CN101346138B - Dha、epa或dha衍生的epa用于治疗细胞氧化损伤相关疾病的用途 - Google Patents
Dha、epa或dha衍生的epa用于治疗细胞氧化损伤相关疾病的用途 Download PDFInfo
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- CN101346138B CN101346138B CN2006800488216A CN200680048821A CN101346138B CN 101346138 B CN101346138 B CN 101346138B CN 2006800488216 A CN2006800488216 A CN 2006800488216A CN 200680048821 A CN200680048821 A CN 200680048821A CN 101346138 B CN101346138 B CN 101346138B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/361—Carboxylic acids having more than seven carbon atoms in an unbroken chain; Salts or anhydrides thereof
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/115—Fatty acids or derivatives thereof; Fats or oils
- A23L33/12—Fatty acids or derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
- A61K31/202—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P27/02—Ophthalmic agents
- A61P27/12—Ophthalmic agents for cataracts
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Ophthalmology & Optometry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Physical Education & Sports Medicine (AREA)
- Birds (AREA)
- Emergency Medicine (AREA)
- Mycology (AREA)
- Food Science & Technology (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Polymers & Plastics (AREA)
- Pain & Pain Management (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Dermatology (AREA)
- Nutrition Science (AREA)
- Psychiatry (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Hospice & Palliative Care (AREA)
Applications Claiming Priority (13)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ESP200503202 | 2005-12-21 | ||
| ESP-200503202 | 2005-12-21 | ||
| ES200503202A ES2277557B1 (es) | 2005-12-21 | 2005-12-21 | Utilizacion de acido docosahexaenoico para el tratamiento del daño celular oxidativo. |
| ESP-200602418 | 2006-09-25 | ||
| ES200602418A ES2315125B1 (es) | 2005-12-21 | 2006-09-25 | Mejoras en el objeto de la patente principal p 200503202, por "utilizacion de acido docosahexaenoico para el tratamiento del daño oxidativo celular". |
| ESP-200602417 | 2006-09-25 | ||
| ES200602417A ES2315124B1 (es) | 2005-12-21 | 2006-09-25 | Mejoras en el objeto de la patente principal p 200503202, por "utilizacion de acido docosahexaenoico para el tratamiento del daño oxidativo celular". |
| ESP200602417 | 2006-09-25 | ||
| ESP200602418 | 2006-09-25 | ||
| PCT/EP2006/070016 WO2007071733A2 (en) | 2005-12-21 | 2006-12-20 | Use of dha, epa or dha-derived epa for treating a pathology associated with cellular oxidative damage |
| ESP-200603231 | 2006-12-20 | ||
| ES200603231A ES2316263B1 (es) | 2005-12-21 | 2006-12-20 | Mejoras en el objeto de la patente principal p 200503202, por "utilizacion de acido docosahexaenoico para el tratamiento del daño oxidativo celular". |
| ESP200603231 | 2006-12-20 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310081953.0A Division CN103263406B (zh) | 2005-12-21 | 2006-12-20 | Dha、epa或dha衍生的epa用于治疗细胞氧化损伤相关疾病的用途 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101346138A CN101346138A (zh) | 2009-01-14 |
| CN101346138B true CN101346138B (zh) | 2013-03-13 |
Family
ID=37728386
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2006800488216A Expired - Fee Related CN101346138B (zh) | 2005-12-21 | 2006-12-20 | Dha、epa或dha衍生的epa用于治疗细胞氧化损伤相关疾病的用途 |
Country Status (16)
| Country | Link |
|---|---|
| US (3) | US9265745B2 (https=) |
| EP (3) | EP1962825B1 (https=) |
| JP (1) | JP2009523414A (https=) |
| KR (1) | KR101256448B1 (https=) |
| CN (1) | CN101346138B (https=) |
| AU (1) | AU2006327064B2 (https=) |
| BR (1) | BRPI0621131A2 (https=) |
| CA (1) | CA2632949C (https=) |
| ES (1) | ES2384701T3 (https=) |
| IL (1) | IL192154A (https=) |
| MX (1) | MX2008008171A (https=) |
| NO (1) | NO341240B1 (https=) |
| NZ (1) | NZ569676A (https=) |
| PL (1) | PL1962825T3 (https=) |
| RU (1) | RU2437583C2 (https=) |
| WO (1) | WO2007071733A2 (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103585140A (zh) * | 2013-11-22 | 2014-02-19 | 苏州麦可旺志生物技术有限公司 | Epa在制备溴酸钾诱导氧化应激性肾损伤药物中的应用 |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8252742B2 (en) * | 2004-12-30 | 2012-08-28 | Hill's Pet Nutrition, Inc. | Methods for enhancing the quality of life of a senior animal |
| ES2277557B1 (es) | 2005-12-21 | 2008-07-01 | Proyecto Empresarial Brudy, S.L. | Utilizacion de acido docosahexaenoico para el tratamiento del daño celular oxidativo. |
| EP1962825B1 (en) | 2005-12-21 | 2014-04-02 | Brudy Technology, S.L. | Use of dha for treating a pathology associated with cellular oxidative damage |
| US20100119600A1 (en) | 2007-06-01 | 2010-05-13 | Joar Opheim | Substances for reducing occurrence of major cardiac events comprising red yeast rice extract and omega-3 polyunsaturated fatty acid or derivative thereof |
| US8343753B2 (en) | 2007-11-01 | 2013-01-01 | Wake Forest University School Of Medicine | Compositions, methods, and kits for polyunsaturated fatty acids from microalgae |
| US8207363B2 (en) | 2009-03-19 | 2012-06-26 | Martek Biosciences Corporation | Thraustochytrids, fatty acid compositions, and methods of making and uses thereof |
| CA2756528A1 (en) * | 2009-04-17 | 2010-10-21 | Celavista Pharmaceuticals Limited | Compositions rich in omega-3 fatty acids with a low content in phytanic acid |
| US9924733B2 (en) | 2010-01-19 | 2018-03-27 | Dsm Ip Assets B.V. | Eicosapentaenoic acid-producing microorganisms, fatty acid compositions, and methods of making and uses thereof |
| US20120252888A1 (en) * | 2011-03-29 | 2012-10-04 | Palupa Medical Ltd. | Compositions and Methods for Treating Neurologic Disorders |
| US20160310456A1 (en) * | 2013-03-12 | 2016-10-27 | Physicians Recommended Nutriceuticals, Llc | Compositions and methods for using same for reducing levels of arachidonic acid in tissue having undergone an invasive procedure |
| US10709680B2 (en) * | 2011-07-18 | 2020-07-14 | Physicians Recommended Nutriceuticals, Llc | Methods for treating dry eye |
| AU2012285806B2 (en) | 2011-07-21 | 2017-09-14 | Dsm Ip Assets B.V. | Fatty acid compositions |
| USRE48077E1 (en) | 2013-02-28 | 2020-07-07 | Anida Pharma Inc. | Methods of treating ototoxicity |
| EP3082405A4 (en) * | 2013-12-18 | 2017-12-13 | Commonwealth Scientific and Industrial Research Organisation | Lipid comprising long chain polyunsaturated fatty acids |
| US11718577B2 (en) | 2013-12-18 | 2023-08-08 | Commonwealth Scientific And Industrial Research Organisation | Lipid compositions comprising triacylglycerol with long-chain polyunsaturated fatty acids |
| EP3906920A1 (en) | 2014-06-06 | 2021-11-10 | Marine Ingredients, LLC | Omega-3 compositions, dosage forms, and methods of use |
| KR20180051737A (ko) * | 2016-11-08 | 2018-05-17 | 차의과학대학교 산학협력단 | 대장염-관련 암 발생을 줄이는 ω-3 폴리불포화지방산 활성 성분으로 포함하는 항암 조성물 |
| US20170156280A1 (en) | 2017-02-13 | 2017-06-08 | Bayer Cropscience Lp | Cotton variety st 5517gltp |
| US20170150690A1 (en) | 2017-02-13 | 2017-06-01 | Bayer Cropscience Lp | Cotton variety fm 1888gl |
| JP7133306B2 (ja) * | 2017-12-01 | 2022-09-08 | 国立大学法人九州大学 | アシルステリルグルコシド、アシルステリルグルコシドの製造方法、組成物、抗酸化剤、血中脂質低下剤、抗肥満剤、抗腫瘍剤及びアテローム性動脈硬化症の予防又は治療剤 |
| US12226390B2 (en) | 2019-07-21 | 2025-02-18 | Scf Pharma Inc. | Cannabinoids compositions with polyunsaturated fatty acid monoglycerides, methods and uses thereof |
| CN110846346B (zh) | 2019-11-26 | 2021-06-22 | 瞿瀚鹏 | 富含Sn-2位DHA的微生物油脂及其制备方法和应用 |
| AU2022322112A1 (en) * | 2021-08-04 | 2024-03-07 | Leiutis Pharmaceuticals Llp | Novel omega 3 carrier preparations for inhalation drug delivery for treating lung inflammation |
| CN113749255B (zh) * | 2021-09-15 | 2022-11-29 | 江南大学 | 一种磷脂组合物在修复肌肉损伤的应用 |
| WO2023122827A1 (en) * | 2021-12-28 | 2023-07-06 | Scf Pharma Inc. | Polyunsaturated fatty acid monoglycerides, compositions, methods and uses thereof |
| CN116687902A (zh) * | 2023-06-14 | 2023-09-05 | 浙江大学 | Dha在制备促进心肌细胞增殖和心脏再生产品中的应用 |
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| WO1998028978A1 (en) * | 1996-05-08 | 1998-07-09 | Weider Nutrition Group, Inc. | Structured glycerols and structured phosphatides |
| EP1247523A1 (en) * | 1999-02-17 | 2002-10-09 | Pharmacia Italia S.p.A. | Essential fatty acids in the prevention of cardiovascular events |
| WO2003068216A1 (en) * | 2002-02-12 | 2003-08-21 | Victorix Assets Ltd. | The use of omega-3 polyunsaturated acids ethyl esters in patients suffering from heart failure |
| WO2004112776A2 (en) * | 2003-06-23 | 2004-12-29 | Advanced Bionutrition (Europe) Limited | Inflammatory disease treatment |
| WO2005013908A2 (en) * | 2003-08-05 | 2005-02-17 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Neuroprotection protects against cellular apoptosis, neural stroke damage, alzheimer’s disease and retinal degeneration |
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| JP2524217B2 (ja) * | 1988-04-18 | 1996-08-14 | マルハ株式会社 | 脳機能改善組成物、学習能力増強剤、記憶力増強剤、痴呆予防剤または痴呆治療剤 |
| GB2218984B (en) * | 1988-05-27 | 1992-09-23 | Renafield Limited | Process for preparing high-concentration mixtures of polyunsaturated fatty acids & their esters and their prophylactic or therapeutic uses |
| GB2223943A (en) | 1988-10-21 | 1990-04-25 | Tillotts Pharma Ag | Oral disage forms of omega-3 polyunsaturated acids |
| SE9101642D0 (sv) * | 1991-05-30 | 1991-05-30 | Kabi Pharmacia Ab | Phospholipids |
| CA2119000A1 (en) * | 1993-03-19 | 1994-09-20 | David Frederick Horrobin | Formulation for use in smokers |
| US20050027004A1 (en) * | 1993-06-09 | 2005-02-03 | Martek Biosciences Corporation | Methods of treating senile dementia and Alzheimer's diseases using docosahexaenoic acid and arachidonic acid compositions |
| PT707487E (pt) * | 1993-06-09 | 2004-08-31 | Martek Biosciences Corp | Metodos e composicoes farmaceuticas uteis no tratamento de disturbios neurologicos |
| JPH07255417A (ja) * | 1994-03-25 | 1995-10-09 | Kanebo Ltd | 機能性健康食品 |
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| US6313167B1 (en) | 1997-06-16 | 2001-11-06 | Nippon Suisan Kaisha Ltd. | Composition having capability of removing risk factor during exercise |
| JPH11239464A (ja) * | 1997-06-16 | 1999-09-07 | Nippon Suisan Kaisha Ltd | 運動時の危険因子除去能を有する組成物 |
| JPH11239465A (ja) * | 1997-06-16 | 1999-09-07 | Nippon Suisan Kaisha Ltd | 健常人が運動能力を高める食品 |
| GB9715444D0 (en) * | 1997-07-22 | 1997-09-24 | Scotia Holdings Plc | Therapeutic and dietary compositions |
| GB9901809D0 (en) | 1999-01-27 | 1999-03-17 | Scarista Limited | Highly purified ethgyl epa and other epa derivatives for psychiatric and neurological disorderes |
| JP2002040014A (ja) * | 2000-07-19 | 2002-02-06 | Nippon Steel Corp | 炭素含有耐火物の耐摩耗性、耐食性及び耐酸化性の評価方法 |
| EP1249523A1 (fr) * | 2001-04-12 | 2002-10-16 | Michel Beckers | Cylindre brouilleur et son utilisation |
| AR039170A1 (es) | 2002-03-28 | 2005-02-09 | Bio Dar Ltd | Co-granulos de dha y romero y metodos de uso |
| US20040209953A1 (en) * | 2002-12-06 | 2004-10-21 | Wai Lee Theresa Siu-Ling | Glyceride compositions and methods of making and using same |
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| JP2005000033A (ja) * | 2003-06-10 | 2005-01-06 | Shinbijuumu:Kk | 食品 |
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| US20050163873A1 (en) | 2004-01-14 | 2005-07-28 | Robert Ritch | Methods and formulations for treating glaucoma |
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| WO2006077495A1 (en) | 2005-01-24 | 2006-07-27 | Pronova Biocare As | Use of a fatty acid composition containing dha for the production of a medical product or a food stuff for the treatment of amyloidos-rerelated diseases |
| FR2882894B1 (fr) | 2005-03-11 | 2009-04-03 | Larena Sa | Composition alimentaire suppletive |
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2006
- 2006-12-20 EP EP06841516.5A patent/EP1962825B1/en active Active
- 2006-12-20 NZ NZ569676A patent/NZ569676A/en not_active IP Right Cessation
- 2006-12-20 KR KR1020087017876A patent/KR101256448B1/ko not_active Expired - Fee Related
- 2006-12-20 US US12/158,205 patent/US9265745B2/en active Active
- 2006-12-20 WO PCT/EP2006/070016 patent/WO2007071733A2/en not_active Ceased
- 2006-12-20 EP EP11189179.2A patent/EP2510927A3/en not_active Withdrawn
- 2006-12-20 JP JP2008546448A patent/JP2009523414A/ja active Pending
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- 2006-12-20 RU RU2008126805/13A patent/RU2437583C2/ru active
- 2006-12-20 CA CA2632949A patent/CA2632949C/en active Active
- 2006-12-20 ES ES06841516.5T patent/ES2384701T3/es active Active
- 2006-12-20 AU AU2006327064A patent/AU2006327064B2/en not_active Ceased
- 2006-12-20 BR BRPI0621131-3A patent/BRPI0621131A2/pt not_active Application Discontinuation
- 2006-12-20 PL PL06841516T patent/PL1962825T3/pl unknown
- 2006-12-20 EP EP17180553.4A patent/EP3263101A1/en not_active Withdrawn
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2008
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- 2008-07-17 NO NO20083187A patent/NO341240B1/no not_active IP Right Cessation
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- 2013-03-14 US US13/803,038 patent/US9259408B2/en active Active
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103585140A (zh) * | 2013-11-22 | 2014-02-19 | 苏州麦可旺志生物技术有限公司 | Epa在制备溴酸钾诱导氧化应激性肾损伤药物中的应用 |
Also Published As
| Publication number | Publication date |
|---|---|
| NO341240B1 (no) | 2017-09-25 |
| EP3263101A1 (en) | 2018-01-03 |
| EP1962825B1 (en) | 2014-04-02 |
| CA2632949C (en) | 2012-05-22 |
| CA2632949A1 (en) | 2007-06-28 |
| ES2384701T3 (es) | 2014-07-02 |
| ES2384701T1 (es) | 2012-07-11 |
| RU2008126805A (ru) | 2010-01-27 |
| KR101256448B1 (ko) | 2013-04-19 |
| JP2009523414A (ja) | 2009-06-25 |
| NZ569676A (en) | 2012-03-30 |
| AU2006327064A1 (en) | 2007-06-28 |
| PL1962825T3 (pl) | 2014-09-30 |
| WO2007071733A3 (en) | 2007-09-07 |
| AU2006327064B2 (en) | 2012-04-26 |
| EP1962825A2 (en) | 2008-09-03 |
| EP2510927A2 (en) | 2012-10-17 |
| EP2510927A3 (en) | 2013-05-01 |
| RU2437583C2 (ru) | 2011-12-27 |
| KR20080081334A (ko) | 2008-09-09 |
| MX2008008171A (es) | 2008-11-12 |
| BRPI0621131A2 (pt) | 2011-11-29 |
| CN101346138A (zh) | 2009-01-14 |
| NO20083187L (no) | 2008-09-19 |
| IL192154A (en) | 2015-04-30 |
| US9259408B2 (en) | 2016-02-16 |
| US9265745B2 (en) | 2016-02-23 |
| WO2007071733A2 (en) | 2007-06-28 |
| US20160151258A1 (en) | 2016-06-02 |
| US20080292681A1 (en) | 2008-11-27 |
| US20130274337A1 (en) | 2013-10-17 |
| IL192154A0 (en) | 2008-12-29 |
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