AU2006247470B2 - Synthesis of bis(thio-hydrazide amide) salts - Google Patents

Synthesis of bis(thio-hydrazide amide) salts Download PDF

Info

Publication number
AU2006247470B2
AU2006247470B2 AU2006247470A AU2006247470A AU2006247470B2 AU 2006247470 B2 AU2006247470 B2 AU 2006247470B2 AU 2006247470 A AU2006247470 A AU 2006247470A AU 2006247470 A AU2006247470 A AU 2006247470A AU 2006247470 B2 AU2006247470 B2 AU 2006247470B2
Authority
AU
Australia
Prior art keywords
methyl
thio
bis
hydrazide amide
organic solvent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2006247470A
Other languages
English (en)
Other versions
AU2006247470A1 (en
Inventor
Shoujun Chen
Zhi-Qiang Xia
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Synta Phamaceuticals Corp
Original Assignee
Synta Phamaceuticals Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synta Phamaceuticals Corp filed Critical Synta Phamaceuticals Corp
Publication of AU2006247470A1 publication Critical patent/AU2006247470A1/en
Application granted granted Critical
Publication of AU2006247470B2 publication Critical patent/AU2006247470B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00—Thiocarboxylic acids
    • C07C327/38—Amides of thiocarboxylic acids
    • C07C327/56—Amides of thiocarboxylic acids having nitrogen atoms of thiocarboxamide groups further bound to another hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AU2006247470A 2005-05-16 2006-05-11 Synthesis of bis(thio-hydrazide amide) salts Ceased AU2006247470B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US68126305P 2005-05-16 2005-05-16
US60/681,263 2005-05-16
PCT/US2006/018653 WO2006124736A2 (en) 2005-05-16 2006-05-11 Synthesis of bis(thio-hydrazide amide) salts

Publications (2)

Publication Number Publication Date
AU2006247470A1 AU2006247470A1 (en) 2006-11-23
AU2006247470B2 true AU2006247470B2 (en) 2010-04-01

Family

ID=37057197

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2006247470A Ceased AU2006247470B2 (en) 2005-05-16 2006-05-11 Synthesis of bis(thio-hydrazide amide) salts

Country Status (16)

Country Link
US (1) US7709683B2 (https=)
EP (1) EP1888520A2 (https=)
JP (1) JP2008540658A (https=)
KR (1) KR20080008399A (https=)
CN (1) CN101223133B (https=)
AU (1) AU2006247470B2 (https=)
BR (1) BRPI0611262A2 (https=)
CA (1) CA2607890A1 (https=)
IL (1) IL187056A (https=)
MX (1) MX2007014314A (https=)
NO (1) NO20075707L (https=)
NZ (1) NZ563124A (https=)
RU (1) RU2407734C2 (https=)
TW (1) TWI387579B (https=)
WO (1) WO2006124736A2 (https=)
ZA (1) ZA200709395B (https=)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI332943B (en) * 2001-07-10 2010-11-11 Synta Pharmaceuticals Corp Taxol enhancer compounds
TWI252847B (en) 2001-07-10 2006-04-11 Synta Pharmaceuticals Corp Synthesis of taxol enhancers
TWI297335B (en) 2001-07-10 2008-06-01 Synta Pharmaceuticals Corp Taxol enhancer compounds
TWI330079B (en) 2003-01-15 2010-09-11 Synta Pharmaceuticals Corp Treatment for cancers
CN1993318B (zh) 2004-06-23 2012-10-03 Synta医药公司 用于治疗癌症的双（硫代-酰肼酰胺）盐
JP5204489B2 (ja) * 2004-11-19 2013-06-05 シンタ ファーマスーティカルズ コーポレイション Ｈｓｐ７０発現を増加するためのビス（チオ‐ヒドラジドアミド）
EP1871350A1 (en) * 2005-04-15 2008-01-02 Synta Pharmaceuticals Corporation Methods of increasing natural killer cell activity for therapy
WO2006113695A1 (en) * 2005-04-15 2006-10-26 Synta Pharmaceuticals Corp. Combination cancer therapy with bis(thiohydrazide) amide compounds
KR20080035642A (ko) * 2005-08-16 2008-04-23 신타 파마슈티칼스 코프. 비스(티오-히드라지드 아미드) 제제
US20100068174A1 (en) * 2006-08-21 2010-03-18 Synta Pharmaceuticals Corp. Combination with bis (thiohydrazide amides) for treating cancer
TWI440632B (zh) 2006-08-21 2014-06-11 Synta Pharmaceuticals Corp 用於治療增生性疾病的化合物
EP2061451A2 (en) * 2006-08-21 2009-05-27 Synta Pharmaceuticals Corporation Bis(thiohydrazide amides) for treating melanoma
WO2008024301A2 (en) * 2006-08-21 2008-02-28 Synta Pharmaceuticals Corp. Bis(thiohydrazide amides) for use in preventing or delaying the recurrence of melanoma
JP2010502616A (ja) * 2006-08-31 2010-01-28 シンタ ファーマシューティカルズ コーポレーション 癌を治療するためのビス（チオヒドラジドアミド）の組み合わせ
US9498528B2 (en) * 2006-09-13 2016-11-22 Genzyme Corporation Treatment of multiple sclerosis (MS)
US7645904B2 (en) 2006-09-15 2010-01-12 Synta Pharmaceuticals Corp. Purification of bis(thiohydrazide amides)
WO2009064374A2 (en) 2007-11-09 2009-05-22 Synta Pharmaceuticals Corp. Oral formulations of bis(thiohydrazide amides)
WO2009105257A1 (en) 2008-02-21 2009-08-27 Synta Pharmaceuticals Corp. Compounds for treating proliferative disorders
WO2009123704A2 (en) * 2008-03-31 2009-10-08 Synta Pharmaceuticals Corp. Process for preparing bis(thiohydrazide amides)
CN102256937B (zh) 2008-10-22 2014-12-17 辛塔医药品有限公司 双[硫代酰肼酰胺]化合物的过渡金属络合物
MX2011004114A (es) 2008-10-22 2011-08-15 Synta Pharmaceuticals Corp Complejos de metales de transicion de un compuesto bis (tiohidrazida amida).
US8525776B2 (en) * 2008-10-27 2013-09-03 Lenovo (Singapore) Pte. Ltd Techniques for controlling operation of a device with a virtual touchscreen
JP5631327B2 (ja) 2008-12-01 2014-11-26 シンタ ファーマシューティカルズ コーポレーション 増殖性障害を治療するための化合物
US8822532B2 (en) 2009-12-04 2014-09-02 Synta Pharmaceuticals Corp. Bis[thiohydrazide amide] compounds for treating leukemia
EP2560627A1 (en) 2010-04-20 2013-02-27 Synta Pharmaceuticals Corp. Use of bis [thiohydrazide amide]compounds such as elesclomol for treating cancers

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003006428A1 (en) * 2001-07-10 2003-01-23 Synta Pharmaceuticals Corp. Taxol enhancer compounds
US20030119914A1 (en) * 2001-07-10 2003-06-26 Shionogi Bioresearch Corp. Taxol enhancer compounds
WO2006009940A1 (en) * 2004-06-23 2006-01-26 Synta Pharmaceuticals Corp. Bis(thio-hydrazide amide) salts for treatment of cancers

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2097737A5 (en) 1970-07-14 1972-03-03 Berlin Chemie Veb Virustatic 4-substd 1-acylthiosemicarbazides -from carboxylic acid - hydrazide and isothiocyanates or from carboxylic acid chloride and 4-
DE2037257A1 (en) 1970-07-28 1972-02-03 Farbwerke Hoechst AG, vorm. Meister Lucius & Brüning, 6000 Frankfurt Poly-(5-amino-1,3,4-thiadiazol-2-yl) derivs prepn - intermediates for drug and polymer prodn
US4012360A (en) 1973-12-03 1977-03-15 Ciba-Geigy Corporation Bis-salicyloyl-dicarboxylic acid dihydrazides as stabilizers for polyolefines
JPS5091056A (https=) 1973-12-17 1975-07-21
US6013836A (en) 1992-02-28 2000-01-11 Rohm And Haas Company Insecticidal N'-substituted-N,N'-disubstitutedhydrazines
FR2697752B1 (fr) 1992-11-10 1995-04-14 Rhone Poulenc Rorer Sa Compositions antitumorales contenant des dérivés du taxane.
CA2232727C (en) 1995-09-22 2002-03-26 Novo Nordisk A/S Novel variants of green fluorescent protein, gfp
US6235787B1 (en) 1997-06-30 2001-05-22 Hoffmann-La Roche Inc. Hydrazine derivatives
GB9727524D0 (en) 1997-12-31 1998-02-25 Pharmacia & Upjohn Spa Synergistic antitumor composition containing a biologically active ureido compound
TW479053B (en) 1998-10-19 2002-03-11 Agro Kanesho Co Ltd Hydrazineoxoacetamide derivatives and pesticides
ES2161594B1 (es) 1998-12-17 2003-04-01 Servier Lab Nuevos derivados de la hidrazida, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen.
US6322303B1 (en) 2000-05-12 2001-11-27 David M. John Dunnage bag and method of making same
EP1164126A1 (de) 2000-06-16 2001-12-19 Basf Aktiengesellschaft Salicylsäurehydrazid-Derivate, Verfahren und Zwischenprodukte zu ihrer Herstellung, sie enthaltende Mittel und ihre Verwendung zur Bekämpfung von Schadpilzen
US6365745B1 (en) 2000-07-14 2002-04-02 Sumika Fine Chemicals Co., Ltd. Method for producing hydrazine derivative
JP2004532187A (ja) 2001-01-25 2004-10-21 ギルフォード ファーマシュウティカルズ インコーポレイテッド 三置換カルボサイクリックサイクロフィリン結合化合物とその用途
US6602907B1 (en) 2001-06-08 2003-08-05 University Of Central Florida Treatment of breast cancer
TWI252847B (en) 2001-07-10 2006-04-11 Synta Pharmaceuticals Corp Synthesis of taxol enhancers
US6924312B2 (en) 2001-07-10 2005-08-02 Synta Pharmaceuticals Corp. Taxol enhancer compounds
TW200408407A (en) 2001-11-30 2004-06-01 Dana Farber Cancer Inst Inc Methods and compositions for modulating the immune system and uses thereof
TWI330079B (en) 2003-01-15 2010-09-11 Synta Pharmaceuticals Corp Treatment for cancers
WO2006033913A2 (en) 2004-09-16 2006-03-30 Synta Pharmaceuticals Corp. Bis (thio-hydrazide amides) for treament of hyperplasia
JP5204489B2 (ja) 2004-11-19 2013-06-05 シンタ ファーマスーティカルズ コーポレイション Ｈｓｐ７０発現を増加するためのビス（チオ‐ヒドラジドアミド）
WO2006113695A1 (en) 2005-04-15 2006-10-26 Synta Pharmaceuticals Corp. Combination cancer therapy with bis(thiohydrazide) amide compounds
EP1871350A1 (en) 2005-04-15 2008-01-02 Synta Pharmaceuticals Corporation Methods of increasing natural killer cell activity for therapy
WO2006113493A2 (en) 2005-04-15 2006-10-26 Synta Pharmaceuticals Corp. Methods of determining cancer prognosis via natural killer cell activity
KR20080035642A (ko) 2005-08-16 2008-04-23 신타 파마슈티칼스 코프. 비스(티오-히드라지드 아미드) 제제

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003006428A1 (en) * 2001-07-10 2003-01-23 Synta Pharmaceuticals Corp. Taxol enhancer compounds
US20030045518A1 (en) * 2001-07-10 2003-03-06 Shionogi Bioresearch Corp. Taxol enhancer compounds
US20030119914A1 (en) * 2001-07-10 2003-06-26 Shionogi Bioresearch Corp. Taxol enhancer compounds
WO2006009940A1 (en) * 2004-06-23 2006-01-26 Synta Pharmaceuticals Corp. Bis(thio-hydrazide amide) salts for treatment of cancers

Also Published As

Publication number Publication date
IL187056A0 (en) 2008-02-09
CA2607890A1 (en) 2006-11-23
EP1888520A2 (en) 2008-02-20
AU2006247470A1 (en) 2006-11-23
KR20080008399A (ko) 2008-01-23
ZA200709395B (en) 2008-10-29
US7709683B2 (en) 2010-05-04
TWI387579B (zh) 2013-03-01
CN101223133A (zh) 2008-07-16
RU2007144216A (ru) 2009-06-27
WO2006124736A2 (en) 2006-11-23
US20060270873A1 (en) 2006-11-30
TW200722411A (en) 2007-06-16
CN101223133B (zh) 2012-02-29
NO20075707L (no) 2007-12-11
JP2008540658A (ja) 2008-11-20
IL187056A (en) 2013-10-31
MX2007014314A (es) 2008-02-11
NZ563124A (en) 2010-12-24
RU2407734C2 (ru) 2010-12-27
BRPI0611262A2 (pt) 2010-08-24
WO2006124736A3 (en) 2007-03-29

Similar Documents

Publication Publication Date Title
AU2006247470B2 (en) Synthesis of bis(thio-hydrazide amide) salts
AU2002316625B2 (en) Synthesis of taxol enhancers
RU2007101898A (ru) Соли бис (тиогидразидамида) для лечения рака
TWI635089B (zh) 螺氧基吲哚衍生物之製造方法
ZA200401054B (en) Taxol enhancer compounds
AU2002354641A1 (en) Taxol enhancer compounds
AU2002316625A1 (en) Synthesis of taxol enhancers
JP2021512146A (ja) キャップ依存性エンドヌクレアーゼ阻害剤
ES2989922T3 (es) Compuestos de carborano y métodos de uso de los mismos
JP2008540658A5 (https=)
WO2009073147A2 (en) Process for preparing bis(thiohydrazide amides)
US9409868B2 (en) Inhibitors of rho associated protein kinases (ROCK) and methods of use
CN117645581A (zh) 一种光催化惰性C(sp3)-H键的系列官能团化合成方法
CN108822002B (zh) 一种超声辅助合成n-芳基磺酰胺的方法
EA018921B1 (ru) Способ синтеза производных 3,6-дигидро-1,3,5-триазина
CN114149353A (zh) 一类n-烷基/n-芳基硫代酰胺衍生物及其合成方法和应用
MXPA04009777A (es) Proceso para preparar sales de acido de gemifloxacin.
CN104583204A (zh) 用于合成取代的γ内酰胺的方法
CN113214224B (zh) 多取代3-亚甲基异吲哚啉酮衍生物的制备方法
CN104761568B (zh) 一类四环萘并噁唑衍生物及其制备方法
CN104961670B (zh) 一种n,o‑双取代的酮亚胺衍生物的制备方法
CN107573302A (zh) 芳基哌嗪化合物及其制备方法和用途
CN104710430B (zh) 一种氨基咔唑类化合物的合成方法
KR20070107119A (ko) 일반적으로 세포독성, 특히 아폽토시스와 관련된 유해상태의 예방 및 치료용 글루타티온-ｓ-트랜스퍼라제 및ｎａｄｐｈ 퀴논 옥시도-리덕타제의 유도인자인[1,2,4]-디티아졸린 및 -디티아졸리딘 유도체
CN107954983A (zh) 嘧啶酮类化合物及其用途

Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired