CN107027783A - A kind of pharmaceutical composition and its application containing the methaldehyde and tropane alkali - Google Patents
A kind of pharmaceutical composition and its application containing the methaldehyde and tropane alkali Download PDFInfo
- Publication number
- CN107027783A CN107027783A CN201710384929.2A CN201710384929A CN107027783A CN 107027783 A CN107027783 A CN 107027783A CN 201710384929 A CN201710384929 A CN 201710384929A CN 107027783 A CN107027783 A CN 107027783A
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- China
- Prior art keywords
- methaldehyde
- tropane
- alkali
- pharmaceutical composition
- snail
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Classifications
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/02—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms
- A01N43/24—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with two or more hetero atoms
Abstract
The invention belongs to technical field of pesticide, specifically related to a kind of pharmaceutical composition and its application containing the methaldehyde and tropane alkali, the active ingredient for the pharmaceutical composition that the present invention is provided is the methaldehyde and tropane alkali, and the mass ratio of the methaldehyde and tropane alkali is 1 30：0.001‑3.In the composition that the present invention is provided, first by tropane alkali applied in the agricultural chemicals for killing snail, antagonism will not be produced with the mutual mixture of the effective active composition methaldehyde, with good synergistic effect, preventive effect apparently higher than single dose, snail efficiency high is killed, reduce the dosage and access times of medicine, saved financial cost, it is to avoid it is drug-fast it is too fast produce, extend the medicine lasting period, residual quantity of the medicament in agricultural product and environment is reduced, beneficial to environment sustainable development；The present composition pair has special efficacy with killing snail.
Description
Technical field
The invention belongs to technical field of pesticide, and in particular to a kind of pharmaceutical composition containing the methaldehyde and tropane alkali and
It is applied.
Background technology
The methaldehyde is that one kind kills a variety of molluscan pharmaceutical preparations such as snail, slug, Pomacea canaliculata, oncomelania, effect
Mode is to tag and stomach toxicity.After the mollusk such as snail foot contacts or takes food the methaldehyde, body can be promoted largely to release
Acetylcholine is put, the internal special mucus of destruction makes its rapid dehydration, neural paralysis, and secretes mucus, due to a large amount of body fluid
It is lost in and cell is destroyed, it is poisoned to death rapidly in a short time, it is low to non-target organism toxicity, to crop safety, fit
For the crop snail such as dry land vegetables, corn and soybean, tobacco, oncomelania, Pomacea canaliculata in aquaculture region and Cultivated water etc.
Preventing and treating.
Tropane alkali, also known as hyoscine, are present in many Important Chinese Medicinal Herbs, a kind of parasympathetic inhibitor.
Often there is different degrees of defect on agricultural insect pests control in the Molluscicides that go out containing single-activity composition,
Such as：The resistance to the action of a drug is also easy to produce after continuous use, pollution of environment etc. will be aggravated more than access times.By the activity of different mechanism of action
Composition, which carries out compounding, can greatly reduce drawbacks described above.Meanwhile, can using the synergistic effect produced by two kinds of active components mixture
To improve preventive effect, delay the drug-fast generation such as snail, reduce environmental pollution, be the important means of integrated control insect.It is existing
In technology, such as Chinese patent CN104472511A, CN104115832A is by two kinds there is the preparation for killing snail to carry out
Compounding, but the harm to environment may also increase, and develop immunity to drugs.At present, have no that the methaldehyde and tropane alkali compounding are gone out
Kill the relevant report of snail.
The content of the invention
For prior art exist kill that snail effect is poor, be also easy to produce the resistance to the action of a drug, exacerbation environmental pressure the problems such as, in order to
The actual requirement of agricultural production is adapted to, the invention provides a kind of pharmaceutical composition containing the methaldehyde and tropane alkali, the group
Compound can play good synergistic effect by the way that the methaldehyde and tropane alkali are compounded according to special ratios, improve
Snail effect is killed, delays drug-fast generation, environmental pollution is small.
In order to achieve the above object, concrete technical scheme of the present invention is：
The invention provides a kind of pharmaceutical composition, the active ingredient of said composition is the methaldehyde and tropane alkali, described four
The mass ratio of metacetaldehyde and tropane alkali is 1-30：0.001-3.
Further, total content of the active ingredient in Molluscicides is 5-50%；It is preferred that active ingredient killing snail
Total content in ox agent is 10-50%.
The formulation of composition provided by the present invention is granule, bait formulation, wettable powder or water dispersible granules；It is preferred that
Formulation be bait formulation or granule.
When above-mentioned formulation is granule, the percentage composition of active ingredient and auxiliary agent is：Active ingredient 5-50%, carrier 36.9-
81.9%, attractant 1-13%, coloring agent 0.1%.
Further, the carrier is according to mass ratio 1 by tea seed powder and bagasse powder：2 compositions.
Further, the attractant is Kelp Powder.
Kelp Powder used in the present invention is prepared from using following methods：Sea-tangle is molten first using 0.5% citric acid
Immersion steeps color protection, is immersed after flushing in beet water, soaks 30min, takes out grind into powder after drying；
The preparation method of the beet water is：According to 1 after beet root is smashed to pieces：10 weight is warming up to 70-80 than adding water
DEG C insulation 30min, adds in filtrate after filtering and accounts for the zinc citrate of beet root weight 1%, stir.
Present invention also offers application of the aforementioned pharmaceutical compositions in snail is killed.
The composition of the methaldehyde and tropane alkali provided by the present invention, can be by known in those skilled in the art
Method, the various any formulations agriculturally allowed are made into known auxiliary agent.
Beneficial effects of the present invention are：
(1) in the composition that provides of the present invention, first tropane alkali is applied to kill in the agricultural chemicals of snail, with effective active into
Point mutual mixture of the methaldehyde will not produce antagonism, with good synergistic effect, preventive effect apparently higher than single dose；
(2) present composition kills snail efficiency high, reduces the dosage and access times of medicine, saved it is economical into
This, it is to avoid develop immunity to drugs, extend medicine lasting period, residual quantity of the medicament in agricultural product and environment is reduced, beneficial to ring
Border sustainable development；
(3) present composition pair has special efficacy with killing snail, equally has to a variety of mollusks such as slug, Pomacea canaliculata, oncomelania
Kill effect.
Embodiment
In order to be better understood from the present invention, further illustrated with reference to specific embodiment.
It is tea seed powder and bagasse powder according to mass ratio 1 that carrier used in granule is prepared in the embodiment of the present invention：2 groups
Into.
Attractant used in granule is prepared in the embodiment of the present invention for Kelp Powder.
The Kelp Powder is prepared from using following methods：Sea-tangle is soaked into shield using 0.5% citric acid solution first
Color, immerses in beet water after flushing, soaks 30min, takes out grind into powder after drying；
The preparation method of the beet water is：According to 1 after beet root is smashed to pieces：10 weight is warming up to 70-80 than adding water
DEG C insulation 30min, adds in filtrate after filtering and accounts for the zinc citrate of beet root weight 1%, stir.
The methaldehyde tropane alkali granule of embodiment 1 5%（1：0.01）
It is formulated and is：The methaldehyde 4.95%, tropane alkali 0.05%, carrier 81.9%, attractant 13%, coloring agent 0.1%.
The methaldehyde tropane alkali granule of embodiment 2 8%（1:0.01）
It is formulated and is：The methaldehyde 7.92%, tropane alkali 0.08%, carrier 81.9%, attractant 10%, coloring agent 0.1%.
The methaldehyde tropane alkali granule of embodiment 3 10%（1：0.01）
It is formulated and is：The methaldehyde 9.901%, tropane alkali 0.099%, carrier 78.95%, attractant 11%, coloring agent 0.05%.
The methaldehyde tropane alkali granule of embodiment 4 10%（1：0.1）
It is formulated and is：The methaldehyde 9.09%, tropane alkali 0.91%, carrier 74.9%, attractant 15%, coloring agent 0.1%.
The methaldehyde tropane alkali granule of embodiment 5 15%（1：0.1）
It is formulated and is：The methaldehyde 13.64%, tropane alkali 1.36%, carrier 74.97%, attractant 10%, coloring agent 0.03%.
The methaldehyde tropane alkali bait formulation of embodiment 6 10%（1：0.01）
It is formulated and is：The methaldehyde 9.901%, tropane alkali 0.099%, Lauxite prepolymer 5%, guar gum 0.2%, Kelp Powder
25%, blackstrap 5%, cracker meal 10%, surplus is sorbierite；
The preparation method of Kelp Powder is ibid.
The methaldehyde tropane alkali wettable powder of embodiment 7 10%（1：0.01）
It is formulated and is：The methaldehyde 9.901%, tropane alkali 0.099%, potassium sulfate, ammonium sulfate, urea, RE microbial fertilizer, dispersant alkane
Base phenol polyethenoxy ether formaldehyde condensate sulfonate 3%, naphthalenesulfonic acid-formaldehyde condensate 1%, wetting agent calcium dodecyl benzene sulfonate
1%th, pull open powder 1%, filler white carbon supply to 100%.
The methaldehyde tropane buck dispersible granule of embodiment 8 10%（1：0.01）
It is formulated and is：The methaldehyde 9.901%, tropane alkali 0.099, foliar fertilizer ammonium chloride 10%, calcium nitrate 20%, ammonium sulfate 9.2%,
Zinc chloride 0.8%, dispersant polyox-yethylene-polyoxypropylene block copolymer 2.5%, naphtholsulfonic acid formaldehyde condensation products sodium salt 1.0%,
Wetting agent fatty acid ester sulfate 1.5%, cornstarch supplies 100%.
The methaldehyde tropane alkali granule of embodiment 9 15%（1：0.01）
It is formulated and is：The methaldehyde 13.64%, tropane alkali 1.36, carrier 71.9%, attractant 13%, coloring agent 0.1%.
The methaldehyde tropane alkali granule of embodiment 10 20%（1：0.01）
It is formulated and is：The methaldehyde 19.81%, tropane alkali 0.19%, carrier 66.9%, attractant 13%, coloring agent 0.1%.
The methaldehyde tropane alkali granule of embodiment 11 30%（1：0.01）
It is formulated and is：The methaldehyde 29.71%, tropane alkali 0.29%, carrier 56.9%, attractant 13%, coloring agent 0.1%.
The methaldehyde tropane alkali granule of embodiment 12 40%（1：0.01）
It is formulated and is：The methaldehyde 39.61%, tropane alkali 0.39%, carrier 46.9%, attractant 13%, coloring agent 0.1%.
The methaldehyde tropane alkali granule of embodiment 13 50%（1：0.01）
It is formulated and is：The methaldehyde 49.51%, tropane alkali 0.49%, carrier 36.9%, attractant 13%, coloring agent 0.1%.
The methaldehyde tropane alkali granule of embodiment 14 20%（1：0.01）
It is formulated and is：The methaldehyde 19.81%, tropane alkali 0.19%, carrier 66.9%, attractant 13%, coloring agent 0.1%；
The carrier Kelp Powder is prepared from using following methods：Sea-tangle is soaked into color protection using 0.5% citric acid solution first
Afterwards after boiling 10min, drying and grinding is taken out into powder.
Effect example
（One）Carry out tropane alkali and compound different ratio to Bradybaena similaris Ferussac 3-4 spiral snail toxicity tests with the methaldehyde（Stomach
Malicious method）, concrete outcome is shown in Table 1.
Table 1
It is summation action when co-toxicity coefficient is between 80-120；It is synergistic effect during higher than 120.In this hair it can be seen from table
In ratio range of the methaldehyde of bright offer with tropane alkali, to killing with synergistic effect for snail, and work as the methaldehyde
It is 1 with tropane alkali proportioning：Co-toxicity coefficient is more than 300, up to 332.38 during 0.001-0.03, and synergy is most obvious, explanation
The methaldehyde is obvious to snail synergy with tropane alkali composition, has and kills effect well, when both ratio exceedes this hair
During the scope of bright offer, its co-toxicity coefficient only shows to be added between 80-120, co-toxicity coefficient is small, and synergistic effect is not obvious
Effect.
（Two）Drug test
Some drugs experiment is set forth below to prove the advantage of medicine of the present invention.
1st, indoor virulence preliminary survey
20 snails of Molluscicides compositions-treated prepared by the embodiment of the present invention, are repeated 3 times, and 3 after medicine, check within 5,7,9 days
The death rate of snail, 3d post-equalization preventive effects reach more than 90%, 5-9 days up to more than 98%.
2nd, field control effectiveness test
Snail disease heavier area in selection cabbage field is tested, and the phase occurs for snail, and investigation snail is total, before dispenser,
Certain amount snail is fixed in each experimental plot with cage, and the composition prepared using embodiment is killed（The each group amount of sharing is equal
For 100 a.i.g/hm2）, after one week, then snail death toll investigation is carried out, calculates preventive effect, output statistics of subsequently following up, setting pair
According to group, control group A 11 is using single 50% methaldehyde granule（100 a.i.g/hm2）, control group A 12 is using single 50% 4 poly- second
Aldehyde granule（300 a.i.g/hm2）, control group B21 is using single 0.5% tropane alkali granule（10 a.i.g/hm2）, control group
B22 is using single 0.5% tropane alkali granule（30 a.i.g/hm2）, blank control group is without using any medicament, and dispenser ought be everyday
Gas is sunny, dusk dispenser.
Concrete outcome is shown in Table 2.
Table 2
Above-mentioned rate of growth, rate of growth is calculated with blank control group.
The methaldehyde and tropane alkali content of the present invention kills snail effect preferably when being 10-50%, beyond killing for this scope
Worm composition for preventing and controlling effect decreases, and when active constituent content is higher than 50%, while adding cost, insect killing effect is not
It is preferable.By data it is known that the present invention improves pest controling effect, the usage amount and access times of medicine are reduced,
It is economical and practical, and ecological and environmental pollution is effectively reduced, crop yield and quality are improved, and the present invention solves existing skill
Overcast and rainy Molluscicides are easily diluted the problems such as effect is reduced in art, are tested by being repeated several times, the composition that the present invention is provided
Insect killing effect is above 96%.
Claims (9)
1. a kind of pharmaceutical composition, it is characterised in that：Active ingredient is the methaldehyde and tropane alkali, the methaldehyde and Liang
The mass ratio of henbane alkane alkali is 1-30：0.001-3.
2. pharmaceutical composition according to claim 1, it is characterised in that the active ingredient always containing in Molluscicides
Measure as 5-50%.
3. pharmaceutical composition according to claim 2, it is characterised in that the active ingredient always containing in Molluscicides
Measure as 10-50%.
4. pharmaceutical composition according to claim 1, it is characterised in that the formulation of the composition be granule, bait formulation,
Wettable powder or water dispersible granules.
5. pharmaceutical composition according to claim 4, it is characterised in that the formulation of the composition is bait formulation or particle
Agent.
6. pharmaceutical composition according to claim 5, it is characterised in that when the formulation is granule, active ingredient and
The percentage composition of auxiliary agent is：Active ingredient 5-50%, carrier 36.9-81.9%, attractant 1-13%, coloring agent 0.1%.
7. pharmaceutical composition according to claim 6, it is characterised in that the carrier be by tea seed powder and bagasse powder by
According to mass ratio 1：2 compositions.
8. pharmaceutical composition according to claim 6, it is characterised in that the attractant is Kelp Powder.
9. application of the pharmaceutical composition described in claim any one of 1-8 in snail is killed.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710384929.2A CN107027783A (en) | 2017-05-26 | 2017-05-26 | A kind of pharmaceutical composition and its application containing the methaldehyde and tropane alkali |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710384929.2A CN107027783A (en) | 2017-05-26 | 2017-05-26 | A kind of pharmaceutical composition and its application containing the methaldehyde and tropane alkali |
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| CN107027783A true CN107027783A (en) | 2017-08-11 |
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| CN201710384929.2A Pending CN107027783A (en) | 2017-05-26 | 2017-05-26 | A kind of pharmaceutical composition and its application containing the methaldehyde and tropane alkali |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110199794A (en) * | 2019-06-21 | 2019-09-06 | 福建省农业科学院果树研究所 | A method of so that dragon fruit snail is gone out shell lethal |
| CN110892896A (en) * | 2019-11-26 | 2020-03-20 | 江苏师范大学 | Formula of low-toxicity compound pesticide molluscicide |
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| CN103766345A (en) * | 2014-01-26 | 2014-05-07 | 江苏艾津农化有限责任公司 | Mollusk killing bait formulation containing niclosamide and application thereof |
| CN106172448A (en) * | 2016-07-28 | 2016-12-07 | 山东省农药科学研究院 | Tropane alkali microcapsule formulation and preparation method thereof |
| CN106614592A (en) * | 2016-12-16 | 2017-05-10 | 张宗斌 | Ampullaria gigas-killing granules containing metaldehyde and tea saponin |
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2017
- 2017-05-26 CN CN201710384929.2A patent/CN107027783A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102217598B (en) * | 2011-04-18 | 2013-08-28 | 江苏艾津农化有限责任公司 | Composition containing niclosamide and metaldehyde and compound suspension thereof |
| CN102986511A (en) * | 2012-10-10 | 2013-03-27 | 肥西县农业技术推广中心 | Dendrobium officinale cultivation method |
| CN103766345A (en) * | 2014-01-26 | 2014-05-07 | 江苏艾津农化有限责任公司 | Mollusk killing bait formulation containing niclosamide and application thereof |
| CN106172448A (en) * | 2016-07-28 | 2016-12-07 | 山东省农药科学研究院 | Tropane alkali microcapsule formulation and preparation method thereof |
| CN106614592A (en) * | 2016-12-16 | 2017-05-10 | 张宗斌 | Ampullaria gigas-killing granules containing metaldehyde and tea saponin |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110199794A (en) * | 2019-06-21 | 2019-09-06 | 福建省农业科学院果树研究所 | A method of so that dragon fruit snail is gone out shell lethal |
| CN110892896A (en) * | 2019-11-26 | 2020-03-20 | 江苏师范大学 | Formula of low-toxicity compound pesticide molluscicide |
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