NO20075707L - Syntese av bis(tio-hydrazid-amid)salter - Google Patents
Syntese av bis(tio-hydrazid-amid)salterInfo
- Publication number
- NO20075707L NO20075707L NO20075707A NO20075707A NO20075707L NO 20075707 L NO20075707 L NO 20075707L NO 20075707 A NO20075707 A NO 20075707A NO 20075707 A NO20075707 A NO 20075707A NO 20075707 L NO20075707 L NO 20075707L
- Authority
- NO
- Norway
- Prior art keywords
- bis
- thiohydrazide amide
- solution
- thiohydrazide
- amide
- Prior art date
Links
- 230000015572 biosynthetic process Effects 0.000 title 1
- 150000003839 salts Chemical class 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- 150000001408 amides Chemical class 0.000 abstract 7
- BZLVMXJERCGZMT-UHFFFAOYSA-N Methyl tert-butyl ether Chemical compound COC(C)(C)C BZLVMXJERCGZMT-UHFFFAOYSA-N 0.000 abstract 4
- 238000000034 method Methods 0.000 abstract 4
- ZWEHNKRNPOVVGH-UHFFFAOYSA-N 2-Butanone Chemical compound CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 abstract 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 abstract 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 3
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 abstract 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 abstract 3
- WQDUMFSSJAZKTM-UHFFFAOYSA-N Sodium methoxide Chemical compound [Na+].[O-]C WQDUMFSSJAZKTM-UHFFFAOYSA-N 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 230000007935 neutral effect Effects 0.000 abstract 2
- 239000003960 organic solvent Substances 0.000 abstract 2
- 238000004108 freeze drying Methods 0.000 abstract 1
- RPDAUEIUDPHABB-UHFFFAOYSA-N potassium ethoxide Chemical compound [K+].CC[O-] RPDAUEIUDPHABB-UHFFFAOYSA-N 0.000 abstract 1
- BDAWXSQJJCIFIK-UHFFFAOYSA-N potassium methoxide Chemical compound [K+].[O-]C BDAWXSQJJCIFIK-UHFFFAOYSA-N 0.000 abstract 1
- 238000001556 precipitation Methods 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- QDRKDTQENPPHOJ-UHFFFAOYSA-N sodium ethoxide Chemical compound [Na+].CC[O-] QDRKDTQENPPHOJ-UHFFFAOYSA-N 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C327/00—Thiocarboxylic acids
- C07C327/38—Amides of thiocarboxylic acids
- C07C327/56—Amides of thiocarboxylic acids having nitrogen atoms of thiocarboxamide groups further bound to another hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US68126305P | 2005-05-16 | 2005-05-16 | |
| PCT/US2006/018653 WO2006124736A2 (en) | 2005-05-16 | 2006-05-11 | Synthesis of bis(thio-hydrazide amide) salts |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO20075707L true NO20075707L (no) | 2007-12-11 |
Family
ID=37057197
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20075707A NO20075707L (no) | 2005-05-16 | 2007-11-08 | Syntese av bis(tio-hydrazid-amid)salter |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US7709683B2 (https=) |
| EP (1) | EP1888520A2 (https=) |
| JP (1) | JP2008540658A (https=) |
| KR (1) | KR20080008399A (https=) |
| CN (1) | CN101223133B (https=) |
| AU (1) | AU2006247470B2 (https=) |
| BR (1) | BRPI0611262A2 (https=) |
| CA (1) | CA2607890A1 (https=) |
| IL (1) | IL187056A (https=) |
| MX (1) | MX2007014314A (https=) |
| NO (1) | NO20075707L (https=) |
| NZ (1) | NZ563124A (https=) |
| RU (1) | RU2407734C2 (https=) |
| TW (1) | TWI387579B (https=) |
| WO (1) | WO2006124736A2 (https=) |
| ZA (1) | ZA200709395B (https=) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI332943B (en) * | 2001-07-10 | 2010-11-11 | Synta Pharmaceuticals Corp | Taxol enhancer compounds |
| TWI252847B (en) | 2001-07-10 | 2006-04-11 | Synta Pharmaceuticals Corp | Synthesis of taxol enhancers |
| TWI297335B (en) | 2001-07-10 | 2008-06-01 | Synta Pharmaceuticals Corp | Taxol enhancer compounds |
| TWI330079B (en) | 2003-01-15 | 2010-09-11 | Synta Pharmaceuticals Corp | Treatment for cancers |
| CN1993318B (zh) | 2004-06-23 | 2012-10-03 | Synta医药公司 | 用于治疗癌症的双（硫代-酰肼酰胺）盐 |
| JP5204489B2 (ja) * | 2004-11-19 | 2013-06-05 | シンタ ファーマスーティカルズ コーポレイション | Ｈｓｐ７０発現を増加するためのビス（チオ‐ヒドラジドアミド） |
| EP1871350A1 (en) * | 2005-04-15 | 2008-01-02 | Synta Pharmaceuticals Corporation | Methods of increasing natural killer cell activity for therapy |
| WO2006113695A1 (en) * | 2005-04-15 | 2006-10-26 | Synta Pharmaceuticals Corp. | Combination cancer therapy with bis(thiohydrazide) amide compounds |
| KR20080035642A (ko) * | 2005-08-16 | 2008-04-23 | 신타 파마슈티칼스 코프. | 비스(티오-히드라지드 아미드) 제제 |
| US20100068174A1 (en) * | 2006-08-21 | 2010-03-18 | Synta Pharmaceuticals Corp. | Combination with bis (thiohydrazide amides) for treating cancer |
| TWI440632B (zh) | 2006-08-21 | 2014-06-11 | Synta Pharmaceuticals Corp | 用於治療增生性疾病的化合物 |
| EP2061451A2 (en) * | 2006-08-21 | 2009-05-27 | Synta Pharmaceuticals Corporation | Bis(thiohydrazide amides) for treating melanoma |
| WO2008024301A2 (en) * | 2006-08-21 | 2008-02-28 | Synta Pharmaceuticals Corp. | Bis(thiohydrazide amides) for use in preventing or delaying the recurrence of melanoma |
| JP2010502616A (ja) * | 2006-08-31 | 2010-01-28 | シンタ ファーマシューティカルズ コーポレーション | 癌を治療するためのビス（チオヒドラジドアミド）の組み合わせ |
| US9498528B2 (en) * | 2006-09-13 | 2016-11-22 | Genzyme Corporation | Treatment of multiple sclerosis (MS) |
| US7645904B2 (en) | 2006-09-15 | 2010-01-12 | Synta Pharmaceuticals Corp. | Purification of bis(thiohydrazide amides) |
| WO2009064374A2 (en) | 2007-11-09 | 2009-05-22 | Synta Pharmaceuticals Corp. | Oral formulations of bis(thiohydrazide amides) |
| WO2009105257A1 (en) | 2008-02-21 | 2009-08-27 | Synta Pharmaceuticals Corp. | Compounds for treating proliferative disorders |
| WO2009123704A2 (en) * | 2008-03-31 | 2009-10-08 | Synta Pharmaceuticals Corp. | Process for preparing bis(thiohydrazide amides) |
| CN102256937B (zh) | 2008-10-22 | 2014-12-17 | 辛塔医药品有限公司 | 双[硫代酰肼酰胺]化合物的过渡金属络合物 |
| MX2011004114A (es) | 2008-10-22 | 2011-08-15 | Synta Pharmaceuticals Corp | Complejos de metales de transicion de un compuesto bis (tiohidrazida amida). |
| US8525776B2 (en) * | 2008-10-27 | 2013-09-03 | Lenovo (Singapore) Pte. Ltd | Techniques for controlling operation of a device with a virtual touchscreen |
| JP5631327B2 (ja) | 2008-12-01 | 2014-11-26 | シンタ ファーマシューティカルズ コーポレーション | 増殖性障害を治療するための化合物 |
| US8822532B2 (en) | 2009-12-04 | 2014-09-02 | Synta Pharmaceuticals Corp. | Bis[thiohydrazide amide] compounds for treating leukemia |
| EP2560627A1 (en) | 2010-04-20 | 2013-02-27 | Synta Pharmaceuticals Corp. | Use of bis [thiohydrazide amide]compounds such as elesclomol for treating cancers |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2097737A5 (en) | 1970-07-14 | 1972-03-03 | Berlin Chemie Veb | Virustatic 4-substd 1-acylthiosemicarbazides -from carboxylic acid - hydrazide and isothiocyanates or from carboxylic acid chloride and 4- |
| DE2037257A1 (en) | 1970-07-28 | 1972-02-03 | Farbwerke Hoechst AG, vorm. Meister Lucius & Brüning, 6000 Frankfurt | Poly-(5-amino-1,3,4-thiadiazol-2-yl) derivs prepn - intermediates for drug and polymer prodn |
| US4012360A (en) | 1973-12-03 | 1977-03-15 | Ciba-Geigy Corporation | Bis-salicyloyl-dicarboxylic acid dihydrazides as stabilizers for polyolefines |
| JPS5091056A (https=) | 1973-12-17 | 1975-07-21 | ||
| US6013836A (en) | 1992-02-28 | 2000-01-11 | Rohm And Haas Company | Insecticidal N'-substituted-N,N'-disubstitutedhydrazines |
| FR2697752B1 (fr) | 1992-11-10 | 1995-04-14 | Rhone Poulenc Rorer Sa | Compositions antitumorales contenant des dérivés du taxane. |
| CA2232727C (en) | 1995-09-22 | 2002-03-26 | Novo Nordisk A/S | Novel variants of green fluorescent protein, gfp |
| US6235787B1 (en) | 1997-06-30 | 2001-05-22 | Hoffmann-La Roche Inc. | Hydrazine derivatives |
| GB9727524D0 (en) | 1997-12-31 | 1998-02-25 | Pharmacia & Upjohn Spa | Synergistic antitumor composition containing a biologically active ureido compound |
| TW479053B (en) | 1998-10-19 | 2002-03-11 | Agro Kanesho Co Ltd | Hydrazineoxoacetamide derivatives and pesticides |
| ES2161594B1 (es) | 1998-12-17 | 2003-04-01 | Servier Lab | Nuevos derivados de la hidrazida, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen. |
| US6322303B1 (en) | 2000-05-12 | 2001-11-27 | David M. John | Dunnage bag and method of making same |
| EP1164126A1 (de) | 2000-06-16 | 2001-12-19 | Basf Aktiengesellschaft | Salicylsäurehydrazid-Derivate, Verfahren und Zwischenprodukte zu ihrer Herstellung, sie enthaltende Mittel und ihre Verwendung zur Bekämpfung von Schadpilzen |
| US6365745B1 (en) | 2000-07-14 | 2002-04-02 | Sumika Fine Chemicals Co., Ltd. | Method for producing hydrazine derivative |
| JP2004532187A (ja) | 2001-01-25 | 2004-10-21 | ギルフォード ファーマシュウティカルズ インコーポレイテッド | 三置換カルボサイクリックサイクロフィリン結合化合物とその用途 |
| US6602907B1 (en) | 2001-06-08 | 2003-08-05 | University Of Central Florida | Treatment of breast cancer |
| TWI252847B (en) | 2001-07-10 | 2006-04-11 | Synta Pharmaceuticals Corp | Synthesis of taxol enhancers |
| TWI297335B (en) | 2001-07-10 | 2008-06-01 | Synta Pharmaceuticals Corp | Taxol enhancer compounds |
| TWI332943B (en) | 2001-07-10 | 2010-11-11 | Synta Pharmaceuticals Corp | Taxol enhancer compounds |
| US6924312B2 (en) | 2001-07-10 | 2005-08-02 | Synta Pharmaceuticals Corp. | Taxol enhancer compounds |
| TW200408407A (en) | 2001-11-30 | 2004-06-01 | Dana Farber Cancer Inst Inc | Methods and compositions for modulating the immune system and uses thereof |
| TWI330079B (en) | 2003-01-15 | 2010-09-11 | Synta Pharmaceuticals Corp | Treatment for cancers |
| CN1993318B (zh) | 2004-06-23 | 2012-10-03 | Synta医药公司 | 用于治疗癌症的双（硫代-酰肼酰胺）盐 |
| WO2006033913A2 (en) | 2004-09-16 | 2006-03-30 | Synta Pharmaceuticals Corp. | Bis (thio-hydrazide amides) for treament of hyperplasia |
| JP5204489B2 (ja) | 2004-11-19 | 2013-06-05 | シンタ ファーマスーティカルズ コーポレイション | Ｈｓｐ７０発現を増加するためのビス（チオ‐ヒドラジドアミド） |
| WO2006113695A1 (en) | 2005-04-15 | 2006-10-26 | Synta Pharmaceuticals Corp. | Combination cancer therapy with bis(thiohydrazide) amide compounds |
| EP1871350A1 (en) | 2005-04-15 | 2008-01-02 | Synta Pharmaceuticals Corporation | Methods of increasing natural killer cell activity for therapy |
| WO2006113493A2 (en) | 2005-04-15 | 2006-10-26 | Synta Pharmaceuticals Corp. | Methods of determining cancer prognosis via natural killer cell activity |
| KR20080035642A (ko) | 2005-08-16 | 2008-04-23 | 신타 파마슈티칼스 코프. | 비스(티오-히드라지드 아미드) 제제 |
-
2006
- 2006-05-11 KR KR1020077028282A patent/KR20080008399A/ko not_active Ceased
- 2006-05-11 CN CN2006800170928A patent/CN101223133B/zh not_active Expired - Fee Related
- 2006-05-11 BR BRPI0611262-5A patent/BRPI0611262A2/pt not_active IP Right Cessation
- 2006-05-11 CA CA002607890A patent/CA2607890A1/en not_active Abandoned
- 2006-05-11 MX MX2007014314A patent/MX2007014314A/es active IP Right Grant
- 2006-05-11 NZ NZ563124A patent/NZ563124A/en not_active IP Right Cessation
- 2006-05-11 RU RU2007144216/04A patent/RU2407734C2/ru not_active IP Right Cessation
- 2006-05-11 EP EP06770334A patent/EP1888520A2/en not_active Withdrawn
- 2006-05-11 AU AU2006247470A patent/AU2006247470B2/en not_active Ceased
- 2006-05-11 US US11/432,307 patent/US7709683B2/en not_active Expired - Fee Related
- 2006-05-11 JP JP2008512390A patent/JP2008540658A/ja active Pending
- 2006-05-11 WO PCT/US2006/018653 patent/WO2006124736A2/en not_active Ceased
- 2006-05-12 TW TW095116857A patent/TWI387579B/zh not_active IP Right Cessation
-
2007
- 2007-10-31 IL IL187056A patent/IL187056A/en not_active IP Right Cessation
- 2007-10-31 ZA ZA200709395A patent/ZA200709395B/xx unknown
- 2007-11-08 NO NO20075707A patent/NO20075707L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| IL187056A0 (en) | 2008-02-09 |
| CA2607890A1 (en) | 2006-11-23 |
| EP1888520A2 (en) | 2008-02-20 |
| AU2006247470A1 (en) | 2006-11-23 |
| KR20080008399A (ko) | 2008-01-23 |
| ZA200709395B (en) | 2008-10-29 |
| US7709683B2 (en) | 2010-05-04 |
| TWI387579B (zh) | 2013-03-01 |
| CN101223133A (zh) | 2008-07-16 |
| RU2007144216A (ru) | 2009-06-27 |
| WO2006124736A2 (en) | 2006-11-23 |
| US20060270873A1 (en) | 2006-11-30 |
| TW200722411A (en) | 2007-06-16 |
| CN101223133B (zh) | 2012-02-29 |
| JP2008540658A (ja) | 2008-11-20 |
| IL187056A (en) | 2013-10-31 |
| MX2007014314A (es) | 2008-02-11 |
| NZ563124A (en) | 2010-12-24 |
| RU2407734C2 (ru) | 2010-12-27 |
| AU2006247470B2 (en) | 2010-04-01 |
| BRPI0611262A2 (pt) | 2010-08-24 |
| WO2006124736A3 (en) | 2007-03-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |