CN101356203A - 制备聚环氧烷羧酸的高效方法 - Google Patents

制备聚环氧烷羧酸的高效方法 Download PDF

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Publication number
CN101356203A
CN101356203A CNA2006800508510A CN200680050851A CN101356203A CN 101356203 A CN101356203 A CN 101356203A CN A2006800508510 A CNA2006800508510 A CN A2006800508510A CN 200680050851 A CN200680050851 A CN 200680050851A CN 101356203 A CN101356203 A CN 101356203A
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CN
China
Prior art keywords
polyalkylene oxide
acid
reaction
solvent system
alkyl ester
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CNA2006800508510A
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English (en)
Chinese (zh)
Inventor
赵洪
安东尼·J·马丁内斯
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Enzon Pharmaceuticals Inc
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Enzon Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Enzon Pharmaceuticals Inc filed Critical Enzon Pharmaceuticals Inc
Publication of CN101356203A publication Critical patent/CN101356203A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/329—Polymers modified by chemical after-treatment with organic compounds
    • C08G65/337—Polymers modified by chemical after-treatment with organic compounds containing other elements
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/329—Polymers modified by chemical after-treatment with organic compounds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/329—Polymers modified by chemical after-treatment with organic compounds
    • C08G65/331—Polymers modified by chemical after-treatment with organic compounds containing oxygen
    • C08G65/332—Polymers modified by chemical after-treatment with organic compounds containing oxygen containing carboxyl groups, or halides, or esters thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/329—Polymers modified by chemical after-treatment with organic compounds
    • C08G65/331—Polymers modified by chemical after-treatment with organic compounds containing oxygen
    • C08G65/332—Polymers modified by chemical after-treatment with organic compounds containing oxygen containing carboxyl groups, or halides, or esters thereof
    • C08G65/3322—Polymers modified by chemical after-treatment with organic compounds containing oxygen containing carboxyl groups, or halides, or esters thereof acyclic

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  • Chemical & Material Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Polyethers (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CNA2006800508510A 2006-01-10 2006-12-28 制备聚环氧烷羧酸的高效方法 Pending CN101356203A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11/328,662 2006-01-10
US11/328,662 US7989554B2 (en) 2006-01-10 2006-01-10 Reacting polyalkylene oxide with base, tertiary alkyl haloacetate, then acid to prepare polyalkylene oxide carboxylic acid

Publications (1)

Publication Number Publication Date
CN101356203A true CN101356203A (zh) 2009-01-28

Family

ID=38256821

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA2006800508510A Pending CN101356203A (zh) 2006-01-10 2006-12-28 制备聚环氧烷羧酸的高效方法

Country Status (11)

Country Link
US (1) US7989554B2 (fr)
EP (1) EP1976896B1 (fr)
JP (1) JP5199125B2 (fr)
KR (1) KR20080083064A (fr)
CN (1) CN101356203A (fr)
AT (1) ATE512994T1 (fr)
AU (1) AU2006335041A1 (fr)
CA (1) CA2636280A1 (fr)
IL (1) IL192409A0 (fr)
TW (1) TW200732374A (fr)
WO (1) WO2007081596A2 (fr)

Families Citing this family (11)

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US7671067B2 (en) * 2006-02-09 2010-03-02 Enzon Pharmaceuticals, Inc. Treatment of non-hodgkin's lymphomas with multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamtothecin
US7462627B2 (en) * 2006-02-09 2008-12-09 Enzon Pharmaceuticals, Inc. Multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamptothecin for treatment of breast, colorectal, pancreatic, ovarian and lung cancers
US20090156629A1 (en) * 2006-06-09 2009-06-18 Enzon Pharmaceuticals, Inc. Indenoisoquinoline-releasable polymer conjugates
JP2010518120A (ja) * 2007-02-09 2010-05-27 エンゾン ファーマスーティカルズ インコーポレイテッド ７−エチル−１０−ヒドロキシカンプトテシンのマルチアームポリマー複合体を用いた抵抗性または難治性の癌の治療方法
HUE027603T2 (en) * 2007-04-20 2016-10-28 Sigma-Tau Rare Disease Ltd Stable, recombinant adenosine deaminase
WO2008131163A1 (fr) * 2007-04-20 2008-10-30 Enzon Pharmaceuticals, Inc. Thérapie anticancéreuse enzymatique
EP2175878A4 (fr) * 2007-07-11 2014-12-03 Belrose Pharma Inc Système d'administration de médicament polymérique contenant un groupement aromatique multi-substitué
TW201010732A (en) * 2008-08-29 2010-03-16 Enzon Pharmaceuticals Inc Method of treating RAS associated cancer
KR20110075029A (ko) * 2008-10-21 2011-07-05 엔즌 파마슈티칼스, 인코포레이티드 7-에틸-10-하이드록시캄토테신의 다중-암 고분자 컨쥬게이트로 신경모세포종의 치료
EP3207130B1 (fr) 2014-10-14 2019-08-07 Halozyme, Inc. Compositions d'adénosine désaminase-2 (ada2), variants de cette dernière et leurs procédés d'utilisation
CN118202030A (zh) * 2021-10-13 2024-06-14 巴斯夫欧洲公司 包含聚合物的组合物、聚合物及其用途

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JPS57206622A (en) 1981-06-10 1982-12-18 Ajinomoto Co Inc Blood substitute
JPS59204172A (ja) 1983-04-28 1984-11-19 Kowa Co アセメタシンの製造法
JPS60156395A (ja) 1984-01-17 1985-08-16 Mihama Hisaharu 修飾リパーゼ
DE3675588D1 (de) 1985-06-19 1990-12-20 Ajinomoto Kk Haemoglobin, das an ein poly(alkenylenoxid) gebunden ist.
US4760176A (en) 1985-12-20 1988-07-26 Borg-Warner Chemicals, Inc. Aminocarboxylic acid-terminated polyoxy-alkylenes and process for the preparation thereof
US4814098A (en) 1986-09-06 1989-03-21 Bellex Corporation Magnetic material-physiologically active substance conjugate
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US5122514A (en) 1990-04-23 1992-06-16 Abbott Laboratories Psoriasis treatment
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JP3051145B2 (ja) 1990-08-28 2000-06-12 住友製薬株式会社 新規なポリエチレングリコール誘導体修飾ペプチド
US5545698A (en) 1990-08-31 1996-08-13 University Of Minnesota Polyethylene glycol derivatives for solid-phase applications
US5145992A (en) 1991-05-06 1992-09-08 G. D. Searle & Co. Process and preparation of α-alkoxy acetic acids and their salts
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Also Published As

Publication number Publication date
WO2007081596A3 (fr) 2007-12-13
EP1976896A2 (fr) 2008-10-08
CA2636280A1 (fr) 2007-07-19
US20070173615A1 (en) 2007-07-26
JP2009523191A (ja) 2009-06-18
EP1976896A4 (fr) 2009-09-02
AU2006335041A1 (en) 2007-07-19
WO2007081596A2 (fr) 2007-07-19
ATE512994T1 (de) 2011-07-15
TW200732374A (en) 2007-09-01
US7989554B2 (en) 2011-08-02
KR20080083064A (ko) 2008-09-12
EP1976896B1 (fr) 2011-06-15
IL192409A0 (en) 2008-12-29
JP5199125B2 (ja) 2013-05-15

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Open date: 20090128