CN101223133B - 双（硫代酰肼酰胺）盐的合成 - Google Patents

双（硫代酰肼酰胺）盐的合成 Download PDF

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Publication number
CN101223133B
CN101223133B CN2006800170928A CN200680017092A CN101223133B CN 101223133 B CN101223133 B CN 101223133B CN 2006800170928 A CN2006800170928 A CN 2006800170928A CN 200680017092 A CN200680017092 A CN 200680017092A CN 101223133 B CN101223133 B CN 101223133B
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methyl
alkali
organic solvent
phenyl
compound
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Expired - Fee Related
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CN2006800170928A
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English (en)
Chinese (zh)
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CN101223133A (zh
Inventor
陈寿军
夏志强
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Synta Phamaceuticals Corp
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Synta Phamaceuticals Corp
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00—Thiocarboxylic acids
    • C07C327/38—Amides of thiocarboxylic acids
    • C07C327/56—Amides of thiocarboxylic acids having nitrogen atoms of thiocarboxamide groups further bound to another hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN2006800170928A 2005-05-16 2006-05-11 双（硫代酰肼酰胺）盐的合成 Expired - Fee Related CN101223133B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US68126305P 2005-05-16 2005-05-16
US60/681,263 2005-05-16
PCT/US2006/018653 WO2006124736A2 (en) 2005-05-16 2006-05-11 Synthesis of bis(thio-hydrazide amide) salts

Publications (2)

Publication Number Publication Date
CN101223133A CN101223133A (zh) 2008-07-16
CN101223133B true CN101223133B (zh) 2012-02-29

Family

ID=37057197

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2006800170928A Expired - Fee Related CN101223133B (zh) 2005-05-16 2006-05-11 双（硫代酰肼酰胺）盐的合成

Country Status (16)

Country Link
US (1) US7709683B2 (https=)
EP (1) EP1888520A2 (https=)
JP (1) JP2008540658A (https=)
KR (1) KR20080008399A (https=)
CN (1) CN101223133B (https=)
AU (1) AU2006247470B2 (https=)
BR (1) BRPI0611262A2 (https=)
CA (1) CA2607890A1 (https=)
IL (1) IL187056A (https=)
MX (1) MX2007014314A (https=)
NO (1) NO20075707L (https=)
NZ (1) NZ563124A (https=)
RU (1) RU2407734C2 (https=)
TW (1) TWI387579B (https=)
WO (1) WO2006124736A2 (https=)
ZA (1) ZA200709395B (https=)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
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TWI332943B (en) 2001-07-10 2010-11-11 Synta Pharmaceuticals Corp Taxol enhancer compounds
TWI252847B (en) * 2001-07-10 2006-04-11 Synta Pharmaceuticals Corp Synthesis of taxol enhancers
TWI297335B (en) 2001-07-10 2008-06-01 Synta Pharmaceuticals Corp Taxol enhancer compounds
TWI330079B (en) * 2003-01-15 2010-09-11 Synta Pharmaceuticals Corp Treatment for cancers
PL1781604T3 (pl) 2004-06-23 2014-01-31 Synta Pharmaceuticals Corp Sole bis(tiohydrazydoamidu) do leczenia nowotworów
AU2005306471B2 (en) * 2004-11-19 2009-12-17 Synta Pharmaceuticals Corp. Bis(thio-hydrazide amides) for increasing Hsp70 expression
US20090042991A1 (en) * 2005-04-15 2009-02-12 James Barsoum Methods of increasing natural killer cell activity for therapy
MX2007012688A (es) 2005-04-15 2008-03-14 Synta Pharmaceuticals Corp Terapia de combinacion para el cancer con compuestos de bis(tiohidrazida) amida.
US7678832B2 (en) * 2005-08-16 2010-03-16 Synta Pharmaceuticals Corp. Bis(thio-hydrazide amide) formulation
WO2008024299A2 (en) * 2006-08-21 2008-02-28 Synta Pharmaceuticals Corp. Combination with bis(thiohydrazide amides) for treating cancer
RU2475478C2 (ru) 2006-08-21 2013-02-20 Синта Фармасьютиклз Корп. Соединения для лечения пролиферативных расстройств
AU2007288340A1 (en) * 2006-08-21 2008-02-28 Synta Pharmaceuticals Corp. Bis (thiohydrazide amides) for treating melanoma
EP2063878A2 (en) * 2006-08-21 2009-06-03 Synta Pharmaceuticals Corporation Bis(thiohydrazide amides) for use in preventing or delaying the recurrence of melanoma
JP2010502616A (ja) * 2006-08-31 2010-01-28 シンタ ファーマシューティカルズ コーポレーション 癌を治療するためのビス（チオヒドラジドアミド）の組み合わせ
US9498528B2 (en) * 2006-09-13 2016-11-22 Genzyme Corporation Treatment of multiple sclerosis (MS)
WO2008033494A2 (en) 2006-09-15 2008-03-20 Synta Pharmaceuticals Corp. Purification of bis(thiohydrazide amides)
WO2009064374A2 (en) 2007-11-09 2009-05-22 Synta Pharmaceuticals Corp. Oral formulations of bis(thiohydrazide amides)
US8581004B2 (en) 2008-02-21 2013-11-12 Synta Pharmaceuticals Corp. Compounds for treating proliferative disorders
US8633323B2 (en) * 2008-03-31 2014-01-21 Synta Pharmaceuticals Corp. Process for preparing bis(thiohydrazide amides)
MX2011004114A (es) 2008-10-22 2011-08-15 Synta Pharmaceuticals Corp Complejos de metales de transicion de un compuesto bis (tiohidrazida amida).
NZ592400A (en) 2008-10-22 2013-09-27 Synta Pharmaceuticals Corp Transition metal complexes of bis[thiohydrazide amide] compounds
US8525776B2 (en) * 2008-10-27 2013-09-03 Lenovo (Singapore) Pte. Ltd Techniques for controlling operation of a device with a virtual touchscreen
EP2370402A2 (en) 2008-12-01 2011-10-05 Synta Pharmaceuticals Corp. Compounds for treating proliferative disorders
WO2011069159A2 (en) 2009-12-04 2011-06-09 Synta Pharmaceuticals Corp. Bis[thiohydrazide amide] compounds for treating leukemia
US8815945B2 (en) 2010-04-20 2014-08-26 Masazumi Nagai Use of bis [thiohydrazide amide] compounds such as elesclomol for treating cancers

Citations (1)

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CN1553894A (zh) * 2001-07-10 2004-12-08 ����ҽҩƷ���޹�˾ 紫杉醇增强化合物

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FR2097737A5 (en) 1970-07-14 1972-03-03 Berlin Chemie Veb Virustatic 4-substd 1-acylthiosemicarbazides -from carboxylic acid - hydrazide and isothiocyanates or from carboxylic acid chloride and 4-
DE2037257A1 (en) 1970-07-28 1972-02-03 Farbwerke Hoechst AG, vorm. Meister Lucius & Brüning, 6000 Frankfurt Poly-(5-amino-1,3,4-thiadiazol-2-yl) derivs prepn - intermediates for drug and polymer prodn
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FR2697752B1 (fr) 1992-11-10 1995-04-14 Rhone Poulenc Rorer Sa Compositions antitumorales contenant des dérivés du taxane.
ATE184613T1 (de) 1995-09-22 1999-10-15 Novo Nordisk As Varianten des grünen fluoreszenzproteins, gfp
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TW479053B (en) 1998-10-19 2002-03-11 Agro Kanesho Co Ltd Hydrazineoxoacetamide derivatives and pesticides
ES2161594B1 (es) 1998-12-17 2003-04-01 Servier Lab Nuevos derivados de la hidrazida, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen.
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EP1164126A1 (de) 2000-06-16 2001-12-19 Basf Aktiengesellschaft Salicylsäurehydrazid-Derivate, Verfahren und Zwischenprodukte zu ihrer Herstellung, sie enthaltende Mittel und ihre Verwendung zur Bekämpfung von Schadpilzen
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US6602907B1 (en) 2001-06-08 2003-08-05 University Of Central Florida Treatment of breast cancer
TWI252847B (en) * 2001-07-10 2006-04-11 Synta Pharmaceuticals Corp Synthesis of taxol enhancers
TWI332943B (en) 2001-07-10 2010-11-11 Synta Pharmaceuticals Corp Taxol enhancer compounds
US6924312B2 (en) * 2001-07-10 2005-08-02 Synta Pharmaceuticals Corp. Taxol enhancer compounds
TW200408407A (en) * 2001-11-30 2004-06-01 Dana Farber Cancer Inst Inc Methods and compositions for modulating the immune system and uses thereof
TWI330079B (en) 2003-01-15 2010-09-11 Synta Pharmaceuticals Corp Treatment for cancers
PL1781604T3 (pl) * 2004-06-23 2014-01-31 Synta Pharmaceuticals Corp Sole bis(tiohydrazydoamidu) do leczenia nowotworów
WO2006033913A2 (en) 2004-09-16 2006-03-30 Synta Pharmaceuticals Corp. Bis (thio-hydrazide amides) for treament of hyperplasia
AU2005306471B2 (en) * 2004-11-19 2009-12-17 Synta Pharmaceuticals Corp. Bis(thio-hydrazide amides) for increasing Hsp70 expression
WO2006113493A2 (en) 2005-04-15 2006-10-26 Synta Pharmaceuticals Corp. Methods of determining cancer prognosis via natural killer cell activity
US20090042991A1 (en) 2005-04-15 2009-02-12 James Barsoum Methods of increasing natural killer cell activity for therapy
MX2007012688A (es) 2005-04-15 2008-03-14 Synta Pharmaceuticals Corp Terapia de combinacion para el cancer con compuestos de bis(tiohidrazida) amida.
US7678832B2 (en) * 2005-08-16 2010-03-16 Synta Pharmaceuticals Corp. Bis(thio-hydrazide amide) formulation

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1553894A (zh) * 2001-07-10 2004-12-08 ����ҽҩƷ���޹�˾ 紫杉醇增强化合物

Also Published As

Publication number Publication date
WO2006124736A2 (en) 2006-11-23
IL187056A0 (en) 2008-02-09
RU2007144216A (ru) 2009-06-27
WO2006124736A3 (en) 2007-03-29
NZ563124A (en) 2010-12-24
IL187056A (en) 2013-10-31
JP2008540658A (ja) 2008-11-20
ZA200709395B (en) 2008-10-29
AU2006247470A1 (en) 2006-11-23
US7709683B2 (en) 2010-05-04
TWI387579B (zh) 2013-03-01
US20060270873A1 (en) 2006-11-30
TW200722411A (en) 2007-06-16
CA2607890A1 (en) 2006-11-23
EP1888520A2 (en) 2008-02-20
NO20075707L (no) 2007-12-11
MX2007014314A (es) 2008-02-11
KR20080008399A (ko) 2008-01-23
RU2407734C2 (ru) 2010-12-27
AU2006247470B2 (en) 2010-04-01
CN101223133A (zh) 2008-07-16
BRPI0611262A2 (pt) 2010-08-24

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Granted publication date: 20120229

Termination date: 20130511