ZA200709395B - Synthesis of bis(thio-hydrazide amide) salts - Google Patents

Synthesis of bis(thio-hydrazide amide) salts

Info

Publication number
ZA200709395B
ZA200709395B ZA200709395A ZA200709395A ZA200709395B ZA 200709395 B ZA200709395 B ZA 200709395B ZA 200709395 A ZA200709395 A ZA 200709395A ZA 200709395 A ZA200709395 A ZA 200709395A ZA 200709395 B ZA200709395 B ZA 200709395B
Authority
ZA
South Africa
Prior art keywords
thio
bis
synthesis
salts
hydrazide amide
Prior art date
Application number
ZA200709395A
Other languages
English (en)
Inventor
Chen Shoujun
Xia Zhi-Qiang
Original Assignee
Synta Pharmaceuticals Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synta Pharmaceuticals Corp filed Critical Synta Pharmaceuticals Corp
Publication of ZA200709395B publication Critical patent/ZA200709395B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00—Thiocarboxylic acids
    • C07C327/38—Amides of thiocarboxylic acids
    • C07C327/56—Amides of thiocarboxylic acids having nitrogen atoms of thiocarboxamide groups further bound to another hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
ZA200709395A 2005-05-16 2007-10-31 Synthesis of bis(thio-hydrazide amide) salts ZA200709395B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US68126305P 2005-05-16 2005-05-16

Publications (1)

Publication Number Publication Date
ZA200709395B true ZA200709395B (en) 2008-10-29

Family

ID=37057197

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200709395A ZA200709395B (en) 2005-05-16 2007-10-31 Synthesis of bis(thio-hydrazide amide) salts

Country Status (16)

Country Link
US (1) US7709683B2 (https=)
EP (1) EP1888520A2 (https=)
JP (1) JP2008540658A (https=)
KR (1) KR20080008399A (https=)
CN (1) CN101223133B (https=)
AU (1) AU2006247470B2 (https=)
BR (1) BRPI0611262A2 (https=)
CA (1) CA2607890A1 (https=)
IL (1) IL187056A (https=)
MX (1) MX2007014314A (https=)
NO (1) NO20075707L (https=)
NZ (1) NZ563124A (https=)
RU (1) RU2407734C2 (https=)
TW (1) TWI387579B (https=)
WO (1) WO2006124736A2 (https=)
ZA (1) ZA200709395B (https=)

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TWI332943B (en) * 2001-07-10 2010-11-11 Synta Pharmaceuticals Corp Taxol enhancer compounds
TWI252847B (en) 2001-07-10 2006-04-11 Synta Pharmaceuticals Corp Synthesis of taxol enhancers
TWI297335B (en) 2001-07-10 2008-06-01 Synta Pharmaceuticals Corp Taxol enhancer compounds
TWI330079B (en) 2003-01-15 2010-09-11 Synta Pharmaceuticals Corp Treatment for cancers
CN1993318B (zh) 2004-06-23 2012-10-03 Synta医药公司 用于治疗癌症的双（硫代-酰肼酰胺）盐
JP5204489B2 (ja) * 2004-11-19 2013-06-05 シンタ ファーマスーティカルズ コーポレイション Ｈｓｐ７０発現を増加するためのビス（チオ‐ヒドラジドアミド）
EP1871350A1 (en) * 2005-04-15 2008-01-02 Synta Pharmaceuticals Corporation Methods of increasing natural killer cell activity for therapy
WO2006113695A1 (en) * 2005-04-15 2006-10-26 Synta Pharmaceuticals Corp. Combination cancer therapy with bis(thiohydrazide) amide compounds
KR20080035642A (ko) * 2005-08-16 2008-04-23 신타 파마슈티칼스 코프. 비스(티오-히드라지드 아미드) 제제
US20100068174A1 (en) * 2006-08-21 2010-03-18 Synta Pharmaceuticals Corp. Combination with bis (thiohydrazide amides) for treating cancer
TWI440632B (zh) 2006-08-21 2014-06-11 Synta Pharmaceuticals Corp 用於治療增生性疾病的化合物
EP2061451A2 (en) * 2006-08-21 2009-05-27 Synta Pharmaceuticals Corporation Bis(thiohydrazide amides) for treating melanoma
WO2008024301A2 (en) * 2006-08-21 2008-02-28 Synta Pharmaceuticals Corp. Bis(thiohydrazide amides) for use in preventing or delaying the recurrence of melanoma
JP2010502616A (ja) * 2006-08-31 2010-01-28 シンタ ファーマシューティカルズ コーポレーション 癌を治療するためのビス（チオヒドラジドアミド）の組み合わせ
US9498528B2 (en) * 2006-09-13 2016-11-22 Genzyme Corporation Treatment of multiple sclerosis (MS)
US7645904B2 (en) 2006-09-15 2010-01-12 Synta Pharmaceuticals Corp. Purification of bis(thiohydrazide amides)
WO2009064374A2 (en) 2007-11-09 2009-05-22 Synta Pharmaceuticals Corp. Oral formulations of bis(thiohydrazide amides)
WO2009105257A1 (en) 2008-02-21 2009-08-27 Synta Pharmaceuticals Corp. Compounds for treating proliferative disorders
WO2009123704A2 (en) * 2008-03-31 2009-10-08 Synta Pharmaceuticals Corp. Process for preparing bis(thiohydrazide amides)
CN102256937B (zh) 2008-10-22 2014-12-17 辛塔医药品有限公司 双[硫代酰肼酰胺]化合物的过渡金属络合物
MX2011004114A (es) 2008-10-22 2011-08-15 Synta Pharmaceuticals Corp Complejos de metales de transicion de un compuesto bis (tiohidrazida amida).
US8525776B2 (en) * 2008-10-27 2013-09-03 Lenovo (Singapore) Pte. Ltd Techniques for controlling operation of a device with a virtual touchscreen
JP5631327B2 (ja) 2008-12-01 2014-11-26 シンタ ファーマシューティカルズ コーポレーション 増殖性障害を治療するための化合物
US8822532B2 (en) 2009-12-04 2014-09-02 Synta Pharmaceuticals Corp. Bis[thiohydrazide amide] compounds for treating leukemia
EP2560627A1 (en) 2010-04-20 2013-02-27 Synta Pharmaceuticals Corp. Use of bis [thiohydrazide amide]compounds such as elesclomol for treating cancers

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US6602907B1 (en) 2001-06-08 2003-08-05 University Of Central Florida Treatment of breast cancer
TWI252847B (en) 2001-07-10 2006-04-11 Synta Pharmaceuticals Corp Synthesis of taxol enhancers
TWI297335B (en) 2001-07-10 2008-06-01 Synta Pharmaceuticals Corp Taxol enhancer compounds
TWI332943B (en) 2001-07-10 2010-11-11 Synta Pharmaceuticals Corp Taxol enhancer compounds
US6924312B2 (en) 2001-07-10 2005-08-02 Synta Pharmaceuticals Corp. Taxol enhancer compounds
TW200408407A (en) 2001-11-30 2004-06-01 Dana Farber Cancer Inst Inc Methods and compositions for modulating the immune system and uses thereof
TWI330079B (en) 2003-01-15 2010-09-11 Synta Pharmaceuticals Corp Treatment for cancers
CN1993318B (zh) 2004-06-23 2012-10-03 Synta医药公司 用于治疗癌症的双（硫代-酰肼酰胺）盐
WO2006033913A2 (en) 2004-09-16 2006-03-30 Synta Pharmaceuticals Corp. Bis (thio-hydrazide amides) for treament of hyperplasia
JP5204489B2 (ja) 2004-11-19 2013-06-05 シンタ ファーマスーティカルズ コーポレイション Ｈｓｐ７０発現を増加するためのビス（チオ‐ヒドラジドアミド）
WO2006113695A1 (en) 2005-04-15 2006-10-26 Synta Pharmaceuticals Corp. Combination cancer therapy with bis(thiohydrazide) amide compounds
EP1871350A1 (en) 2005-04-15 2008-01-02 Synta Pharmaceuticals Corporation Methods of increasing natural killer cell activity for therapy
WO2006113493A2 (en) 2005-04-15 2006-10-26 Synta Pharmaceuticals Corp. Methods of determining cancer prognosis via natural killer cell activity
KR20080035642A (ko) 2005-08-16 2008-04-23 신타 파마슈티칼스 코프. 비스(티오-히드라지드 아미드) 제제

Also Published As

Publication number Publication date
IL187056A0 (en) 2008-02-09
CA2607890A1 (en) 2006-11-23
EP1888520A2 (en) 2008-02-20
AU2006247470A1 (en) 2006-11-23
KR20080008399A (ko) 2008-01-23
US7709683B2 (en) 2010-05-04
TWI387579B (zh) 2013-03-01
CN101223133A (zh) 2008-07-16
RU2007144216A (ru) 2009-06-27
WO2006124736A2 (en) 2006-11-23
US20060270873A1 (en) 2006-11-30
TW200722411A (en) 2007-06-16
CN101223133B (zh) 2012-02-29
NO20075707L (no) 2007-12-11
JP2008540658A (ja) 2008-11-20
IL187056A (en) 2013-10-31
MX2007014314A (es) 2008-02-11
NZ563124A (en) 2010-12-24
RU2407734C2 (ru) 2010-12-27
AU2006247470B2 (en) 2010-04-01
BRPI0611262A2 (pt) 2010-08-24
WO2006124736A3 (en) 2007-03-29

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