CN102217598A - Composition containing niclosamide and metaldehyde and compound suspension thereof - Google Patents
Composition containing niclosamide and metaldehyde and compound suspension thereof Download PDFInfo
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- CN102217598A CN102217598A CN2011100977906A CN201110097790A CN102217598A CN 102217598 A CN102217598 A CN 102217598A CN 2011100977906 A CN2011100977906 A CN 2011100977906A CN 201110097790 A CN201110097790 A CN 201110097790A CN 102217598 A CN102217598 A CN 102217598A
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- niclosamide
- methaldehyde
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- RJMUSRYZPJIFPJ-UHFFFAOYSA-N niclosamide Chemical compound OC1=CC=C(Cl)C=C1C(=O)NC1=CC=C([N+]([O-])=O)C=C1Cl RJMUSRYZPJIFPJ-UHFFFAOYSA-N 0.000 title claims abstract description 61
- 229960001920 niclosamide Drugs 0.000 title claims abstract description 60
- 239000000203 mixture Substances 0.000 title claims abstract description 21
- 150000001875 compounds Chemical class 0.000 title abstract description 4
- 239000005956 Metaldehyde Substances 0.000 title abstract 6
- GKKDCARASOJPNG-UHFFFAOYSA-N metaldehyde Chemical compound CC1OC(C)OC(C)OC(C)O1 GKKDCARASOJPNG-UHFFFAOYSA-N 0.000 title abstract 6
- 239000000725 suspension Substances 0.000 title abstract 3
- 241000565675 Oncomelania Species 0.000 claims abstract description 20
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 20
- 239000007900 aqueous suspension Substances 0.000 claims abstract description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 11
- 239000003814 drug Substances 0.000 claims abstract description 8
- 239000008367 deionised water Substances 0.000 claims abstract description 5
- 229910021641 deionized water Inorganic materials 0.000 claims abstract description 5
- 239000002270 dispersing agent Substances 0.000 claims abstract description 5
- 239000003755 preservative agent Substances 0.000 claims abstract description 5
- 230000002335 preservative effect Effects 0.000 claims abstract description 5
- 239000002562 thickening agent Substances 0.000 claims abstract description 5
- 239000000080 wetting agent Substances 0.000 claims abstract description 5
- 230000002147 killing effect Effects 0.000 claims abstract description 4
- 238000002360 preparation method Methods 0.000 claims abstract description 3
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 claims description 58
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 18
- 239000000375 suspending agent Substances 0.000 claims description 16
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims description 12
- 239000013530 defoamer Substances 0.000 claims description 8
- -1 polyoxyethylene Polymers 0.000 claims description 7
- 239000000843 powder Substances 0.000 claims description 7
- 239000005711 Benzoic acid Substances 0.000 claims description 6
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 6
- 235000008331 Pinus X rigitaeda Nutrition 0.000 claims description 6
- 235000011613 Pinus brutia Nutrition 0.000 claims description 6
- 241000018646 Pinus brutia Species 0.000 claims description 6
- 235000010233 benzoic acid Nutrition 0.000 claims description 6
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 6
- 229920001296 polysiloxane Polymers 0.000 claims description 6
- 229920001285 xanthan gum Polymers 0.000 claims description 6
- LCRMGUFGEDUSOG-UHFFFAOYSA-N naphthalen-1-ylsulfonyloxymethyl naphthalene-1-sulfonate;sodium Chemical compound [Na].C1=CC=C2C(S(=O)(OCOS(=O)(=O)C=3C4=CC=CC=C4C=CC=3)=O)=CC=CC2=C1 LCRMGUFGEDUSOG-UHFFFAOYSA-N 0.000 claims description 5
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 4
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 4
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 4
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims description 4
- 229920005646 polycarboxylate Polymers 0.000 claims description 4
- 201000004409 schistosomiasis Diseases 0.000 claims description 4
- 239000011734 sodium Substances 0.000 claims description 4
- 229910052708 sodium Inorganic materials 0.000 claims description 4
- RCEAADKTGXTDOA-UHFFFAOYSA-N OS(O)(=O)=O.CCCCCCCCCCCC[Na] Chemical group OS(O)(=O)=O.CCCCCCCCCCCC[Na] RCEAADKTGXTDOA-UHFFFAOYSA-N 0.000 claims description 3
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims description 3
- 239000002253 acid Substances 0.000 claims description 3
- 239000003905 agrochemical Substances 0.000 claims description 3
- 125000001931 aliphatic group Chemical group 0.000 claims description 3
- 229920000056 polyoxyethylene ether Polymers 0.000 claims description 3
- 229940051841 polyoxyethylene ether Drugs 0.000 claims description 3
- 108010010803 Gelatin Proteins 0.000 claims description 2
- 229920000084 Gum arabic Polymers 0.000 claims description 2
- 229920001732 Lignosulfonate Polymers 0.000 claims description 2
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical class CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 claims description 2
- 241000978776 Senegalia senegal Species 0.000 claims description 2
- 235000010489 acacia gum Nutrition 0.000 claims description 2
- 239000000205 acacia gum Substances 0.000 claims description 2
- 229960000583 acetic acid Drugs 0.000 claims description 2
- WMGSQTMJHBYJMQ-UHFFFAOYSA-N aluminum;magnesium;silicate Chemical compound [Mg+2].[Al+3].[O-][Si]([O-])([O-])[O-] WMGSQTMJHBYJMQ-UHFFFAOYSA-N 0.000 claims description 2
- 239000000440 bentonite Substances 0.000 claims description 2
- 229910000278 bentonite Inorganic materials 0.000 claims description 2
- 235000012216 bentonite Nutrition 0.000 claims description 2
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 claims description 2
- 239000004202 carbamide Substances 0.000 claims description 2
- 239000000839 emulsion Substances 0.000 claims description 2
- 239000008273 gelatin Substances 0.000 claims description 2
- 229920000159 gelatin Polymers 0.000 claims description 2
- 235000019322 gelatine Nutrition 0.000 claims description 2
- 235000011852 gelatine desserts Nutrition 0.000 claims description 2
- 239000012362 glacial acetic acid Substances 0.000 claims description 2
- 235000011187 glycerol Nutrition 0.000 claims description 2
- 229930182470 glycoside Natural products 0.000 claims description 2
- 229920000570 polyether Polymers 0.000 claims description 2
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 claims description 2
- 239000004299 sodium benzoate Substances 0.000 claims description 2
- 235000010234 sodium benzoate Nutrition 0.000 claims description 2
- 239000011780 sodium chloride Substances 0.000 claims description 2
- 239000004562 water dispersible granule Substances 0.000 claims description 2
- 230000008901 benefit Effects 0.000 abstract description 4
- 239000004480 active ingredient Substances 0.000 abstract description 3
- 230000002265 prevention Effects 0.000 abstract description 3
- 241001465754 Metazoa Species 0.000 abstract description 2
- 239000003960 organic solvent Substances 0.000 abstract description 2
- 238000001228 spectrum Methods 0.000 abstract description 2
- 239000002518 antifoaming agent Substances 0.000 abstract 1
- 238000007710 freezing Methods 0.000 abstract 1
- 231100000053 low toxicity Toxicity 0.000 abstract 1
- 239000002131 composite material Substances 0.000 description 9
- 230000000694 effects Effects 0.000 description 6
- 230000002013 molluscicidal effect Effects 0.000 description 5
- 238000009736 wetting Methods 0.000 description 5
- 238000000034 method Methods 0.000 description 4
- 239000004576 sand Substances 0.000 description 4
- XYCDHXSQODHSLG-UHFFFAOYSA-N 4-chloro-2-[(2-chloro-4-nitrophenyl)carbamoyl]phenolate;2-hydroxyethylazanium Chemical compound NCCO.OC1=CC=C(Cl)C=C1C(=O)NC1=CC=C([N+]([O-])=O)C=C1Cl XYCDHXSQODHSLG-UHFFFAOYSA-N 0.000 description 3
- 235000014347 soups Nutrition 0.000 description 3
- 230000002195 synergetic effect Effects 0.000 description 3
- 206010059866 Drug resistance Diseases 0.000 description 2
- 229920005551 calcium lignosulfonate Polymers 0.000 description 2
- RYAGRZNBULDMBW-UHFFFAOYSA-L calcium;3-(2-hydroxy-3-methoxyphenyl)-2-[2-methoxy-4-(3-sulfonatopropyl)phenoxy]propane-1-sulfonate Chemical compound [Ca+2].COC1=CC=CC(CC(CS([O-])(=O)=O)OC=2C(=CC(CCCS([O-])(=O)=O)=CC=2)OC)=C1O RYAGRZNBULDMBW-UHFFFAOYSA-L 0.000 description 2
- 239000006185 dispersion Substances 0.000 description 2
- 230000000857 drug effect Effects 0.000 description 2
- 230000001804 emulsifying effect Effects 0.000 description 2
- 238000011835 investigation Methods 0.000 description 2
- 239000003750 molluscacide Substances 0.000 description 2
- 239000000575 pesticide Substances 0.000 description 2
- 238000005507 spraying Methods 0.000 description 2
- 231100000419 toxicity Toxicity 0.000 description 2
- 230000001988 toxicity Effects 0.000 description 2
- 208000034657 Convalescence Diseases 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 241000237852 Mollusca Species 0.000 description 1
- 241001442514 Schistosomatidae Species 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000008485 antagonism Effects 0.000 description 1
- 238000009395 breeding Methods 0.000 description 1
- 230000001488 breeding effect Effects 0.000 description 1
- 230000003750 conditioning effect Effects 0.000 description 1
- 238000006298 dechlorination reaction Methods 0.000 description 1
- SYHPANJAVIEQQL-UHFFFAOYSA-N dicarboxy carbonate Chemical compound OC(=O)OC(=O)OC(O)=O SYHPANJAVIEQQL-UHFFFAOYSA-N 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000000428 dust Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000002360 explosive Substances 0.000 description 1
- 238000011010 flushing procedure Methods 0.000 description 1
- 238000007654 immersion Methods 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 230000001018 virulence Effects 0.000 description 1
Abstract
The invention discloses a composition containing niclosamide and metaldehyde and a compound suspension thereof. The niclosamide and the metaldehyde are used as active ingredients of the composition, and the mass ratio of the niclosamide to the metaldehyde is (1-50):(1-10). The composition can be applied to preparation of medicaments for preventing and treating trematodiasis. The aqueous suspension containing the niclosamide and the metaldehyde comprises 1-50 percent of niclosamide, 1-10 percent of metaldehyde, 1-5 percent of wetting agent, 1-20 percent of dispersant, 1-10 percent of anti-freezing agent, 0.1-1 percent of preservative, 0.1-1 percent of pH regulator, 0.1-1 percent of defoaming agent, 0.1-2 percent of thickening agent and the balance of deionized water which complements the volume to 100 percent. The aqueous suspension has the advantages of large prevention and treatment spectrum, good oncomelania killing effect, nonuse of an organic solvent, low volatility, low toxicity, safety to people, animals and environments, low granularity, high suspension rate, convenience in use and obvious comprehensive and economic benefits.
Description
Technical field
The invention belongs to the blood fluke prevention and control field, be specifically related to a kind of composition that contains the niclosamide and the methaldehyde with and aqueous suspension agent.
Background technology
The niclosamide and the methaldehyde are mainly used in popular with the prevention and control bilharziasis of mollusk extremely.Niclosamide stimulates the aerobic metabolism of oncomelania when low concentration, promote the escape of oncomelania and swash, and influences tricarbonic acid cycle during high concentration and causes oncomelania death; The methaldehyde also is a kind of application molluscacide very widely, and its outstanding advantage is can suppress oncomelania to swash, and is low to aquatile toxicity.
But the problem that both all exist medication difficulty and pesticide resistance to produce is difficult to effectively control the popular of schistosomiasis.And the two is the medicine that is insoluble in water, and its wetting powder drug effect is not high, and dosage is big, and dust easily drifts about, and easily contaminated environment is used inconvenient.
Summary of the invention
The objective of the invention is to overcome the drug resistance problem of existing niclosamide, a kind of Synergistic composition that contains the niclosamide and the methaldehyde is provided.
Another object of the present invention provides a kind of application of above-mentioned composition.
A further object of the invention provides the composite suspending agent of a kind of snail-killing medicine niclosamide.
Purpose of the present invention can reach by following measure:
A kind of composition that contains the niclosamide and the methaldehyde, said composition is an active component with the niclosamide and the methaldehyde, and wherein the mass ratio of the niclosamide and the methaldehyde is 1～50: 1～10, is preferably 1～50: 1～5, more preferably 1～50: 1, most preferably be 25～30: 1～5.
Said composition is an active component with the niclosamide and the methaldehyde, is aided with that acceptable auxiliary can be made into acceptable forms on the various agricultural chemicals on the agricultural chemicals, as emulsion, water dispersible granules or suspending agent.
The above-mentioned composition that contains the niclosamide and the methaldehyde can be applicable to preparation control bilharziasis medicine aspect, particularly is applied to the killing oncomelania aspect.
The present invention also provides a kind of aqueous suspension agent that contains the niclosamide and the methaldehyde, and it comprises following component:
Niclosamide 1～50%, the methaldehyde 1～10%, wetting agent 1～5%, dispersant 1～20%, antifreezing agent 1～10%, preservative 0.1～1%, pH regulator agent 0.1～1%, defoamer 0.1～1%, thickener 0.1～2%, deionized water complements to 100%.Wherein the content of niclosamide is preferably 1～50%, and methaldehyde content is preferably 1～5%, most preferably is 1%.
In the above-mentioned aqueous suspension agent, wetting agent is lauryl sodium sulfate, draw back one or more the compound uses in powder, alkylphenol polyoxyethylene, fatty alcohol-polyoxyethylene ether, aliphatic acid polyethenoxy ether, the alkyl glycoside.
Dispersant is one or more the compound uses among sodium methylene bis-naphthalene sulfonate, lignosulfonates, polycarboxylate sodium, alkylphenol polyoxyethylene phosphate, the SOPA (speed pool) 270.
Antifreezing agent is ethylene glycol, glycerine, urea, sodium chloride.Preservative is selected Sodium Benzoate, card pine, formaldehyde for use.The PH conditioning agent is benzoic acid, glacial acetic acid, citric acid, hydrochloric acid.Defoamer is organic silicone, polyethers, butanols.Thickener xanthans, gelatin, gum Arabic, bentonite, aluminium-magnesium silicate.
Above-mentioned each component is mixed the back can make aqueous suspension agent by being ground to 1～10um.
Experiment finds that the composition of this killing oncomelania has obvious role in synergism, can effectively overcome the drug resistance problem of oncomelania.The niclosamide that the present invention makes and methaldehyde aqueous suspension agent control spectrum further enlarges, and molluscicidal effect is good, and not with an organic solvent, volatility is little, toxicity is low, safe for human and animal and environment; Nonflammable explosive, storing safety.Fine size, general particle diameter 2～5um, the suspensibility height, drug effect is than wetting powder height; Can mix with arbitrary proportion with water, easy to use, have significantly comprehensive and economic benefit.
Embodiment
Embodiment 1:15% niclosamide+1% methaldehyde suspending agent
By percentage to the quality, niclosamide 15%, the methaldehyde 1%, aliphatic acid polyethenoxy ether 2%, sodium methylene bis-naphthalene sulfonate salt 5%, calcium lignosulfonate 5%, ethylene glycol 5%, benzoic acid 0.3%, organic silicone defoamer 0.5%, card pine 0.2%, xanthans 0.3%, deionized water complements to 100%.Each component mixes with the high-shear emulsifying dispersion machine with this ratio, is ground to 2～3um through multistage sand mill, makes 15% niclosamide+1% methaldehyde SC.
Embodiment 2:25% niclosamide+1% methaldehyde suspending agent
By percentage to the quality, niclosamide 25%, the methaldehyde 1%, lauryl sodium sulfate 2%, sodium methylene bis-naphthalene sulfonate salt 5%, calcium lignosulfonate 5%, ethylene glycol 5%, benzoic acid 0.3%, organic silicone defoamer 0.5%, card pine 0.2%, xanthans 0.3%, deionized water complements to 100%.Each component mixes with the high-shear emulsifying dispersion machine with this ratio, is ground to 2～3um through multistage sand mill, makes 25% niclosamide+1% methaldehyde SC.
Embodiment 3:30% niclosamide+1% methaldehyde suspending agent
By percentage to the quality, niclosamide 30%, the methaldehyde 1%, alkylphenol polyoxyethylene 2%, the polycarboxylate sodium 2%, sodium methylene bis-naphthalene sulfonate salt 3%, ethylene glycol 5%, benzoic acid 1%, organic silicone defoamer 0.5%, card pine 0.2%, xanthans 0.2%, be ground to 2～3um through multistage sand mill, make 30% niclosamide+1% methaldehyde SC.
Embodiment 4:45% niclosamide+1% methaldehyde suspending agent
By percentage to the quality, niclosamide 45%, the methaldehyde 1%, fatty alcohol-polyoxyethylene ether 3%, the polycarboxylate sodium 2%, SOPA (speed pool) 2703%, ethylene glycol 5%, benzoic acid 1%, organic silicone defoamer 0.5%, card pine 0.2%, xanthans 0.1%, it is qualified to grind through multistage sand mill, makes 45% niclosamide+1% methaldehyde SC.
Embodiment 5: spend coefficient together
Pour into the 100ml soup in the beaker respectively and be settled to 200ml, every beaker put into 3 bags in the spiral shell bag that contains 30 oncomelanias, and the soup degree of depth exceeds spiral shell bag 2～3cm, establishes clear water (dechlorination water) contrast simultaneously.Immerse behind the soup at the spiral shell bag and respectively to take out 1 bag behind 24h, the 48h and 72h, after clear water is cleaned and dried, raises the back through 72h convalescence and identify that with hammering method oncomelania is dead and the number of surviving.
Calculate the LD50 value of obtaining various single agent and different assembly with Finny (1952) probit value analytical method, calculate co-toxicity coefficient (CTC) according to Sun method (1960) then, co-toxicity effect with composite dose of CTC value judgement, be summation action about CTC value 80-120, being significantly less than at 80 o'clock is antagonism, is synergistic effect greater than 120 o'clock obviously.
From the data of table 1 as can be seen, after the niclosamide and the methaldehyde are composite, comparatively obvious synergistic effect is arranged.
The 72h co-toxicity effect of table 1 niclosamide-methaldehyde
| Group number | Pesticide species | Virulence regression equation | Co-toxicity coefficient |
| 1. | Niclosamide | Y＝7.7977+3.4980X | / |
| 2. | The methaldehyde | Y＝5.3103+1.6816X | / |
| 3. | Niclosamide: the methaldehyde (10: 1) | Y＝8.8075+4.3354X | 129 |
| 4. | Niclosamide: the methaldehyde (25: 1) | Y＝7.9559+2.7934X | 187 |
| 5. | Niclosamide: the methaldehyde (50: 1) | Y＝7.8788+3.1312X | 134 |
| 6. | Niclosamide: the methaldehyde (1: 1) | Y＝6.2037+1.5598X | 151 |
Embodiment 6: oncomelania effect is extremely soaked in the laboratory
The niclosamide that the laboratory obtains with embodiment 2 in the time of 25 ℃ and the composite suspending agent of the methaldehyde are configured to active ingredient concentration 0.5,0.25,0.125,0.0625 and 0.0313 mg/litre and soak and killed spiral shell 24 hours, 48 hours and 72 hours, compare test with 50% niclosamide ethanolamine salt wetting powder and 1% methaldehyde suspending agent.The composite suspending agent active ingredient of niclosamide methaldehyde concentration 0.125 mg/litre immersion oncomelania becomes spiral shell to kill spiral shell in the time of 24 hours can reach 100%, LC50 (24 hours) is 0.0625 mg/litre, the LC50 of 50% niclosamide ethanolamine salt wetting powder (24 hours) is 0.1250 mg/litre, the LC50 of 1% methaldehyde suspending agent (24 hours) is greater than 0.5 mg/litre, and the composite suspending agent of niclosamide has molluscicidal effect (table 2) preferably.
Oncomelania effect is extremely soaked in table 2 laboratory
Embodiment 7: oncomelania effect is extremely soaked at the scene
Select the Nanjing Xixia District to carry out on-the-spot spraying molluscicide,, choose oncomelania density＞10/frame (0.1m by the baseline investigation
2) the oncomelania breeding place, be divided into 5 sub-districts, the about 100m in each sub-district
2, removing is higher than the weeds of 5cm and shifts out the test region in the sub-district.Wherein 3 sub-districts are experimental group, get embodiment 3 products respectively by 4.0,2.0 and 1.0g/m
2Spraying medicine, 1 sub-district is medicine control group 50% niclosamide ethanolamine salt wetting powder 2.0g/m
2, 1 sub-district is the blank group.Execute back 1,3 and 7d approximately, with checkerboard type methods of sampling investigation oncomelania, extract 10 frames in each test region and check plot respectively, catch whole oncomelanias in the frame, with the frame is that unit wraps with paper bag, record number, catches spiral shell number etc., returns indoor flushing with clean water, after 48h recovers to raise, identify oncomelania death toll and survival number with hammering method.The result shows that composite suspending agent has molluscicidal effect (table 3) preferably.
The on-the-spot sprinkling of table 3 killed the spiral shell result of the test
Above result shows the effective dose calculating by the composite suspending agent of niclosamide, and suspending agent is using 2.0g/m
2The time (effective dose 1.0g/m
2), can reach 50% bayluscid 2.0g (is effective dose 1.0g/m
2) molluscicidal effect, promptly consumption reduces by half, and can reach equal effect.
Claims (10)
1. composition that contains the niclosamide and the methaldehyde, it is characterized in that: said composition is an active component with the niclosamide and the methaldehyde, wherein the mass ratio of the niclosamide and the methaldehyde is 1～50: 1～10.
2. the composition that contains the niclosamide and the methaldehyde according to claim 1 is characterized in that: the mass ratio of the described niclosamide and the methaldehyde is 25～30: 1～5.
3. the composition that contains the niclosamide and the methaldehyde according to claim 1 is characterized in that: said composition is an active component with the niclosamide and the methaldehyde, is aided with on the agricultural chemicals acceptable auxiliary and makes emulsion, water dispersible granules or suspending agent.
4. the described application of composition aspect preparation control bilharziasis medicine that contains the niclosamide and the methaldehyde of claim 1.
5. the described application of composition aspect killing oncomelania that contains the niclosamide and the methaldehyde of claim 1.
6. aqueous suspension agent that contains the niclosamide and the methaldehyde is characterized in that: the component that comprises following mass content:
Niclosamide 1～50%, the methaldehyde 1～10%, wetting agent 1～5%, dispersant 1～20%, antifreezing agent 1～10%, preservative 0.1～1%, pH regulator agent 0.1～1%, defoamer 0.1～1%, thickener 0.1～2%, deionized water complements to 100%.
7. the aqueous suspension agent that contains the niclosamide and the methaldehyde according to claim 6 is characterized in that: the content of described niclosamide is 1～50%, and described methaldehyde content is 1～5%.
8. the aqueous suspension agent that contains the niclosamide and the methaldehyde according to claim 6 is characterized in that: described wetting agent is selected from lauryl sodium sulfate, draws back powder, in the alkylphenol polyoxyethylene, fatty alcohol-polyoxyethylene ether, aliphatic acid polyethenoxy ether, alkyl glycoside one or more.
9. the aqueous suspension agent that contains the niclosamide and the methaldehyde according to claim 6 is characterized in that: described dispersant is selected from one or more in sodium methylene bis-naphthalene sulfonate, lignosulfonates, polycarboxylate sodium, alkylphenol polyoxyethylene phosphate, the speed pool 270.
10. the aqueous suspension agent that contains the niclosamide and the methaldehyde according to claim 6 is characterized in that: described antifreezing agent is selected from one or more in ethylene glycol, glycerine, urea, the sodium chloride; Described preservative is selected one or more in Sodium Benzoate, card pine, the formaldehyde for use; Described pH regulator agent is selected from one or more in benzoic acid, glacial acetic acid, citric acid, the hydrochloric acid; Described defoamer is selected from one or more in organic silicone, polyethers, the butanols; Described thickener is selected from one or more in xanthans, gelatin, gum Arabic, bentonite, the aluminium-magnesium silicate.
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| CN 201110097790 CN102217598B (en) | 2011-04-18 | 2011-04-18 | Composition containing niclosamide and metaldehyde and compound suspension thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201110097790 CN102217598B (en) | 2011-04-18 | 2011-04-18 | Composition containing niclosamide and metaldehyde and compound suspension thereof |
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| CN102217598B CN102217598B (en) | 2013-08-28 |
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Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103583513A (en) * | 2013-12-03 | 2014-02-19 | 四川省化学工业研究设计院 | Suspending agent of chlorosalicylamide as snail control drug and preparation method thereof |
| CN103766345A (en) * | 2014-01-26 | 2014-05-07 | 江苏艾津农化有限责任公司 | Mollusk killing bait formulation containing niclosamide and application thereof |
| CN103891720A (en) * | 2012-12-27 | 2014-07-02 | 陕西汤普森生物科技有限公司 | Luokuwei-containing compound gastropod-killing composition |
| CN104115832A (en) * | 2014-08-12 | 2014-10-29 | 广州农密生物科技有限公司白云分公司 | Efficient snail controlling suspending agent and preparation method thereof |
| CN104970046A (en) * | 2014-12-02 | 2015-10-14 | 肖哲西 | Pesticide for killing mollusk pests |
| CN104970019A (en) * | 2014-12-02 | 2015-10-14 | 铜陵县明晋生产力促进中心有限公司 | Preparation method of insecticide killing schistosoma and eggs |
| CN104982436A (en) * | 2015-07-15 | 2015-10-21 | 广西农战士高工效农业技术有限公司 | Insecticidal composition containing niclosamide and neonicotinoid pesticide |
| CN104996452A (en) * | 2015-07-03 | 2015-10-28 | 天峨县科学技术情报研究所 | Pesticide composition containing niclosamide ethanolamine and thiacloprid |
| CN107006459A (en) * | 2017-05-19 | 2017-08-04 | 广东农密生物科技有限公司 | A kind of mollusk control water dispersible granules and preparation method thereof |
| CN112961527A (en) * | 2019-12-13 | 2021-06-15 | 徐州诺特化工有限公司 | Processing technology of metaldehyde and melamine modified urea-formaldehyde glue compounded ship body protective agent |
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| CN107027783A (en) * | 2017-05-26 | 2017-08-11 | 山东省农药科学研究院 | A kind of pharmaceutical composition and its application containing the methaldehyde and tropane alkali |
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| CN103891720A (en) * | 2012-12-27 | 2014-07-02 | 陕西汤普森生物科技有限公司 | Luokuwei-containing compound gastropod-killing composition |
| CN103891720B (en) * | 2012-12-27 | 2016-02-17 | 陕西汤普森生物科技有限公司 | A kind ofly kill spiral shell composition containing the composite of the withered prestige of spiral shell |
| CN103583513A (en) * | 2013-12-03 | 2014-02-19 | 四川省化学工业研究设计院 | Suspending agent of chlorosalicylamide as snail control drug and preparation method thereof |
| CN103766345B (en) * | 2014-01-26 | 2015-11-18 | 江苏艾津农化有限责任公司 | A kind of containing niclosamide kill mollusk bait formulation and application thereof |
| CN103766345A (en) * | 2014-01-26 | 2014-05-07 | 江苏艾津农化有限责任公司 | Mollusk killing bait formulation containing niclosamide and application thereof |
| CN104115832A (en) * | 2014-08-12 | 2014-10-29 | 广州农密生物科技有限公司白云分公司 | Efficient snail controlling suspending agent and preparation method thereof |
| CN104970019A (en) * | 2014-12-02 | 2015-10-14 | 铜陵县明晋生产力促进中心有限公司 | Preparation method of insecticide killing schistosoma and eggs |
| CN104970046A (en) * | 2014-12-02 | 2015-10-14 | 肖哲西 | Pesticide for killing mollusk pests |
| CN104996452A (en) * | 2015-07-03 | 2015-10-28 | 天峨县科学技术情报研究所 | Pesticide composition containing niclosamide ethanolamine and thiacloprid |
| CN104982436A (en) * | 2015-07-15 | 2015-10-21 | 广西农战士高工效农业技术有限公司 | Insecticidal composition containing niclosamide and neonicotinoid pesticide |
| CN104982436B (en) * | 2015-07-15 | 2017-12-01 | 广西农战士高工效农业技术有限公司 | A kind of Pesticidal combination containing niclosamide and anabasine pesticide |
| CN107006459A (en) * | 2017-05-19 | 2017-08-04 | 广东农密生物科技有限公司 | A kind of mollusk control water dispersible granules and preparation method thereof |
| CN112961527A (en) * | 2019-12-13 | 2021-06-15 | 徐州诺特化工有限公司 | Processing technology of metaldehyde and melamine modified urea-formaldehyde glue compounded ship body protective agent |
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