CN101309905A - 取代的异吲哚酮及其作为代谢型谷氨酸受体增效剂的用途 - Google Patents
取代的异吲哚酮及其作为代谢型谷氨酸受体增效剂的用途 Download PDFInfo
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- CN101309905A CN101309905A CNA2006800353774A CN200680035377A CN101309905A CN 101309905 A CN101309905 A CN 101309905A CN A2006800353774 A CNA2006800353774 A CN A2006800353774A CN 200680035377 A CN200680035377 A CN 200680035377A CN 101309905 A CN101309905 A CN 101309905A
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- alkyl
- dihydro
- isoindole
- methyl
- benzyl
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Classifications
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- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
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- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/46—Iso-indoles; Hydrogenated iso-indoles with an oxygen atom in position 1
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
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- Organic Chemistry (AREA)
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- Chemical Kinetics & Catalysis (AREA)
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- General Chemical & Material Sciences (AREA)
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- Ophthalmology & Optometry (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US2005/028760 WO2006020879A1 (en) | 2004-08-13 | 2005-08-12 | Isoindolone compounds and their use as metabotropic glutamate receptor potentiators |
| USPCT/US2005/028760 | 2005-08-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101309905A true CN101309905A (zh) | 2008-11-19 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2006800353774A Pending CN101309905A (zh) | 2005-08-12 | 2006-02-15 | 取代的异吲哚酮及其作为代谢型谷氨酸受体增效剂的用途 |
| CNA2006800363117A Pending CN101277934A (zh) | 2005-08-12 | 2006-02-15 | 使代谢型谷氨酸-受体-增效的异吲哚酮 |
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| CNA2006800363117A Pending CN101277934A (zh) | 2005-08-12 | 2006-02-15 | 使代谢型谷氨酸-受体-增效的异吲哚酮 |
Country Status (4)
| Country | Link |
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| EP (2) | EP1912939A1 (https=) |
| JP (2) | JP5031745B2 (https=) |
| CN (2) | CN101309905A (https=) |
| WO (2) | WO2007021308A1 (https=) |
Cited By (5)
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| CN102791706A (zh) * | 2010-01-07 | 2012-11-21 | 阿斯利康(瑞典)有限公司 | 制备亲代谢性谷氨酸受体正向变构调节剂-874的方法 |
| CN105837557A (zh) * | 2016-05-05 | 2016-08-10 | 青岛辰达生物科技有限公司 | 一种用于治疗ii型糖尿病的阿格列汀的制备方法 |
| CN106279182A (zh) * | 2016-07-29 | 2017-01-04 | 中国药科大学 | 一种吡咯并[2，1‑a]异吲哚酮类化合物及其合成方法 |
| CN110498759A (zh) * | 2019-09-12 | 2019-11-26 | 天津瑞岭化工有限公司 | 异吲哚啉酮类化合物的合成方法 |
| CN111148744A (zh) * | 2017-09-26 | 2020-05-12 | 布拉格玛治疗公司 | 作为mglur7调节剂的新的杂环化合物 |
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2006
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- 2006-02-15 JP JP2008525976A patent/JP5031745B2/ja not_active Expired - Fee Related
- 2006-02-15 CN CNA2006800363117A patent/CN101277934A/zh active Pending
- 2006-02-15 WO PCT/US2006/005246 patent/WO2007021308A1/en not_active Ceased
- 2006-02-15 EP EP06720758A patent/EP1912939A1/en not_active Withdrawn
- 2006-02-15 WO PCT/US2006/005247 patent/WO2007021309A1/en not_active Ceased
- 2006-02-15 JP JP2008525977A patent/JP2009509921A/ja active Pending
- 2006-02-15 EP EP06720759A patent/EP1912940A1/en not_active Withdrawn
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102791706A (zh) * | 2010-01-07 | 2012-11-21 | 阿斯利康(瑞典)有限公司 | 制备亲代谢性谷氨酸受体正向变构调节剂-874的方法 |
| CN105837557A (zh) * | 2016-05-05 | 2016-08-10 | 青岛辰达生物科技有限公司 | 一种用于治疗ii型糖尿病的阿格列汀的制备方法 |
| CN106279182A (zh) * | 2016-07-29 | 2017-01-04 | 中国药科大学 | 一种吡咯并[2，1‑a]异吲哚酮类化合物及其合成方法 |
| CN111148744A (zh) * | 2017-09-26 | 2020-05-12 | 布拉格玛治疗公司 | 作为mglur7调节剂的新的杂环化合物 |
| CN110498759A (zh) * | 2019-09-12 | 2019-11-26 | 天津瑞岭化工有限公司 | 异吲哚啉酮类化合物的合成方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2009509921A (ja) | 2009-03-12 |
| JP5031745B2 (ja) | 2012-09-26 |
| EP1912940A1 (en) | 2008-04-23 |
| EP1912939A1 (en) | 2008-04-23 |
| JP2009509920A (ja) | 2009-03-12 |
| WO2007021308A1 (en) | 2007-02-22 |
| WO2007021309A1 (en) | 2007-02-22 |
| CN101277934A (zh) | 2008-10-01 |
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