CN101317591A - Synergistic and residual pesticidal compositions containing plant essential oils. - Google Patents
Synergistic and residual pesticidal compositions containing plant essential oils. Download PDFInfo
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- CN101317591A CN101317591A CNA2008100885103A CN200810088510A CN101317591A CN 101317591 A CN101317591 A CN 101317591A CN A2008100885103 A CNA2008100885103 A CN A2008100885103A CN 200810088510 A CN200810088510 A CN 200810088510A CN 101317591 A CN101317591 A CN 101317591A
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N53/00—Biocides, pest repellants or attractants, or plant growth regulators containing cyclopropane carboxylic acids or derivatives thereof
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N31/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
- A01N31/02—Acyclic compounds
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N31/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
- A01N31/04—Oxygen or sulfur attached to an aliphatic side-chain of a carbocyclic ring system
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N31/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
- A01N31/08—Oxygen or sulfur directly attached to an aromatic ring system
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N31/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
- A01N31/08—Oxygen or sulfur directly attached to an aromatic ring system
- A01N31/14—Ethers
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
- A01N65/08—Magnoliopsida [dicotyledons]
- A01N65/12—Asteraceae or Compositae [Aster or Sunflower family], e.g. daisy, pyrethrum, artichoke, lettuce, sunflower, wormwood or tarragon
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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Abstract
Synergistic and residual pesticidal compositions contains rosemary oil and/or principal ingredients of rosemary oil are disclosed, in combination with the known rosemary oil doped with active insecticidal compounds and/or principal ingredients thereof, or rosemary oil doped with other compounds and/or principal ingredients thereof, these compounds were not used as active ingredients of insecticide formulation, for example, so-called signal transduction modulator. In addition, the invention relates to a method for controlling pests, namely, the particular amount of synergistic and residual pesticidal compositions having insecticidal effect hereinbefore are applied to the locations that are in need of pest control.
Description
The application for enter the China national stage on international filing date on July 28th, 1999, international application no PCT/US99/17097 in January 22 calendar year 2001, application number 99809097.2, denomination of invention " contain the synergy of plants essential oil and residual insecticides " divides an application.
The application relates to U.S. Provisional Patent Application series number No.60/094,463, application on July 28th, 1998, U.S. Provisional Patent Application series number No.60/100, application on September 16th, 613,1998, with U.S. Provisional Patent Application series number No.60/122, application on March 3rd, 803,1999, all of these patent applications openly are hereby incorporated by reference.
Invention field
The present invention relates to insecticides on the whole, particularly contains synergy and the residual insecticides of plants essential oil and/or plants essential oil main component.On the one hand, the present invention relates to include the insecticides of synergy of mixture of the synergy of plants essential oil and/or their main component.On the other hand, the present invention relates to the insecticides of synergy, its include some and the blending of known active parasite killing compound together plants essential oil and/or their main component.On the other hand, the present invention relates to residual insecticides, its include some and known active parasite killing compound and the blending of other compound together plants essential oil and/or their main component, in the former insecticides of described other compound not as active constituent, for example, at field of medicaments be the so-called signal transduction modulator of known favourable application.Last aspect the present invention relates to a kind of method of Pest Control, and promptly above-mentioned synergy and the residual insecticides that has an insecticidal effect by some is used in the place that needs carry out insect control.
Background of invention
Insect (invertebrate, insect, spider guiding principle animal, mite class and their larva etc.) has numerous reason annoying.Cause the crop loss of multi-million dollar and for control they spend mint of money to the mankind their every year.For example, agriculturally, the loss that insect is caused comprises that crop failure, quality descend and increase results expense.
For many years, He Cheng chemical insecticide provides the means of effective Pest Control.For example, a kind of means of previous Pest Control relate to the application of complex compound organic insecticide, and are as U.S. Patent No. 4,376, disclosed in 784 and 4,308,279.Other previous control device is used the organic polymer that absorbs effect, is widely used in the dehydration of insect, referring to U.S. Patent No. 4,985,251; 4,983,390; 4,818,534 and 4,983,389.Mineral salt also were studied as the application of farm chemical ingredients, as U.S. Patent No. 2,423,284 and 4,948,013, disclosed in european patent application No.462347, chemical abstracts (CA) 199 (5): 43357q (1993) and the agricultural chemicals handbook C102 page or leaf (1987).
Yet the extensive use that more and more is apparent that the synthetic chemistry insecticide that become has caused harmful environmental influence, and human and other animal all are harmful to.For example, the public has begun to pay close attention to the amount of holding the residual chemical of staying in food, surface water and the environment, and they are poisonous, carcinogenic or incompatible to the mankind, domestic animal and/or fish.And, some target pests even shown many synthetic chemistry insecticides commonly used are produced resistances.Recently, the administration guide rule limits the application of some synthetic pesticides by strictness, encourages the insecticides of the low harmfulness of exploitation.As a result, the elimination of effective insecticide has limited the economy of Pest Control and effectively selection on the market.As alternative, vegetable insecticide is extremely important, because they are natural insecticides, that is, the noxious material that they are plant-derived is to the mankind and Environmental security.In history, vegetable insecticide, dried rhizome and root, quassia, camphor and turpentine oil as tobacco leaf, Dalmatian chrysanthemum, trifoliate jewelvine, white black false hellebore are using always.In vegetable insecticide, Dalmatian chrysanthemum (also claiming Caucasia Dalmatian chrysanthemum, Pyrethrum Dalmatian, Chrysanthemum insecticide, pyrethrum and pyrethrins) is found to have been widely used.
Dalmatian chrysanthemum, extraction acts on insect from the flower that is grown in Kenya and Ecuadorian Chrysanthemum, and insect is benumbed fast, and shows under effective insecticidal concentration human and the negligible poisonous effect of warm blooded animal.Yet, pyrethrins industry and agriculture application facet be accompanied by several disadvantageous aspect, for example, be easy to degrade when they are directly exposed to sunlight following time, thereby they need frequently be used.Pyrethrins also has neurotoxicity to cold-blooded animal, as fish, reptile etc.And the supply of pyrethrins is restricted, and needs a large amount of steps that natural prodcuts are put on market, and large-scale production is very expensive.Remove the not sum synergist and make preparation together, the insect of many initial paralysis recovers to become insect once more.
Synergist is more such compounds, although they generally do not have direct toxic effect under using dosage, they can significantly improve the observation toxicity that mixes the agricultural chemicals of use with them.Synergist is present in many family expenses, poultry thing, pet with in the aerosol, to increase the effect that insecticide such as Dalmatian chrysanthemum, allethrin and Chryson are knocked down flying insect fast.In containing the pesticidal preparations of Dalmatian chrysanthemum, need synergist, for example, because target insect produces a kind of enzyme (cytochrome P-450) attack Dalmatian chrysanthemum and its branch is taken off, therefore make its knock down aspect the insect effective, but under a lot of situations aspect the kill insects to no effect.In this case, these synergist roles are the many matrix monooxygenase (PSMOs) that suppress the dependence P-450 of microsome generation, this microsome is the subcellular fraction unit in mammalian liver and some insect tissues, can the degrade pesticide compound of Dalmatian chrysanthemum and other is such as Dalmatian chrysanthemum, allethrin, Chryson etc.
Piperonyl butoxide (PBO) is a kind of commercial main pesticide synergistic agent.Yet PBO is a kind of synthetic product, is subjected to the careful examination of management organization and some other tissues recently.As a result, industrially turn to synthetic pyrethroid, it has good photostability, is effective to most agricultural insect insects in general.Yet pyrethroid has and hold the shortcoming of staying the long period in environment not as Dalmatian chrysanthemum safety.And disadvantageously many insects are developed into pyrethroid are produced resistance.
Many natural productss that comprise plants essential oil as insecticide can not provide the effect of enough Pest Control, their instabilities, and very fast branch is taken off, and therefore can not provide the residual toxicity characteristic.Product as the Dalmatian chrysanthemum class, when although it correctly uses in formulation of insecticides, insect there is good contact toxicity, but it is not the effective insecticidal agent under many circumstances, because they lack residual characteristic, therefore, increased frequency of utilization and insecticide cost of use, also increased exposure harm environment.
Therefore, be necessary very much new synergy and residual insecticides, it does not contain or contains very a spot of synthetic pyrethroid, chlorohydrocarbon, organic phosphor, carbamate etc.In addition, also need to solve the use of insecticide method for compositions of the problem of mentioning in the description of front, that is,, just can obtain acceptable insect and insect control level with lower cost to human and environment safety.
Summary of the invention
Main purpose of the present invention provides new insecticides, and it comprises at least a plants essential oil, their derivative, and/or their constituent is as synergist and at least a known traditional pesticide compound.
Another object of the present invention provides insecticides, and it comprises the mixture or the admixture of the synergy of plants essential oil and/or their main constituent.
Another purpose more of the present invention provides the new application of signal transduction modulator in insecticides, and this insecticides includes at least a plants essential oil, its derivative and/or their main constituent, and/or traditional insecticide.
A further object of the invention provides insecticides, and wherein the composition of active synergy of the present invention can use under the situation of consumption and still can reach desirable insect control effect reducing.
Another object of the present invention provides new residual insecticides, it comprises some the natural or synthetic compounds and the mixture of some plants essential oils and/or their main constituent, and the effect of this plants essential oil and/or their main constituent is to make the insecticides that includes plants essential oil and/or their main constituent have the residual toxicity effect.
Another object of the present invention provides a kind of by using composition among the present invention to the place that need carry out this insect control and the method that Pest Control is grown.
Another object of the present invention provides a kind of insecticides and unconscious and Pest Control consciously, for example, and invertebrate, insect, spider guiding principle class animal, the method for their larva etc.
Another object of the present invention provides a kind of insecticides safety, nontoxic and method with environmental sound.
A further object of the invention provides a kind of insecticides and method, and it has pleasant aromatic odor, and uses under the situation that can not need safety precaution.
A further object of the invention provides a kind of top described insecticides and method, and it can be produced or use cheaply.
Another object of the present invention provides a kind of insecticides and method, and it can make insect not produce resistance.
Above-mentioned purpose with other is realized and has finished in following several respects by the present invention, (1) a kind of synergy and residual insecticides, comprise at least two plant species essential oils, their derivative, and/or their main constituent, (2) synergy and residual insecticides, comprise plants essential oil and/or their main constituent and with known active insecticide compound, (3) synergy and residual insecticides, comprise plants essential oil and/or their main constituent and with the compound that was not used as in the past the active component in the pesticide compound, for example, signal transduction modulator (inhibitor and/or activator) mixes, or (4) synergy with residual insecticides, include known active parasite killing immunomodulator compounds and with the compound that was not used as in the past the active component in the pesticide compound, for example, the signal transduction modulator mixes.The meaning that is appreciated that term " signal transduction modulator " by this description will comprise inhibitor and/or activator.In addition, the present invention relates to above-mentioned synergy and residual insecticides by using insecticidal effective dose to the place that needs Pest Control and the method for Pest Control.
Other purpose of the present invention and attendant advantages will partly put forward in the following description, or recognize by practice or the application of the invention.Objects and advantages of the present invention can be by the means particularly enumerated in the appended claims and in conjunction with being familiar with and obtaining.Should be appreciated that, aforesaid general describe and detailed description described later only is exemplary with illustrative, rather than to desired qualification of the present invention.
The detailed description of preferred embodiment
All patents of quoting in this manual, its full content of patent application and document is incorporated the present invention into as a reference.Under inconsistent situation, will comprise that definition is as the criterion with the disclosure.
In a kind of embodiment, the invention provides a kind of synergy and residual insecticides, said composition includes at least two plant species essential oil compounds or their derivative that mixes with a kind of suitable carriers and optionally mix with a kind of suitable surfactant, comprises racemic mixture, enantiomer, diastereomer, hydrate, salt, solvate, metabolite, isoreagent, homologue etc.
Each plants essential oil or derivatives thereof can extract from natural resources and obtain or make by synthetic, generally comprise a kind of acyclic monoterpene enol or aldehyde as main constituent, a kind of benzenoid form aromatic that comprises at least one oxidation substituting group or side chain, or a kind of a hexatomic ring arranged usually, the terpenes of the substituent monocyclic carbocyclic ring of one or more oxidations is arranged on the ring.The example of this class plants essential oil or their main constituent includes, but not limited to be selected from by C
16Aldehydes (pure), α-terpineol, amyl cinnamic aldehyde, salicylic acid amyl group ester, anisaldehyde, benzylalcohol, benzyl acetate, cinnamic acid, cinnamyl alcohol, carvacrol, carveol, citral, citronellal, citronellol, the salicylic acid dimethyl esters, cineole (cineole), eugenol, different-eugenol, Jiale muskiness, geraniol, the fragrant phenol of guaiaci lignum, ionone, the d-limonene, menthol, the anthranilic acid methyl ester, irone, the salicylic acid methyl ester, α-phellandrene, pennyroyal oil, perillaldehyde, 1-or 2-phenylethanol, propionic acid 1-or 2-phenylethylester, the pepper ester, piperonyl acetate, piperitol, the D-pulegone, terpinene-4-alcohol, terpinyl acetate, acetate 4-tert-butylcyclohexyl ester, thyme linaloe oil (white and red), thymol, trans-anethole, vanillin, in the group that ethyl vanillin etc. are formed.Just because of these plants essential oil compounds are compound known and once were used for other purposes that they can be made by known method routine by those skilled in the art.
In addition, the invention provides a kind of application of so-called signal transduction modulator newly.The signal transduction modulator has demonstrated result of treatment or very potential at field of medicaments, but up to the present, does not also show its effect at pesticide field.Therefore, the synergy among the present invention can comprise known active parasite killing immunomodulator compounds and/or at least a above-mentioned plants essential oil compound and at least a signal transduction modulator with residual insecticides.Preferred signal transduction modulator comprises can effectively disturb ring-type adenylic acid (cAMP)/cAMP-dependent kinases, tyrosine kinase, MEK 1 or MEK 2, with phosphide calcium proteins associated kinases (PKC), the mitogen activated protein kinase member of family, with calmodulin proteins associated kinases, growth factor receptors, those signal transduction modulators of octopamine acceptor etc.Preferred signal transduction modulator comprises, but be not limited to, forskolin, PD98059 (be also referred to as 2-(2-amino-3-anisyl)-4-oxo-4H-[1] chromene or 2 '-amino-3 '-methoxyl group-flavones), geldanamycin, lavendustin A, lavendustin B, lavendustin C, genistein, oxamycin A, 2-hydroxyl-5-(2,5-two-hydroxy benzo) amino-benzoic acid, 2,5-dihydroxycinnamic acid methyl esters, tyrphostin, staurospore, cytochalasin B, or the like.
In another preferred embodiment, the present invention includes a kind of insecticides that is used for the synergy of agricultural, include the mixture of eugenol, α-terpineol, citronellal, thymol and trans-anethole.Below data show that trans-anethole has synergistic effect to the thyme linaloe oil that is considered to resist insect mitochondria electric transmission path and thyme linaloe oil derivative such as thymol and carvacrol.
In another preferred embodiment, the present invention relates to be used to control the insecticides of the synergy of house pest, include α-terpineol, benzylalcohol, 2-phenylethanol and/or propionic acid 2-phenylethylester.Below data show with only compare with independent plants essential oil, this embodiment has very high effect to fiery ant and cockroach, promptly shows the toxicity of increase.
In another preferred embodiment, the present invention relates to synergy and residual insecticides, include at least a plants essential oil compound and at least a insecticide that is selected from natural insecticide compound, chlorohydrocarbon, organic phosphor, carbamate etc., and mix with suitable carriers and optionally a kind of suitable surfactant.Preferred insecticide comprises, but be not limited to, allethrin, azadirachtin (chinaberry), sevin, chlopyrifos, dichlorodiphenyl trichloroethane, nitrile chlorobenzene phenothrin, malathion, imido Crow get (imidacloprid), Permanone, Dalmatian chrysanthemum, Chryson, rotenone, pyrethroid etc.
In another preferred embodiment, the present invention includes synergy and residual insecticides, include at least a above-mentioned plants essential oil compound and one or more and be selected from composition in the group of being formed by pyrethron, allethrin ketone, chrysanthemumic acid, alantol, cis-jasmone and dimethyl sulfoxide (DMSO) (DMSO), and mix with suitable carriers and optionally suitable surfactant.
In another preferred embodiment, the present invention relates to a kind of synergy and residual insecticides, include at least a above-mentioned plants essential oil compound, a kind of insecticide and a kind of signal transduction modulator.
Those skilled in the art will find synergy of the present invention and residual insecticides under the condition of sublethal dose, that is: use the active insecticide reagent table to reveal beyond thought excellent insecticidal activity under than the low situation of single compound concentrations.And, those skilled in the art will find that synergy of the present invention and residual insecticides unexpectedly show the insecticidal activity (that is, can only provide very a spot of residual insecticidal activity with native compound itself as residual insecticide) of longer time.Not expecting by following one theory, might be that plants essential oil can resist insect neuroceptor or may be as the P-450 inhibitor.Also may be that plants essential oil can work by a kind of reaction alternating pattern.Be under the situation of the insecticide that mixes with one or more plants essential oils Dalmatian chrysanthemum, think that Dalmatian chrysanthemum has promoted to the chitinous infiltration of insect, thereby increased the chance of the neuroceptor of plants essential oil contact insect.Also have, another may be, Dalmatian chrysanthemum and other insecticide on biochemistry synergy plants essential oil.The energy level of insecticide in also can the metabolic process of interference insect, thus synergy the opposing reaction of so-called octopamine infringement.Under arbitrary situation, the toxicity of the composition of disclosed synergy of the present invention here increases and enhanced reaction of modification is not clear up till now and do not expect.
Use and synergy of the present invention generally can obtain 100% the lethality that contacts, and the residual toxicity characteristic at least two weeks is provided with residual insecticides.Like this, they are for example, but be not limited to agricultural, organic farming, family, special insect control, pet supplies, forest, or submergence articles for use, solids processing, earth mixture articles for use, rice shoot box are handled, stem injection and plant treatment, ornamental plants and remove in the fields such as termite, mosquito, fiery ant, head louse, dirt mite and can be advantageously used for insecticide under water.
When being used for plant, the anti-Changes in weather of insecticides energy this synergy and residual, comprise that rainwater causes wash away, UV-induced decomposition, oxidation, the hydrolysis in the presence of moisture or, at least this decomposition, oxidation and hydrolysis will reduce the insecticidal property of composition expectation synergy and residual widely, or give not desired characteristics synergy and residual composition.This synergy or residual composition is non-gross chemistry inertia, and they can be compatible with other numerous spray form components, and they can be used in the soil, on the seed, or on the root of plant and do not injure the root of seed or plant.They also can be mixed together use with other biocidal activity compound.
A kind of material represented here in term " carrier ", can be inorganic or organic, with can be synthesize or crude, can be mixed together or be mixed with preparation with reactive compound with it, be beneficial to its application in other target of plant, seed, soil or processing, or help its storage, transportation and/or operation.In general, any material that is used as carrier usually in Insecticides (tech) ﹠ Herbicides (tech) or fungicide preparation all is suitable for doing in the present invention carrier.The synergy of inventing among the present invention can use separately with residual insecticides; or when needed with this solid-state and/or liquid dispersible carrier intermediate and/or other known compatible active agent; plant protection product particularly; as other insecticide; miticide; nematocide; fungicide; bactericide; rodenticide; weed killer herbicide; chemical fertilizer; the form of the mixture of growth regulator etc. is used; or be the form of special mode of administration with the preparation of special dosage; such as aqueous solvent; emulsion; suspending agent; pulvis; the form of paste and granule is used, and they use easily.As needs, synergy among the present invention and residual insecticides can with traditional inert (being plant perhaps weeding inertia mutually) farm chemicals diluent or spendable filler such as traditional agricultural chemicals dispersible carrier medium such as gas in traditional pesticidal preparations or composition, solution, emulsion, suspending agent, emulsifiable concentrates, the spraying pulvis, the pasty state agent, soluble powder, the agent of dirt shape, particle, foam, paste, tablet, aerosol, natural and synthetic material with the active substance dipping, microcapsules, the application composition that is used for seed, cartridge is steamed in preparation such as sootiness that combustion apparatus uses, fumigation tank and stifling coil, and cold mist of ULV and hot mist preparation etc. mix use.
Including the preparation with residual composition synergy of the present invention can prepare with any known mode, such as, by with synergy and residual composition with traditional agricultural chemicals dispersible attitude carrier and/or dispersible solid carrier, optionally use carrier intermediate auxiliary agent such as traditional pesticide surfactant, comprising that emulsifier and/or dispersant are expanded prepares, like this, and for example, as under the situation of thinner, organic solvent can be used as cosolvent and adds at water.Suitable liquid diluent or carrier comprise water, petroleum cuts, or other contains or do not contain the liquid-carrier of surfactant.The selection of dispersant and emulsifier and usage amount are promoted the ability decision of the dispersiveness of synergy of the present invention and residual composition by the character of composition and reagent.Usually use a spot of reagent as far as possible, synergy and residual composition in when spraying and the present invention dispersed consistent, rainwater, dew, mist etc. can not make composition emulsification synergy and residual among the present invention again after it uses on the plant like this, wash away from plant.Nonionic, anion, both sexes or cation dispersion and emulsifier also can be used, for example, and alkylene oxide and phenol and organic acid condensation product, alkyl aryl sulfonate, compound ether alcohol, quarternary ammonium salt compound etc.
Liquefied concentrate can be by preparing with the non-plant toxicity dissolution with solvents and with synergy of the present invention the decomposition with suitable surface-active emulsification and dispersion reagent with residual composition composition of the present invention in water.The example that is used for traditional carrier intermediate of this purpose includes, but not limited to be at normal temperatures and pressures the aerosol propellants of gas, as fluorine Lyons; The dispersible liquid diluting carrier of inertia comprises inert organic solvents, such as aromatic hydrocarbon such as benzene,toluene,xylene, Fluhyzon etc.; Halo is the aromatic hydrocarbon of chloro such as chlorobenzene class etc. particularly, cyclic alkane such as cyclohexane etc., alkane such as benzinum or mineral oil fraction, chlorinated aliphatic hydrocarbon such as carrene, vinyl chloride etc., alcohols such as methyl alcohol, ethanol, propyl alcohol, butanols, ethylene glycol etc., and their ether and ester such as glycol monoethyl ether etc., amine such as monoethanolamine etc., acid amides such as dimethyl formamide etc., inferior alum such as dimethyl alum etc., acetonitrile, ketone such as acetone, MEK, methylisobutylketone, cyclohexanone etc., and/or water, and the solid carrier of the dispersible segmentation of inertia, such as natural mineral matter that grinds such as kaolin, clay, vermiculite, alumina, silica, chalk is a calcium carbonate, talcum, attapulgite, imvite, diatomite etc., and the synthetic mineral matter that grinds such as the silicic acid of high dispersive, silicate such as alkali silicate etc.
The surfactant that can use together with the present invention is that traditional carrier intermediate auxiliary agent comprises, but be not limited to, emulsifier, for example nonionic and/or anion emulsifier such as neopelex, the polyoxyethylene ester of fatty acid, the APEO of fatty alcohol, alkyl sulfate, alkyl sulfonic ester, aromatic yl sulphonate, albumin hydrolysate etc., alkylaryl polyglycol ether particularly, dolomol, enuatrol etc.
According to principle of the present invention, insecticide also can be made the form of water or oil-based suspension.The active substance of known quantity can be distributed in water or the oil, use machine such as colloid mill, Wei Lin Shi blender, the high-speed stirred of high speed homogenization device or lightweight agitator.These apparatus systems can be distributed to big energy in the liquid, produce the very little drop that disperses each other.If water is continuous phase, be exactly water base suspension.If continuous phase is oil, is exactly oil-based suspension.For helping a kind of liquid dispersion in another liquid, can add emulsifier and dispersant.These reagent can be nonionic and/or anion emulsifier (as the APEO of the polyoxyethylene ester of fatty acid, fatty alcohol, alkyl sulfate, alkyl sulfonic ester, aromatic yl sulphonate, albumin hydrolysate etc., particularly alkylaryl polyglycol ether).For making stabilized with mixture, prevent that drop from assembling for a long time, with the viscosity that some reagent such as xanthans, polyacrylamide or polyacrylate and expanded clay such as attapulgite, swelled ground or fillite are regulated liquid, the size of preferred suspended particles is the 3-5 micrometer range.The concentration range of active substance is 0.01-70%, and typical concentrations is approximately 1-50%W/W.
At wettable pulvis, in the preparation of dust agent or granular preparation, active component is dispersed in the carrier of suitable fineness.In the preparation of wettable pulvis, in above-mentioned dispersant of mentioning and lignosulfonate are also included within.Dust agent be contain segmentation as the solid of insecticide carrier such as talcum, the unbodied or silica smoked, the mixture of attapulgite clay, kaolin, diatomite, pyrophyllite, chalk, diatomite, vermiculite, calcium phosphate, calcium carbonate and magnesium carbonate, sulphur, flour and other organic and inoganic solids component.The solid of these segmentations preferably has the mean particle size less than 50 microns.A kind of dust agent that typically is used to control insect contains 1 part of synergy and residual composition and 99 parts of diatomite or vermiculite.
Granule can comprise particle porous or atresia.Particle is relatively large, and the exemplary particles size diameter is the 400-2500 micron.Particle is with the solution impregnation or the coating of insecticides of the present invention.Granule generally contains 0.05-15%, and the active component of preferred 0.5-5% is as effective desinsection dosage.Therefore, the preparation of wanting to obtain contains the natural minerals of solid carrier or dilution such as bentonite, diatomite, pulverizing, as silicic acid, alumina and the silicate of kaolin, clay, chalk, quartz, attapulgite, imvite or diatomite, vermiculite and synthetic mineral of pulverizing such as high dispersive, mill and natural rock such as calcite, marble, float stone, sepiolite and dolomite and synthetic inorganic and organic particle matter, organic substance particle such as peanut shell, paper refuse, sawdust, cocoa husk, maize cob and the tobacco stem of classification.Adhesive, as carboxymethyl cellulose, natural and synthetic polymer, (as gum Arabic, polyvinyl alcohol and polyvinylacetate), etc., also can be used in the preparation with the form of pulvis, granule or emulsible concentrate.
If desired, colouring agent is inorganic pigment for example, also can use as iron oxide, titanium oxide and Prussian blue and organic dyestuff such as alizarin dyes, azo dyes or metal phthalocyanine dyestuff and trace element such as iron, magnesium, boron, copper, cobalt, molybdenum and zinc salt.
If desired; VOC is suitable as fragrance ingredient; be used in the preparation of family and pet use; comprise; but be not limited to amyl salicylate; citronellol; citronellol oxygen acetaldehyde; primrose aldehyde; the citronellal isobutyrate; coumarin; the cyclohexyl-acetic acid ester; the cyclohexyl butyrate; diethyl malonate; 2-acetyl group-5-oxo ethyl hexanoate; isobornyl acetate; linalool; benzyl carbinol; tip-nip; jasmonal H; the 2-methyl cyclohexanol; hexanol; phenylacetaldehyde; cis-3-hexyl-1-alcohol; cyclohexyl-n-sulfonate; veronal phenol; clove tree alcohol; Jiale muskiness; citral; ambrette; the tyerpinyl acetic acid esters; geraniol; α-damascone; Alpha-Methyl ionone etc.The example of volatile essential oil has peppermint oil, cedar leaf, China fir, geranium, lavender, white cdear, sandalwood oil, rose extract, galbanum oil.Synthetic organic aromatic substance has description in some publications, as United States Patent(USP) Nos. 4,314,915; 4,422,829; With 4,434,306.
In commercial or agricultural are used, the present invention includes the carrier compositions mixture, wherein synergy and residual composition in mixture basically with 0.01-95 weight %, the amount of preferred 0.5-90 weight % exists, and the amount of general its reactive compound of carrier compositions mixture that use in suitable directly use or field is about 0.0001-10% of mixture weight, preferred 0.01-1%.Therefore, the present invention includes all and contain traditional dispersible carrier intermediate, as (1) a kind of dispersible inertia segmentation carrier solid, and/or the preparation of the mixture of (2) a kind of dispersible carrier liquid such as inert organic solvents and/or water, the carrier intermediate auxiliary agent that preferably contains the surface-active effective dose, for example surfactant such as emulsifier and/or dispersant, with can reach this purpose and be generally about 0.0001-95% of mixture weight, the reactive compound of the amount of preferred 0.01-95.
Synergy and residual composition also can use according to the ultralow volume process of what is called, promptly by using this compound or by using the fluid composition that contains this compound, through very effective atomization plant, form with segmentation, as 50-100 micron or littler average particulate diameter, be that vaporific form is used, for example, use by a large amount of spray applications of aircraft.Only need several liters/hectare at most.In this process, might use highly concentrate have a vectorial fluid composition of said liquid carrier, wherein contain 20-95 weight % synergy and residual composition or even 100% active substance is only arranged, as synergy and the residual composition of about 20-100 weight %.The mixture of active substance also can be non-exclusively can provide about 0.2-2, and the effective dose of the active substance/acre of preferably about 0.5-1.5 pound is used.And every acre of the synergy of the requirement that herein comprises and residual composition can be with 1-200 gallon or more liquid-carrier and/or dilutions or with the inert solid carrier and/or the dilution processing of about 5-500 pound.The general excursion of concentration in the liquid concentrate is about 10-95 weight %, is about 0.5-90 weight % in solid pharmaceutical preparation.Satisfied general every acre of active synergy and the residual composition that contains the 1/4-15 pound of having an appointment of spray, dust agent or granule.
And; the present invention includes and kill, resist or the method for Pest Control; this method comprise with antagonism accordingly, of the present invention specific synergy insecticidal effective dose or toxic dosage and residual composition be administered at least a corresponding (a) this insect and (b) habitat of corresponding this insect separately or with above-mentioned carrier together; promptly on the area that will protect; for example be administered to the crops of growing, will grow on the place or domestic animal in crops.Preparation of directly using or composition can be used with any suitable common mode, for example by spray, atomize, evaporate, spread, dust, water, spray, spill, sprinkle, sootiness etc.The method of control insect comprises composition of the present invention, and a kind of in the preparation normally above-mentioned is administered to the certain area coverage of the evil that exempts from insect that will protect, on plant leaf and/or fruit.Certainly, the amount of compound administration should enough be brought into play desirable effect.This dosage depends on many factors, comprises that target pest, used carrier, the method for using and condition, local preparation are the aerocolloidal form or the form of film, or as the form existence of the particle that disperses, the thickness of film or the size of particle etc.Consider rightly and determine these factors, the essential dosage of the reactive compound of the protection zone is provided, belong to very masterful technique of this field.Yet; in general, The compounds of this invention is in the effective dose in the zone that will protect, i.e. the insect dosage that begins to contact; gross weight based on the preparation of using is 0.001-0.5%, although under some environmental conditions on same basis effectively concentration with little to 0.0001% or as many as 20%.
Insect in synergy of the present invention and residual insecticides and method can be resisted on a large scale very effectively should be understood that insect cited among the embodiment here and evaluation are this very large-scale representative example.For example, the present invention can be used for controlling infringement plant or warm blooded animal, the product of storage and the insect of fabric.The representative crops plant that can handle like this includes, but not limited to cotton, corn, paddy rice, soybean, sugar beet, tobacco, wheat etc.The representative animal that can be protected by the present invention and handle includes, but not limited to people, horse, dog, cat, ox, sheep, goat, pig etc.Can be included, but not limited to millet, face and flour product, tobacco and tobacco product, processed food etc. by the representational stored prod that exempts from the insect infringement that the present invention protects.The representational fabric that exempts from the insect infringement that can be protected by the present invention is hair, cotton, silk, flax etc.
The compositions and methods of the invention will be further elaborated among the non-limiting embodiment below.These embodiment only are the elaborations of different embodiments, do not limit and relevant claims of the present invention such as the material of narrating here, condition, part by weight, machined parameters.
Embodiment 1
The synergistic effect of plants essential oil and/or their main component and Dalmatian chrysanthemum antagonism U.S. cockroach
Glass jar is handled with the acetone soln of variable concentrations test chemicals.Allow the acetone volatilization remove, and the cockroach placement is exposed in this glass jar.Each orthogonal processing is with 10 cockroaches.Every single component, except that Dalmatian chrysanthemum, consumption is 100 a milligrams/cylinder.In the simultaneously treated test that does not have Dalmatian chrysanthemum, each chemicals usage is 20 a milligrams/cylinder.In the common Processing Test that Dalmatian chrysanthemum (25% pure Dalmatian chrysanthemum) arranged, the consumption of each plants essential oil is 20 a milligrams/cylinder.The consumption of Dalmatian chrysanthemum is 2 a milligrams/cylinder.The result is as follows.
Embodiment 2
The synergistic effect of plant edible vegetable oil and/or their Main Ingredients and Appearance and Dalmatian chrysanthemum antagonism U.S. cockroach
Glass jar is handled with the acetone soln of variable concentrations test chemicals.Allow the acetone volatilization remove, and cockroach is exposed in this glass jar.Each orthogonal processing is with 5 cockroaches, and each is handled parallel 2 times.This test repeats 3 times.In containing the common Processing Test of Dalmatian chrysanthemum, the usage amount of plants essential oil and/or their main component is 10 a milligrams/cylinder.The Dalmatian chrysanthemum consumption is 1 a milligram/cylinder in all tests, and the result is as follows.
| Handle | 24 hours lethality % |
| Contrast | 0 |
| 1-thymol (20mg/ cylinder) | 0 |
| 2-thymol (20mg/ cylinder) | 0 |
| 3-admixture 5 (20mg/ cylinder) | 0 |
| 4-eugenol (20mg/ cylinder) | 0 |
| 5-Dalmatian chrysanthemum (1mg/ cylinder) | 0 |
| 1 (10mg/ cylinder)+Dalmatian chrysanthemum | 50 |
| 2 (10mg/ cylinder)+Dalmatian chrysanthemums | 70 |
| 3 (10mg/ cylinder)+Dalmatian chrysanthemums | 80 |
| 4 (10mg/ cylinder)+Dalmatian chrysanthemums | 100 |
The proof load of thyme linaloe oil, thymol and admixture 5 is for until to handling back 5 days female mouse (all mouse of 8-10) not caused any death or toxicity disease million (body weight and appetite).Admixture 5 is the plants essential oil mixtures that contain thymol, eugenol, trans-time fragrant brain, α-terpineol and citronellal.
Embodiment 1 and 2.The composition that these embodiment show the synergy that contains plants essential oil and/or their main component and Dalmatian chrysanthemum (25% pure pyrethrins) is than under the small concentration, and promptly each all has the activity of synergy at sublethal dose.
Embodiment 3
Synergy and the residual effect of the mixture of plants essential oil and Dalmatian chrysanthemum and Dalmatian chrysanthemum derivative antagonism U.S. cockroach
Glass jar is handled with the acetone soln of variable concentrations test chemicals.Allow the acetone volatilization remove, and cockroach is exposed in this cylinder.Each orthogonal processing pats row 2 times with 5 cockroaches, everywhere.This experiment repeats 2 times.Average result is as follows.
One or more plants essential oils of above-mentioned digital proof are with Dalmatian chrysanthemum, have synergy and residual effect.The toxicity of the increase of the admixture of synergy and the residual action of increase are unexpected, and tangible benefit is provided, and surpass existing insecticidal technology.
Embodiment 4
Synergy of thymol and Dalmatian chrysanthemum and residual effect
Glass jar is handled with the acetone soln of variable concentrations test compounds.Allow acetone remove, and cockroach is exposed in this glass jar through volatilization.Each orthogonal processing is used 5 cockroaches, and each is handled parallel 2 times.This experiment repeats 2 times.The result is as follows.
The Dalmatian chrysanthemum of these digital proof thymols and sub-lethal dose has the residual toxicity of clear and definite synergistic effect and increase.The residual action of this synergistic effect and increase is unexpected and significant under low like this consumption level.
Embodiment 5
The synergy of the mixture of plants essential oil main component and pyrethrins and dimethyl alum and residual effect
The preparation ratio is the acetone soln sample (the 1st sample) of the pyrethrins of 1 part of pyrethrins and 100 parts of acetone.Preparation contains the 2nd sample of 4 plant species derived essential oils (α-terpineol, benzylalcohol, benzyl carbinol and phenyl ethyl propionate ester), and the weight ratio of each composition is identical.Then, the 1st sample and the 2nd sample mix are in the same place, ratio is 1: 1, obtains a kind of 4-admixture composition of synergy, and 1 part of 4-admixture composition is to there being 0.01 part of pyrethrins.4-admixture composition with this synergy is administered in the 9cm glass incubator that lid does not cover each 100 microlitre then.With the 2nd sample administration in the 9cm glass incubator of not adding a cover, each 500 microlitre.Expose after 1 hour, allow acetone volatilization remove, put into 10 fiery ants in each incubator, observe to measure and finish the required time of LD90, LD90 be kill 90% tried the required lethal dose of worm.
The 4-admixture of observing the synergy of the 100 microlitres speed of killing only has only fast 3 times of 4-admixture than 500 microlitres.The 4-admixture of the synergy of 100 microlitres killed fiery ant in 1 minute 50 seconds, and the independent 4-admixture of 500 microlitres killed fiery ant in 4 minutes and 45 seconds.The ant that is exposed to 4-admixture composition shows and strengthens the neurotoxicity effect, and comprising trembles shakes and lack the coordination ability.The amount of the plants essential oil of the desinsection in the composition of the synergy among data show the present invention of this group can reduce to the low dosage of the active component in the preparation of suitable last use, from 5%-1%, add 0.01% pyrethrins, be issued in low expense and knock down and kill effect faster.And, after exposure at least 14 days, to compare with non-beneficiated sample, the sample of synergy provides residual faster knocking down and lethality (to fiery ant) continuously.Similar experiment is carried out with dimethyl alum, has also confirmed the synergy of plants essential oil, and the sample of synergy also has residual toxicity.
Embodiment 6
The synergy of thymol and Dalmatian chrysanthemum derivative and residual effect
Glass jar is handled with the acetone soln of variable concentrations test compounds.Allow acetone remove, and cockroach is exposed in this glass jar through volatilization.Each orthogonal processing is used 5 cockroaches, and each is handled parallel 2 times.This experiment repeats 2 times.The result is as follows.
The Dalmatian chrysanthemum of these digital proof thymols and sub-lethal dose has the residual toxicity of clear and definite synergistic effect and increase.The residual action of this synergistic effect and increase is unexpected and significant under low like this consumption level.
Embodiment 7
Synergy and the residual effect of the mixture antagonism U.S. cockroach of thymol and Dalmatian chrysanthemum derivative and signal transduction modulator
Glass jar is handled with the acetone soln of the test compounds of variable concentrations.Allow acetone remove, and cockroach is exposed in this glass jar through volatilization.Each orthogonal processing is used 5 cockroaches, and each is handled parallel 2 times.This experiment repeats 2 times.The result is as follows.
Synergy and the residual effect of above-mentioned data show thymol and Dalmatian chrysanthemum derivative cis-jasmone and signal transduction modulator such as PD98059 and Lavandustin A.The toxicity of the increase of the admixture of synergy and the residual action of increase are unexpected, prove fabulous effect, have surpassed existing insecticidal technology.These group data also show the necessary ratio of residual toxicity effect that produces.
Embodiment 8
The synergy and the residual effect of benzylalcohol and Dalmatian chrysanthemum and other synergist
Glass jar is handled with the acetone soln of the test compounds of variable concentrations.Allow acetone remove, and cockroach is exposed in this glass jar through volatilization.Each orthogonal processing is used 5 cockroaches, and each is handled parallel 2 times.This experiment repeats 2 times.The result is as follows.
These data show benzylalcohol and synergist the residual toxicity of obvious synergistic effect and increase is arranged.The residual of this synergy and raising is unexpected and significant at low like this concentration level.
Embodiment 9
The synergy of benzylalcohol and chrysanthemum monocarboxylate and residual effect
Glass jar is handled with the acetone soln of the test compounds of variable concentrations.Allow acetone remove, and cockroach is exposed in this glass jar through volatilization.Each orthogonal processing is used 5 cockroaches, and each is handled parallel 2 times.This experiment repeats 2 times.The result is as follows.
These data show benzylalcohol and synergist the residual toxicity of obvious synergistic effect and increase is arranged.The residual of this synergy and raising is unexpected and significant at low like this concentration level.These group data have also shown the necessary ratio of generation residual toxicity effect.
Embodiment 10
The synergy of benzylalcohol and synergist and residual effect
Glass jar is handled with the acetone soln of the test compounds of variable concentrations.Allow acetone remove, and cockroach is exposed in this glass jar through volatilization.Each orthogonal processing is used 5 cockroaches, and each is handled parallel 2 times.This experiment repeats 2 times.The result is as follows.
These data show benzylalcohol and synergist the residual toxicity of obvious synergistic effect and increase is arranged.The residual of this synergy and raising is unexpected and significant at low like this concentration level.These group data have also shown the necessary ratio of generation residual toxicity effect.
Embodiment 11
The synergy of benzylalcohol and signal transduction modulator and residual effect
Glass jar is handled with the acetone soln of the test compounds of variable concentrations.Allow acetone remove, and cockroach is exposed in this glass jar through volatilization.Each orthogonal processing is used 5 cockroaches, and each is handled parallel 2 times.This experiment repeats 2 times.The result is as follows.
These data show benzylalcohol and signal transduction modulator the residual toxicity of increase is arranged.The residual of this synergy and raising is unexpected and significant at low like this concentration level.These group data have also shown the necessary ratio of generation residual toxicity effect.
Embodiment 12
The synergistic effect of thymol and traditional insecticide
Glass jar is handled with the acetone soln of the test compounds of variable concentrations.Allow acetone remove, and cockroach is exposed in this glass jar through volatilization.Each orthogonal processing is used 5 cockroaches, and each is handled parallel 2 times.This experiment repeats 2 times.The result is as follows.
These digital proof thymols and decis be together the time, even also have synergy under low-down concentration level.This synergy is unexpected and significant.
Embodiment 13
The synergy of thymol and alkene denapon and residual effect
Glass jar is handled with the acetone soln of the test compounds of variable concentrations.Allow acetone remove, and cockroach is exposed in this glass jar through volatilization.Each orthogonal processing is used 5 cockroaches, and each is handled parallel 2 times.This experiment repeats 2 times.The result is as follows.
Even these data show thymol and sevin synergy and residual toxicity are also arranged under low-down concentration level.This synergy and residual are unexpected and significant.
Embodiment 14
The synergy and the residual effect of thymol and traditional insecticide
Glass jar is handled with the acetone soln of the test compounds of variable concentrations.Allow acetone remove, and cockroach is exposed in this glass jar through volatilization.Each orthogonal processing is used 5 cockroaches, and each is handled parallel 2 times.This experiment repeats 2 times.The result is as follows.
These digital proof thymols and decis and permethrin just have synergy and residual toxicity at low-down concentration level.This synergy and residual are unexpected and significant.Malathion and thymol are antagonistic effect.
Embodiment 15
The synergistic effect of plants essential oil and/or their main component and Dalmatian chrysanthemum antagonism U.S. cockroach
This experiment is to be synergy or opposite in order to measure Dalmatian chrysanthemum (Dalmatian chrysanthemum of 25% purity) to plants essential oil and/or their Main Ingredients and Appearance.Each orthogonal processing is used 5 cockroaches, and each is handled parallel 2 times.This experiment repeats 2 times.The result is as follows.
| Handle | 24 hours lethality % |
| Contrast | 0 |
| 1-thymol (50mg/ cylinder) | 20 |
| 2-thymol (35mg/ cylinder) | 30 |
| 3-admixture 5 (40mg/ cylinder) | 30 |
| 4-Dalmatian chrysanthemum (1mg/ cylinder) | 0 |
| The 1+ Dalmatian chrysanthemum | 70 |
| The 2+ Dalmatian chrysanthemum | 90 |
| The 3+ Dalmatian chrysanthemum | 100 |
The dosage that U.S. cockroach is not caused the Dalmatian chrysanthemum of any lethal effect is 1 part with the test concentrations with respect to plants essential oil and/or their main component to be mixed.Do not wish that by following theory it shows that Dalmatian chrysanthemum plays synergist to the plants essential oil of test and their main component.None causes any toxicity to female mouse proof load.
Embodiment 16
Synergy toxicity between the plant-derived essential oil
Carried out a plurality of experiments and played synergistic effect with the binary mixture that the plants essential oil compound is described.The 5th early stage Spodoptera litura larvae in age (15-20mg) is carried out Local treatment with pure compound as the dosage of standard at the back.Larva after the processing is put in 5 centimetres the plastic culture device and takes food, and observes and handles back 24 hours lethality.The everywhere pats row 4 times, uses 10 larvas at every turn.The result is as follows.
Experiment 2-5 shows that thymol is by citronellal synergy when using identical dosage.Experiment 6-10 shows that thymol is not by α-terpineol or eugenol synergy.Eugenol can not show by α-terpineol or citronellal synergy.Yet α-terpineol and citronellal it seems synergistic effect (experiment 9).Experiment 11 and 12 shows that trans-anethole is the strong synergist of thymol, even be 1: 8 o'clock in ratio.Experiment 13-15 shows that trans-anethole is the effective synergy reagent of eugenol, α-terpineol and citronellal.
Embodiment 17
Plants essential oil and propargite resist the synergistic effect of two zebra shark mites
The mixture of 5-admixture (thymol, trans-anethole, α-terpineol, eugenol and citronellal) separately and with commodity miticide propargite (Omite
TM) test the ripe mite on the anti-beans leaf floral disc together.Processing comprises sprays ripe mite (directly toxicity) and observes toxicity by survival condition.Each handles parallel processing 5 times, each 10 mites.Measure lethality.The result is as follows.
Conclusion: in the time of on directly being sprayed onto ripe acarid, be 5-admixture or Omite up to 72 hours avirulences all.Yet these two kinds of products mix and demonstrate the toxicity enhancing.These data are unexpected, and the advantage that surpasses existing insecticidal technology is provided.
Embodiment 18
Plants essential oil and traditional insecticide resist the synergistic effect of prodenia litura
5-admixture (thymol, trans-anethole, α-terpineol, eugenol and citronellal) and traditional insecticide are tested 5 the biggest Spodoptera litura larvae (the 2nd age) on the cabbage leaf fragment that is immersed in the test solution together.Observe the lethality of 24 hours and 48 hours.The everywhere pats row 5 times, each 50 larvas of parallel usefulness (n=250).The result is as follows.
Conclusion: in this test, the 5-admixture at 24 hours and 48 hours energy to special cloth branch (tebufenozide) synergistic effect.The result who contains Fenvalerate is owing to initial toxicity does not have convincingness.These data are unexpected, and the advantage that surpasses existing insecticidal technology is provided.
Embodiment 19
The synergistic effect of plants essential oil and Chrysanthemum ester antagonism prodenia litura
The mixture of 5-admixture (thymol, trans-anethole, α-terpineol, eugenol and citronellal) and potential synergist are tested, and are administered on the cabbage leaf floral disc that is immersed in 1% the emulsion, and each processing has 4 leaf floral discs.10 3 the biggest (the 2nd age) Spodoptera litura larvae are arranged on each floral disc.Potential synergist and insecticide are dissolved in the prominent literary composition of THFA/ 20 (carrier/emulsifier), and activity component concentration is 10%; Mix with the 5-admixture, the ratio of synergist and 5-admixture is 1: 10.Observe the lethality of 24 hours and 48 hours.The everywhere pats row 5 times, uses 50 larvas (n=250) at every turn.The result is as follows.
Conclusion: in this experiment, be 10: 1 o'clock in ratio, the 5-admixture is by cis-jasmone and the synergy of chrysanthemum ester.In fact in the 5-of synergy admixture is handled blade is not damaged, damage is 30% when the 5-admixture is only arranged, and damage is greater than 80% in remaining is handled.The leaf of control group is withered fully at 48 hours.
Embodiment 20
The synergistic effect of benzylalcohol and Dalmatian chrysanthemum antagonism prodenia litura
The mixture of 5-admixture and synergist is applied on the cabbage that immerses in 1% emulsion to measure its influence.Each processing has 4 leaves; 10 3 the biggest (the 2nd age) Spodoptera litura larvae are arranged on every.Potential synergist and insecticide are dissolved in the prominent literary composition 20 of THFA/, and active component concentration is 10%; With 1: 10 ratio (synergist: the 5-admixture) mix with the 5-admixture.In this experiment, 6: 1 percentage of T HFA/ tweens are used as the carrier/emulsifier of Dalmatian chrysanthemum (20% pure Dalmatian chrysanthemum) and other test compounds.The sample size of each processing is 40 (parallel 4 times, each 10 insects) prodenia litura.The result is as follows.
| Handle | Lethality % 24 hours |
| Contrast (THFA/ polysorbas20) | 10 |
| Dalmatian chrysanthemum 40: 1 (ratio of components) | 37.5 |
| Dalmatian chrysanthemum 20: 1 | 40 |
| Dalmatian chrysanthemum 10: 1 | 100 |
| Benzylalcohol | 15 |
| Benzylalcohol+Dalmatian chrysanthemum 40: 1 | 72.5 |
| Benzylalcohol+Dalmatian chrysanthemum 20: 1 | 82.5 |
| Benzylalcohol+Dalmatian chrysanthemum 10: 1 | 100 |
Conclusion: as if benzylalcohol can the synergy Dalmatian chrysanthemum, at least when low-level active component.Effect is difficult to distinguish at high proportion the time, because lethality is 100% when only Dalmatian chrysanthemum being arranged.These data are not expected, and the advantage that surpasses existing insecticidal technology is provided.
Embodiment 21
The synergy and the residual effect of plants essential oil and conventional pesticides, synergist and signal transduction modulator
Glass jar is handled with the acetone soln of variable concentrations chemicals to be measured.Allow the acetone volatilization remove, and U.S. cockroach is exposed in this glass jar.Each orthogonal processing is used 5 cockroaches, and each is handled parallel twice.This experiment repeats 2 times.The result is as follows.
These digital proofs plants essential oil and Dalmatian chrysanthemum and signal transduction modulator have synergy and residual toxicity at very low concentration level.This synergy and residual toxicity are unexpected and important.But the signal transduction modulator is traditional agricultural chemicals and the chrysanthemum ester of synergy also, as here with Dalmatian chrysanthemum and chrysanthemum monocarboxylate.
Embodiment 22
The synergy of benzylalcohol and trans-anethole and residual effect
Glass jar is handled with the acetone soln of the chemicals to be measured of variable concentrations.Allow the acetone volatilization remove, and U.S. cockroach is exposed in this glass jar.Each orthogonal processing is used 5 cockroaches, and each is handled parallel twice.This experiment repeats 2 times.The result is as follows.
These digital proofs plants essential oil and Dalmatian chrysanthemum and signal transduction modulator together the time, have synergy and residual toxicity at very low concentration level.This synergy and residual toxicity are unexpected and important.But the signal transduction modulator is traditional insecticide and the chrysanthemum ester of synergy also, as here to Dalmatian chrysanthemum and chrysanthemum monocarboxylate.
Embodiment 23
The synergy of thymol and Dalmatian chrysanthemum and signal transduction modulator and residual effect
Glass jar is handled with the acetone soln of the chemicals to be measured of variable concentrations.Allow the acetone volatilization remove, and U.S. cockroach is exposed in this glass jar.Each orthogonal processing is used 5 cockroaches, and each is handled parallel twice.This experiment repeats 2 times.The result is as follows.
After exposing 15 fens kinds, all cockroaches in all 3 kinds of products go off at full score, and can not walk on the wall of cylinder.These data show thymol and other plants essential oil and Dalmatian chrysanthemum and signal transduction modulator when admixing together, have synergy and residual toxicity at very low concentration level.This synergy and residual toxicity are unexpected and important.
Embodiment 24
The synergistic effect of propionic acid phenylethylester and plants essential oil and thymol
In this Bioexperiment, thymol or 5-mix its thing (thymol, trans-anethole, eugenol, α-terpineol and citronellal) aqueous emulsions (1: 400 active component: water) with the propionic acid phenylethylester or do not contain propionic acid phenethyl ester (PEP) and be administered on the cabbage blade, 3 age Spodoptera litura larvae be exposed to and handle on the dried blade.Test parallel 5 times, each 10 larvas, this test repeats 2 times.Expose and observe lethality after 24 hours.The result is as follows.
| Handle | Lethality % 24 hours |
| Contrast | 1 |
| The 5-admixture | 73 |
| PEP | 8 |
| 5-admixture+PEP (1: 1) | 84 |
| Thymol | 98 |
| PEP | 2 |
| Thymol+PEP (1: 1) | 84 |
Conclusion: propionic acid phenethyl ester demonstrates synergy thymol and 5-admixture.PEP can be used as the thinner of thymol and 5-admixture, does not have significant loss of activity.These data are unexpected, and the advantage that surpasses existing insecticide technology is provided.
By above-mentioned discussion as can be seen, synergy and the residual mixture according to reactive compound of the present invention is better than the known insecticide/reactive compound that is used for family and farming region Pest Control routinely significantly.The insecticidal effect significance ground (with surprisingly) of the synergy of the new especially of reactive compound of the present invention and residual mixture is higher than the summation of the effect of single reactive compound.
Although the embodiment as illustration of the present invention has been done detailed description, still should be realized that and the invention is not restricted to these clear and definite embodiments, under the situation that deviates from the defined scope of the invention of claims and spirit, those skilled in the art can carry out various changes and improvements.
Claims (6)
1. insecticides, said composition contains the active insecticidal components of desinsection acceptable carrier and insecticidal effective dose, and this active insecticidal components contains Dalmatian chrysanthemum and propionic acid phenylethylester.
2. insecticides, said composition contains the active insecticidal components of desinsection acceptable carrier and insecticidal effective dose, and this active insecticidal components is made up of Dalmatian chrysanthemum and propionic acid phenylethylester.
3. claim 1 or 2 insecticides, wherein active insecticidal components disturbs the neurotransmission of invertebrate.
4. claim 1 or 2 insecticides, wherein active insecticidal components disturbs the octopamine receptor site of invertebrate.
5. claim 1 or 2 insecticides, wherein Dalmatian chrysanthemum is selected from 1: 50 with the ratio of propionic acid phenylethylester, and 1: 40,1: 30,1: 20,1: 10 and 1: 5.
6. the method for a Pest Control, this method comprises that the insecticides with the claim 1 of insecticidal effective dose or 2 is administered to the zone that needs Pest Control.
Applications Claiming Priority (6)
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| US9446398P | 1998-07-28 | 1998-07-28 | |
| US60/094,463 | 1998-07-28 | ||
| US10061398P | 1998-09-16 | 1998-09-16 | |
| US60/100,613 | 1998-09-16 | ||
| US12280399P | 1999-03-03 | 1999-03-03 | |
| US60/122,803 | 1999-03-03 |
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| CNB998090972A Division CN100388888C (en) | 1998-07-28 | 1999-07-28 | Synergistic and residual pesticidal compositions contaiing plant essential oils |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101317591A true CN101317591A (en) | 2008-12-10 |
Family
ID=27377746
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| Application Number | Title | Priority Date | Filing Date |
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| CNA2008100885103A Pending CN101317591A (en) | 1998-07-28 | 1999-07-28 | Synergistic and residual pesticidal compositions containing plant essential oils. |
| CNB998090972A Expired - Fee Related CN100388888C (en) | 1998-07-28 | 1999-07-28 | Synergistic and residual pesticidal compositions contaiing plant essential oils |
| CNA2008100885090A Pending CN101317590A (en) | 1998-07-28 | 1999-07-28 | Synergistic and residual pesticidal compositions containing plant essential oils. |
| CNA2008100885086A Pending CN101317589A (en) | 1998-07-28 | 1999-07-28 | Synergistic and residual pesticidal compositions containing plant essential oils. |
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| CNB998090972A Expired - Fee Related CN100388888C (en) | 1998-07-28 | 1999-07-28 | Synergistic and residual pesticidal compositions contaiing plant essential oils |
| CNA2008100885090A Pending CN101317590A (en) | 1998-07-28 | 1999-07-28 | Synergistic and residual pesticidal compositions containing plant essential oils. |
| CNA2008100885086A Pending CN101317589A (en) | 1998-07-28 | 1999-07-28 | Synergistic and residual pesticidal compositions containing plant essential oils. |
Country Status (20)
| Country | Link |
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| EP (4) | EP1779730A3 (en) |
| JP (1) | JP2002521406A (en) |
| KR (1) | KR100912554B1 (en) |
| CN (4) | CN101317591A (en) |
| AT (1) | ATE306190T1 (en) |
| AU (1) | AU5237999A (en) |
| BR (1) | BR9912691A (en) |
| CA (1) | CA2338361A1 (en) |
| CZ (1) | CZ2001304A3 (en) |
| DE (1) | DE69928672T2 (en) |
| ES (1) | ES2247823T3 (en) |
| HU (1) | HUP0103024A2 (en) |
| ID (1) | ID28727A (en) |
| IL (1) | IL140849A0 (en) |
| MX (1) | MXPA01000697A (en) |
| NO (1) | NO20010466L (en) |
| PL (1) | PL345684A1 (en) |
| TR (1) | TR200100151T2 (en) |
| WO (1) | WO2000005964A1 (en) |
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- 1999-07-28 EP EP07002824A patent/EP1779730A3/en not_active Withdrawn
- 1999-07-28 CN CNA2008100885103A patent/CN101317591A/en active Pending
- 1999-07-28 DE DE69928672T patent/DE69928672T2/en not_active Expired - Lifetime
- 1999-07-28 HU HU0103024A patent/HUP0103024A2/en unknown
- 1999-07-28 JP JP2000561831A patent/JP2002521406A/en active Pending
- 1999-07-28 BR BR9912691-5A patent/BR9912691A/en not_active Application Discontinuation
- 1999-07-28 TR TR2001/00151T patent/TR200100151T2/en unknown
- 1999-07-28 ID IDW20010486A patent/ID28727A/en unknown
- 1999-07-28 MX MXPA01000697A patent/MXPA01000697A/en not_active IP Right Cessation
- 1999-07-28 EP EP07002822A patent/EP1779728A3/en not_active Withdrawn
- 1999-07-28 AT AT99937574T patent/ATE306190T1/en not_active IP Right Cessation
- 1999-07-28 WO PCT/US1999/017097 patent/WO2000005964A1/en active IP Right Grant
- 1999-07-28 CN CNB998090972A patent/CN100388888C/en not_active Expired - Fee Related
- 1999-07-28 ES ES99937574T patent/ES2247823T3/en not_active Expired - Lifetime
- 1999-07-28 EP EP99937574A patent/EP1102540B1/en not_active Expired - Lifetime
- 1999-07-28 CZ CZ2001304A patent/CZ2001304A3/en unknown
- 1999-07-28 AU AU52379/99A patent/AU5237999A/en not_active Abandoned
- 1999-07-28 CN CNA2008100885090A patent/CN101317590A/en active Pending
- 1999-07-28 CA CA002338361A patent/CA2338361A1/en not_active Abandoned
- 1999-07-28 CN CNA2008100885086A patent/CN101317589A/en active Pending
- 1999-07-28 IL IL14084999A patent/IL140849A0/en not_active IP Right Cessation
- 1999-07-28 PL PL99345684A patent/PL345684A1/en not_active Application Discontinuation
- 1999-07-28 EP EP07002823A patent/EP1779729A3/en not_active Withdrawn
- 1999-07-28 KR KR1020017001171A patent/KR100912554B1/en not_active IP Right Cessation
-
2001
- 2001-01-26 ZA ZA200100754A patent/ZA200100754B/en unknown
- 2001-01-26 NO NO20010466A patent/NO20010466L/en not_active Application Discontinuation
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102823584A (en) * | 2012-08-24 | 2012-12-19 | 中国热带农业科学院环境与植物保护研究所 | Plant-source hot fogging concentrate for preventing and controlling whitefly insects and preparation method thereof |
| CN102823584B (en) * | 2012-08-24 | 2014-07-09 | 中国热带农业科学院环境与植物保护研究所 | Plant-source hot fogging concentrate for preventing and controlling whitefly insects and preparation method thereof |
| CN115191433A (en) * | 2022-07-22 | 2022-10-18 | 中国人民解放军海军特色医学中心 | Application of functional additive in cockroach killing composition, cockroach killing composition and application of cockroach killing composition |
| CN115191433B (en) * | 2022-07-22 | 2024-05-28 | 中国人民解放军海军特色医学中心 | Application of functional auxiliary agent in cockroach killing composition, cockroach killing composition and application thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| AU5237999A (en) | 2000-02-21 |
| EP1779728A2 (en) | 2007-05-02 |
| EP1779728A3 (en) | 2007-09-05 |
| BR9912691A (en) | 2001-10-09 |
| HUP0103024A2 (en) | 2002-01-28 |
| ZA200100754B (en) | 2002-01-28 |
| ATE306190T1 (en) | 2005-10-15 |
| DE69928672D1 (en) | 2006-01-05 |
| EP1779729A2 (en) | 2007-05-02 |
| WO2000005964A1 (en) | 2000-02-10 |
| JP2002521406A (en) | 2002-07-16 |
| EP1102540A1 (en) | 2001-05-30 |
| CN100388888C (en) | 2008-05-21 |
| IL140849A0 (en) | 2002-02-10 |
| NO20010466D0 (en) | 2001-01-26 |
| CN1322110A (en) | 2001-11-14 |
| MXPA01000697A (en) | 2002-04-08 |
| ID28727A (en) | 2001-06-28 |
| ES2247823T3 (en) | 2006-03-01 |
| NO20010466L (en) | 2001-03-27 |
| CA2338361A1 (en) | 2000-02-10 |
| KR100912554B1 (en) | 2009-08-19 |
| EP1102540B1 (en) | 2005-10-12 |
| CN101317589A (en) | 2008-12-10 |
| EP1779730A3 (en) | 2007-09-05 |
| EP1779729A3 (en) | 2007-09-05 |
| CZ2001304A3 (en) | 2001-12-12 |
| TR200100151T2 (en) | 2001-05-21 |
| KR20010079574A (en) | 2001-08-22 |
| PL345684A1 (en) | 2002-01-02 |
| DE69928672T2 (en) | 2006-04-20 |
| CN101317590A (en) | 2008-12-10 |
| EP1779730A2 (en) | 2007-05-02 |
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Open date: 20081210 |