CN103340198B - Anticoagulant rodenticide penetrant as well as preparation method and application thereof - Google Patents
Anticoagulant rodenticide penetrant as well as preparation method and application thereof Download PDFInfo
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- CN103340198B CN103340198B CN201310316842.3A CN201310316842A CN103340198B CN 103340198 B CN103340198 B CN 103340198B CN 201310316842 A CN201310316842 A CN 201310316842A CN 103340198 B CN103340198 B CN 103340198B
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- Prior art keywords
- rodenticide
- bleeding agent
- anticoagulation rodenticide
- penetrant
- anticoagulation
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- 239000003128 rodenticide Substances 0.000 title claims abstract description 57
- 238000002360 preparation method Methods 0.000 title claims abstract description 10
- 239000003146 anticoagulant agent Substances 0.000 title abstract description 9
- 229940127219 anticoagulant drug Drugs 0.000 title abstract description 9
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims abstract description 42
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims abstract description 26
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 22
- 230000000694 effects Effects 0.000 claims abstract description 14
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 14
- 239000011780 sodium chloride Substances 0.000 claims abstract description 13
- 239000003513 alkali Substances 0.000 claims abstract description 10
- 230000010100 anticoagulation Effects 0.000 claims description 47
- 230000000740 bleeding effect Effects 0.000 claims description 45
- 239000003795 chemical substances by application Substances 0.000 claims description 45
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 15
- 239000005966 Bromadiolone Substances 0.000 claims description 11
- OWNRRUFOJXFKCU-UHFFFAOYSA-N Bromadiolone Chemical compound C=1C=C(C=2C=CC(Br)=CC=2)C=CC=1C(O)CC(C=1C(OC2=CC=CC=C2C=1O)=O)C1=CC=CC=C1 OWNRRUFOJXFKCU-UHFFFAOYSA-N 0.000 claims description 11
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 claims description 7
- 239000007788 liquid Substances 0.000 claims description 5
- 238000000034 method Methods 0.000 claims description 3
- 235000013339 cereals Nutrition 0.000 abstract description 16
- 239000003814 drug Substances 0.000 abstract description 13
- 235000007164 Oryza sativa Nutrition 0.000 abstract description 4
- 239000010903 husk Substances 0.000 abstract description 4
- 235000009566 rice Nutrition 0.000 abstract description 4
- 230000003628 erosive effect Effects 0.000 abstract description 3
- 230000002195 synergetic effect Effects 0.000 abstract description 3
- 229940079593 drug Drugs 0.000 abstract 2
- 240000007594 Oryza sativa Species 0.000 abstract 1
- 239000002574 poison Substances 0.000 description 13
- 231100000614 poison Toxicity 0.000 description 13
- 239000000203 mixture Substances 0.000 description 8
- 235000019629 palatability Nutrition 0.000 description 8
- 238000012360 testing method Methods 0.000 description 4
- 241000209094 Oryza Species 0.000 description 3
- 230000009471 action Effects 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 230000035515 penetration Effects 0.000 description 3
- 230000008901 benefit Effects 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 238000011010 flushing procedure Methods 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 239000003960 organic solvent Substances 0.000 description 2
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 241001529533 Apodemus agrarius Species 0.000 description 1
- 241000981748 Rattus losea Species 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 239000003899 bactericide agent Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000023555 blood coagulation Effects 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 239000012452 mother liquor Substances 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 1
- 239000000575 pesticide Substances 0.000 description 1
- 231100000572 poisoning Toxicity 0.000 description 1
- 230000000607 poisoning effect Effects 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 229960004889 salicylic acid Drugs 0.000 description 1
- 238000003900 soil pollution Methods 0.000 description 1
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- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention belongs to the technical field of deratization, and discloses an anticoagulant rodenticide penetrant as well as a preparation method and application thereof. The anticoagulant rodenticide penetrant contains 6-8% of alkali in mass fraction, 3-5% of sodium chloride in mass fraction, 15-20% of ethanol in volume fraction, 5-7.5% of dimethyl sulfoxide in volume fraction, and the balance of water. The anticoagulant rodenticide penetrant improves the water solubility of an anticoagulant rodenticide, so that the penetrability of the anticoagulant rodenticide is improved, the content of the drug entering rice grains in husks is increased, the utilization rate of the drug is promoted, and the deratization effect is improved by 150% under the condition that the usage amount of the anticoagulant rodenticide is not increased. Meanwhile, the rain drop erosion resistance of the rodenticide is improved, so that the anticoagulant rodenticide penetrant has a significant synergistic effect.
Description
Technical field
The invention belongs to technical field of deratization, particularly a kind of anticoagulation rodenticide bleeding agent and its preparation method and application.
Background technology
Anticoagulation rodenticide is also known as chronic rodenticide, and compared with Apodemus agrarius, the advantage such as good palatability, deratization effect are high, use safety that it has, is therefore at home and abroad widely applied rapidly.The usage amount of this kind of rat-bane accounts for 90 ~ 95% of rat-bane total amount, but variety source is few, only has a two Dai Jinshi kind.Owing to using anticoagulation rodenticide in a large number for a long time, current home mouse both domestic and external and vole create pesticide resistance to a certain degree to such medicine, and deratization effect declines year by year, some areas face without medicine can passive situation.For this reason, carry out some to the synergist of anticoagulant both at home and abroad to explore and research, tentatively specify that some chemical compositions have synergistic effect to anticoagulation rodenticide, as some bactericide, salicylic acid material etc., these compositions mainly play collaborative blood coagulation resisting function to anticoagulation rodenticide.Because the solvability under most anticoagulation rodenticide normal temperature is slightly soluble or water insoluble, and southern area rainfall is frequent, and the medicine being attached on paddy top layer is easy to come off or be subject to rain drop erosion and reduce preventive effect, and causes water body and soil pollution.And bleeding agent mainly utilizes anticoagulation rodenticide to be insoluble in water, dissolves in the chemical property of organic solvent, increase the water-soluble of medicine, improve the availability of medicine, thus indirectly play synergistic effect, have no the correlative study report of anticoagulation rodenticide bleeding agent at present.
Summary of the invention
In order to overcome the shortcoming of above-mentioned prior art with not enough, primary and foremost purpose of the present invention is to provide a kind of anticoagulation rodenticide bleeding agent.This bleeding agent, by improving the water-soluble of anticoagulation rodenticide, improves the penetration of rat-bane, increases the content that medicine enters the grain of rice in husk, thus improves the availability of medicine, under extreme weather, significantly improve deratization effect.
Another object of the present invention is the preparation method providing a kind of above-mentioned anticoagulation rodenticide bleeding agent.
Still a further object of the present invention is to provide above-mentioned anticoagulation rodenticide bleeding agent improving the application in rat-bane deratization effect.
Object of the present invention is realized by following proposal:
A kind of anticoagulation rodenticide bleeding agent, comprise the alkali of mass fraction 6 ~ 8%, the sodium chloride of mass fraction 3 ~ 5%, the ethanol of volume fraction 15 ~ 20%, the dimethyl sulfoxide (DMSO) of volume fraction 5 ~ 7.5%, all the other are water.
Preferably, described anticoagulation rodenticide bleeding agent comprises the alkali of mass fraction 8%, the sodium chloride of mass fraction 5%, the ethanol of volume fraction 15%, the dimethyl sulfoxide (DMSO) of volume fraction 5%, and all the other are water.
Described alkali refers at least one in sodium hydroxide (NaOH) and potassium hydroxide (KOH).
A preparation method for above-mentioned anticoagulation rodenticide bleeding agent, comprises following steps: alkali, sodium chloride (NaCl) is soluble in water, then adds ethanol and dimethyl sulfoxide (DMSO), mixes, namely obtains anticoagulation rodenticide bleeding agent.
Above-mentioned anticoagulation rodenticide bleeding agent, improving the application in rat-bane deratization effect, is realized by following methods: by anticoagulation rodenticide bleeding agent and rat-bane 1:(25 ~ 50 in mass ratio) ratio mix, namely can be used for killing mouse.
Described rat-bane refers to second generation anticoagulation rodenticide.
Preferably, described rat-bane refers to 0.5wt% Bromadiolone mother liquid or 0.5wt% Talon mother liquor.
Mechanism of the present invention is:
By with an organic solvent ethanol, dimethyl sulfoxide (DMSO) and alkali, improve the water-soluble of anticoagulation rodenticide, thus improve the penetration of anticoagulation rodenticide, increase the content that medicine enters the grain of rice in husk, improve the availability of medicine, meanwhile, the sodium chloride of interpolation can improve the palatability of rat-bane, thus improves deratization effect.
The present invention has following advantage and beneficial effect relative to prior art:
(1) anticoagulation rodenticide bleeding agent of the present invention is used, improve the water-soluble of anticoagulation rodenticide, thus improve the penetration of anticoagulation rodenticide, increase the content that medicine enters the grain of rice in husk, improve the availability of medicine, deratization effect can be improved when not improving anticoagulation rodenticide usage amount, the highlyest improving 150%.
(2) southern area rainfall is frequent, can improve the performance of the anti-rain drop erosion of rat-bane, have significant synergies under extreme weather conditions after using anticoagulation rodenticide bleeding agent of the present invention.
(3) anticoagulation rodenticide bleeding agent of the present invention with the addition of sodium chloride, improves the palatability of rat-bane, reaches better deratization effect.
Embodiment
Below in conjunction with embodiment, the present invention is described in further detail, but embodiments of the present invention are not limited thereto.
Embodiment 1: the preparation of anticoagulation rodenticide bleeding agent
Weigh 8g NaOH and 5g NaCl respectively, be dissolved in 80ml water, then add 15ml ethanol and 5ml dimethyl sulfoxide (DMSO), mix, namely obtain anticoagulation rodenticide bleeding agent.
Embodiment 2: the preparation of anticoagulation rodenticide bleeding agent
Weigh 6g NaOH and 5g NaCl respectively, be dissolved in 75ml water, then add 20ml ethanol and 5ml dimethyl sulfoxide (DMSO), mix, namely obtain anticoagulation rodenticide bleeding agent.
Embodiment 3: the preparation of anticoagulation rodenticide bleeding agent
Weigh 8g KOH and 3g NaCl respectively, be dissolved in 77.5ml water, then add 15ml ethanol and 7.5ml dimethyl sulfoxide (DMSO), mix, namely obtain anticoagulation rodenticide bleeding agent.
Embodiment 4: the palatability of anticoagulation rodenticide bleeding agent
The palatability of the anticoagulation rodenticide bleeding agent that embodiment 1 prepares is tested.The ratio of above-mentioned bleeding agent 1:25 is in mass ratio mixed with 0.5wt% Bromadiolone mother liquid (purchased from Henan Shangqiu City David Chemical Co., Ltd.), mix with the cereal of 50 times of quality again, obtain 0.01wt%(Bromadiolone+bleeding agent) poison grain, carry out bait throwing in experiment, do not add the 0.01wt% Bromadiolone poison grain of bleeding agent as a comparison, the nontoxic cereal of equal in quality is as optional food materials.Result of the test shows, is having under the experimental condition selecting food materials, 0.01wt%(Bromadiolone+bleeding agent) poison grain all has good palatability to small white mouse and main farmland mouse Rattus losea, and coefficient of ingesting is better than the Bromadiolone poison bait not adding bleeding agent:
To ingest coefficient=poison grain intake/without poison grain intake
Palatability test result is in table 1:
The palatability of table 1 anticoagulation rodenticide bleeding agent
Embodiment 5: the action effect of anticoagulation rodenticide bleeding agent
Three kinds of modes are adopted to measure " 0.5wt% Bromadiolone mother liquid+bleeding agent " action effect to small white mouse respectively.The ratio of anticoagulation rodenticide bleeding agent embodiment 1 prepared 1:25 in mass ratio mixes with 0.5wt% Bromadiolone mother liquid (purchased from Henan Shangqiu City David Chemical Co., Ltd.), mix with the cereal of 50 times of quality again, obtain (Bromadiolone+bleeding agent) poison grain that concentration is 0.01wt%, carry out bait throwing in experiment.Do not add the 0.01wt% Bromadiolone poison grain of bleeding agent in contrast.
Mode A: adopt without selecting quantitative feeding method, every only examination mouse day injected volume is 5% of examination mouse body weight, and raise poison continuously 3 days, every day more renews bait.
Mode B: first artificially-simulated rainfall washes away poison bait, rainfall is 100mm, is dried by poison bait after flushing, then feeds by A mode and tries mouse.
Mode C: artificially-simulated rainfall washes away poison bait, rainfall is 30mm, is dried by poison bait after flushing, then feeds by A mode and tries mouse.Test result is in table 2.
Test result shows, the cereal adding anticoagulation rodenticide bleeding agent of the present invention has higher poisoning rate to small white mouse, and shortens the death time, especially can significantly improve deratization effect in option b and scheme C, the highlyest improve 150%, difference has statistical significance (χ
1 2=3.956, p
1<0.05; χ
2 2=5.227, p
2<0.05), illustrate that bleeding agent facilitates rat-bane and better enters in cereal, improve weather resistance energy.
The action effect of table 2 anticoagulation rodenticide bleeding agent
Above-described embodiment is the present invention's preferably embodiment; but embodiments of the present invention are not restricted to the described embodiments; change, the modification done under other any does not deviate from Spirit Essence of the present invention and principle, substitute, combine, simplify; all should be the substitute mode of equivalence, be included within protection scope of the present invention.
Claims (4)
1. an anticoagulation rodenticide bleeding agent, is characterized in that: the alkali comprising mass fraction 6 ~ 8 %, the sodium chloride of mass fraction 3 ~ 5 %, the ethanol of volume fraction 15 ~ 20 %, the dimethyl sulfoxide (DMSO) of volume fraction 5 ~ 7.5 %, and all the other are water;
Described alkali refers at least one in sodium hydroxide and potassium hydroxide;
Described rat-bane refers to 0.5 wt% Bromadiolone mother liquid.
2. anticoagulation rodenticide bleeding agent according to claim 1, is characterized in that: the alkali comprising mass fraction 8 %, the sodium chloride of mass fraction 5 %, the ethanol of volume fraction 15 %, the dimethyl sulfoxide (DMSO) of volume fraction 5 %, and all the other are water.
3. the preparation method of the anticoagulation rodenticide bleeding agent according to any one of claim 1 ~ 2, it is characterized in that comprising following steps: alkali, sodium chloride is soluble in water, add ethanol and dimethyl sulfoxide (DMSO) again, mix, namely obtain anticoagulation rodenticide bleeding agent.
4. the anticoagulation rodenticide bleeding agent according to any one of claim 1 ~ 2 is improving the application in rat-bane deratization effect, it is characterized in that being realized by following methods: by anticoagulation rodenticide bleeding agent and rat-bane 1:(25 ~ 50 in mass ratio) ratio mix, namely can be used for killing mouse.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310316842.3A CN103340198B (en) | 2013-07-25 | 2013-07-25 | Anticoagulant rodenticide penetrant as well as preparation method and application thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310316842.3A CN103340198B (en) | 2013-07-25 | 2013-07-25 | Anticoagulant rodenticide penetrant as well as preparation method and application thereof |
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| Publication Number | Publication Date |
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| CN103340198A CN103340198A (en) | 2013-10-09 |
| CN103340198B true CN103340198B (en) | 2015-05-06 |
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| CN201310316842.3A Expired - Fee Related CN103340198B (en) | 2013-07-25 | 2013-07-25 | Anticoagulant rodenticide penetrant as well as preparation method and application thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| GB2521632B (en) * | 2013-12-23 | 2020-12-16 | Linscott Goode Steven | Vermin control compositions |
| CN111685110A (en) * | 2020-06-29 | 2020-09-22 | 广东省农业科学院植物保护研究所 | Application of N, N-dimethylformamide in anticoagulant rodenticide penetrant |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1072064A (en) * | 1991-11-05 | 1993-05-19 | 中国科学院长沙农业现代化研究所 | Preparing method for compound rat-killing agent |
| CN1194781A (en) * | 1995-10-04 | 1998-10-07 | 生物医药研究所 | Method for obtainment of biological rodenticide |
| CN101356916A (en) * | 2008-08-22 | 2009-02-04 | 广东省农业科学院植物保护研究所 | Anticoagulation rodenticide synergist, preparation method and use thereof |
| CN103109796A (en) * | 2013-03-14 | 2013-05-22 | 商丘市大卫化工厂 | Bromadiolone mother liquid preparation method |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0704695A (en) * | 2007-12-19 | 2008-05-20 | W Y Yamaguchi & Cia Ldta Me | attractive cereal bait for control of rats, rats and mice |
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1072064A (en) * | 1991-11-05 | 1993-05-19 | 中国科学院长沙农业现代化研究所 | Preparing method for compound rat-killing agent |
| CN1194781A (en) * | 1995-10-04 | 1998-10-07 | 生物医药研究所 | Method for obtainment of biological rodenticide |
| CN101356916A (en) * | 2008-08-22 | 2009-02-04 | 广东省农业科学院植物保护研究所 | Anticoagulation rodenticide synergist, preparation method and use thereof |
| CN103109796A (en) * | 2013-03-14 | 2013-05-22 | 商丘市大卫化工厂 | Bromadiolone mother liquid preparation method |
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| CN103340198A (en) | 2013-10-09 |
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