CN101233856A - Emamectin-benzoate and cyhalothrin microemulsion - Google Patents
Emamectin-benzoate and cyhalothrin microemulsion Download PDFInfo
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- CN101233856A CN101233856A CNA2007100099483A CN200710009948A CN101233856A CN 101233856 A CN101233856 A CN 101233856A CN A2007100099483 A CNA2007100099483 A CN A2007100099483A CN 200710009948 A CN200710009948 A CN 200710009948A CN 101233856 A CN101233856 A CN 101233856A
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- emamectin
- benzoate
- cyhalothrin
- microemulsion
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Abstract
The invention relates to a microemulsion of emamectin-benzoate and cyhalothrin, which comprises original drugs, a solvent, a latent solvent, an emulsifier and water; wherein, weight percentage of every components are 0.5-5 percent of emamectin-benzoate, 1-10 percent of cyhalothrin, 5-20 percent of solvent, 1-10 percent of latent solvent, 5-30 percent of emulsifier and the rest is water. The preparation method comprises the processes: the original drugs of the components are dissolved by using the solvent and the latent solvent and then added with the emulsifier; the obtained mixture is well mixed and then added with water under the condition of stirring, thus homogeneous and transparent product is finally obtained. Due to a part of organic solvent is replaced by water, the microemulsion product is environmental friendly and safe to users, and improves drug effect.
Description
Technical field the present invention relates to a kind of agricultural plant protection Chemical composition that, is emamectin-benzoate and Cyhalothrin complex microemulsion specifically.
Technical background played the whole nation and forbids high-toxic pesticide after using on the agricultural on January 1st, 2007, and high-toxic pesticide can be eliminated under the effect of ban gradually, and the market demand of the environmental protection type agricultural chemical of efficient, low toxicity, low-residual can be increasing.Along with people's environmental consciousness constantly strengthens and to the attention of ecotope, on the domestic market to anti-cure the disease, the environment protection biological agricultural chemicals and the chemical pesticide demand of efficient, the low toxicity of worm, grass and nuisanceless production demand, low-residual can be increasing, and efficient in the market, low toxicity, environmental protection type agricultural chemical are supplied less.For a long time, emulsifiable concentrates for agricultural chemicals is the important formulation of pesticidal preparations always, and emulsifiable concentrates for agricultural chemicals contains a large amount of organic solvents, strict to production, storing, use etc., otherwise take place easily to poison or produce poisoning, and a large amount of organic solvents causes environmental pollution easily, and these problems have caused people's extensive concern.
Microemulsion (microemulsion, ME) be the organic solvent solution of liquid or solid pesticide active ingredient and Thermodynamically stable, isotropism, optical clear or the translucent dispersion that water forms under Action of Surfactant, it is a kind of thermodynamic stable system, and particle is trickle, belong to nanoscale, having characteristics such as flash-point height, storing safety, good disinsection effect, cost are low, environmentally friendly is to replace emulsifiable concentrates for agricultural chemicals (emulsifiable concentrate, desirable formulation EC).
Emamectin-benzoate (be called for short first dimension salt) English name: emamectionbenaoate chemical name: 4 " Biao-4 "-deoxidation-emamectin-benzoates are a kind of efficient, wide spectrum, harmless boilogical insecticides that Merck company develops.It is a farm antibiotics Avermectin B1 structure modified outcome, and the insecticidal activity that compares the lepidoptera pest larva with the parent Avermectin is significantly improved, and toxicity but reduces greatly.Prove through the test of pesticide effectiveness repeatedly, first dimension salt pair resistant bollworm and diamond-back moth special efficacy, active in the parent Avermectin, be better than conventional dose simultaneously.Its mechanism of action is the effect that strengthens neurotransmitter such as glutamate and aminobutyric acid, thereby makes a large amount of chlorions enter nerve cell, makes the cell function forfeiture, upsets nerve conduction.Larva stops feed very soon behind the contact medicament, irreversible paralysis takes place.Medicament can be penetrated into the epidermis of target crop, forms the storage layers of an active ingredient, and long-term drug effect is arranged.
Cyhalothrin (having another name called the time) English name: cyhalothrin chemical name: 3-(2-chloro-3,3,3-fluoro-1-acrylic)-2,2-dimethyl ethylene-acetic acid cyano group (3-Phenoxyphenyl) methyl esters, molecular formula C
23H
19ClF
3NO
3Be a kind of pyrethroid insecticides, have extremely strong stomach toxicity and action of contace poison, the desinsection wide spectrum.Very high activity is arranged, and insecticidal action is fast, and is also lower to the toxicity of beneficial insect.
Emamectin-benzoate and Cyhalothrin are active high, so formulation content is generally lower, main in the market preparation is a missible oil, need to consume a large amount of organic solvents such as dimethylbenzene, both make environmental pollution easily, wasted resource again, increased cost.
Application number is 02156624.0 patent of invention " a kind of three cyhalothrins (time) microemulsion and production method thereof ", introduced a kind of three cyhalothrins pest killing micro emulsion in (time) that contains, it is characterized in that: be made up of time, cosolvent, emulsifier and water, wherein the percentage by weight of each component is: time 1-10%, cosolvent 1～20%, emulsifier 2～20%, water 30～80%.
Application number is 03109748.0 patent of invention " a kind of lambda-cyhalothrin (time) microemulsion and production method thereof ", introduced a kind of three cyhalothrins pest killing micro emulsion in (time) that contains, it is characterized in that: be made up of Cyhalothrin, poly-chitose, citric acid, cosolvent, emulsifier and water, wherein the percentage by weight of each component is: Cyhalothrin 1-10%, poly-chitose 1～10%, citric acid 1～10%, cosolvent 1～20%, emulsifier 5～20%, water 30～70%.
Application number is 200510012996.9 patent of invention " pest killing micro emulsion that contains Affirm (Merck Co.) ", introduced a kind of pest killing micro emulsion that contains Affirm (Merck Co.), form microemulsion by Affirm (Merck Co.), solvent, emulsifier, stabilizing agent, antifreezing agent and water, it forms content (is 100% in microemulsion weight): Affirm (Merck Co.) 0.2-10%, solvent 10～20%, emulsifier 8～15%, stabilizing agent 1～3%, antifreezing agent 2～3%, all the other are that water is formed.
Application number is 200610012555.3 patent of invention " emamectin-benzoate and cypermethrin microemulsion and method for making thereof ", the microemulsion and the method for making thereof of a kind of emamectin-benzoate and cypermethrin have been introduced, it is characterized in that, form by the component of following percentage by weight is composite: emamectin-benzoate 0.01%～10%, cypermethrin 0.1%～50%, cyclohexanone 10%～20%, alkyl phenol formaldehyde resin polyoxyethylene ether 0.1%～20%, styrene phenol APEO 0.1%～20%, calcium dodecyl benzene sulfonate 0.1%～20%, surplus are water.
Summary of the invention the purpose of this invention is to provide a kind of safety, good, the lower-cost microemulsion that contains emamectin-benzoate and Cyhalothrin of the feature of environmental protection.Reduce the use of organic solvent to greatest extent, alleviate pollution, improve safe in utilization environment.
The objective of the invention is to realize by the following method:
A kind of emamectin-benzoate and cyhalothrin microemulsion are made up of former medicine, solvent, cosolvent, emulsifier, water.Wherein each weight percentages of components is:
The raw material weight percentage
Emamectin-benzoate 0.5～10%
Cyhalothrin 0.1～10%
Solvent 1～20%
Cosolvent 1～10%
Emulsifier 5～30%
Water supplies 100%
In order to further specify, provide the optimum ratio of a kind of emamectin-benzoate and cyhalothrin microemulsion below:
Emamectin-benzoate 0.5～5%
Cyhalothrin 1～10%
Solvent 5～20%
Cosolvent 1～10%
Emulsifier 5～20%
Water supplies 100%
The solvent of a kind of emamectin-benzoate and cyhalothrin microemulsion is one or more the composition in aromatic solvent, cyclohexanone, dimethyl formamide, the acetone.Described aromatic solvent is benzene or toluene or dimethylbenzene.
The cosolvent of a kind of emamectin-benzoate and cyhalothrin microemulsion is one or more the composition in methyl alcohol, ethanol, ethylene glycol, n-butanol, n-amyl alcohol, n-hexyl alcohol, n-octyl alcohol, the laruyl alcohol.
The emulsifier of a kind of emamectin-benzoate and cyhalothrin microemulsion is the emulsifier that anion surfactant and non-ionic surface active agent are formed, and anion surfactant is that calcium dodecyl benzene sulfonate, non-ionic surface active agent are one or more the composition in alkylphenol polyoxyethylene, benzylphenol APEO, styryl phenol polyethenoxy ether, the triphenyl vinyl phenol APEO polyethenoxy ether.
The present invention is processed into microemulsion with emamectin-benzoate and cyhalothrin microemulsion, water replaces most of organic solvent wherein, not only can reduce organic solvent in the cream preparation to the pollution of environment but also can reduce cost, have good benefits in environment and economic benefit.
Toxicity Determination
With 1% first dimension salt missible oil, 5% Cyhalothrin missible oil is contrast, with the length of time unanimity three age diamondback moth larvae serve as the examination worm, carry out Toxicity Determination.Adopting leaf dipping method, respectively with 5% first dimension salt. time microemulsion (containing 1% first dimension salt and 4% time), 1% first dimension salt missible oil, 5% Cyhalothrin missible oil are blank with 6 series of tests concentration of running water dilution with the running water.Select cauliflower blade fresh, that the children is tender, bigger for use, immerse soup and blank 10s respectively, take out In Shade drying, the petiole place encases with moistening cotton, encases cotton with aluminium-foil paper again and keeps leaf water, blade is placed insect box, insert diamondback moth larvae, 30 in every box is in 25 ℃ of temperature, relative moisture 75%, round the clock than being condition under to raise at 16: 8, if a repetition is with LC
50Value is calculated relative virus force index.The 48h toxicity test the results are shown in Table 1.
The Toxicity Determination of table 1 first dimension salt pair diamond-back moth
| Handle medicament | Virulence regression equation (Y=) | LC 50(95% confidence limit) mg/L | Correlation coefficient (r) | Relative virus force index |
| 5% first dimension salt. time ME 5% Cyhalothrin EC 1% first dimension salt EC | 5.782+2.631 x 3.513+2.905X 5.226+1.596 x | 0.401 (0.356～0.512) 150.4632 (116.0854～ 180.7434) 0.721 (0.513～0.854) | 0.9947 0.9821 0.9887 | 1.80 0.00479 1.0 |
From LC
50Being worth as can be seen first dimension salt. the time microemulsion has higher virulence to the diamond-back moth third-instar larvae, and the action effect of microemulsion is apparently higher than the missible oil with isoconcentration under the same application condition.
Embodiment
Example 1: a kind of emamectin-benzoate and cyhalothrin microemulsion contain the former medicine 0.5kg of emamectin-benzoate, Cyhalothrin 1kg, dimethylbenzene 5kg, dimethyl formamide 5kg, n-butanol 2kg, calcium dodecyl benzene sulfonate 4kg, alkylphenol polyoxyethylene 6kg in the microemulsion of every 100kg; All the other are water.
Example 2: a kind of emamectin-benzoate and cyhalothrin microemulsion contain the former medicine 1kg of emamectin-benzoate, Cyhalothrin 5kg, dimethylbenzene 3kg, dimethyl formamide 4kg, cyclohexanone 3kg, n-butanol 2kg, calcium dodecyl benzene sulfonate 4kg, styryl phenol polyethenoxy ether 3kg, alkylphenol polyoxyethylene 5kg in the microemulsion of every 100kg; All the other are water.
Example 3: a kind of emamectin-benzoate and cyhalothrin microemulsion contain the former medicine 0.5kg of emamectin-benzoate, Cyhalothrin 10kg, dimethylbenzene 5kg, dimethyl formamide 10kg, n-butanol 2kg, calcium dodecyl benzene sulfonate 5kg, styryl phenol polyethenoxy ether 3kg, alkylphenol polyoxyethylene 7kg in the microemulsion of every 100kg; All the other are water.
Example 4: a kind of emamectin-benzoate and cyhalothrin microemulsion contain the former medicine 5kg of emamectin-benzoate, Cyhalothrin 10kg, cyclohexanone 6kg, dimethyl formamide 14kg, n-butanol 2kg, calcium dodecyl benzene sulfonate 8kg, styryl phenol polyethenoxy ether 6kg, alkylphenol polyoxyethylene 10kg in the microemulsion of every 100kg; All the other are water.
A kind of emamectin-benzoate and cyhalothrin microemulsion processing method are: the former medicine of emamectin-benzoate and the former medicine of Cyhalothrin, solvent, cosolvent, emulsifier are dosed into modulation kettle by the prescription metering, fully mix, again the limit being stirred in the waterside that measures adds, stir, promptly obtain product.
Microemulsion is compared with missible oil, same pesticide active ingredient, and the use microemulsion can be less with even not being processed into the pesticide liquid body preparation with organic solvent.Make medium with water to replace organic solvent, can reduce the production cost of preparation.Make comparisons (to produce one ton of product) in example 2 of the present invention, former medicine cost is disregarded, and only calculates other cost, and the surfactant price is in 20000 yuan/ton, and solvent is in 8000 yuan/ton, and cosurfactant the results are shown in Table 2 in 4000 yuan/ton.
Table 2 first dimension salt. time microemulsion and first dimension salt. time missible oil production cost is relatively
| Raw material | First dimension salt. the time microemulsion | First dimension salt. time missible oil |
| 1 former medicine 2 solvents 3 surfactants 4 cosurfactants 5 amount to (unit/ton) | 60kg 830kg, 6640 yuan 10%, 2000 yuan 0 8640 yuan | 60kg 100kg, 800 yuan of 15%, 3000 yuan of 20kg, 80 yuan 3880 yuan |
Microemulsion reduces by 8640 yuan-3880 yuan=4760 yuan/ton than missible oil cost
The selected solvent of the present invention, cosolvent, emulsifier are the commercially available prod, and loose to water quality requirement, processing technology is simple, are easy to batch production production, and water substitutes and uses the necessary most of solvent of missible oil, has reduced cost, has alleviated environmental pollution.
Claims (5)
1, a kind of emamectin-benzoate and cyhalothrin microemulsion is characterized in that each weight percentages of components is:
Emamectin-benzoate 0.5～10%
Cyhalothrin 0.1～10%
Solvent 1～20%
Cosolvent 1～10%
Emulsifier 5～30%
Water supplies 100%
2, a kind of emamectin-benzoate according to claim 1 and cyhalothrin microemulsion is characterized in that each weight percentages of components is:
Emamectin-benzoate 0.5～5%
Cyhalothrin 1～10%
Solvent 5～20%
Cosolvent 1～10%
Emulsifier 5～30%
Water supplies 100%
3, a kind of emamectin-benzoate according to claim 1 and 2 and cyhalothrin microemulsion is characterized in that solvent is one or more the composition in aromatic solvent, cyclohexanone, dimethyl formamide, the acetone.
4, a kind of emamectin-benzoate according to claim 1 and 2 and cyhalothrin microemulsion is characterized in that cosolvent is an alcohols.
5, emamectin-benzoate according to claim 1 and 2 and cyhalothrin microemulsion, it is characterized in that emulsifier is the emulsifier that anion surfactant and non-ionic surface active agent are formed, anion surfactant is that calcium dodecyl benzene sulfonate, non-ionic surface active agent are one or more the composition in alkylphenol polyoxyethylene, benzylphenol APEO, styryl phenol polyethenoxy ether, the triphenyl vinyl phenol APEO polyethenoxy ether.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2007100099483A CN101233856A (en) | 2007-12-07 | 2007-12-07 | Emamectin-benzoate and cyhalothrin microemulsion |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2007100099483A CN101233856A (en) | 2007-12-07 | 2007-12-07 | Emamectin-benzoate and cyhalothrin microemulsion |
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| CN101233856A true CN101233856A (en) | 2008-08-06 |
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|---|---|---|---|
| CNA2007100099483A Pending CN101233856A (en) | 2007-12-07 | 2007-12-07 | Emamectin-benzoate and cyhalothrin microemulsion |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102017989A (en) * | 2010-12-15 | 2011-04-20 | 广西安泰化工有限责任公司 | Efficient cyhalothrin and emamectin benzoate composition and preparations thereof |
| CN103598202A (en) * | 2013-11-29 | 2014-02-26 | 苏州佳辉化工有限公司 | Insecticidal composition containing emamectin benzoate and efficient cyhalothrin |
| CN104211529A (en) * | 2014-08-26 | 2014-12-17 | 广东中迅农科股份有限公司 | Controlled-release pesticide fertilizer granules |
| CN106332901A (en) * | 2016-08-03 | 2017-01-18 | 广东中迅农科股份有限公司 | Insecticidal granules of emamectin and cyfluthrin and preparation method thereof |
| CN108967422A (en) * | 2018-08-24 | 2018-12-11 | 浙江大学 | Emamectin-benzoate nano-emulsion and preparation method thereof |
| CN111011368A (en) * | 2019-11-11 | 2020-04-17 | 南京华洲药业有限公司 | Composite insecticidal and acaricidal nano-water agent containing efficient cyhalothrin and emamectin benzoate and application thereof |
-
2007
- 2007-12-07 CN CNA2007100099483A patent/CN101233856A/en active Pending
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102017989A (en) * | 2010-12-15 | 2011-04-20 | 广西安泰化工有限责任公司 | Efficient cyhalothrin and emamectin benzoate composition and preparations thereof |
| CN103598202A (en) * | 2013-11-29 | 2014-02-26 | 苏州佳辉化工有限公司 | Insecticidal composition containing emamectin benzoate and efficient cyhalothrin |
| CN104211529A (en) * | 2014-08-26 | 2014-12-17 | 广东中迅农科股份有限公司 | Controlled-release pesticide fertilizer granules |
| CN106332901A (en) * | 2016-08-03 | 2017-01-18 | 广东中迅农科股份有限公司 | Insecticidal granules of emamectin and cyfluthrin and preparation method thereof |
| CN108967422A (en) * | 2018-08-24 | 2018-12-11 | 浙江大学 | Emamectin-benzoate nano-emulsion and preparation method thereof |
| CN111011368A (en) * | 2019-11-11 | 2020-04-17 | 南京华洲药业有限公司 | Composite insecticidal and acaricidal nano-water agent containing efficient cyhalothrin and emamectin benzoate and application thereof |
| WO2021093266A1 (en) * | 2019-11-11 | 2021-05-20 | 南京华洲药业有限公司 | Compound insecticidal and acaricidal nano aqueous formulation containing lambda-cyhalothrin and emamectin benzoate, and use thereof |
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Open date: 20080806 |