CN101222933A - 具有抗菌活性的半合成糖肽 - Google Patents

具有抗菌活性的半合成糖肽 Download PDF

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Publication number
CN101222933A
CN101222933A CNA2006800146971A CN200680014697A CN101222933A CN 101222933 A CN101222933 A CN 101222933A CN A2006800146971 A CNA2006800146971 A CN A2006800146971A CN 200680014697 A CN200680014697 A CN 200680014697A CN 101222933 A CN101222933 A CN 101222933A
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CN
China
Prior art keywords
amino
alkyl
aryl
heteroaryl
replacement
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CNA2006800146971A
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English (en)
Chinese (zh)
Inventor
D·楚
M·普列奥布拉任卡娅
S·普林特塞夫斯卡娅
E·奥尔苏夫耶瓦
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis Vaccines and Diagnostics Inc
Original Assignee
Novartis Vaccines and Diagnostics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Vaccines and Diagnostics Inc filed Critical Novartis Vaccines and Diagnostics Inc
Publication of CN101222933A publication Critical patent/CN101222933A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/14—Peptides containing saccharide radicals; Derivatives thereof, e.g. bleomycin, phleomycin, muramylpeptides or vancomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C07K9/006—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure
    • C07K9/008—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure directly attached to a hetero atom of the saccharide radical, e.g. actaplanin, avoparcin, ristomycin, vancomycin

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CNA2006800146971A 2005-02-28 2006-02-27 具有抗菌活性的半合成糖肽 Pending CN101222933A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US65729705P 2005-02-28 2005-02-28
US60/657,297 2005-02-28

Publications (1)

Publication Number Publication Date
CN101222933A true CN101222933A (zh) 2008-07-16

Family

ID=36941732

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA2006800146971A Pending CN101222933A (zh) 2005-02-28 2006-02-27 具有抗菌活性的半合成糖肽

Country Status (10)

Country Link
US (1) US7632918B2 (enExample)
EP (1) EP1861115A4 (enExample)
JP (2) JP2008531702A (enExample)
KR (1) KR20080004455A (enExample)
CN (1) CN101222933A (enExample)
AU (1) AU2006218665A1 (enExample)
BR (1) BRPI0607702A2 (enExample)
CA (1) CA2600453A1 (enExample)
MX (1) MX2007010478A (enExample)
WO (1) WO2006093947A2 (enExample)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101928330A (zh) * 2009-06-26 2010-12-29 上海来益生物药物研究开发中心有限责任公司 一种新的化合物及其应用
CN101343313B (zh) * 2008-09-03 2011-11-16 南京农业大学 一种葡萄糖二肽类化合物及其制备方法和用途
WO2018010476A1 (zh) * 2016-07-15 2018-01-18 上海来益生物药物研究开发中心有限责任公司 糖肽类衍生物及其药学可接受的盐、制备方法和应用
CN108774158A (zh) * 2018-06-20 2018-11-09 南京肽业生物科技有限公司 一种Fmoc和疏水性氨基酸的反应
CN109422800A (zh) * 2017-08-22 2019-03-05 复旦大学 抗革兰氏阳性菌季铵盐糖肽类化合物及其药用用途
WO2020057422A1 (zh) * 2018-09-21 2020-03-26 中国科学院上海药物研究所 一类万古霉素硫鎓衍生物、其制备方法、药物组合物和用途

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070185015A1 (en) * 2005-02-28 2007-08-09 Chiron Corporation and North China Pharmaceutical Corporation Semi-synthetic desmethyl-vancomycin-based glycopeptides with antibiotic activity
US7632918B2 (en) 2005-02-28 2009-12-15 Novartis Vaccines And Diagnostics, Inc. Semi-synthetic glycopeptides with antibiotic activity
US7368422B2 (en) * 2005-02-28 2008-05-06 Novartis Vaccines And Diagnostics Inc. Semi-synthetic rearranged vancomycin/desmethyl-vancomycin-based glycopeptides with antibiotic activity
KR20100109936A (ko) * 2007-12-26 2010-10-11 리드 테라퓨틱스, 인크. 항박테리아제로서의 신규한 반(半)-합성 글리코펩티드
WO2010048340A2 (en) * 2008-10-24 2010-04-29 Lead Therapeutics, Inc. Novel semi-synthetic glycopeptides as antibacterial agents
GB2465863A (en) * 2008-12-05 2010-06-09 Lead Therapeutics Inc Semi-synthetic heptapeptidic glycopeptides for the treatment of bacterial infections
CA2972276A1 (en) 2014-12-25 2016-06-30 Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR) Glycopeptides and uses thereof
EP3281942A4 (en) * 2015-09-16 2018-08-15 Xuanzhu Pharma Co., Ltd. B-lactamase inhibitor and application thereof
IL270686B (en) * 2017-05-22 2022-09-01 Insmed Inc Derivatives of glycopeptides and their uses
JP2022511715A (ja) * 2018-11-21 2022-02-01 インスメッド インコーポレイテッド グリコペプチド誘導体化合物およびそれらの使用
JP2023091200A (ja) * 2021-12-20 2023-06-30 花王株式会社 有機化合物、試薬、及び分析方法

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3011278B1 (de) 1980-03-24 1981-04-02 Rohde & Schwarz GmbH & Co KG, 8000 München Funkpeiler
US4698327A (en) 1985-04-25 1987-10-06 Eli Lilly And Company Novel glycopeptide derivatives
GB8522574D0 (en) 1985-09-12 1985-10-16 Lepetit Spa Amides of teicoplanin compounds
GB8701872D0 (en) 1987-01-28 1987-03-04 Lepetit Spa N15-alkyl & n15,n15-dialkyl derivatives
CA1339808C (en) 1988-10-19 1998-04-07 Manuel Debono Glycopeptide antibiotics
US5500410A (en) 1989-03-29 1996-03-19 Gruppo Lepetit S.P.A. Substituted alkylamide derivatives of teicoplanin
US5840684A (en) 1994-01-28 1998-11-24 Eli Lilly And Company Glycopeptide antibiotic derivatives
TW457248B (en) 1994-01-28 2001-10-01 Lilly Co Eli Glycopeptide antibiotic derivatives
US5488131A (en) 1994-03-23 1996-01-30 California Institute Of Technology Synthesis of compounds with predetermined chirality
US5919756A (en) * 1996-06-28 1999-07-06 Eli Lilly And Company Amides
BRPI9914221B8 (pt) * 1998-12-23 2021-05-25 Advanced Medicine Inc derivados de glicopeptídeos e composições farmacêuticas contendo os mesmos
CA2370782A1 (en) 1999-04-02 2000-10-12 The Trustees Of Princeton University Desleucyl glycopeptide antibiotics and methods of making same
US6699836B2 (en) 1999-04-02 2004-03-02 The Trustees Of Princeton University Vancomycin analogs
US6498238B1 (en) 1999-05-19 2002-12-24 Princeton University Glycopeptide antibacterial compounds, compositions containing same and methods of using same
JP2003522197A (ja) 2000-02-11 2003-07-22 イーライ リリー アンド カンパニー Ａ８２８４６グリコペプチドアナログの選択的ｎ−アシル化
US20030008812A1 (en) 2001-02-02 2003-01-09 Christensen Burton G. Glycopeptide derivatives
US7348309B2 (en) 2001-03-30 2008-03-25 Wisconsin Alumni Research Foundation Glycorandomization and production of novel vancomycin analogs
KR20060091049A (ko) 2002-08-30 2006-08-17 케이.유.루벤 리서치 앤드 디벨럽먼트 글리코펩티드 항생제 및 그것의 반합성 유도체 및 항바이러스제로서의 그것의 사용
AU2003287605A1 (en) 2002-11-12 2004-06-03 Enzon Pharmaceuticals, Inc. Polymeric prodrugs of vancomycin
US7521418B2 (en) * 2003-05-27 2009-04-21 Theravance, Inc. Use of a polyene macrolide antifungal agent in combination with a glycopeptide antibacterial agent
US7368422B2 (en) 2005-02-28 2008-05-06 Novartis Vaccines And Diagnostics Inc. Semi-synthetic rearranged vancomycin/desmethyl-vancomycin-based glycopeptides with antibiotic activity
US20070185015A1 (en) 2005-02-28 2007-08-09 Chiron Corporation and North China Pharmaceutical Corporation Semi-synthetic desmethyl-vancomycin-based glycopeptides with antibiotic activity
US7632918B2 (en) 2005-02-28 2009-12-15 Novartis Vaccines And Diagnostics, Inc. Semi-synthetic glycopeptides with antibiotic activity

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101343313B (zh) * 2008-09-03 2011-11-16 南京农业大学 一种葡萄糖二肽类化合物及其制备方法和用途
CN101928330A (zh) * 2009-06-26 2010-12-29 上海来益生物药物研究开发中心有限责任公司 一种新的化合物及其应用
CN101928330B (zh) * 2009-06-26 2013-10-16 上海来益生物药物研究开发中心有限责任公司 一种新的化合物及其应用
WO2018010476A1 (zh) * 2016-07-15 2018-01-18 上海来益生物药物研究开发中心有限责任公司 糖肽类衍生物及其药学可接受的盐、制备方法和应用
CN109422800A (zh) * 2017-08-22 2019-03-05 复旦大学 抗革兰氏阳性菌季铵盐糖肽类化合物及其药用用途
CN108774158A (zh) * 2018-06-20 2018-11-09 南京肽业生物科技有限公司 一种Fmoc和疏水性氨基酸的反应
WO2020057422A1 (zh) * 2018-09-21 2020-03-26 中国科学院上海药物研究所 一类万古霉素硫鎓衍生物、其制备方法、药物组合物和用途

Also Published As

Publication number Publication date
US7632918B2 (en) 2009-12-15
AU2006218665A1 (en) 2006-09-08
JP2008531702A (ja) 2008-08-14
EP1861115A2 (en) 2007-12-05
BRPI0607702A2 (pt) 2009-11-03
EP1861115A4 (en) 2011-03-16
JP2009102446A (ja) 2009-05-14
CA2600453A1 (en) 2006-09-08
KR20080004455A (ko) 2008-01-09
WO2006093947A2 (en) 2006-09-08
US20060276623A1 (en) 2006-12-07
WO2006093947A3 (en) 2007-05-31
MX2007010478A (es) 2008-02-07

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C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication

Open date: 20080716