazolinone wettable powder have stronger to cucumber bacterial angular leaf spot germ
Inhibitory activity, its toxicity index microemulsion is 1.91 times of wettable powder, and microemulsion drug effect is substantially better than wettable powder.
The raw benziothiazolinone microemulsion of embodiment 2 3% of surveying the results are shown in Table 2 to pear scab Toxicity Determination
The benziothiazolinone microemulsion of table 2 3% is to scab Toxicity Determination
The result of table 2 shows that benziothiazolinone microemulsion and benziothiazolinone wettable powder have to pear scab germ and is lived compared with high inhibition
Property, its toxicity index microemulsion is 1.79 times of wettable powder, and microemulsion drug effect is substantially better than wettable powder.
Claims (6)
1. the composition of benziothiazolinone is contained, it is characterised in that it is the microemulsion with benziothiazolinone as active material.
2. the composition containing benziothiazolinone according to claim 1, it is characterised in that wherein 2-8% containing benziothiazolinone, by matter
Amount percentages.
3. the composition containing benziothiazolinone according to claim 1, it is characterised in that the microemulsion comprising following component and
Content range, by mass percentage：
4. the composition containing benziothiazolinone according to claim 1,2 or 3, it is characterised in that emulsifying agent in the microemulsion
Selected from one or more in nonionic surfactant and anion surfactant, nonionic surfactant is selected from alkyl
Phenol polyethenoxy ether, APES phosphate, APES formaldehyde condensation product, benzylbiphenyl phenol polyoxy
Vinethene；Anion surfactant is selected from alkylbenzenesulfonate, C8- 20 sodium alkyl sulfates, styrene APEO sulfuric acid
Ammonium salt；The preferably mixture of nonionic surfactant and anion surfactant.
5. the composition containing benziothiazolinone according to claim 1,2 or 3, it is characterised in that organic molten in the microemulsion
Agent is selected from water miscible cyclohexanone, cyclohexanol, dimethylformamide；Cosolvent is selected from water miscible methyl alcohol, ethanol, isopropanol.
6. the composition containing benziothiazolinone according to claim 1,2 or 3, it is characterised in that antifreezing agent in the microemulsion
Selected from ethylene glycol, propane diols, glycerine；Bleeding agent is selected from sodium laureth sulfate, JFC, sodium lignin sulfonate.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611078467.3A CN106818723A (en) | 2015-12-04 | 2015-12-04 | Composition containing benziothiazolinone and preparation method thereof |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611078467.3A CN106818723A (en) | 2015-12-04 | 2015-12-04 | Composition containing benziothiazolinone and preparation method thereof |
| CN201510881173.3A CN105432606B (en) | 2015-12-04 | 2015-12-04 | Composition containing benziothiazolinone and preparing method thereof |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510881173.3A Division CN105432606B (en) | 2015-12-04 | 2015-12-04 | Composition containing benziothiazolinone and preparing method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106818723A true CN106818723A (en) | 2017-06-13 |
Family
ID=55543603
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510881173.3A Active CN105432606B (en) | 2015-12-04 | 2015-12-04 | Composition containing benziothiazolinone and preparing method thereof |
| CN201611078467.3A Pending CN106818723A (en) | 2015-12-04 | 2015-12-04 | Composition containing benziothiazolinone and preparation method thereof |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510881173.3A Active CN105432606B (en) | 2015-12-04 | 2015-12-04 | Composition containing benziothiazolinone and preparing method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (2) | CN105432606B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106305779A (en) * | 2016-08-22 | 2017-01-11 | 陕西西大华特科技实业有限公司 | Microbicide composition containing benziothiazolinone and copper hydroxide and applications thereof |
| CN107306972A (en) * | 2017-06-13 | 2017-11-03 | 中国农业科学院植物保护研究所 | Thymol and combinations thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH02268199A (en) * | 1989-04-07 | 1990-11-01 | Ichikawa Gosei Kagaku Kk | Novel cyclic peptide, its production, intermediate therefor and metal cluster complex |
| CN102224818A (en) * | 2011-04-22 | 2011-10-26 | 河北工程大学 | Benziothiazolinone nanoemulsion and preparation method thereof |
| CN104488906A (en) * | 2014-12-18 | 2015-04-08 | 广西田园生化股份有限公司 | Compound composition and bactericide containing methylsulfonyl azole and benziothiazolinone |
| EP2885971A1 (en) * | 2012-08-13 | 2015-06-24 | Jiangsu Huifeng Agrochemical Co., Ltd. | Synergistic fungicide composition |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101669486B (en) * | 2009-10-16 | 2012-06-06 | 深圳诺普信农化股份有限公司 | Benzolkresoxim-methyl containing bactericide composition |
| CN104041508B (en) * | 2013-06-09 | 2016-06-01 | 江苏辉丰农化股份有限公司 | Fungicidal composition containing benziothiazolinone |
-
2015
- 2015-12-04 CN CN201510881173.3A patent/CN105432606B/en active Active
- 2015-12-04 CN CN201611078467.3A patent/CN106818723A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH02268199A (en) * | 1989-04-07 | 1990-11-01 | Ichikawa Gosei Kagaku Kk | Novel cyclic peptide, its production, intermediate therefor and metal cluster complex |
| CN102224818A (en) * | 2011-04-22 | 2011-10-26 | 河北工程大学 | Benziothiazolinone nanoemulsion and preparation method thereof |
| EP2885971A1 (en) * | 2012-08-13 | 2015-06-24 | Jiangsu Huifeng Agrochemical Co., Ltd. | Synergistic fungicide composition |
| CN104488906A (en) * | 2014-12-18 | 2015-04-08 | 广西田园生化股份有限公司 | Compound composition and bactericide containing methylsulfonyl azole and benziothiazolinone |
Non-Patent Citations (1)
| Title |
|---|
| 韦超等: "《药剂学》", 31 August 2012, 河南科学技术出版社 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN105432606A (en) | 2016-03-30 |
| CN105432606B (en) | 2017-02-22 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN104365591A (en) | Pesticide synergist as well preparation method and application thereof | |
| CN103598192B (en) | A kind of bactericidal composition containing tetramycin and Zhongshengmycin | |
| CN107417640B (en) | The preparation method of nanometer zinc thiazole | |
| CN101248793A (en) | Bactericial composition containing pyrazole aether bacterium ester and multiple anti-teichomycin and uses thereof | |
| CN106259391A (en) | A kind of pyraclostrobin potentiation aqueous suspension agent and preparation method thereof | |
| CN105394044A (en) | Miticidal composition and application thereof | |
| CN102334493B (en) | Novel fluopicolide-containing antibacterial composition | |
| CN102365958A (en) | Synergistic insecticidal composition containing rotenone and emamectin benzoate | |
| CN105432606B (en) | Composition containing benziothiazolinone and preparing method thereof | |
| CN104756991A (en) | An environmental-friendly type fungicide formula and a preparing method thereof | |
| CN103609572B (en) | A kind of bactericidal composition containing tetramycin and amino-oligosaccharide | |
| CN105340913A (en) | Sterilization composition containing benziothiazolinone and kasugamycin | |
| CN102885036A (en) | Microemulsion pesticide and production method thereof | |
| CN104904721A (en) | Fungicide composition, preparation of fungicide composition and application of preparation | |
| CN105010367A (en) | Sterilization composition containing copper quinolate and zhongshengmycin | |
| CN105340927A (en) | Sterilization composition containing benziothiazolinone and Zhongshengmycin | |
| CN105076130A (en) | Compound emulsifier for pesticide emulsifiable oil | |
| CN102308817B (en) | Bactericidal composition | |
| CN103238607B (en) | The Herbicidal combinations of a kind of Han isoxazole humulone and fluroxypyr | |
| CN105052950A (en) | Bactericidal composition containing tetramycin and ethylicin | |
| CN107156182A (en) | A kind of preparation method containing plant saponin biopesticide synergist | |
| CN105394039A (en) | Bactericidal composition containing oxine-copper and ethylicin | |
| CN102308813B (en) | Germicide composition containing spiroxamine and tridemorph | |
| CN101356916A (en) | Anticoagulation rodenticide synergist, preparation method and use thereof | |
| CN101828549B (en) | Composition containing pesticide methylpyridine phosphorus microemulsion and preparation thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20170613 |