CN102217598B - Composition containing niclosamide and metaldehyde and compound suspension thereof - Google Patents
Composition containing niclosamide and metaldehyde and compound suspension thereof Download PDFInfo
- Publication number
- CN102217598B CN102217598B CN 201110097790 CN201110097790A CN102217598B CN 102217598 B CN102217598 B CN 102217598B CN 201110097790 CN201110097790 CN 201110097790 CN 201110097790 A CN201110097790 A CN 201110097790A CN 102217598 B CN102217598 B CN 102217598B
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- China
- Prior art keywords
- niclosamide
- percent
- methaldehyde
- metaldehyde
- agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- RJMUSRYZPJIFPJ-UHFFFAOYSA-N niclosamide Chemical compound OC1=CC=C(Cl)C=C1C(=O)NC1=CC=C([N+]([O-])=O)C=C1Cl RJMUSRYZPJIFPJ-UHFFFAOYSA-N 0.000 title claims abstract description 48
- 229960001920 niclosamide Drugs 0.000 title claims abstract description 47
- 239000000203 mixture Substances 0.000 title abstract description 14
- 150000001875 compounds Chemical class 0.000 title abstract description 4
- 239000005956 Metaldehyde Substances 0.000 title abstract 6
- GKKDCARASOJPNG-UHFFFAOYSA-N metaldehyde Chemical compound CC1OC(C)OC(C)OC(C)O1 GKKDCARASOJPNG-UHFFFAOYSA-N 0.000 title abstract 6
- 239000000725 suspension Substances 0.000 title abstract 3
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 11
- 239000007900 aqueous suspension Substances 0.000 claims abstract description 8
- 239000008367 deionised water Substances 0.000 claims abstract description 5
- 229910021641 deionized water Inorganic materials 0.000 claims abstract description 5
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 claims description 42
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 18
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims description 12
- 239000013530 defoamer Substances 0.000 claims description 7
- 239000005711 Benzoic acid Substances 0.000 claims description 6
- 235000008331 Pinus X rigitaeda Nutrition 0.000 claims description 6
- 235000011613 Pinus brutia Nutrition 0.000 claims description 6
- 241000018646 Pinus brutia Species 0.000 claims description 6
- 235000010233 benzoic acid Nutrition 0.000 claims description 6
- 229920001296 polysiloxane Polymers 0.000 claims description 6
- 229920001285 xanthan gum Polymers 0.000 claims description 6
- LCRMGUFGEDUSOG-UHFFFAOYSA-N naphthalen-1-ylsulfonyloxymethyl naphthalene-1-sulfonate;sodium Chemical compound [Na].C1=CC=C2C(S(=O)(OCOS(=O)(=O)C=3C4=CC=CC=C4C=CC=3)=O)=CC=CC2=C1 LCRMGUFGEDUSOG-UHFFFAOYSA-N 0.000 claims description 5
- 239000004576 sand Substances 0.000 claims description 5
- RCEAADKTGXTDOA-UHFFFAOYSA-N OS(O)(=O)=O.CCCCCCCCCCCC[Na] Chemical compound OS(O)(=O)=O.CCCCCCCCCCCC[Na] RCEAADKTGXTDOA-UHFFFAOYSA-N 0.000 claims description 3
- 229920005551 calcium lignosulfonate Polymers 0.000 claims description 3
- RYAGRZNBULDMBW-UHFFFAOYSA-L calcium;3-(2-hydroxy-3-methoxyphenyl)-2-[2-methoxy-4-(3-sulfonatopropyl)phenoxy]propane-1-sulfonate Chemical compound [Ca+2].COC1=CC=CC(CC(CS([O-])(=O)=O)OC=2C(=CC(CCCS([O-])(=O)=O)=CC=2)OC)=C1O RYAGRZNBULDMBW-UHFFFAOYSA-L 0.000 claims description 3
- 239000006185 dispersion Substances 0.000 claims description 3
- 230000001804 emulsifying effect Effects 0.000 claims description 3
- 241000565675 Oncomelania Species 0.000 abstract description 19
- 239000003814 drug Substances 0.000 abstract description 7
- 230000008901 benefit Effects 0.000 abstract description 4
- 239000004480 active ingredient Substances 0.000 abstract description 3
- 239000002270 dispersing agent Substances 0.000 abstract description 3
- 230000002147 killing effect Effects 0.000 abstract description 3
- 239000003755 preservative agent Substances 0.000 abstract description 3
- 230000002335 preservative effect Effects 0.000 abstract description 3
- 230000002265 prevention Effects 0.000 abstract description 3
- 239000002562 thickening agent Substances 0.000 abstract description 3
- 239000000080 wetting agent Substances 0.000 abstract description 3
- 241001465754 Metazoa Species 0.000 abstract description 2
- 239000003960 organic solvent Substances 0.000 abstract description 2
- 238000002360 preparation method Methods 0.000 abstract description 2
- 238000001228 spectrum Methods 0.000 abstract description 2
- 239000002518 antifoaming agent Substances 0.000 abstract 1
- 238000007710 freezing Methods 0.000 abstract 1
- 231100000053 low toxicity Toxicity 0.000 abstract 1
- 239000000375 suspending agent Substances 0.000 description 15
- 239000002131 composite material Substances 0.000 description 9
- 230000000694 effects Effects 0.000 description 6
- 239000000843 powder Substances 0.000 description 6
- 230000002013 molluscicidal effect Effects 0.000 description 5
- 238000009736 wetting Methods 0.000 description 5
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- -1 polyoxyethylene Polymers 0.000 description 4
- XYCDHXSQODHSLG-UHFFFAOYSA-N 4-chloro-2-[(2-chloro-4-nitrophenyl)carbamoyl]phenolate;2-hydroxyethylazanium Chemical compound NCCO.OC1=CC=C(Cl)C=C1C(=O)NC1=CC=C([N+]([O-])=O)C=C1Cl XYCDHXSQODHSLG-UHFFFAOYSA-N 0.000 description 3
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 229920005646 polycarboxylate Polymers 0.000 description 3
- 201000004409 schistosomiasis Diseases 0.000 description 3
- 239000011734 sodium Substances 0.000 description 3
- 229910052708 sodium Inorganic materials 0.000 description 3
- 235000014347 soups Nutrition 0.000 description 3
- 230000002195 synergetic effect Effects 0.000 description 3
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 2
- 206010059866 Drug resistance Diseases 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 239000003905 agrochemical Substances 0.000 description 2
- 125000001931 aliphatic group Chemical group 0.000 description 2
- 230000003750 conditioning effect Effects 0.000 description 2
- 230000000857 drug effect Effects 0.000 description 2
- 238000011835 investigation Methods 0.000 description 2
- 239000003750 molluscacide Substances 0.000 description 2
- 239000000575 pesticide Substances 0.000 description 2
- 229920000056 polyoxyethylene ether Polymers 0.000 description 2
- 229940051841 polyoxyethylene ether Drugs 0.000 description 2
- 238000005507 spraying Methods 0.000 description 2
- 231100000419 toxicity Toxicity 0.000 description 2
- 230000001988 toxicity Effects 0.000 description 2
- 208000034657 Convalescence Diseases 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- 229920000084 Gum arabic Polymers 0.000 description 1
- 229920001732 Lignosulfonate Polymers 0.000 description 1
- 241000237852 Mollusca Species 0.000 description 1
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical class CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 1
- 241001442514 Schistosomatidae Species 0.000 description 1
- 241000978776 Senegalia senegal Species 0.000 description 1
- 235000010489 acacia gum Nutrition 0.000 description 1
- 239000000205 acacia gum Substances 0.000 description 1
- 229960000583 acetic acid Drugs 0.000 description 1
- WMGSQTMJHBYJMQ-UHFFFAOYSA-N aluminum;magnesium;silicate Chemical compound [Mg+2].[Al+3].[O-][Si]([O-])([O-])[O-] WMGSQTMJHBYJMQ-UHFFFAOYSA-N 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000008485 antagonism Effects 0.000 description 1
- 239000000440 bentonite Substances 0.000 description 1
- 229910000278 bentonite Inorganic materials 0.000 description 1
- 235000012216 bentonite Nutrition 0.000 description 1
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 description 1
- 238000009395 breeding Methods 0.000 description 1
- 230000001488 breeding effect Effects 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- 238000006298 dechlorination reaction Methods 0.000 description 1
- SYHPANJAVIEQQL-UHFFFAOYSA-N dicarboxy carbonate Chemical compound OC(=O)OC(=O)OC(O)=O SYHPANJAVIEQQL-UHFFFAOYSA-N 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000000428 dust Substances 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000002360 explosive Substances 0.000 description 1
- 238000011010 flushing procedure Methods 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 239000012362 glacial acetic acid Substances 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 229930182470 glycoside Natural products 0.000 description 1
- 238000007654 immersion Methods 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 229920000570 polyether Polymers 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
- 239000004299 sodium benzoate Substances 0.000 description 1
- 235000010234 sodium benzoate Nutrition 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 230000001018 virulence Effects 0.000 description 1
- 239000004562 water dispersible granule Substances 0.000 description 1
Abstract
Description
Group number | Pesticide species | Virulence regression equation | Co-toxicity coefficient |
1. | Niclosamide | Y=7.7977+3.4980X | / |
2. | The methaldehyde | Y=5.3103+1.6816X | / |
3. | Niclosamide: the methaldehyde (10: 1) | Y=8.8075+4.3354X | 129 |
4. | Niclosamide: the methaldehyde (25: 1) | Y=7.9559+2.7934X | 187 |
5. | Niclosamide: the methaldehyde (50: 1) | Y=7.8788+3.1312X | 134 |
6. | Niclosamide: the methaldehyde (1: 1) | Y=6.2037+1.5598X | 151 |
Claims (1)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN 201110097790 CN102217598B (en) | 2011-04-18 | 2011-04-18 | Composition containing niclosamide and metaldehyde and compound suspension thereof |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN 201110097790 CN102217598B (en) | 2011-04-18 | 2011-04-18 | Composition containing niclosamide and metaldehyde and compound suspension thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
CN102217598A CN102217598A (en) | 2011-10-19 |
CN102217598B true CN102217598B (en) | 2013-08-28 |
Family
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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CN 201110097790 Active CN102217598B (en) | 2011-04-18 | 2011-04-18 | Composition containing niclosamide and metaldehyde and compound suspension thereof |
Country Status (1)
Country | Link |
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CN (1) | CN102217598B (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN107027783A (en) * | 2017-05-26 | 2017-08-11 | 山东省农药科学研究院 | A kind of pharmaceutical composition and its application containing the methaldehyde and tropane alkali |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103891720B (en) * | 2012-12-27 | 2016-02-17 | 陕西汤普森生物科技有限公司 | A kind ofly kill spiral shell composition containing the composite of the withered prestige of spiral shell |
CN103583513A (en) * | 2013-12-03 | 2014-02-19 | 四川省化学工业研究设计院 | Suspending agent of chlorosalicylamide as snail control drug and preparation method thereof |
CN103766345B (en) * | 2014-01-26 | 2015-11-18 | 江苏艾津农化有限责任公司 | A kind of containing niclosamide kill mollusk bait formulation and application thereof |
CN104115832B (en) * | 2014-08-12 | 2016-06-15 | 广州农密生物科技有限公司白云分公司 | One is gone out spiral shell suspension agent and its preparation method |
CN104970019A (en) * | 2014-12-02 | 2015-10-14 | 铜陵县明晋生产力促进中心有限公司 | Preparation method of insecticide killing schistosoma and eggs |
CN104970046A (en) * | 2014-12-02 | 2015-10-14 | 肖哲西 | Pesticide for killing mollusk pests |
CN104996452A (en) * | 2015-07-03 | 2015-10-28 | 天峨县科学技术情报研究所 | Pesticide composition containing niclosamide ethanolamine and thiacloprid |
CN104982436B (en) * | 2015-07-15 | 2017-12-01 | 广西农战士高工效农业技术有限公司 | A kind of Pesticidal combination containing niclosamide and anabasine pesticide |
CN107006459B (en) * | 2017-05-19 | 2020-12-04 | 广东农密生物科技有限公司 | Mollusk control water dispersible granule and preparation method thereof |
CN112961527A (en) * | 2019-12-13 | 2021-06-15 | 徐州诺特化工有限公司 | Processing technology of metaldehyde and melamine modified urea-formaldehyde glue compounded ship body protective agent |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN100455194C (en) * | 2007-01-25 | 2009-01-28 | 戴建荣 | A compound suspension of molluscicidal drug niclosamide ethanolamine salt and its preparation method |
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2011
- 2011-04-18 CN CN 201110097790 patent/CN102217598B/en active Active
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN107027783A (en) * | 2017-05-26 | 2017-08-11 | 山东省农药科学研究院 | A kind of pharmaceutical composition and its application containing the methaldehyde and tropane alkali |
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Publication number | Publication date |
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CN102217598A (en) | 2011-10-19 |
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Legal Events
Date | Code | Title | Description |
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C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: Composition containing niclosamide and metaldehyde and compound suspension thereof Effective date of registration: 20150323 Granted publication date: 20130828 Pledgee: Bank of Beijing, Limited by Share Ltd, Nanjing branch Pledgor: Jiangsu Aijin Agrochemical Co., Ltd. Registration number: 2015320000002 |
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PLDC | Enforcement, change and cancellation of contracts on pledge of patent right or utility model | ||
PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20160824 Granted publication date: 20130828 Pledgee: Bank of Beijing, Limited by Share Ltd, Nanjing branch Pledgor: Jiangsu Aijin Agrochemical Co., Ltd. Registration number: 2015320000002 |
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PLDC | Enforcement, change and cancellation of contracts on pledge of patent right or utility model | ||
PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: Composition containing niclosamide and metaldehyde and compound suspension thereof Effective date of registration: 20190424 Granted publication date: 20130828 Pledgee: Hongwu Branch of Nanjing Bank Co., Ltd. Pledgor: Jiangsu Aijin Agrochemical Co., Ltd. Registration number: 2019320000196 |
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CP03 | Change of name, title or address | ||
CP03 | Change of name, title or address |
Address after: 65 shuangxiang Road, Xiongzhou street, Liuhe District, Nanjing City, Jiangsu Province, 210000 Patentee after: Jiangsu Aijin crop Technology Group Co., Ltd Address before: 211511, No. 58, Lane No. 2, Hongshan Fine Chemical Industrial Park, Liuhe District, Jiangsu, Nanjing Patentee before: JIANGSU ESSENCE AGROCHEMICAL Co.,Ltd. |